טבלאות פרמקולוגיה קרדיו

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a table of some common drugs used to treat cardio-vascular disease - in hebrew

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- ,BP=blood pressure, CO=cardiac output, PVR=peripheral vascular resistance, HR=heart rate ..SV=stroke volume, EF=ejection fraction .BP=COPVR. CO=HRSV: 1 , - - 2 , 1> - 2 , - - 2 . , , , . - ( -). . " , , , , , , , , , . = Bioavailability %57 T1/2 = 8-12h %05 bbb 2 . NE NE- CNS - ". - SV. -venous pooling - preload -.SV - ,CNS " Centrally active sympatholy tics

" . (Neutral

= Bioavailability " " %52 ,DOPA T1/2 = 2h 3/2 -NE )False )transmitter -CNS " reuptake .NE .. -4 6 '. .

4 , Orthostatic Hypotension , 1 . .1 Lipid Neutral ( 2 .), . , . " %53> ,.EF ", , -3 Orthostatic -CHD ,Hypotension, , , , , , , .

,NE NE NE

1-. Labetalol . HR SV 1 - +. PVR 2 Carvedilo , , CO l , , = : 1 " 1:01. - 1 ,PVR ( .) - 2/1( T ). " . " 1 , -Time ,dependant EF . Prazosin

T1/24h Vd, -%09 .CNS

. .

Propranol (ol " ,Nadolol ,Timolol )Pindolol

" . , , . , "

Atenolol Acebuto )lol --5 :2/1CNS. T .8h , , ,

" >001, - MI >54,

%04 :Bioavailability T1/2: 3-4h

1 1

Metoprol ol

( ,Esmolol

. - . NSAID . ( -1 ) - . . ", , ,flushing, , . %09 . . ( ), SA/AV nodes , SA . ( "). , . .AV-node PVR Nifedipin e Dehydro pyrmidi nes

, " , , ,

"

,

, ", " -SA/AV , ", , . SA .

", , ,flushing - ( SA-nodal arrest ). . . " ( ) , , . -( bbb) - ,CNS

%09 , T1/2=30-50h %08-07 . %09

Amlodipi ne Diltiazem NonDHP

Verapami l

. '. ", " " (/ ), .." , " . IV ( ) 3 . ,PO 02-5 ( SL(, non-DHP 03 . , , DM . , , . .