【 般若黑洞 】 出品

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般般般般般般 Northwestern Polytechnic Universit 般般般般般般般般般 般般般般 Polymeric Tumor-Targeting Drug Controlled Release PPT 般般 www.pptbz.com 般般般般

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PPT 宝藏 www.pptbz.com 提供下载. 基于 大分子 的. Polymeric. 肿瘤靶向. Tumor-Targeting. 药物控释. Drug Controlled Release. 【 般若黑洞 】 出品. Northwestern Polytechnic University. 定位. 释放. 装载. Targeting. Drug Release. Drug Load. 树枝状聚合物. 胶束. Dendrimers. Micelles. 装载. Drug Load. 聚合物 - 药物 偶联物. 微脂囊. - PowerPoint PPT Presentation

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Page 1: 【 般若黑洞 】 出品

【般若黑洞】出品Northwestern Polytechnic University

基于大分子的

药物控释肿瘤靶向

Polymeric

Tumor-Targeting

Drug Controlled Release

PPT 宝藏 www.pptbz.com 提供下载

Page 2: 【 般若黑洞 】 出品

Drug Load装载 定位

Targeting Drug Release释放

Page 3: 【 般若黑洞 】 出品

胶束Micelles

树枝状聚合物Dendrimers

Liposomes

微脂囊聚合物 -药物偶联物

Polymer-drugconjugates

Drug Load装载

Page 4: 【 般若黑洞 】 出品

定位

主动active

被动passive

Targeting

配合基 -受体Ligand-receptor

EPR效应EPR Effect

叶酸cRGD

Page 5: 【 般若黑洞 】 出品

正常组织癌变部位

Page 6: 【 般若黑洞 】 出品

Drug Release释放

pH

温度

降解

磁场

UV

电场

内因外因

PDEAEMA

PNIPAM

-s-s-

hydrazone bonds

Page 7: 【 般若黑洞 】 出品

多层分子设计Molecular Design

嵌段

分子量

端基

ATRP

RAFT

点击化学

超分子 星形

开环

Page 8: 【 般若黑洞 】 出品

Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy

Xiang Lan Wu, Jong Ho Kim

Page 9: 【 般若黑洞 】 出品

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles asDrug Nanocarriers for Targeted Cancer Therapy

Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla

Page 10: 【 般若黑洞 】 出品

PEG-SS-PPS: Reduction-Sensitive Disulfide Block CopolymerVesicles for Intracellular Drug Delivery

Xiang Lan Wu, Jong Ho Kim

Page 11: 【 般若黑洞 】 出品

Folate-Conjugated Thermoresponsive Block Copolymers:Highly Efficient Conjugation and Solution Self-Assembly

Priyadarsi De, Sudershan R. Gondi, and Brent S. Sumerlin

Page 12: 【 般若黑洞 】 出品

Development of multiple-layer polymeric particles for targeted andcontrolled drug delivery

Bhanuprasanth Koppolu, MS, Maham Rahim,

Page 13: 【 般若黑洞 】 出品

O

Si

OSi

O Si

SiO

Si

OSi

Si

OSi

OSi

OSi

O Si H

SiO

Si

O

Si

H

OSi

O Si H

SiO

Si

HN

H2N

HN

H2N

HN

H2N

HN

NH2

grafted PNIPAM Shell

β-CD based HBP Core

Thermo-Responsive Hyperbranched poly(β-CD)s-g-PNIPAM

Page 14: 【 般若黑洞 】 出品

Thank you!Polymeric Tumor-Targeting Drug Controlled Release

Northwestern Polytechnic University

PPT 宝藏 www.pptbz.com 提供下载