1

schizophrenia

extrapyramidal symptoms1989 clozapine atypical antipsychotics

pyramidal

tractbasal gangliasubthalamic nucleussubstantia nigrared nucleusbrain stem reticular formationnigrostriatal dopamine pathway D2 dopamine D2 receptors 3

acute and tardive syndromesacute dystoniaakathisiaparkinsonismtardive dyskinesiatardive dystonia

psychotic agitation

5

Antipsychotic-induced parkinsonism rigiditybradykinesiatremorhypomimiashuffline gaitstooped posture

lip smackingtongue protrusiongrimacingpiano or guitar playing

Barnes Akathisia Scale

Simpson Angus ScaleAbnormal Involuntary Movement Scaler Extrapyramidal Symptom Rating Scale

haloperidol 78.3 %resperidone 55.1 %quetiapine 39.5 %olanzapine 36.8 % resperidone olanzapine resperidone 4-6 mg/day

meta-analysis haloperidol>10 mg/day

vitamin E vitamin E

6

meta-analysis vitamin E

40

benzatropine diphenhydraminepropranolol 2

clozapine

Cochrane Collaboration meta-analysis reserpinetetrebenazinealpha-methyl-para-tyrosine

Cochrane meta-analysis levodopa

trihexyphenidy clozapine GABA benzodiazepinevalproic acid vitamin E vitamin E melatonin 10 mg vitamin E

5HT2 receptor D2

1. Joseph M. Pierre. Extrapyramidal Symptoms with Atypical Antipsychotics Incidenc, Prevention and

Management. Drug safety, 2005;28(3):191-208.

2. Bertram G.Katzung. Basic & Clinical Pharmacology, ninth edition, p447-482.

3. Arthur C. Guyton, MD and John E. Hall, PhD, Human Physiology and Mechanisms of Disease, sixth

edition, p465-470.

7

33 ritonavir combivir kaletra efavirenz 332 mg/dL 1109 mg/dL abacavirdidanosine stavudine atorvastatin 2 157 mg/dL 213 mg/dL statin 208 mg/dL 389 mg/dL ARTantiretroviral therapydyslipidemia

ART metabolic syndrome

morphologic abnormalitiesMurata Sekhar 2000 2002

glucose uptake receptors2002 Ware nucleoside analogues

HIV ART HIV

Protease Inhibitor

2002 Walmsley ART stavudine lamivudine lopinavir / ritonavirkaletra nelfinavirkaletra kaletra nelfinavir 7 % 1 %P < 0.12003 Nadler fosamprenavirunboosted fosamprenavir nelfinavir fosamprenavir ritonavir kaletra

2003 BMS AI424-043

8

atazanavir400 mg qd kaletra3 bid atazanavir 2 %kaletra 17 % P < 0.0001 atazanavir 6 %kaletra 5 %P

9

Lipotest cohort stavudine tenofovir 24 252 mg/dL 208 mg/dL 366 mg/dL 216 mg/dLstavudine

HIV stavudine stavudine abacavirdidanosinetenofovir zidovudine

HIV BHIVABHIVA

tenofovirzidovudineabacavire didanosine stavudine CD4 200 cells/mm3 ART

omega-3 fatty acids HIV

omega-3 fatty acids ART stavudine zidovudine abacavir tenofovir

statins fibrates Cytochrome P450 ritonavir nelfinavir CYP 450 CYP 450 statins pravastatinsimvastatin simvastatin lovastatin atorvastatin atorvastatin creatine kinase

Statins fibrates

kaletra efavirenz 1109 mg/dL kaletra HIV statins fibrates stavudinezidovudine kaletra efavirenz abacivirdidanosine stavudineatorvastatin 2 atorvastatin HIV ART stavudine zidovudine DHHSDepartment of Health and Human Services ART 1 efavirenzlamivudine

10

tenofovir tenofovir efavirenzlamivudine didanosine nevirapinelamivudine didanosine ART CD4 82 /mcL 432 /mcLHIV-1 RNA 400 copie/mL 400 copie/mL abacivirdidanosine stavudine

HIV statin fibrate

ART HIV atazanavir tenofovir HIV 1. Developed by the Panel on Clinical Practices for Treatment of HIV Infection convened by the

Department of Health and Human Services (DHHS), November 10, 2003.

2. Graeme J: Lipid Abnormalities During ART. AIDS Read, 2004;14 (1): 15.

3. http://www.bhiva.orgBritish HIV Association (BHIVA) guidelines for the treatment of HIV-infected

adults with antiretroviral therapy July 2003.

4. Murata H et al: The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol

Chem, 2000; 275: 20251.

5. Nadler J et al: The NEAT Study: GW433908 efficacy and safety in ART-naive subjects, final 48-week

analysis. In: Program and abstracts of the 10th Conference on Retroviruses and Opportunistic

Infections; February 10-14, 2003; Boston. Abstract 177.

6. Nieto-Cisneros L et al. Antiviral efficacy, metabolic changes and safety of atazanavir (ATV) versus

lopinavir/ritonavir (LPV/RTV) in combination with two NRTIs in patients who have experienced

virological failure with prior PI-containing regimen(s): 24-week results from BMS AI424-043. In:

Program and abstracts of the 2nd International AIDS Society Conference on HIV Pathogenesis and

Treatment; 2003 July 13-16; Paris. Abstract 117.

7. Sekhar RV et al: Metabolic basis of HIV-lipodystrophy syndrome. Am J Physiol Endocrinol Metab,

2002; 283:E332.

8. van Leth F et al. Results of the 2NN Study: a randomized comparative trial of first-line antiretroviral

therapy with regimens containing either nevirapine alone, efavirenz alone or both drugs combined,

together with stavudine and lamivudine. In: Program and abstracts of the 10th Conference on

Retroviruses and Opportunistic Infections, 2003 February 10-14; Boston. Abstract 176.

9. Ware LJ et al:The paradox of improved antiretroviral therapy in HIV: potential for nutritional

modulation? Proc Nutr Soc, 2002;61:131.

9.

11

1 Adults: Data from US DHHS ( Department of Health and Human Services ) guideline

NNRTI

1. Efavirenz + lamivudine + ( zidovudine or tenofovir DF or stavudine* ) --

1. Efavirenz + emtricitabine + ( zidovudine or tenofovir DF or stavudine* ) --

**

2. Efavirenz + ( lamivudine or emtricitabine ) + didanosine --

**

3. Nevirapine + ( lamivudine or emtricitabine ) + ( zidovudine or stavudine* or

didanosine )

PI

1. lopinavir/ritonavir ( kaletra ) + lamivudine + ( zidovudine or stavudine )

1. Amprenavir/ritonavir + ( lamivudine or emtricitabine ) + ( zidovudine or stavudine )

2. Atazanavir + ( lamivudine or emtricitabine ) + ( zidovudine or stavudine* )

3. Indinavir + ( lamivudine or emtricitabine) + ( zidovudine or stavudine* )

4. Indinavir/ritonavir + ( lamivudine or emtricitabine ) + ( zidovudine or stavudine* )

5. Lopinavir/ritonavir ( kaletra ) + emitricitabine + ( zidovudine or stavudine* )

6. Nelfinavir + ( lamivudine or emtricitabine ) + ( zidovudine or stavudine* )

7. Saquinavir ( sgc or hgc ) / ritonavir + ( lamivudine or emtricitabine ) + ( zidovudine

or stavudine* )

3 NRTI -NNRTI PI

NNRTI PI Abacavir + lamivudine + zidovudine ( or stavudine ) * Stavudine NRTIs stavudine

** ritonavir ( 100-400 mg ) Nelfinavir 250 mg 625 mg sgc=soft gel capsule ; hgc=hard gel capsule tenofovir DF: tenofovir disoproxil fumarat

12

1960 FDA hormonal contraceptive

estrogen progestin progestin

0.1 % 2 % 3 %

21 7 28 7 7

2 2

estrogen estrogen progestinsnorgestimatedesogestrel estrogen progestin

10

Estrogen

6

Acetamainophen ascorbic acid estrogen

warfarin

warfarin phenytoinbarbituratescarbamazepine

estrogens progestins

1. The Practice Committee of the American Society for Reproductive Medicine. Hormonal Contraception:

recent advances and

11

2. controversies. Fertility and Sterility 2004; 82 (Suppl 1):S26-32.

3. Micromedex: USP DI Drug Information for the Health Care Professional 2005.

Micromedex Healthcare Series Vol.125 expires9/2005

50

12

adenocarcinoma adenosquamous carcinoma

adenoacanthoma

progestins

HPV

13

paclitaxel 1960

cremophor EL 50 %

dexamethasonediphenhydramine cimetidine ranitidine cremophor EL PVC DEHPdi ( 2-ethylhexyl ) phthalate PVC 1-2

FDA 2005/1/7 Pharmaceutical PartnersAPP American bioscienceABIabraxane, ABI-007, ABXAmerican pharmaceutical partnersabraxane TMmetastatic breast cancer 6 anthracycline 3

Paclitaxel

paclitaxel paclitaxel G2 M 1

Abraxane ABI nab TM abraxane paclitaxel1 % 130

abraxane gp60 3

14

3 Abraxane 30

27 3 abraxane 260 mg/m2 30 paclitaxel 175 mg/m2 3

abraxane paclitaxel 43 % 53 % abraxane abraxane 260 mg/m2 30 4 % abraxane 20 % 3

460 260 mg/m2 30 n = 233 175 mg/m2 3 n = 22764 %79 %76 %59 %77 % anthracycline 21.5 % vs. 11.5 %p = 0.003 6 85 %15.5 % vs. 8.4 % 129 1433

106 100 mg/m2 abraxane 28 1815 30 15 %12 38 %40 % 4 30 % 6 4

neutropenia 80 %abraxane ANC < 500 /mm3 22 % 8 %thrombocytopeniaanemia 3-4

abraxane 71 % 10 % 56 % 2 % abraxane 3-4

15

abraxane 4 % 12 % 2 %3-4

ECG ALTAST 3-4

abraxane

20 0.9 % abraxane 100 mg 900 mg 5 mg abraxane 3

6 abraxane 260 mg/m2 30 3ANC < 500 /mm3 220 mg/m2 180 mg/m2 3

PVC DEHP 3

Abraxane 1500 /mm3 abraxane abraxane

1500 /mm3 100,000 /mm3 3

Abraxane 1.5 mg/dL 2 mg/dL 4Abraxane D 3

abraxane 3

16

FDA 1. 48 % 78 %

2. 30

3 3.

4. DEHP

5-6 abraxane

1. Product Information: Taxol, paclitaxel. Mead Johnson, Oncology Products, Princeton, NJ, USA,

reviewed 7/2000.

2. Gelderblom H, Verweij J, Nooter K, Sparreboom A. Cremophor EL: the drawbacks and advantages of

vehicle selection for drug formulation. Eur J Cancer. 2001; 37(13): 1590-1598.

3. Product Information: Abraxane(TM) for Injectable Suspension, paclitaxel protein-bound particles for

injectable suspension. Abraxis Oncology, Schaumburg, IL, 2005.

4. Blum JL, Savin MA, Edelman G et al: Long term disease control in taxane-refractory metastatic breast

cancer treated with nab paclitaxel (abstract). J Clin Oncol, 2004; 22(14S): 543.

5. Anon: ABI 007. Drugs RD, 2004; 5(3): 155-159.

6. Damascelli B, Patelli GL, Lanocita R et al: A novel intraarterial chemotherapy using paclitaxel in

albumin nanoparticles to treat advanced squamous cell carcinoma of the tongue: preliminary findings. AJR,

2003; 181: 253-260.

17

1.

2.

3.

4.

18

5.

6.

1. 82

2. 181

3. 82

4. 82

5. 77

19

Roaccutane

IsotretinoinRoaccutane

Isotretinoin A FDA iPLEDGE 1

Isotretinoin Roaccutane 20 mg

Propionibacterium acnes

Isotretinoin 0.5 mg/kg 0.5-1.0 mg/kg 2.0 mg/kg 16 8

transaminase

isotretinoin A

cheilitisconjunctivitsdry mouthepistaxis

2 FDA 2000 isotretinoin 1982 2000 431

10 3 2004 4992

isotretinoin hippocampusorbitofrontalisotretinoin 1

18 isotretinoin 134

20

Roaccutane

1982 9 1983 7 FDA 29 42002SMARTThe System to Manage Accutane Related Teratogenicity isotretinoin 5 FDA isotretinoin

isotretinoin iPLEDGE

1 isotretinoin

6

1. FDA http://www.fda.gov/cder/drug/ InfoSheets/HCP/IsotretinoinHCP.pdf.

2. Micromedex 2005.

3. Wysowski DK, Pitts M, Beitz J. An analysis of reports of depression and suicide in patients treated with

Isotretinoin. J. Am. Acad. Dermatol, 2001; 45(4): 515-519.

4. Epidemiologic Notes and Reports Isotretinoin-A Newly Recognized Human Teratogen. MMWR Morb

Mortal Wkly Rep, 1984; 33: 171-173.

5. Siobhan M. Dolan, MD, MPH. Isotretinoin and Pregnancy-A Continued Risk for Birth Defects. Medscape

Ob/Gyn & Womens Health, 2004; 9(2).

6. :

http://www.doh.gov.tw/cht/index.aspx

21

92 94

( )

( fluoroquinolones bisphosphonate ) 1-2

( ) cytochrome P450 3A4 ( CYP3A4 ) 15 % CYP1A2 ( theophyllinewarfarin)CYP1A2 CYP1A2

K warfarin

Joint

Committee on the Accreditation of Healthcare Organization ( JCAHO )

22

1. Eric RL, Robert LD, Leslie AS. Food-drug interaction: Careful drug selection and patient counseling can

reduce the risk in order patients, Geriatrics, 2004;59(3):19-24.

2. Shannon FM, Michael S. Drug interaction-A Review, Clinicial Pediatric Emergency Medicine,

2005;6(2):93-102.

3. Hansten and Horn: Managing clinically important drug interactions. Facts Comparisons, 2003.

4. Micromedex 2005.

27

1-4

()

Cardiovascular Agent Digoxin (Lanoxin) (

)

CHF/Afib

Amiodarone (Amiorone) CYP3A4

Metoprolol (Denex) -blocker

Propranolol (Cardiolol)

Labetalol (Trandate)

Acebutolol (Sectral) -blocker

Nadolol (Corgard)

Captopril (CapotenCabudan) ( 30-40 % ) CHF/HTN

Losartan (Hyzaar) CYP3A4

Spironolactone (Aldactone)

(

( noni juice ) )

Hydrochlorothiazide

Hydralazine (Apresoline)

Verapamil (Isomil) Verapamil

CYP3A4

Amlodipine (Norvasc) CYP3A4

Felodipine (Plendil) Nifedipine (Nifehexal Adalat OROS)

Nimodipine (Nimotop)

Diltiazem (CardizemDiltisser)

Quinidine

Nitroglycerin (Nitrostat) Warfarin (Coumadin) vitamine K

(

)

prothrombin time

INR prothrombin

time Atorvastatin (Lipitor) CYP3A4

Simvastatin (Zocor)

Cilostazol (Pletaal)

28

() CNS Medication Buspirone (Busron ) CYP3A4

Diazepam (Vanconin)

Triazolam (Halcion)

Carbamazepine (Tegretol)

Trazodone (Mesyrel)

Sertraline (Zoloft)

Fluvoxamine (Luvox) CYP3A

P-glycoprotein

Clomipramine (Clopran) ( CYP1A2

3A42D6 )

Quetiapine (Seroquel) CYP3A4

Aspirin (Bokey)

Acetaminophen (Panamol)

( CYP2E1 )

Zolpidem (Stilnox)

Lithium

Levodopa & Benserazid (Madopar)

Phenobarbital CNS

CNS

Moclobemide (Eutac) tyramine (

)

Selegiline (Parkryl)

tyramine (

)

29

() Anti-infective Agents Erythromycin Stearate

Azithromycin (Zithromax )

Isoniazide (INH)

tyramine (

)

INH

Rifampin

Tetracycline ( Ca, Mg, Fe, Zn )

Cefuroxime (Zinnat Susp.)

Amoxicillin (HiconcilPamoxicillin)

Penicillin V ( )

Linezolid (Zyvox) tyramine (

)

Norfloxacin (Baccidal)

Ciprofloxacin (Ciproxin)

( Ca, Mg, Fe, Zn ) ( )

caffeine caffeine caffeine

Levofloxacin (Cravit)

Moxifloxacin (Avelox)

( Ca, Mg, Fe, Zn ) ( )

Lomefloxacin (Lomebact)

Fluconazole (DiflucanFluene) caffeine caffeine caffeine

Itraconazole (Sporanox)

Ketoconazole (Cotrizine)

acetaldehyde disulfiram effect

Metronidazole (Flagyl) acetaldehyde disulfiram effect

Indinavir (Crixivan)

Zidovudine (RetrovirCombivir)

30

() Endocrine Medication Glipizide (Glidiab)

Metformin (Glibudon)

Levothyroxine (Eltroxine)

Alendronate (Fosamax)

Estridiol (ActivelleClimenDivinaEstradePremarinSevina)

CYP3A4

Methylprednisolone (MedninMep) CYP3A4

GI Tract Medications Sucralfate (Sucrate) sucralfate sucralfate GI

Metoclopramide (Promeran)

(BalunaOxetacainAluzaineAcidenSpa-GasgelTopaal NacidSwecon)

Respiratory Tract Medications Theophylline SR (XanthiumThion)

caffeine

( CYP1A2 )

Montelukast (Singulair)

Allergic Conditions Chlorpheniramine Maleate (Orolisin)

Cetirizine (Alltec)

Fexofenadine (Allegra) ( organic anion transporting polypeptide )

Loratadine (Finska-LP S.R.F.C)

CYP3A4

31

() Immunosupressants Cyclosporin (Sandimmun Neoral) CYP3A4

Tacrolimus (Prograf) CYP3A4

Sirolimus (Rapamune)

Methotrexate (Trexan)

Antineoplastic Agents Melphanlan (Alkeran)

Procarbazine (Natulan) acetaldehyde

disulfiram effect

tyramine (

)

Other Sildenafil (Viagra) CYP3A4

Dihydroergotamine (Seglor) CYP3A4

Ergonovine (Ergometrin)

( ergotism )

Ergotamine (Cafergot)

Methylergonovine (Methergin)

32

Problem-Based Learning

problem-based learningPBL

effective

efficientcost effective ethical

33

PBL PBL

PBL

PBL PBL

student-facilitator PBL 5-7

PBL

faculty consultants

PBL

PBL cases

standardized patients

room assignments

PBL

learning resourcesPBL

Medline

schedulePBL PBL

PBL

34

PBL PBL

PBL

PBL

PBL

problem-based learning

1. Gettman D.A. & Arneson D.: Pharmacoethics:

a problem-based approach, USA, CRC Press.

2003: 1-26.

35

94 6 94 8

Dutasteride (Avodart) 0.5 mg/cap 52 Eptacog Alfa (Factor VIIa; NovoSeven)

60 KIU/vial (=1.2mg)

28,759

Felinamin 10 ml/amp (Each amp: Thiamine 50 mg; Pyridoxine 100 mg; Hydroxocobalamin 1000 mcg)

Bthiamine

50

Methylphenidate Hcl (Concerta) 18 mg/tab

Ritalin 55

Desloratadine (Denosin) 5 mg/tab 12.2 Megestrol Acetate Susp (Megest)

40 mg/ml; 240 ml/bot

3532

Cladribine (Leustatin) 1 mg/ml; 10 ml/vial

15,480

Bio-Three tablet (B.mesentericus,C.butyricum & S.faecalis)

10

Mepivacaine With Adrenaline (Scandonest) 2 % 1.8 ml/amp

Bevacizumab (Avastin) 100 mg/4 ml/vial Avastin irinotecan/-5-FU/leucovorin 5-FU/leucovorin

19,200

Pravastatin Sodium (Mevalotin) 40 mg/tab

20mg/tab 57

Drotrecogin Alfa (Xigris) 2 mg/ml, 2.5 ml/vial

( APACHE II )

10,594 Diclofenac Potassium (Peiflam)

50 mg/tab

3.52

Nitroglycerin 50 mg/10 ml/vial

-

242

Cephalexin (ULEX) 500 mg/cap

4.47

Niulackmin (Lactobacillus & Lysine) 0.23 Methimazole (Lica) 5 mg/tab 0.96 Acyclovir (Yutam) Cream

5 % 3 gm/tube 99

Fusidic Acid (Fulosin) Cream 2 % 5 gm/tube

fusidic acid

78

Ambroxol (Axol) HCl 30 mg/tab 2

36

Midodrine (Midorine) 2.5 mg/tab

4.32

Flutamide (Fuprostate) 250 mg/tab 43.2 Chemix 400 mg/tab (Sulfamethoxazole &

Trimethoprim)

1.09

Loperamide (Undiarrhea) 2 mg/tab 0.67 UFT

(Tegafur 100 mg & Uracil 224 mg) cap cisplatin

77

Haemo influenzae (Act-HIB) 0.5 ml/vial

b

615

Human Albumin (Plasbumin-20) 10 gm/50 ml/bt

1212

Acetaminophen (Paran) 500 mg/tab 0.69 Gentamicin (Gentamycin) Cream 0.1 %

15 gm/tube

77

Isosorbide-5-mononitrate (Coxine) 20 mg/tab

3.6

Anbicyn (Amoxicillin & Clavulanic Acid ) 600 mg/vial

251

Zopiclone (pms-Zopiclone) 7.5 mg/tab

8.9

Pamidronate di-Na (Pamisol) 15 mg/5 ml/vial

1924

Betadine (Biodyne) Surgical Scrub 7.5 mg/ml; 3800 ml/bot

-

YF NO.1 500cc/bot 41.2 YF NO.5 500cc/bot

55

Mirtazapine (Remeron) 30 mg/tab 41.6

Metoclopramide HCl (Primperan) 5mg/tab

1.08

Thiamine (Vitamin B1) 100 mg/5 ml/amp

Thioridazine (MelZin) 25 mg/tab Methylphenidate HCl (Ritalin)

10 mg/tab

Acetylcysteine (Acetein) 20%, 2ml/amp

mercaptoethanesul-Phonate ( siruta ) 200 mg/ml, 3 ml/amp

Vinblastin 10mg/10ml/vial Pravastatin Sodium (Mevalotin) 20mg/tab Piroxicam (Pirocan)

20 mg/1 ml/amp

Acetylcysteine (Fluimucil) 300 mg/3 cc/amp

Leflunomide (Arava) 10 mg/tab leflunomide 20 mg/tab

37

N/S 0.9 % 1000 ml/bot

37.8

Leflunomide (Arheuma) 20 mg/tab

X

126

Ethyl Alcohol 99.5%10ml/vial

Tacrolimus (Prograf) 0.5 mg/cap

cyclosporin

63

Exemestane (Aromasin) 25 mg/SC tab

156

Dioctahedral Smectite (Smecta) 3 gm/pk 8.3

Mycophenolate Na (Myfortic) 180 mg/tab cyclosporin(microemulsion)

53

Betahistine (Betaserc) 16 mg/tab

4.68

Atropine Sulfate Eye drops (Colircusi) 0.5 % 10 ml/bot

37.8

Etodolac (Eric SR) 600 mg/tab

16.7

Pravastatin sodium (Mevalotin) 40 mg/tab protect

1.:

( ) mevalotin2.:

3.:

57

Mirtazapine (Remeron) 30 mg/tab 41.6

Cephalexin (Ulex) 500 mg/cap

3.68

Mebendazole 100 mg/tab

2.1

Felinamin 10 ml/amp

50

Folinic acid (Rescuvolin) 50 mg/vial

Methotrexate

153

38

Chloralhydrate soln 10 % 100 mg/ml

6 Sodium 2-Mercaptoethanesulphonate

( Mesna) (Siruta) 600 mg/3 ml/amp 71

Ribavirin (Robatrol) 200 mg/cap

- interferon 1. - interferon C 2. C

47.5

Bevacizumab (Avastin) 100 mg/4 ml/vial

Avastin ( bevacizumab ) irinotecan/ 5-fluorouracil/leucovorin 5-fluorouracil/ leucovorin

17600

Methimazole (Mepazole) 5 mg/tab 0.26 Tegafur & Uracil (UFT)100 mg/224 mg cisplatin

71

Midodrine Hcl (Midorine) 2.5 mg/tab

4.32

Atenolol (Tenolol) 100 mg/tab 7.5 Magnesium Oxide 250 mg/tab

0.2

Labetalol Hcl (Latol) 200 mg/tab 6.6 Acebutolol Hcl (Gentolol) 400 mg/tab

10.9

Bisacodyl (Bisadyl) Supp 10 mg/pill 3.6 Pancrelipase (Protease)

(Lipase/protease/amylase) 280 mg /cap (20000/75000/66400USP Units)

8.8

Clomiphene Citrate (Clomiphene) 50 mg/tab

8.9

Furosemid (Rasitol) 40 mg/tab 2.68 Cefazolin Na (Stazolin) 1 gm/vial

76

Azathioprine 50mg/tab

25.76

Isosorbide-5-mononitrate (Coxine) 20 mg/tab

2.23

Ritodrine Hcl (Anpo) 50 mg/5 ml/amp 8.9 Acyclovir (Acylete cream) 5 % 5 gm/tube 96 Hydrotalcite (Swecon) 500 mg/tab

0.73

Progesterone (Progeffik) 100 mg/cap :

13.5

Eprazinone Di-HCl (Resplen) 20 mg/tab

1.76

Scopolamine Butylbromide (Buspan) 10 mg/tab

1.94

39

Telmisartan (Micardis) 40 mg/tab 25.5

Candesartan cilexetil (Blopress) 8 mg/tab

27.6

Esomeprazole (Nexium) 40 mg/tab

48.3

Butorphanol (Butaro ) 10 mg/mL, 2.5 mL/bot

2095

Estradiol (Estrade) 2 mg/tab

2.68

Mesalazine (Colasa Enema) 2 g/100 mL/bot

277

Esmolol (Brevibloc ) 100 mg/10 mL/vial

385

Montelukast (Singulair ) 4 mg/tab

seasonal allergic rhinitis

26.3

Barnidipine Hcl (Hypoca ) 10 mg/cap 13.3 Ziprasidone (Geodon ) 40 mg/cap 55 Teriparatide (Forteo )

750 mcg/3 mL/set

15766

Lactobacillus casei (Antibiophilus) 250 mg/cap

5.6

Metoprolol (Denex) 100 mg/tab 8 Imiquimod Cream (Aldara)

5 % 250 mg/pk

330 Methylphenidate HCl (Concerta)

18 mg/tab 55

Na2HPO4 & NaH2PO4 (Fleet Phospho-soda ) 90 ml/bt

X

318 Tretinoin Cream (Airol) 0.05% 20 g/tube 203 Codeine Phosphoate (Codeine)

15 mg/mL/amp 18

Urokinase (Urokinase-GCSA) 250 000 IU/vial

3823

Acitretin (Neotigason) 25 mg/cap 77 Mycophenolate mofetil (CellCept)

250 mg/cap cyclosporin

52

Tadalafil (Cialis) 20 mg/tab 576

Vardenafil (Levitra) 10 mg/tab 420

40

Gadobenate dimeglumine (MultiHance)

20 mL/vial 1. ( CNS ) ( MRI ) 2. ( ) 3. ( MRI )

Ketorolac (Keto) 10 mg/tab 11.3 Ramipril (Tritace) 10 mg/tab

25.4

Salicylic Acid & Lactic Acid Solution (Duofilm) 15 ml/bt

195

Felinamin (Felinamin) 10 mL/amp

50

Benzydamine hydrochloride (Comfflam) 30 mL/bt

:

270

Procaterol (Procarol) syr. 5 mcg/mL; 60 mL/bt

72

Streptococcus Pyogenes (Picibanil) 5 KE/vial

2876

Methalazine (Pentasa) 500 mg/tab 18.8 Alcohol 99 % 5 mL/vial 180 Acebutolol (Sectral) 400 mg/tab 14.4 Ticlopidine (Licodin) 100 mg/tab 9.8 Etodolac (Eric SR) 600 mg/tab 16.7 Papaverine Hydrochloride (Paparin)

30 mg/mL/amp 52

Piroxicam (Piroxim) 10 mg/cap

4.86

Kaolin Pectin (Pecolin) 120 mL/bt 21.5 Perindopril (Acertil) 4 mg/tab 24.9 Risperidone (Risperidal Consta) 25

mg/vial 3795

Penicillin V 4MU/tab

1.24

Amoxycillin & Clavulanate potassium (Augmentin F.C.) 1 g/tab

28

Gabexate mesilate (Foy) 100 mg/vial 315 Methotrexate 50 mg/ 2 mL/vial

232

Prochlorperazine (Novamin) 5 mg/mL/amp

15.3

Tobramycin & Dexamethasone (Tobradex) 5 mL/bt

167

41

Tears Naturale (Tears Naturale)

0.03 FL OZ/vial

380 Pravastatin (Mevalotin) 40 mg/tab 1.:

() mevalotin 2.:

3.:

57

Peace (Triprolidine HCl 2.5 mg & Pseudophedrine HCl 60 mg /tab)

1.13

Lutein & Zeaxanthin (Catasod) : Lutein/ Zeaxanthin 5 mg/tab

768

Isosorbide Dinitrate (Angidil) 0.1 % 10 mg/10 ml/amp

410

Cephalexin (Ulex) 500 mg/cap

3.68

Meclizine (Clizine) 25 mg/tab

1.06

Pyrazinamide (Mide) 500 mg/tab 2.67 Fentanyl Injection 0.05mg/ml;10ml/amp 98 Ferric Hydroxide Sucrose (Fe-Back)

100 mg/5 mL/vial 97

Methimazole (Lica) 5mg/tab 0.26