【 般若黑洞 】 出品
DESCRIPTION
PPT 宝藏 www.pptbz.com 提供下载. 基于 大分子 的. Polymeric. 肿瘤靶向. Tumor-Targeting. 药物控释. Drug Controlled Release. 【 般若黑洞 】 出品. Northwestern Polytechnic University. 定位. 释放. 装载. Targeting. Drug Release. Drug Load. 树枝状聚合物. 胶束. Dendrimers. Micelles. 装载. Drug Load. 聚合物 - 药物 偶联物. 微脂囊. - PowerPoint PPT PresentationTRANSCRIPT
【般若黑洞】出品Northwestern Polytechnic University
基于大分子的
药物控释肿瘤靶向
Polymeric
Tumor-Targeting
Drug Controlled Release
PPT 宝藏 www.pptbz.com 提供下载
Drug Load装载 定位
Targeting Drug Release释放
胶束Micelles
树枝状聚合物Dendrimers
Liposomes
微脂囊聚合物 -药物偶联物
Polymer-drugconjugates
Drug Load装载
定位
主动active
被动passive
Targeting
配合基 -受体Ligand-receptor
EPR效应EPR Effect
叶酸cRGD
正常组织癌变部位
Drug Release释放
pH
温度
降解
磁场
UV
电场
内因外因
PDEAEMA
PNIPAM
-s-s-
hydrazone bonds
多层分子设计Molecular Design
嵌段
分子量
端基
ATRP
RAFT
点击化学
超分子 星形
开环
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Priyadarsi De, Sudershan R. Gondi, and Brent S. Sumerlin
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Bhanuprasanth Koppolu, MS, Maham Rahim,
O
Si
OSi
O Si
SiO
Si
OSi
Si
OSi
OSi
OSi
O Si H
SiO
Si
O
Si
H
OSi
O Si H
SiO
Si
HN
H2N
HN
H2N
HN
H2N
HN
NH2
grafted PNIPAM Shell
β-CD based HBP Core
Thermo-Responsive Hyperbranched poly(β-CD)s-g-PNIPAM
Thank you!Polymeric Tumor-Targeting Drug Controlled Release
Northwestern Polytechnic University
PPT 宝藏 www.pptbz.com 提供下载