-25

-20

-15

-10

-5

0

5

10

-10-15 -5 0 5 10 15 20 25 30

214 2479 4745 7011 9276 11540

●

●●

●●

●

●

●

●

●●

●

●

●

●●●● ●

●

●

●

●

●

●●

●

●

●

●

●

●

● ●

●

●

●

●

●●●●

Sco

re o

f P

C2

Score of PC1

-0.15

-0.10

-0.05

0.00

0.05

0.10

0.15

0.20

0 200 400 600 800 1000 1200 1400

-Glc

Cre

Cre

GPCPC

Cho

Taum-Ino

Lac

Chemical shift

Load

ing

of P

C1

0

2000

4000

6000

8000

10000

12000

0 2000 4000 6000 8000 10000 12000

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●

●

●●

●

●

●●

●●

●

●

●

●

●●

●●

●●

●

●

●●

●

●

● ●

●

● ●●

●

●●●

●

●●●●

Pre

dict

ed t

umor

cel

l den

sity

(ce

lls/m

m2 )

Measured tumor cell density (cells/mm2)

r = 0.80p < 0.001

C

A

B