T T T

,Thymus; , , ;TD-Ag

T

T

T

ZAP-701TCRCD3

T TCR TCR ; TTCR , , (V) (C) 1TCRT cell antigen receptor

, ITAM2CD3

ZAP-70

CD4 , 4Ig , 2MHC-; CD8 , ; Ig , MHC-I CD4CD8 TCRCD4 HIV gpl20 , CD4HIVCD4+2CD4CD8

31CD28CTLA-4CDl52 B7 CD28, 90CD4+T 50 CD8 + T ; TLCTLA-4CD4 +CD8 + T B7 CD28 ITIMT

2ICOSinducible costimulator B7T CD28ICOSB7-H2 CD28TTTT

3CD40 Th B CD40B B

4 CD2: 1LFA-2 LFA-3CD58 2 (SRBC)E- 395T50-70%NK 4T 5T

5LFA-1-1 ICAM-1-1T T

411 2T3 ACon A PHA PWM

T1L-1R IL-2R IL-4R IL-6RFasL(CD95) T T2

T (naiveT cell)(effector T cell) T(memory T cell) TCR TTCD4CD8 CD4+ TCD8+TTT reg (helper T cell, Th)(cytotoxicTcell,Tc)

1TTT1T: T2TIL-2(3)TGoCD44 GoCD45RAL-

2TT1TCD2+CD3+ CD4+CD8+SPT60%70%T

2T CD2+CD3+CD4-CD8-DNCD8+5%15%,, T

1CD4 160-65%TCRT2TCD3+CD4+CD8-CD4+T 3CD4+T13-17MHC-IITh3CD4+CD8+T TCR

2CD81) 30-35%TCRTTCR T ;2)TCD3+CD4-CD8+CD8+T 3)CD8+T8-10 MHC-I TcCTL

1CD4+TCD4+Th1CD4+Th Th0 ThThlTh2 Th3 Tr1IL-10Th1 ()T

2CD4+Th Th0 TGF- IL-4 IL-10Th3

Thl Th2

2CD8+T Fas / FasL

T

CTL

3CD4+CD25+TTrCD4+CD8+T1. 2. IL-103. APC

B B B B

B

B BBBB BCR

Mature B cellsImmature B cellsPre-B cellsPro-B cells

VHDHJHDHJH VLJLIgMIgDIgM BBB BRAG-1/2 VHDHJH DHJHVHDHJHVHDHJH VLJL VLJL++--mmm+dk or lk or lVpre-B + l5 k + lVpre-B + l5 k + l B --

B

B

1BCRBmIgMIg/IgBCR (B cell antigen receptor) : BCR B(mIg)BmIgMmIgD

mIgBCR- Ig/Ig: BCR Ig2Ig/Ig(CD79a/CD79b)

2 BBCRBCRB1CD19/CD21/CD81CD225

CD21CD19CD812 BC3dCDl9/CD21/CD8l /CD225BCRCDl9 BCRBCRB

B

CD40BThCD40LBCD80CD86B7.1B7.2: TBB TCD28TTCTLA-4 3.

B B-1 CD5+B-1 BCR, IgM Th

B-2CD5-B, , CD5B: B

B B1 B2CD5 + -B 5-10% 90%Ig Ig IgM IgG TI-Ag TD-Ag /

B 1.

ADCC,,

NKTBTCRBCRNKNK

1NK2NK3NKADCCNK

HLA-I(KIR)KARITAMNKITIMNK1NK

*

*

NK

2NKDNA

NKTcTCR-CD3+MHCI++NKTcMHCCD16,CD56+MHCI

*ADCC3ADCC

T APC: - B,MHC-IIAPC : antigen-presenting cellAPC

dendritic cellDC1

CD1aCD11cCD83MHC-IICD80CD86CD40CD54T

2 DCDC DC

DCDCDCDC

-Mf TTB BCR

MHCMHC

APC APC- MHCAPC - MHCTTT

APC LMP()TAP()

1 MHC ) (LMP) 8-13aa (TAP) /MHC I APC CD8+T

Ii*MHC-II**MHC-IICLIP(IIIi MHC II HLA-DMCLIPMHC-. 2MHC-

AgabMHC- /IiIiCLIPMHCHLA-DMMHC - 2 1 Ag

MHC I -

MHCII - CD8+ T

CD4+T::MHC - - TCR CD4/CD8 MHC-/MHC- 1

APCT + T

MHCMHC APC MHC MHC MHC MHC CD8T CD4T MHC/

-T-T; -TMHC ;MHC;-T , CDl (HSP) ; MHC -T -T -T ,