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Introduction7Develop a novel probabilistic integrated assessment (PIA) framework PIA framework: Probabilistic PBPK/PD model Risk diagrams Risk-based consumption advice Biosystems Modeling and Control LabDepartment of Bioenvironmental Systems Engineering, National Taiwan UniversityProbabilistic Integrated Framework Can Assess Human As Exposure RisksLing, M. P. 78

Materials and Methods9Concentrationresponse profile: F (PiCH,i), F (IiCH,i)

Effect AnalysisReconstraction of PD-Based DoseResponse Profile based on PD-Based HILL MODELBiosystems Modeling and Control LabDepartment of Bioenvironmental Systems Engineering, National Taiwan UniversityProbabilistic Integrated Framework Can Assess Human As Exposure RisksLing, M. P. 9Oxygen isotopes are also useful in sulfide oxidation studies (Van Stempvoort and Krouse, 1994; Taylor and Wheeler, 1994). There are two sources of oxygen for formation of SO4 from oxidation of sulfides. Oxygen can come either entirely from H2O (Eq. (1)) or from dissolved atmospheric O2 and H2O (Eq. (2)) (Taylor et al., 1984b; van Everdingen and Krouse, 1985): Introduction - O isotopes & S isotopes SystemSO4 form sea waterH2OAtmospheric O2 and H2OMaterials and Methods11Risk management and communicating results to interested partiesConsumption Advice for Arsenic

Potential carcinogenic risk-based consumption limitsBiosystems Modeling and Control LabDepartment of Bioenvironmental Systems Engineering, National Taiwan UniversityProbabilistic Integrated Framework Can Assess Human As Exposure RisksLing, M. P. 12

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Contents15IntroductionLiterature Review Research ObjectivesMaterials and MethodsResults and Discussion1.2.3.4.5.Future Work6.15My contents divide into 6 parts, introduction, research objectives, literature review, materials and methods, results and discussion, and future work.16Introduction1617Literature Review1718False mussel Mytilopsis salleiSpread modelQuantify the factorof invasion riskInvasion18The literature review has 4 parts, invasion, false mussel (Mytilopsis sallei), spread model, and quantify the factor of invasion risk.First, invasion19False mussel Mytilopsis salleiSpread modelQuantify the factorof invasion riskInvasion19secondly, false mussel EC50AsBL (nM)4.93 nM0.79 nMr2=0.91Predication of time dependent EC50AsBL29

As of core samples in aquitards v.s. As of ground water As of core samples in aquifers v.s. As of ground water

Department of Bioenvironmental Systems Engineering NTU21These figures show the correlation between arsenic in aquitard and aquifer and arsenic in groundwater.The correlation of As in aquitards and groundwater is higher than that in aquifers.These results indicated the arsenic concentration of core samples in the aquitard influenced the arsenic in vicinal groundwater,And may be the primary source of arsenic in groundwater.

Clark et al., 199723

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