, , , . E.C. Lambert ... ..

( ) 2% 15%

. .. (VII 2000 ) 400

127/18 02.04.2002 . , .

18 60 22,5% 14,9% , 3,4% , 1,5% ; 0,62% 0,2% 5 18 34,6% ,

- 300 000000

- 30 000000

- ??????????

, 34% 11% 10% 6% 6% 7% 7% 19%

1

34

11

10

6

6

7

7

19

1

34

11

10

6

6

7

7

19

(-) 1,47-1,97% (0,4%) 4,26% (1,2%) .

- . -.+/- .+ +++++-%-%-%-%-% 1291126898,21100,77110,8610,0810,081018100198,3880,7490,880 0 0076374998,1670,91 6 0,81 0,130094392998,536 0,6380,84000039238598,0330,7640,9910,250057756798,2650,865 0,86000021120295,7410,4762,8420,9500

, .

(10 ) ., 2004; .., .. .., 2001

, ,

in vitro

, ,

- - - -

- E221 ( )- 223 ()- 385 ()- 524 ( )- 218 ()

, : ; ,

:

- : , , ( ) , ( , )

(ana phylaxis ). , 1902 .

(allos ergon ), , 1906 . , , 1923 .

(, , , ).

, , . , , , , . , .

-

()

///, /-/ /

( Gell P., Coombs R., 1969)

V ( ) - , , ,

IgE- IgG1, IgG3 IgG3 TCR ( - ( ) , 10-30 , 2 2 3-8 24-48 , , , , - , , , , , , () , , , , , , ,

Th0Th1TT.Th2B

IgM IgG IgA IgE IgD

HLAII Y--2 HLA I - 4,5,10,13

IgEFabFabFc

IgE

1 , . , IgE- .

2 .

3 . , .

, 1 2-

1 + 2-

1- 2- 1) , , , , , 2) 3) , 4) 5) 6) 7) (, )8) 9) 1) 2) 3) ( 1-)4) 5) -6) 7)

1. ().

2. (, ).

3. (, ).

4. (, , ).

5. (, ).

, IgE- ( )

, ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; , , ; - ; ; ; ; , , ; - ; ; ; ; , , , , , , , ; ;

, 0,3-1 0,1% . , 0,2- 0,5 0,1% 2 10-15 .

-, 60-90 160-1200 5% .

- 0,2-1,0 0,2% 0,5-2 1% 400 5% .

10 2,4% .

1-2 2% , 2-4 0,1% , 5 1% .

0,3-0,5 0,05% , 20-40 .

2 , 10% 2 , 1,5% 2-3 , 2-4 2-4 .

- 0,5 0,1% 100 4% , ( IV 2 0,5 0,1% , 10 10% ).

0,1% - 10 .0,2% -10 .1% -10 .3% -10 .2,4% -10 .10% -10 .5% -2 500 .0,9% -10 .01% -10 .10% -10 .2% -10 .2,5% () -10

0,05% -10 . 2% ()-10 . . . 2 . (20, 10, 5, 2, 1). -2. -1. -1. 70% -100. -1.

1.

2.

3.

4. , ,

5.

6. ,

7.

Atopic dermatitis of childhood Atopic dermatitis of the folds in a child Acute exudative contact dermatitis Vesicular contact dermatitis

Scaly dry erythematous contact dermatitis Acute irritant dermatitis Atopic dermatitis of the face in an infant Infected retro-auricular dermatitis

Atopic cheilitis Atopic dermatitis in the adult: xerosis, lichenification and pruriqo Atopic dermatitis of the hands in the adult Atopic conjunctivitis

Latex contact urticaria Prick test with latex Provocative use test with latex gloves Pressure urticaria

Cold urticaria Solar urticaria Urticated weals Papular urticaria

Figured urticaria Hereditary angio-oedema Urticarial vasculitis Dermographism

Drug-induced phototoxic eruption Drug-induced photoallergic eruption Acneiform facial eruption Psoriatiform eruption

I . -

.

III .

. , , . , .

IV .

, . , , -.

I - , . - , , .

, , , ; , , ; , ; , , , , , , .

( , , , , .);

, ( ) : - , ;

, , . , . , .

I

1. ) - 30 ) - 1002. ) - 30 ) , , .. - 103. ( , , ..) ) ( , ..) - 100 ) , , .. - 404. ) - 70 ) 10 - 705. ( ) ) - 20 ) - 06. ) - 20 ) , , ; - 1007. ) , , 20

03070

(-)

.-.-/+.+.++.+++1993 3078305917200256120181939264751332 99972000

. IgE - I- ,

13,5

4-

, 76% . : - 52% ; - 24%

49%; 34%; - 9%; 5%; 2%; - 1%

80%

--- 20 - 20

-....... n=6 5015133 n=18 1611171162 n=211821192165

, , .

127/18 02.04.2002 . . ( , , .).

, :

, , , ;

( ) ;

-, , , .

-:

,

1- -

2- / /

3-

, -.!

, 70% ( 42-001 -97) , 10 , 2 ( ), ( ) ( - 5). ( ) , , 180 180 ( -). 5-10 ( ).

20 . ( 3 ) ' ( ) . ( 3 ) (, ) ( ) .

1 - , , -.

2. ( ), .

3. , , .

4. , .

5. 5 ( , ).

6. (, , ), .

7. 3 , - 7 .

, , - ( ) - , in vitro , .!!!

!!! (, ), . , .

() - , IV .

in vivo in vitro

1 : 200000 1 : 100000 -

94%77%78% 544 1,522 /3,322 20 90-120 114-192

16 1/2 6

-

95-98% , ,

. , 6% . . , . - , , , , . . 2/3 . .

10 , . , 1/6 1/4 . , . : , , . : 4 + IV=8

** 1 : 200000

, , IVV497%92%594%87%689%77%

, , . , .

, , , . . 4- 1 (1,7) 4% 1 : 200000 1 3% 10 *

No pain less stress. Vision or reality for dental patients? 4-

* , . , . , . , .