Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

الرحيم الرحمن الله الرحيم بسم الرحمن الله الرحيم بسم الرحمن الله الرحيم بسم الرحمن الله بسم

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Dr. Osama I Nassif. MD, Dr. Osama I Nassif. MD, FRCPC.FRCPC.

Associate professor & consultant Associate professor & consultant pathologist.pathologist.

Pathology Dept. King Abdullaziz Pathology Dept. King Abdullaziz University.University.

Dr. Osama I Nassif. MD, Dr. Osama I Nassif. MD, FRCPC.FRCPC.

Associate professor & consultant Associate professor & consultant pathologist.pathologist.

Pathology Dept. King Abdullaziz Pathology Dept. King Abdullaziz University.University.

NEOPLASIANEOPLASIANEOPLASIANEOPLASIA

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

NEOPLASIANEOPLASIA

What

Why

Where

When

How

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

An abnormal mass the growth of which exceeds and is uncoordinated with that of the normal tissue and persists in the same excessive manner after the cessation of stimuli which evoked the change .

Definition : Definition :

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

DIFINITIONSDIFINITIONS

TUMOR VS NEOPLASMONCOLOGY= ONCOS + LOGOSBENIGN = RELATIVELY INNOCENT MALIGNANT = CANCER ( CRAB )

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA NomenclatureNomenclature

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign tumors: oma + cell typeBenign tumors: oma + cell type

Papilloma : benign surface neoplasm

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign tumorsBenign tumors

A Polyp : mass projecting above a mucosal surface

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign tumorsBenign tumors

An Adenoma: benign epithelial neoplasm producing or arising from glands

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign tumors connective tissueBenign tumors connective tissue

Leiomyoma : A benign neoplasm of smooth muscle

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Leiomyoma Leiomyoma

DR OSAMA I NASSIF FRCPC

NEOPLASIA NEOPLASIA LEIOMYOMA HPF LEIOMYOMA HPF

NEOPLASIA NEOPLASIA LEIOMYOMA HPF LEIOMYOMA HPF

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

NomenclatureNomenclature

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign tumorsBenign tumors

Fibroadenoma :

more than one cell type ,

from one germ layer

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign tumorsBenign tumors

Mixed tumor of salivary glands (pleomorphic adenoma) Derived from one germ layer

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

NomenclatureNomenclature

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign neoplasmsBenign neoplasms

Mature teratoma :more than one neoplastic cell type derived from more Mature teratoma :more than one neoplastic cell type derived from more than one germ layer.than one germ layer.

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Malignant tumorsMalignant tumors

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign Vs malignant Benign Vs malignant

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Malignant neoplasmsdifferentiation and anaplasiaMalignant neoplasmsdifferentiation and anaplasia

Adenocarcinoma

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Malignant neoplasmsMalignant neoplasms

Squamous cell carcinoma:

Well-differentiated .

Differentiation and anaplasia

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

Benign vs Malignant

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

AnaplasiaAnaplasia

Pleomorphism Hyperchromasia High N/C ratio Polynuclearity High mitotic rate Bizarre shapes/sizes Atypical mitoses

Dr. Osama I Nassif. MD, FRCPC.Dr. Osama I Nassif. MD, FRCPC.Associate professor & consultant pathologist.Associate professor & consultant pathologist.

Pathology Dept. King Abdulaziz University.Pathology Dept. King Abdulaziz University.NEOPLASIANEOPLASIA

HAVE

A

NICE

DAY