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Archive of SID ﭘﮋوﻫﺸﯽ ﻣﺠ ــ ﻠـــ ـ داﻧ ــﻪ ـ ﺸـــــﮕﺎه ـ ـ ﭘـﺰﺷ ــــــﻮم ــ ﻣــ ﮑـــــــﯽ ـ ﺎزﻧـــ ــ ــــﺪران دوره ﻫﻔ ﺷﻤﺎره ﺪﻫﻢ57 اردﯾﺒﻬﺸﺖ و ﻓﺮوردﯾﻦ ﺳﺎل1386 ) 31 - 25 ( ﭘﺰﺷﮑﯽ ﻋﻠﻮم داﻧﺸﮕﺎه ﻣﺠﻠﻪ ﻣﺎزﻧﺪران دوره ﻫﻔﺪ ﺷﻤﺎره، ﻫﻢ57 ، اردﯾﺒﻬﺸﺖ و ﻓﺮوردﯾﻦ1386 25 ﻣﻘﺎﯾﺴﻪ اﺛﺮ درﻣﺎن در ﻓﯿﻨﺎﺳﺘﺮاﯾﺪ ﻗﺮص و ژل ﻣﺮداﻧﻪ ﻣﻮی ﻃﺎﺳﯽ ﺣﯿﺪری ﺣﺎج زﻫﺮه+ * (M.D.) اﮐﺒﺮی ﺟﻌﻔﺮ**(Ph.D.) ﺳﻌﯿﺪی ﻣﺠﯿﺪ**(Ph.D.) ﺷﮑﻮﻫﯽ ﻟﯿﻼ***(M.D.) ﭼﮑﯿﺪه ﺳــﺎﺑﻘﻪ ﻫــﺪف و: ﺗﯿــﭗ ﻣﻬﺎرﮐﻨﻨــﺪه ﻓﯿﻨﺎﺳــﺘﺮاﯾﺪII آﻧــﺰﯾﻢ5 ﻣــﯽ آﻟﻔﺎردوﮐﺘــﺎز ﻣﻘــﺎدﯾﺮ ﮐــﺎﻫﺶ ﺑﺎﻋــﺚ ﮐــﻪ ﺑﺎﺷــﺪ دﻫﯿﺪروﺗﺴ درﻣﺎن در و ﺷﺪه ﺘﻮﺳﺘﺮون ﻣﺮداﻧﻪ ﻣﻮی ﻃﺎﺳﯽ ﻣﺆﺛﺮ اﺳﺖ. در ﻣﻄﺎﻟﻌﻪ اﯾﻦ اﺛﺮ ﺑﺎ ﻣﻮﺿﻌﯽ ﻓﯿﻨﺎﺳﺘﺮاﯾﺪ ﻧﻮع ﺧـﻮراﮐﯽ آن در درﻣﺎن ﮔﯿﺮد ﻣﯽ ﻗﺮار ﻣﻘﺎﯾﺴﻪ ﻣﻮرد ﺑﯿﻤﺎری اﯾﻦ. روش و ﻣﻮاد ﻫﺎ: ﻣﻄﺎﻟﻌﻪ ﻧﻮع از دوﺳﻮﮐﻮر ﺑﺎﻟﯿﻨﯽ ﮐﺎرآزﻣﺎﯾﯽ ﻣﯽ ﺑﺎﺷﺪ. 45 درﻣﺎﻧﮕﺎه ﺑﻪ ﻣﺮاﺟﻌﯿﻦ از ﺑﺎﻟﻎ ﻣﺮد ﺑﯿﻤﺎر و ﻫﺎ ﻣﻄﺐ ﻣﺒﺘﻼ ﺑﺎﻟﯿﻨﯽ وﻣﻌﺎﯾﻨﻪ ﺣﺎل ﺷﺮح ﺑﺮاﺳﺎس ﮐﻪ ﺳﺎری ﺷﻬﺮ ﺧﺼﻮﺻﯽ ﻫﺎی ﻣﻄﺎﻟﻌﻪ ﺑﻪ ورود ﻣﻌﯿﺎرﻫﺎی و ﺑﻮدﻧﺪ ﻣﺮداﻧﻪ ﻃﺎﺳﯽ ﺑﻪ ﺷﺪﻧﺪ اﻧﺘﺨﺎب داﺷﺘﻨﺪ را. ﺑﯿﻤﺎران ﺗﺼﺎدﻓﯽ ﺻﻮرت ﺑﻪ و ﺷﺪه ﻣﻄﺎﻟﻌﻪ وارد ﻣﺎه ﺷﺶ ﻃﯽ در ﺷﺮاﯾﻂ واﺟﺪ ﮔﺮوه دو ﺑﻪA ) ژل ﭘﻼﺳﺒﻮ ﻗﺮص و ﻓﯿﻨﺎﺳﺘﺮاﯾﺪ( ﮔﺮوه وB ) ﻗﺮص ﯿﻨ ﭘﻼﺳﺒﻮ ژل و ﺎﺳﺘﺮاﯾﺪ( ﺷﺪﻧﺪ ﺗﻘﺴﯿﻢ. ﺟﻬﺖ دارو ﺗﺎﺛﯿﺮ ارزﯾﺎﺑﯽ، و ﺑﻬﺒﻮدی ﺳﯿﺮ ﻋﻮارض ﺑﯿﻤﺎران آن، از ﻗﺒﻞ در درﻣﺎن، ﺷﺪﻧﺪ ﭘﯿﮕﯿﺮی ﺑﺎﻟﯿﻨﯽ ﻣﺸﺎﻫﺪات ﺑﺎ ﻣﺎه ﻫﺮ ﭘﺎﯾﺎن در ﺳﭙﺲ و اول ﻫﻔﺘﻪ ﭘﺎﯾﺎن و ﻣﺘﻐﯿﺮﻫﺎی ﺿﺎﯾﻌﻪ، وﺳﻌﺖ ﺿﺨﯿﻢ ﻣﻮی ﺗﻌﺪاد و ﻣﻮ ﺗﻌﺪاد ﺷﺪ ﺑﺮرﺳﯽ ﻧﺪ. آﻣﺎری ﺗﺤﻠﯿﻞ و ﺗﺠﺰﯾﻪ ﻓﺮﻣﻮل ﺎی آﻣﺎر ی دو ﮐﺎی و ﺗﻮﺻﯿﻔﯽ ﺷﺪ اﻧﺠﺎم. ﯾﺎﻓﺘﻪ ﻫﺎ: ﺑﯿﻤﺎران در ﻣﻮ رﯾﺰش زﻣﺎن ﻣﺘﻮﺳﻂ8 / 18 ± 10 / 23 ﺑﻮد ﻣﺎه. داری ﻣﻌﻨﯽ ﺗﻔﺎوت ﯿﻦ ﺿﺨﺎﻣﺖ ﻧﻈﺮ از ﮔﺮوه دو و ﺗﻌﺪاد ﻣﻮ وﺳﻌﺖ و ﻃﺎﺳﯽ ﻣﻨﻄﻘﻪ ﻧﺪاﺷﺖ وﺟﻮد ﻣﺎه ﻫﺮ ﭘﺎﯾﺎن در. اﻧﺪازه ﮔﯿﺮی ﺎی ﻣﺘﻮاﻟﯽ ﻣﻮﻫـ ﺗﻌـﺪاد اﻓـﺰاﯾﺶ ﮐـﻪ داد ﻧﺸﺎن و در ﺗﺮﻣﯿﻨﺎل ﻣﻮی اﻓﺰاﯾﺶ ﺷﺮوع در درﻣﺎﻧﯽ دوﮔﺮوه ﻫﺮ ﭘﺎﯾﺎن و ﻣﻌﻨﯽ ﺑﻮد داری. اﺳﺘﻨﺘﺎج: ﺣﺪ در ﻣﺮداﻧﻪ ﻃﺎﺳﯽ ﺑﻪ ﻣﺒﺘﻼ ﺑﯿﻤﺎران ﺑﺮ ﻓﯿﻨﺎﺳﺘﺮاﯾﺪ ﻗﺮص و ژل داروی دو ﻫﺮ درﻣﺎﻧﯽ اﺛﺮات ﮐﻪ داد ﻧﺸﺎن ﻧﺘﺎﯾﺞ ﺑﻮد ﻣﺘﻮﺳﻂ. ﮐﻠﯿﺪی ﻫﺎی واژه: آﻟﻮﭘﺴﯽ، آﻧﺪروژﻧﺘﯿﮏ ژل و ﻓﯿﻨﺎﺳﺘﺮاﯾﺪ ﻗﺮص ﻣﻘ ﺪﻣﻪ ﺷﺎﯾﻊ از ﻃﺎﺳﯽ و ﻣﻮ رﯾﺰش ﺟﻮاﻣﻊ ﻣﺸﮑﻼت ﺗﺮﯾﻦ اﻣﺮوزی ﺑﻮده ﺑﺮﺟﺎی رواﻧﯽ و اﻗﺘﺼﺎدی ﺑﺴﯿﺎر اﺛﺮات و ﻣﯽ ﮔﺬارد. در ﺳﺎل اﺧﯿﺮ ﻫﺎی ﺗﻼش ﺟﻬﺖ ﺑﺴﯿﺎری ﻫﺎی درﻣ ـ ﺎن ﻣﺸﮑﻞ اﯾﻦ ﮔﺮﻓﺘﻪ ﺻﻮرت از ﺑﺮﺧـﯽ در ﮐﻪ ﻣﻮارد ﺷﻤﺎره ﻃﯽ ﺗﺤﻘﯿﻖ اﯾﻦ40 - 82 و ﺷﺪه ﺛﺒﺖ داﻧﺸﮕﺎه ﭘﮋوﻫﺸﯽ ﺷﻮرای در اﺳﺖ ﺷﺪه اﻧﺠﺎم ﻣﺎزﻧﺪران ﭘﺰﺷﮑﯽ ﻋﻠﻮم داﻧﺸﮕﺎه ﻣﺎﻟﯽ ﺣﻤﺎﯾﺖ. * ﻋﻠﻤﯽ ﻫﯿﺎت ﻋﻀﻮ ﭘﻮﺳﺖ، ﻣﺘﺨﺼﺺ) اﺳﺘﺎدﯾﺎر( ﻣﺎزﻧﺪران ﭘﺰﺷﮑﯽ ﻋﻠﻮم داﻧﺸﮕﺎه+ ﻣﺴ ﻣﻮﻟﻒ ﻮل: ﺳﺎری- ﭘﺎﺳﺪاران ﺑﻠﻮار، ﺳﯿﻨﺎ ﺑﻮﻋﻠﯽ درﻣﺎﻧﯽ آﻣﻮزﺷﯽ ﻣﺮﮐﺰ، ﭘﻮﺳﺖ ﺑﺨﺶEmail: zhajheydari@yahoo .com ** ﻓﺎرﻣﺎﺳﯿﺘﻮﺗﯿﮑﺲ ﻣﺘﺨﺼﺺ ﻋﻠﻤﯽ ﻫﯿﺎت ﻋﻀﻮ، ) داﻧﺸﯿﺎر( ﻣﺎزﻧﺪران ﭘﺰﺷﮑﯽ ﻋﻠﻮم داﻧﺸﮕﺎه*** ﺳﺎری ﺑﻮﻋﻠﯽ ﺑﯿﻤﺎرﺳﺘﺎن درﻣﺎﻧﯽ آﻣﻮزﺷﯽ ﻣﺮﮐﺰ ﺑﺎﻟﯿﻨﯽ ﺗﺤﻘﯿﻘﺎت ﺗﻮﺳﻌﻪ واﺣﺪ ﻋﻤﻮﻣﯽ ﭘﺰﺷﮏ ﺗﺎرﯾ درﯾﺎﻓﺖ: 4 / 7 / 85 اﺻﻼﺣﺎت ﺟﻬﺖ ارﺟﺎع ﺗﺎرﯾﺦ: 27 / 8 / 85 ﺗﺼﻮﯾﺐ ﺗﺎرﯾﺦ: 9 / 12 / 85 www.SID.ir

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