(cytokineCK)

1 1 660 KD,

2

(1) (2) (3)

3 (1) 10-12mol/L (2) (3) (4) (5) (6) (7)

---

interleukinsILsinterferonIFNtumor necrosis factorTNFcolony- stimulating factorCSFchemokinesgrowth factorGF

interleukinsILs

IL-1 () 1. 2. IL-1IL-1 3. 1APCT B 2

IL-2 (T,TCGF) 1. T 2. 3. 1T 2NKNK LAK 3B 4

IL-4 1. Th2 2. 1 2IgG1 IgE 3Th0Th2 4Th1 5IL-3

IL-6 1. Th2 2. 1 2CTL 3 4

IL-10 1. Th2 2. 1 2MHC -IIB-7 3TIL-2IFN- 4B

IL-12 1. -B 2. 1NKIFN- 2Th0Th1IL-2IFN- 3CD8+ CTL 4IL-2LAK 5Th0Th2IgE

(interferon, IFN) () 1. I IFN-IFN- 1 1IFN- 2IFN- 2polyI-C (RNA) 2. II IFN- 1 Th1 CD8+ CTL NK 2

1. 1 1 2NK 3MHC-CTL 2

2. 1 1 2APC(s)MHC- 3MHC-CTL; 4) NK 5B 6Th22()

Microbiology and Immunology on-line

1

IFN-166CD118MHC IIFN-166CD118MHCIIFN-143CD119TNKMHCTh2

(tumor necrosis factorTNF) TNF- TNF-

TNF- 1. , 51 KD 2. TNK

3. (1) --- 1) ICAM-1 (IL-1IL-6IL-8TNF-) 2) MHC-ICTL( ) 3)

(2) --- 1 2IL-1IL-6 3 4 5

TNF- lymphotoxinLTTNF-28%

1. T 2. 1TNF- 2LT-

2

(colony- stimulating factorCSF) 1. 2. SCFFlt3LGM-CSFG-CSF M-CSFEPOTPO IL-3multi-CSFIL-7

1. stem cell factor SCFc-Kit 1 2 3 1 2 2. Flt3Flt3 ligandFL 1 2 3

3. -(GM-CSF) 1 T- 2 1 2

4. (G-CSF) 1 T- 2 1 2

5. M-CSF(1) - (2) 1- 2- 6. erythropoietin, EPO(1) (2) 7. (thrombopoietin, TPO) (1) (2)

3

Dr Colin Hewitt

Dr Colin Hewitt

B

chemokines 1. CXC 1-IL-8--- 1 - 2)

2. CC()--- MCP-1(-1) 1) T 2) T 3. C()--- 1) lymphotactin-lymphotactin- 2) 4. CX3C--- 1) Fractalkine 2)

4

growth factorGF

() 1. TGF-(transforming growth factor- -) 2. EGF(epithelial growth factor ) 3. FGF(fibroblast growth factor ) 4. NGF(nerve growth factor ) 5. PDGF(platelet-derived growth factor ) 6. VEGF(vascular endothelial cell growth factor )

()TGF-TGF-1 TGF-2TGF-3 1. TB

2. (1)T (2)BT (3)NKIL-2LAK (4)M (5) (6)TGF-

1. (1) (2) IL-1IL-6M-CSFSCF

2.() 1 C Trp-Ser-X- Trp-SerWSXWSX2 IL-2IL-3IL-4IL-5 IL-6 IL-7IL-9 IL-11IL-13IL-15GM-CSFG-CSF

3. ()1 2 I IIIFN

4. (TNF/NGF) 1 2 TNFNGFFas CD405. (G) 1 7 ( - )G(GTP) 2 CXCR --- CXC IL- 8CCR --- CCMCP-1

1. (1) --- EPOG-CSF (2) --- IL-3IL-5GM-CS (3) --- IL-2IL-15

2()(1) (2) 1) c IL-2IL-4IL-7IL- 9 IL-15 2) IL-3IL-5GM-CSF 3) gp130 IL-6IL-12

1. 2. sIL-1sIL-2sIL-4 sIL-5 sIL-6sIL-7sIL-8sG-CSFsGM-CSF sIFN-sTNF 3. 1 2 ,

TNF-IL-1IL-6IL-8 TGF-IL-10 IL-6 IL-2IFN-

1. IL-2(X) IL-2 IL-4IL-7IL-9IL-15 2. IL-4 IFN- 3. IFN-IL-2

.

1

TIL-2IL-4IL-5IFN-TNF-IL-1IL-6TNF- AIDSsIL-2R

IL-1

2-1

2-2

IL-2IL-3IL-6GM-CSFIL-10IL-2McAb

CSFsEPOM-CSF

1 . 2 .

Dr Colin Hewitt