( f c ^ 2 j . ^ 20mg, +30mg€¦ · 1) ß+® ¥ &9Ú") ú ã ê9Ú &"n 2003; 85...
TRANSCRIPT
20mg, 30mg
2 ( 2) : CTD ( )
2.7.5
2.7.5
2.7.5 ............................................................................................................................................... 3
- 2 -
2.7.5
(1)
(2)
1) Relling MV, Lin JS, Ayers GD, Evans WE. Racial and gender differences in N-acetyltransferase,
xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 1992; 52: 643-58.
2) Sesardic D, Boobis AR, Edwards RJ, Davies DS. A form of cytochrome P450 in man, orthologous
to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette
smoking. Br J Clin Pharmacol 1988; 26: 363-72.
3) Meyer JH, Wilson AA, Ginovart N, Goulding V, Hussey D, Hood K. Occupancy of serotonin
transporters by paroxetine and citalopram during treatment of depression: a [11C]DASB PET
imaging study. Am J Psychiatry 2001; 158: 1843-9.
4) Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ. Serotonin transporter occupancy
of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission
tomography study. Am J Psychiatry 2004; 161: 826-35.
5) Takano A, Suhara T, Ichiyama T, Yasuno F, Suzuki K. Time course of in vivo 5-HTT transporter
occupancy by fluvoxamine. J Clin Psychopharmacol 2006;26:188-91.
(3)
1) 2003; 85 (7): 2042-7.
2) 3 ; 2010.
p.103-114.
3) Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, et al. Gabapentin for the
symptomatic treatment of painful neuropathy in patients with diabetes mellitus. A randomized
controlled trial. JAMA 1998; 280 (21): 1831-6.
4) CHMP (Committee for medicinal products for human use). Guideline on clinical investigation of
medicinal products intended for treatment of neuropathic pain. November 2004.
5) Mallinckrodt CH, Kaiser CJ, Watkin JG, Molenberghs G, Carroll RJ. The effect of correlation
structure on treatment contrasts estimated from incomplete clinical trial data with likelihood-based
repeated measures compared with last observation carried forward ANOVA. Clinical Trials 2004; 1:
477-89.
6) 2002; 17 (2):
125-38.
7) (distal symmetric polyneuropathy)
2003; 14 (2): 225-7.
8) Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA. A practical two-step
quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic
- 3 -
neuropathy. Diabetes care 1994; 17: 1281-9.
9) Meyer JH, Wilson AA, Ginovart N, Goulding V, Hussey D, Hood K, et al. Occupancy of serotonin
transporters by paroxetine and citalopram during treatment of depression: a [11C]DASB PET
imaging study. Am J Psychiatry 2001; 158: 1843-9.
10) Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ, et al. Serotonin transporter
occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron
emission tomography study. Am J Psychiatry 2004; 161: 826-35.
11) Depression Frontier 2005; 3: 72-7.
(4)
1) Friedman RA, Leon AC. Expanding the black box — depression, antidepressants, and the risk of
suicide. N Engl J Med 2007; 356: 2343-6.
2) Relling MV, Lin JS, Ayers GD, Evans WE. Racial and gender differences in N-acetyltransferase,
xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 1992; 52: 643-58.
- 4 -
20mg, 30mg
2 ( 2) : CTD ( )
2.7.6
2.7.6
2.7.6 ........................................................................................................................... 5
2.7.6.1 ................................................................................................ 7
2.7.6.1.1 ......................................................................................................................... 7
2.7.6.1.2 ............................................................................................................................... 76
2.7.6.1.3 2 ..................................................................................................... 159
2.7.6.1.4 3 ..................................................................................................... 183
2.7.6.2 ................................................................................................ 206
2.7.6.2.1 2 ............................................................................................................. 206
2.7.6.2.2 3 ............................................................................................................. 280
2.7.6.2.3 2 ................................................................. 395
2.7.6.2.4 ............................................................................................................. 416
- 2 -
BAI Beck
BDI-II Beck -II
BID 1 2
BMI Body Mass Index
BPI
CGI-
DSM-IV 4
EQ-5D Euro QOL EQ-5D
FAS
HAM-D17 Hamilton 17 01 02 03
04 05 06 07 08
09 10 11 12
13 14 15
16 17
ITT
LOCF Last observation carried forward
MAO
M.I.N.I.
MNSI
MNSS
NOS
NRS Numerical Rating Scale
PGI-
PPS
QD 1 1
SFMPQ McGill
SF-36 QOL
5-HT
- 3 -
MedDRA ALT AST -GTP
CK
ALP LDH
BUN
HbA1c
- 4 -
2.7.
6
2.7.
6-1
2.7
.6-1
a)
2.7.
6
12N
0821
5.3.
5.1-
01
11
20
mg
112
20 m
g13
40
mg
120
mg
212
40 m
g13
13
20 m
g4
760
mg
120
mg
240
mg
312
60 m
g13
13
40 m
g4
720
mg
113
218
20 m
g54
40
mg
54
60 m
g55
55
12 1
2.7.
6.1.
1
15
N08
315.
3.5.
1-02
11
40
mg
120
mg
212
40 m
g13
13
20 m
g4
760
mg
120
mg
240
mg
312
60 m
g13
13
40 m
g4
720
mg
113
339
40 m
g86
60
mg
86 16
7
12 1
2.7.
6.1.
2
2
F1J-
MC
- H
MAW
5.
3.5.
1-03
60 m
g B
ID
12
()
20
mg
QD
112
20 m
g Q
D
60 m
g Q
D1
1260
mg
QD
60
mg
BID
13
40 m
g B
ID4
1260
mg
BID
457
20 m
g Q
D11
560
mg
QD
114
60 m
g B
ID11
311
5
12
2.7.
6.1.
3
3
F1J-
MC
- H
MAV
(a)
5.3.
5.1-
04
60 m
g B
ID
12
()
60
mg
QD
112
60 m
g Q
D13
30 m
g Q
D
60 m
g B
ID1
360
mg
QD
412
60 m
g B
ID13
60 m
g Q
D1
13
334
60 m
g Q
D11
460
mg
BID
112
108
12 1
2.7.
6.1.
4
- 5 -
2.7
.6-1
()
a)
2.7.
6
2
13
N08
225.
3.5.
2-01
1
1
40 m
g1
20 m
g2~
5040
mg
60 m
g1
20 m
g2
40 m
g3
40 m
g60
mg
4~50
60 m
g51
40 m
g52
20 m
g
149
40 m
g12
60
mg
137
50 2
2.7.
6.2.
1
3
16
N08
325.
3.5.
2-02
1
1
40 m
g1
20 m
g2~
5140
mg
5220
mg
60 m
g1
20 m
g2
40 m
g3~
5060
mg
5140
mg
5220
mg
258
40 m
g12
9 60
mg
129
50 51 1
2
2.7.
6.2.
2
2
F1J-
MC
- H
MAW
- Ex
tens
ion
5.3.
5.2-
03
60 m
g B
ID
1
2 (
)
60 m
g B
ID1
340
mg
BID
452
60 m
g B
ID
152
337
60 m
g B
ID22
211
5
522.
7.6.
2.3
F1J-
MC
- H
MB
T 5.
3.5.
2-04
60
mg
BID
1
2 (
)
160
mg
QD
2860
mg
QD
60
mg
BID
227
60 m
g B
ID
120
mg
QD
227
120
mg
QD
449
60 m
g B
ID33
412
0 m
g Q
D11
5
282.
7.6.
2.4
a)
20
mg
QD
120
mg
11
60 m
g Q
D1
60 m
g 1
160
mg
BID
160
mg
12
120
mg
QD
112
0 m
g 1
1
- 6 -
2.7.6.1
2.7.6.1.1
2.7.6.1.1.1
2.7.6.1.1-1
2.7.6.1.1-1
[ 5.3.5.1-01 ] 12N0821
( )
20 40 60 mg1 1 3
15 16 1 2 12 11 4 12
14 24 ( )
1 1 40 mg 20 mg1 40 mg 60 mg 20 mg 1
40 mg 1 60 mg
20 mg
P
P
20 mg 40 mg
20 mg P
40 mg60 mg
40 mg 20 mg
Visit
0 1 2 3 4 6 8 10 12 13
2 ( ) 31 4 5 6 7 8 9
20 mg
40 mg
60 mg 20 mg
a)
14-2 -1
a) 2 P
- 7 -
1) 20 75 2) 1 2 *
6 *
2
2
1 2
3 2 1 2 3
1
1) 2)
2
2 3 C128 10 4
[ (distal symmetric polyneuropathy) ( 2002 1 18 ) ]
3)
1) Visit1 HbA1c 9% 2) Visit2 7 24
4 3) Visit1 Visit2 80%
1) Visit1 7 MAO (Monoamine oxidase) 2)
()
3) 4) 5) 6)
7)
8) ( )
- 8 -
9) 10) Visit1 30 11) 1 12) ( )
1) Visit1 ALT 100 U/L 2) Visit1 2.0 mg/dL 3) Visit2 74) Visit2 1 Beck -II
( BDI-II) 20 2
1. 2 1
2. 2
( MINI (Mini international neuropsychiatric interview) )
5) Visit1 45 75 HbA1c Visit1±1.0%
6) ( )
200 ( 50 ) 218
(20 mg 54 40 mg 54 60 mg 55 55 )
Full Analysis Set (FAS) 216 (20 mg 54 40 mg 54 60 mg 55 53 )
Per Protocol Set (PPS) 188 (20 mg 49 40 mg 44 60 mg 45 50 )
218 (20 mg 54 40 mg 54 60 mg 55 55 )
( ) 1 50 (4 200 )
[ 5.3.5.1-03 ]
( ± ) -1.64±2.18 20 mg1 1 -2.16±2.45 60 mg 1 1 -2.70±2.54
40 mg 20 mg 60 mg2.5 1 50
60.8% 60 mg54.3% 60 mg
2 50.8%
1 20 mg
- 9 -
1 1 3
13
3 4 1
( A) 2
( B) 3 12
( C) ( D) ( E)
20 mg 20 mg 20 mg 20 mg 0 mg 0 mg 40 mg 20 mg 40 mg 40 mg 20 mg 0 mg 60 mg 20 mg 40 mg 60 mg 40 mg 20 mg
0 mg 0 mg 0 mg 0 mg 0 mg
A B C D E 1
13 ( 12 1 )
Visit2 7
1) (1 1.5 g
) 2) ( ®) 3) 4) ( ) 5) ( ) 6) 7) 2 ( ) 8) /
( ® ) (
®) ( ® ) 5-HT3 (® ) 5-HT4 ( ® ) 5-HT1B/1D (
® ) ( ® ) 9) 10) MAO ( ®) 11) ( ®) 12)
1) 2) 3) 4) 5) 6) 7)
Visit1 2
1)
- 10 -
2) 3) ( ) 4) ( ® ) 5) ( ® ) 6) ( ® ) 7) E1
( ® ) ( )
1) 9)
(BPI)
(PGI- ) Beck -II (BDI-II)
24 24 BPI-
PGI- BDI-II
/
(FAS)
(PPS) 1 ( )
15% Freeman-Halton Kruskal-Wallis
4
24 Last observation carried forward
(LOCF) ( -) 0.05
( 0.025) ( 0.025) 2
95%
Fisher (0.05)
54
20 20
- 11 -
Visit 1 2 - 3 - 4 5 6 7 8 9 - -2 -1 0 1 2 3 4 6 8 10 12
13/ 14
BPI PGI- BDI-II
b)
b)
a) b) BPI PGI- BDI Beck a) Visit2 b)
2.7.6.1.1.2
(1)
2.7.6.1.1-1
264 218 (20 mg 54 40 mg 54 60 mg
55 55 ) 218
40 (20 mg 9 40 mg 11 60 mg 11 9 )
178 (20 mg 45 40 mg 43 60 mg 44 46 )
264
46 42 4
218 20 mg 54 40 mg 54 60 mg 55 55
40 20 mg 9 40 mg 11 60 mg 11 9
178 20 mg 45 40 mg 43 60 mg 44 46
2.7.6.1.1-1
[ 5.3.5.1-01 10-1 ]
- 12 -
2.7.6.1.1-2
32 (20 mg 7 40 mg 10 60 mg
9 6 ) 3 (60 mg 1 2 )
2 (20 mg 1 1 ) 3 (20 mg 1 40 mg 1
60 mg 1 )
2.7.6.1.1-2
20 mg 40 mg 60 mg % % % % %
9 16.7 11 20.4 11 20.0 9 16.4 40 18.3 7 13.0 10 18.5 9 16.4 6 10.9 32 14.7 1 2 4 2 1 9 1 -2 1 1 3 5 3 -6 1 4 2 4 11 7 -12 3 1 2 1 7 12 0 0 0.0 0 0.0 1 1.8 2 3.6 3 1.4 1 0 1 -2 1 1 3 -6 0 7 -12 2 2 12 0 1 1.9 0 0.0 0 0.0 1 1.8 2 0.9 1 1 1 1 -2 1 1 3 -6 0 7 -12 0 12 0 1 1.9 1 1.9 1 1.8 0 0.0 3 1.4 1 0 1 -2 0 3 -6 1 1 7 -12 1 1 2 12 0 %
( ) 1 7 1 -2 8-14 3 -6 15-42 7 -12 43-84 12 85
[ 5.3.5.1-01 10-1 ]
2.7.6.1.1-2 2.7.6.1.1-3
218 (20 mg 54 40 mg 54 60 mg 55 55
) FAS 2 (
2 ) 216 (20 mg 54 40 mg 54 60 mg 55
53 ) PPS FAS 6 (20 mg 1 40 mg 1 60 mg
3 1 ) 22 (20 mg 4 40 mg 9 60 mg
- 13 -
7 2 ) 188 (20 mg 49 40 mg 44 60 mg
45 50 ) PPS
(13 ) (4 )
FAS PPS
218
20 mg 54 40 mg 54 60 mg 55 55
218 20 mg 54 40 mg 54 60 mg 55 55
2 2
FAS 216 20 mg 54 40 mg 54 60 mg 55 53
6 20 mg 1 40 mg 1 60 mg 3 1
22 20 mg 4 40 mg 9 60 mg 7 2
PPS 188 20 mg 49 40 mg 44 60 mg 45 50
2.7.6.1.1-2
[ 5.3.5.1-01 11-1 12-1 ]
2.7.6.1.1-3
FAS PPS
0158 × 0214 × 0228 ( ) × 0292 ×
20 mg
0371 × 0152 × 0283 × 0287 × 0326 × 0345 × 0423 × 0466 × 0592 × 0611 Visit1 2 1 3 ×
40 mg
0746 80% ( 1 )
×
- 14 -
2.7.6.1.1-3 ( )
FAS PPS
0071 × 0151 × 0156 × 0223 × 0314 × 0401 × 0453 Visit3 64.3%
Visit4 50.0% 42.9%
×
0575 × 0581 ×
60 mg
0745 × 0114 ( ) × 0298 Visit3
× ×
0468 × × 0582 ×
0616 × [ 5.3.5.1-01 11-2 ]
2.7.6.1.1-4
FAS 70.4% (152/216 ) 29.6% (64/216 ) (
± ) 60.2±9.4 4.78±4.25
(p=0.0856)
2.7.6.1.1-4 (FAS)
20 mg 40 mg 60 mg % % % % %
a)
216 100.0 54 100.0 54 100.0 55 100.0 53 100.0 Pe=0.2775
152 70.4 34 63.0 43 79.6 39 70.9 36 67.9 64 29.6 20 37.0 11 20.4 16 29.1 17 32.1
( ) Pk=0.2855 20 30 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 30 40 8 3.7 4 7.4 1 1.9 1 1.8 2 3.8 40 50 18 8.3 3 5.6 8 14.8 2 3.6 5 9.4 50 65 106 49.1 26 48.1 25 46.3 26 47.3 29 54.7 65 75 84 38.9 21 38.9 20 37.0 26 47.3 17 32.1 60.2 59.9 59.4 61.5 60.1 9.4 9.4 9.1 8.9 10.1 30 37 37 37 30 61.0 62.0 60.0 62.0 60.0 75 73 74 75 74
- 15 -
2.7.6.1.1-4 (FAS)( )
20 mg 40 mg 60 mg % % % % %
a)
216 100.0 54 100.0 54 100.0 55 100.0 53 100.0 (cm) Pk=0.1755
150 15 6.9 3 5.6 3 5.6 6 10.9 3 5.7 150 160 58 26.9 15 27.8 11 20.4 16 29.1 16 30.2 160 170 102 47.2 25 46.3 25 46.3 26 47.3 26 49.1 170 41 19.0 11 20.4 15 27.8 7 12.7 8 15.1 162.78 162.39 164.19 161.92 162.62 8.36 8.16 8.72 8.52 8.09 142.2 143.0 142.2 146.2 148.5 163.70 163.60 165.30 162.40 162.70 188.8 177.0 182.2 185.0 188.8
(kg) Pk=0.5722 50 26 12.0 9 16.7 6 11.1 5 9.1 6 11.3 50 60 64 29.6 13 24.1 16 29.6 22 40.0 13 24.5 60 70 72 33.3 17 31.5 17 31.5 19 34.5 19 35.8 70 54 25.0 15 27.8 15 27.8 9 16.4 15 28.3 62.81 63.34 62.59 60.84 64.54 12.00 13.57 11.40 8.70 13.73 36.1 38.3 38.0 36.1 42.6 62.75 62.55 62.45 60.00 64.00 109.0 101.0 87.0 76.1 109.0 BMI (kg/m2) Pk=0.6719 18.5 15 6.9 4 7.4 3 5.6 3 5.5 5 9.4 18.5 25.0 132 61.1 29 53.7 34 63.0 38 69.1 31 58.5 25.0 30.0 61 28.2 19 35.2 17 31.5 14 25.5 11 20.8 30.0 35.0 6 2.8 2 3.7 0 0.0 0 0.0 4 7.5 35.0 40.0 2 0.9 0 0.0 0 0.0 0 0.0 2 3.8 40.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 23.64 23.88 23.13 23.17 24.39 3.75 4.04 3.31 2.63 4.70 15.8 16.4 15.9 15.8 16.2 23.35 23.36 23.30 23.25 23.49 37.9 34.9 30.0 29.0 37.9
Pe=1.0000
7 173 80.1 43 79.6 43 79.6 44 80.0 43 81.1 7 43 19.9 11 20.4 11 20.4 11 20.0 10 18.9
Pe=0.9689 1 9 4.2 2 3.7 3 5.6 2 3.6 2 3.8 2 207 95.8 52 96.3 51 94.4 53 96.4 51 96.2
( ) Pk=0.9518 5 41 19.0 8 14.8 10 18.5 14 25.5 9 17.0 5 10 51 23.6 16 29.6 14 25.9 9 16.4 12 22.6 10 124 57.4 30 55.6 30 55.6 32 58.2 32 60.4 12.52 11.49 13.21 12.10 13.30 8.12 7.48 8.47 7.82 8.75 0.7 0.9 0.8 0.7 0.7 10.88 10.36 11.46 10.56 13.47 41.6 41.6 33.2 29.7 35.9
- 16 -
2.7.6.1.1-4 (FAS)( )
20 mg 40 mg 60 mg % % % % %
a)
216 100.0 54 100.0 54 100.0 55 100.0 53 100.0
( ) Pe=0.9928
2 56 25.9 14 25.9 13 24.1 15 27.3 14 26.4 2 160 74.1 40 74.1 41 75.9 40 72.7 39 73.6 4.78 4.22 4.58 4.91 5.44 4.25 3.60 3.97 3.90 5.35 0.5 0.6 0.7 0.5 0.6 3.56 3.28 3.27 3.84 4.59 30.9 21.2 21.8 15.9 30.9
Pe=0.5253 179 82.9 45 83.3 45 83.3 48 87.3 41 77.4 27 12.5 7 13.0 5 9.3 4 7.3 11 20.8 8 3.7 2 3.7 3 5.6 2 3.6 1 1.9 2 0.9 0 0.0 1 1.9 1 1.8 0 0.0
Pk=0.0856
0 179 82.9 39 72.2 47 87.0 48 87.3 45 84.9 1 2 4 1.9 1 1.9 0 0.0 2 3.6 1 1.9 3 5 6 2.8 2 3.7 2 3.7 1 1.8 1 1.9 6 10 10 4.6 3 5.6 3 5.6 2 3.6 2 3.8 11 17 7.9 9 16.7 2 3.7 2 3.6 4 7.5 2.5 4.7 1.5 1.3 2.3 7.3 10.0 5.4 5.0 7.2 0 0 0 0 0 0.0 0.0 0.0 0.0 0.0 42 42 35 33 35
Pe=0.5812 81 37.5 20 37.0 23 42.6 22 40.0 16 30.2 135 62.5 34 63.0 31 57.4 33 60.0 37 69.8
Pe=0.4285 6 2.8 3 5.6 0 0.0 2 3.6 1 1.9 210 97.2 51 94.4 54 100.0 53 96.4 52 98.1
Pe=0.3838 5 2.3 0 0.0 1 1.9 3 5.5 1 1.9 211 97.7 54 100.0 53 98.1 52 94.5 52 98.1
Pe=0.9412
117 54.2 28 51.9 31 57.4 29 52.7 29 54.7 99 45.8 26 48.1 23 42.6 26 47.3 24 45.3
Pe=0.2096 56 25.9 9 16.7 17 31.5 13 23.6 17 32.1 160 74.1 45 83.3 37 68.5 42 76.4 36 67.9
Pe=0.7442
214 99.1 53 98.1 53 98.1 55 100.0 53 100.0 2 0.9 1 1.9 1 1.9 0 0.0 0 0.0
- 17 -
2.7.6.1.1-4 (FAS)( )
20 mg 40 mg 60 mg % % % % %
a)
216 100.0 54 100.0 54 100.0 55 100.0 53 100.0
Pe=0.8224
90 mL/min 106 49.1 25 46.3 26 48.1 26 47.3 29 54.7 90 mL/min 110 50.9 29 53.7 28 51.9 29 52.7 24 45.3 94.17 96.32 93.94 89.86 96.70 31.76 29.88 36.39 27.04 33.49 28.8 45.5 28.8 41.6 49.0 89.22 87.31 87.55 88.08 96.62 237.9 159.3 196.9 155.4 237.9 a) Pe Freeman-Halton Pk Kruskal-Wallis p 0.15
[ 5.3.5.1-01 11-4 ]
(4)
(A)
(a)
2.7.6.1.1-5
(p=0.0004)
2.7.6.1.1-5 (FAS)
t a)
0.2268 0.5746 211 0.39 Pr=0.6935 0.0036 0.0054 211 0.65 Pr=0.5143
-0.3453 0.0952 211 -3.63 Pr=0.0004 1 0.3653 0.6097 211 0.60 Pr=0.5497 2 0.0000 2 -0.2384 0.2783 211 -0.86 Pr=0.3925 2 0.0000
a) Pr p
[ 5.3.5.1-01 11-7 ]
(b)
(LOCF) 2.7.6.1.1-6
(LOCF)
- 18 -
( ± ) 20 mg -1.80±0.38 40 mg
-1.80±0.37 60 mg -1.24±0.38 -1.50±0.38
2.7.6.1.1-6 (LOCF) (FAS)
95%
a)
20 mg 54 -1.80 0.38 -2.55 -1.06 - 40 mg 54 -1.80 0.37 -2.53 -1.07 - 60 mg 55 -1.24 0.38 -1.99 -0.50 -
53 -1.50 0.38 -2.24 -0.75 - 20 mg- - -0.31 0.33 -0.96 0.34 Pac=0.3504 40 mg- - -0.31 0.33 -0.96 0.35 Pac=0.3570 60 mg- - 0.25 0.33 -0.40 0.90 Pac=0.4484 a) Pac p
[ 5.3.5.1-01 11-8 ]
2.7.6.1.1-7
× ×
20 mg
1 4 (p=0.0011 0.0473) 12 ( ±
) 20 mg -2.04±0.30 40 mg -2.20±0.30 60 mg -1.50±0.30 -1.70±0.30
2.7.6.1.1-7 (FAS)
1 2 3 4 5 6 7 8 9 10 11 1220 mg
54 52 50 50 50 50 47 46 45 45 45 45
a) -0.87 ±0.20
-1.09 ±0.22
-1.30 ±0.24
-1.42±0.25
-1.59±0.26
-1.67±0.26
-1.87±0.28
-1.85±0.28
-1.85 ±0.28
-1.93 ±0.29
-2.04 ±0.29
-2.04±0.30
95% -0.48 -0.67 -0.83 -0.93 -1.09 -1.15 -1.33 -1.30 -1.30 -1.36 -1.47 -1.4695% -1.25 -1.52 -1.78 -1.91 -2.09 -2.18 -2.41 -2.40 -2.40 -2.49 -2.62 -2.62
(Pm) b) 0.0011 0.0261 0.0473 0.0465 0.0687 0.1618 0.1430 0.1881 0.2871 0.2723 0.1534 0.341040 mg
54 50 49 47 47 45 45 45 43 43 43 43
a) -0.46 ±0.19
-0.78 ±0.22
-1.09 ±0.24
-1.34±0.25
-1.57±0.25
-1.70±0.26
-1.92±0.28
-2.04±0.28
-2.14 ±0.28
-2.12 ±0.29
-2.19 ±0.29
-2.20±0.30
95% -0.08 -0.36 -0.62 -0.85 -1.07 -1.18 -1.38 -1.49 -1.58 -1.55 -1.61 -1.6195% -0.83 -1.21 -1.56 -1.83 -2.06 -2.21 -2.46 -2.59 -2.69 -2.69 -2.76 -2.78
(Pm) b) 0.2880 0.3897 0.2284 0.0893 0.0825 0.1381 0.1082 0.0605 0.0589 0.0996 0.0701 0.1694
- 19 -
2.7.6.1.1-7 (FAS)( )
1 2 3 4 5 6 7 8 9 10 11 1260 mg
55 53 48 48 46 46 45 45 45 45 45 44
a) -0.57 ±0.20
-0.82 ±0.22
-0.94 ±0.24
-1.04±0.25
-1.21±0.26
-1.23±0.26
-1.34±0.28
-1.30±0.28
-1.30 ±0.28
-1.37 ±0.29
-1.47 ±0.29
-1.50±0.30
95% -0.19 -0.39 -0.47 -0.55 -0.71 -0.71 -0.79 -0.75 -0.75 -0.80 -0.90 -0.9295% -0.96 -1.24 -1.42 -1.53 -1.72 -1.75 -1.88 -1.85 -1.85 -1.94 -2.05 -2.08
(Pm) b) 0.0906 0.3112 0.5129 0.4940 0.5785 0.9815 0.8799 0.7554 0.5661 0.6308 0.8580 0.5909
53 53 53 53 51 50 49 49 47 47 46 46
a) -0.26 ±0.20
-0.59 ±0.22
-0.77 ±0.24
-0.85±0.25
-1.05±0.26
-1.24±0.26
-1.39±0.28
-1.41±0.28
-1.49 ±0.28
-1.54 ±0.29
-1.54 ±0.29
-1.70±0.30
95% 0.13 -0.16 -0.29 -0.35 -0.55 -0.72 -0.85 -0.86 -0.95 -0.97 -0.97 -1.1295% -0.65 -1.02 -1.24 -1.34 -1.55 -1.75 -1.93 -1.95 -2.04 -2.11 -2.11 -2.27a) ± b) Pm p
× × [ 5.3.5.1-01 14.2-2 ]
2.7.6.1.1-8 2.7.6.1.1-9
30% 30%
30% 30% (50% 75% 100%
) 30%
2 30% 2
20%
Fisher Cochran-armitage
30% 41.5% 40 mg
51.9% 50% 24.5% 40 mg 40.7% 10 15%
- 20 -
2.7.6.1.1-8 (FAS) a)
20 mg 40 mg 60 mg 20 mg 40 mg 60 mg
b)
54 54 55 53 30% 25 28 23 22 30% (%) 46.3 51.9 41.8 41.5
Pe=0.6981 Pe=0.3346 Pe=1.0000 Pca=0.8412
50% 16 22 10 13 50% (%) 29.6 40.7 18.2 24.5
Pe=0.6646 Pe=0.0993 Pe=0.4851 Pca=0.7510
75% 7 7 5 5 75% (%) 13.0 13.0 9.1 9.4
Pe=0.7608 Pe=0.7608 Pe=1.0000 Pca=0.9485
100% 2 1 1 0 Pe=0.4953 Pe=1.0000 Pe=1.0000 Pca=0.6698100% (%) 3.7 1.9 1.8 0.0 a) Pe Fisher p b) Pca Cochran-Armitage p
[ 5.3.5.1-01 11-13 ]
2.7.6.1.1-9 (FAS) a)
20 mg 40 mg 60 mg 20 mg 40 mg 60 mg
b)
54 54 55 53 24 26 19 19 Pe=0.4319 Pe=0.2414 Pe=1.0000 Pca=0.9780 (%) 44.4 48.1 34.5 35.8
a) Pe Fisher p b) Pca Cochran-Armitage p
[ 5.3.5.1-01 11-14 ]
30% 2.7.6.1.1-10
2.7.6.1.1-11
30% 30%
30%
2.7.6.1.1-10 30% (FAS)
a)
( )
( ) b)
20 mg 54 27 1 6.5 Pl=0.6224 40 mg 54 25 1 4.5 Pl=0.2586 60 mg 55 28 1 5.0 Pl=0.5347
53 27 1 9.0 - a) b) Pl p
[ 5.3.5.1-01 11-15 ]
- 21 -
2.7.6.1.1-11 (FAS)
a)
( )
( ) b)
20 mg 54 30 1 8.5 Pl=0.2189 40 mg 54 28 1 4.5 Pl=0.0571 60 mg 55 36 1 10.0 Pl=0.7965
53 34 1 12.0 - a) b) Pl p
[ 5.3.5.1-01 11-16 ]
2.7.6.1.1-12
2.7.6.1.1-13
( )
( ) 2
1
BDI-II 2 BDI-II
1 (0.0018)
BDI-II (p=0.0102)
BDI-II
100%
100%
2.7.6.1.1-12 (FAS)
t a) 1 -1.6163 0.2189 205 -7.38 Pr 0.0001
0.0018 0.0056 205 0.32 Pr=0.7472 BDI-II
0.0631 0.0244 205 2.59 Pr=0.0102
2 -2.3419 0.6048 206 -3.87 Pr=0.0001 -0.0020 0.0160 206 -0.13 Pr=0.8986 a) Pr p
[ 5.3.5.1-01 11-19 ]
2.7.6.1.1-13 (FAS)
107.7% -7.7%
[ 5.3.5.1-01 11-20 ]
- 22 -
(B)
(a)
(LOCF)
2.7.6.1.1-14
PGI- (p=<0.0001
0.0005)
2.7.6.1.1-14 (LOCF) (FAS)
t a)
0.0051 0.0058 211 0.87 Pr=0.3846 0.0037 0.0057 211 0.65 Pr=0.5157
0.0063 0.0063 206 1.00 Pr=0.3202 BPI- 0.0022 0.0059 206 0.36 Pr=0.7162
0.0053 0.0058 206 0.91 Pr=0.3626 0.0020 0.0061 206 0.32 Pr=0.7471
0.0010 0.0064 206 0.15 Pr=0.8789 BPI- -0.0046 0.0063 206 -0.73 Pr=0.4637
0.0064 0.0065 206 0.99 Pr=0.3254 -0.0065 0.0066 206 -0.98 Pr=0.3277 -0.0007 0.0062 206 -0.11 Pr=0.9156 0.0023 0.0063 206 0.37 Pr=0.7105 -0.0064 0.0068 206 -0.94 Pr=0.3472 7 -0.0006 0.0057 206 -0.10 Pr=0.9214 PGI- 0.0036 0.0035 204 1.05 Pr=0.2933 BDI-II -0.0026 0.0148 203 -0.18 Pr=0.8592
-0.0005 0.0022 206 -0.21 Pr=0.8334 -0.0002 0.0019 206 -0.09 Pr=0.9278 -0.0042 0.0023 206 -1.85 Pr=0.0663 0.0004 0.0016 206 0.24 Pr=0.8130 BPI PGI- BDI Beck a) Pr p
[ 5.3.5.1-01 11-11 ]
(b)
(LOCF) 2.7.6.1.1-15
20 mg BPI-
(p=0.0013) (p=0.0320) (p=0.0058)
(p=0.0066) (p=0.0065) (p=0.0344) (p=0.0022) 7
(p=0.0020) 40 mg BPI-
(p=0.0373) (p=0.0448) 60 mg
- 23 -
2.7.6.1.1-15 (LOCF)(FAS) a)
20 mg 54 -1.80 0.41 Pac=0.6259 40 mg 54 -1.64 0.40 Pac=0.9748 60 mg 55 -1.32 0.41 Pac=0.3746 53 -1.63 0.41 -
20 mg 54 -1.75 0.40 Pac=0.6903 40 mg 54 -1.73 0.39 Pac=0.7355 60 mg 55 -1.35 0.40 Pac=0.4726 53 -1.61 0.40 - BPI- 20 mg 53 -1.8 0.4 Pac=0.6940 40 mg 51 -1.7 0.4 Pac=0.9228 60 mg 54 -1.2 0.4 Pac=0.2969 53 -1.6 0.4 - 20 mg 53 -1.2 0.4 Pac=0.8488 40 mg 51 -1.6 0.4 Pac=0.4829 60 mg 54 -1.0 0.4 Pac=0.4601 53 -1.3 0.4 - 20 mg 53 -1.7 0.4 Pac=0.4308 40 mg 51 -1.8 0.4 Pac=0.3597 60 mg 54 -1.1 0.4 Pac=0.2938 53 -1.4 0.4 - 20 mg 53 -1.2 0.4 Pac=0.7324 40 mg 51 -1.6 0.4 Pac=0.2475 60 mg 54 -0.9 0.4 Pac=0.4981 53 -1.1 0.4 - BPI- 20 mg 53 -2.3 0.4 Pac=0.0013 40 mg 51 -1.7 0.4 Pac=0.0822 60 mg 54 -1.1 0.4 Pac=0.7408 53 -1.0 0.4 - 20 mg 53 -2.1 0.4 Pac=0.0320 40 mg 51 -1.8 0.4 Pac=0.1846 60 mg 54 -1.7 0.4 Pac=0.3038 53 -1.3 0.4 - 20 mg 53 -2.0 0.5 Pac=0.0058 40 mg 51 -1.4 0.5 Pac=0.2042 60 mg 54 -0.6 0.4 Pac=0.5677 53 -0.9 0.4 - 20 mg 53 -1.9 0.5 Pac=0.0066 40 mg 51 -1.6 0.5 Pac=0.0373 60 mg 54 -1.3 0.5 Pac=0.1803 53 -0.8 0.5 - 20 mg 53 -1.4 0.4 Pac=0.0065 40 mg 51 -0.9 0.4 Pac=0.1435 60 mg 54 -0.6 0.4 Pac=0.5772 53 -0.4 0.4 - 20 mg 53 -2.2 0.4 Pac=0.0344 40 mg 51 -1.8 0.4 Pac=0.2530 60 mg 54 -1.4 0.4 Pac=0.9764 53 -1.4 0.4 -
- 24 -
2.7.6.1.1-15 (LOCF)(FAS)( )
a)
20 mg 53 -2.0 0.5 Pac=0.0022 40 mg 51 -1.6 0.5 Pac=0.0448 60 mg 54 -1.3 0.5 Pac=0.1586 53 -0.7 0.5 - 7 20 mg 53 -2.03 0.40 Pac=0.0020 40 mg 51 -1.56 0.40 Pac=0.0844 60 mg 54 -1.16 0.39 Pac=0.5525 53 -0.96 0.40 - PGI- 20 mg 52 2.9 0.2 Pac=0.8669 40 mg 51 2.9 0.2 Pac=0.9828 60 mg 54 3.1 0.2 Pac=0.1994 52 2.9 0.2 - BDI-II 20 mg 51 -3.4 1.1 Pac=0.8319 40 mg 51 -3.1 1.1 Pac=0.9264 60 mg 54 -3.4 1.0 Pac=0.7766 52 -3.2 1.1 -
20 mg 53 -0.6 0.2 Pac=0.1777 40 mg 51 -0.4 0.2 Pac=0.9463 60 mg 54 -0.5 0.2 Pac=0.5421 53 -0.4 0.2 - 20 mg 53 -0.4 0.1 Pac=0.7331 40 mg 51 -0.4 0.1 Pac=0.8552 60 mg 54 -0.3 0.1 Pac=0.9910 53 -0.3 0.1 - 20 mg 53 -0.4 0.2 Pac=0.4242 40 mg 51 -0.5 0.2 Pac=0.1395 60 mg 54 -0.5 0.2 Pac=0.0885 53 -0.2 0.2 - 20 mg 53 -0.2 0.1 Pac=0.9868 40 mg 51 -0.3 0.1 Pac=0.3182 60 mg 54 -0.2 0.1 Pac=0.5127 53 -0.2 0.1 - BPI PGI- BDI Beck a) Pac p
[ 5.3.5.1-01 11-12 ]
12 2.7.6.1.1-16
× ×
12 20 mg BPI-
(p=0.0007) (p=0.0277)
(p=0.0025) (p=0.0079) (p=0.0058) (p=0.0228)
(p=0.0019) 7 (p=0.0011) 40 mg
- 25 -
60 mg BPI- (p=0.0256)
2.7.6.1.1-16 12 (FAS) a)
20 mg 45 -2.25 0.31 Pm=0.6840 40 mg 43 -2.34 0.32 Pm=0.4979 60 mg 44 -1.90 0.31 Pm=0.4732 46 -2.12 0.31 -
20 mg 45 -2.10 0.33 Pm=0.6128 40 mg 43 -2.22 0.33 Pm=0.4265 60 mg 44 -1.73 0.33 Pm=0.6334 46 -1.91 0.32 - BPI- 20 mg 43 -2.0 0.4 Pm=0.5122 40 mg 42 -2.0 0.4 Pm=0.5095 60 mg 43 -1.5 0.4 Pm=0.6567 46 -1.7 0.4 - 20 mg 43 -1.2 0.4 Pm=0.9068 40 mg 42 -1.5 0.4 Pm=0.4498 60 mg 43 -1.1 0.4 Pm=0.8370 46 -1.2 0.4 - 20 mg 43 -1.9 0.4 Pm=0.3807 40 mg 42 -2.0 0.4 Pm=0.2886 60 mg 43 -1.4 0.4 Pm=0.6062 46 -1.6 0.4 - 20 mg 43 -1.2 0.4 Pm=0.7087 40 mg 42 -1.6 0.4 Pm=0.1651 60 mg 43 -1.0 0.4 Pm=0.9174 46 -1.1 0.4 - BPI- 20 mg 43 -2.4 0.4 Pm=0.0007 40 mg 42 -1.7 0.4 Pm=0.1056 60 mg 43 -1.5 0.4 Pm=0.3490 46 -1.1 0.4 - 20 mg 43 -2.2 0.4 Pm=0.0277 40 mg 42 -1.9 0.4 Pm=0.1373 60 mg 43 -2.0 0.4 Pm=0.0800 46 -1.4 0.4 - 20 mg 43 -2.2 0.4 Pm=0.0025 40 mg 42 -1.6 0.4 Pm=0.1220 60 mg 43 -1.1 0.4 Pm=0.7533 46 -1.0 0.4 - 20 mg 43 -1.7 0.4 Pm=0.0079 40 mg 42 -1.4 0.5 Pm=0.0701 60 mg 43 -1.4 0.4 Pm=0.0660 46 -0.6 0.4 - 20 mg 43 -1.4 0.4 Pm=0.0058 40 mg 42 -0.8 0.4 Pm=0.2572 60 mg 43 -0.9 0.4 Pm=0.1450 46 -0.4 0.4 -
- 26 -
2.7.6.1.1-16 12 (FAS)( )
a)
20 mg 43 -2.5 0.4 Pm=0.0228 40 mg 42 -2.1 0.4 Pm=0.1910 60 mg 43 -1.8 0.4 Pm=0.5690 46 -1.6 0.4 - 20 mg 43 -1.7 0.4 Pm=0.0019 40 mg 42 -1.2 0.4 Pm=0.0591 60 mg 43 -1.4 0.4 Pm=0.0256 46 -0.4 0.4 - 7 20 mg 43 -2.11 0.35 Pm=0.0011 40 mg 42 -1.57 0.37 Pm=0.0921 60 mg 43 -1.45 0.35 Pm=0.1770 46 -0.98 0.35 - PGI- 20 mg 43 2.9 0.2 Pm=0.8030 40 mg 42 2.6 0.2 Pm=0.4125 60 mg 43 3.0 0.2 Pm=0.4245 46 2.8 0.2 - BDI-II 20 mg 43 -2.8 1.0 Pm=0.9330 40 mg 42 -3.1 1.0 Pm=0.8286 60 mg 43 -3.7 1.0 Pm=0.3563 46 -2.9 1.0 -
20 mg 43 -0.7 0.1 Pm=0.1669 40 mg 42 -0.6 0.2 Pm=0.6965 60 mg 43 -0.7 0.1 Pm=0.2594 46 -0.5 0.1 - 20 mg 43 -0.4 0.1 Pm=0.5747 40 mg 42 -0.4 0.1 Pm=0.6316 60 mg 43 -0.4 0.1 Pm=0.7967 46 -0.3 0.1 - 20 mg 43 -0.4 0.1 Pm=0.4965 40 mg 42 -0.6 0.1 Pm=0.1088 60 mg 43 -0.6 0.1 Pm=0.0558 46 -0.3 0.1 - 20 mg 43 -0.2 0.1 Pm=0.9380 40 mg 42 -0.4 0.1 Pm=0.1458 60 mg 43 -0.2 0.1 Pm=0.9633 46 -0.2 0.1 - BPI PGI- BDI Beck a) Pm p
× × [ 5.3.5.1-01 14.2-43 ]
(5)
(A)
2.7.6.1.1-17
( ) 20 mg 47/54 (87.0%) 196 40 mg 47/54 (87.0%)
- 27 -
226 60 mg 47/55 (85.5%) 189 44/55 (80.0%) 140
( )
( ) 20 mg 45/54 (83.3%) 40 mg 46/54
(85.2%) 60 mg 45/55 (81.8%) 42/55 (76.4%)
( )
( ) 20 mg 19/54 (35.2%) 40 mg
18/54 (33.3%) 60 mg 19/55 (34.5%) 13/55 (23.6%)
( )
( ) 20 mg 32/54 (59.3%) 109 40 mg 42/54 (77.8%)
118 60 mg 38/55 (69.1%) 92 24/55 (43.6%) 52
( ) 40
mg (p=0.0004) 60 mg (p=0.0121) ( ) 20 mg 28/54
(51.9%) 40 mg 40/54 (74.1%) 60 mg 34/55 (61.8%)
22/55 (40.0%) ( )
40 mg (p=0.0005) 60 mg (p=0.0354) (
) 20 mg 14/54 (25.9%) 40 mg 7/54 (13.0%) 60 mg
11/55 (20.0%) 5/55 (9.1%) ( )
20 mg (p=0.0244)
2.7.6.1.1-17
20 mg 40 mg 60 mg 20 mg 40 mg 60 mg
54 54 55 55 54 54 55 55
47 47 47 44 32 42 38 24 (%) 87.0 87.0 85.5 80.0 59.3 77.8 69.1 43.6
95% (%) 94.6 94.6 93.5 89.6 72.4 88.0 80.9 57.7 95% (%) 75.1 75.1 73.3 67.0 45.0 64.4 55.2 30.3
p a) Pe=0.4402 Pe=0.4402 Pe=0.6148 - Pe=0.1265 Pe=0.0004 Pe=0.0121 -
45 46 45 42 28 40 34 22 (%) 83.3 85.2 81.8 76.4 51.9 74.1 61.8 40.0
95% (%) 92.1 93.4 90.9 86.8 65.7 85.0 74.6 54.1 95% (%) 70.7 72.9 69.1 63.0 37.8 60.3 47.7 27.0
p a) Pe=0.4752 Pe=0.3320 Pe=0.6398 - Pe=0.2512 Pe=0.0005 Pe=0.0354 -
19 18 19 13 14 7 11 5 (%) 35.2 33.3 34.5 23.6 25.9 13.0 20.0 9.1
95% (%) 49.4 47.5 48.6 37.0 39.7 24.9 33.0 20.0 95% (%) 22.7 21.1 22.2 13.2 15.0 5.4 10.4 3.0
p a) Pe=0.2116 Pe=0.2939 Pe=0.2939 - Pe=0.0244 Pe=0.5563 Pe=0.1751 - a) Fisher
[ 5.3.5.1-01 14.3-1 ]
- 28 -
(MedDRA )
2.7.6.1.1-18
5% 20 mg 15 (27.8%) 16 8
(14.8%) 8 6 (11.1%) 7 6 (11.1%) 6 CK
5 (9.3%) 6 5 (9.3%) 5 4 (7.4%) 6
ALT 4 (7.4%) 4
/ 3 (5.6%) 3 40 mg
16 (29.6%) 18 15 (27.8%) 15 7 (13.0%)
9 7 (13.0%) 7 -GTP 6 (11.1%) 6 5 (9.3%)
6 ALT AST HbA1c 4 (7.4%) 4 3 (5.6%) 7
CK
3 (5.6%) 3 60 mg
17 (30.9%) 19 10 (18.2%) 12 7 (12.7%) 8
7 (12.7%) 7 6 (10.9%) 6 -GTP
4 (7.3%) 4 3 (5.5%) 5 BUN
/ ALP 3 (5.5%) 3
8 (14.5%) 9 6 (10.9%) 6 5 (9.1%)
5 ALT AST 3 (5.5%) 3
(20 mg p=0.0139
40 mg p=0.0077) (40 mg p=0.0059)
20 mg 39 (72.2%) 122 29 (53.7%) 69
3 (5.6%) 5 40 mg 40 (74.1%) 144
33 (61.1%) 79 3 (5.6%) 3 60 mg 43 (78.2%) 122
26 (47.3%) 67 0 30 (54.5%)
72 31 (56.4%) 67 1 (1.8%) 1
24 2 6 20 mg
4 40 mg 8 60 mg 2 20 mg 1 60 mg 1
5% 20 mg 12 (22.2%) 13 8 (14.8%)
8 5 (9.3%) 5 ALT 4 (7.4%) 4 3 (5.6%)
4 / 3
(5.6%) 3 40 mg 15 (27.8%) 16 15 (27.8%) 15
6 (11.1%) 8 6 (11.1%) 6 3 (5.6%) 7
5 (9.3%) 5 -GTP HbA1c 3 (5.6%) 3
60 mg 17 (30.9%) 18 9 (16.4%) 10
6 (10.9%) 6 4 (7.3%) 4 -GTP ALP 3 (5.5%) 3
- 29 -
7 (12.7%) 8 5 (9.1%) 5 3
(5.5%) 3
(20 mg p=0.0271)
(20 mg p=0.0130 40 mg p=0.0018) (40 mg p=0.0128)
(60 mg p=0.0363)
20 mg 29 (53.7%) 80 11 (20.4%) 27
1 (1.9%) 2 40 mg 36 (66.7%) 87 18
(33.3%) 30 1 (1.9%) 1 60 mg 34 (61.8%) 68
14 (25.5%) 24 0 19 (34.5%) 33
13 (23.6%) 19 0
- 30 -
2.7
.6.1
.1-1
8
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
39(
122)
72.
2% 4
0(14
4) 7
4.1%
43(
122)
78.
2% 3
0 (7
2) 5
4.5%
29
(80)
53.
7% 3
6 (8
7) 6
6.7%
34
(68)
61.
8% 1
9 (3
3) 3
4.5%
29
(69)
53.
7% 3
3 (7
9) 6
1.1%
26
(67)
47.
3% 3
1 (6
7) 5
6.4%
11
(27)
20.
4% 1
8 (3
0) 3
3.3%
14
(24)
25.
5% 1
3 (1
9) 2
3.6%
3
(5)
5.6%
3
(3)
5.6%
0
(0)
0.0%
1
(1)
1.8%
1
(2)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
4
7(19
6) 8
7.0%
47(
226)
87.
0% 4
7(18
9) 8
5.5%
44(
140)
80.
0% 3
2(10
9) 5
9.3%
42(
118)
77.
8% 3
8 (9
2) 6
9.1%
24
(52)
43.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
3 (4
) 5.
6%
3 (3
) 5.
5%
1 (1
) 1.
8%
0
(0)
0.0%
3
(4)
5.6%
1
(1)
1.8%
1
(1)
1.8%
1
(1)
1.9%
2
(3)
3.7%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3 (3
) 5.
6%
4 (7
) 7.
4%
3 (3
) 5.
5%
1 (1
) 1.
8%
2
(2)
3.7%
3
(5)
5.6%
1
(1)
1.8%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 31 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.7%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
2 (2
) 3.
6%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.6%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
6 (6
) 11
.1%
2
(2)
3.6%
2
(2)
3.6%
0 (0
) 0.
0%
2 (2
) 3.
7%
2 (2
) 3.
6%
0 (0
) 0.
0%
- 32 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
3
(3)
5.5%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
1 (1
) 1.
9%
1 (1
) 1.
8%
5 (5
) 9.
1%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
- 33 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
1
9 (2
7) 3
5.2%
18
(27)
33.
3% 1
1 (1
6) 2
0.0%
6
(8)
10.9
%
13
(18)
24.
1% 1
7 (2
6) 3
1.5%
10
(13)
18.
2%
4 (6
) 7.
3%
9 (1
4) 1
6.7%
11
(14)
20.
4% 1
1 (1
7) 2
0.0%
10
(13)
18.
2%
6
(9)
11.1
%
8 (8
) 14
.8%
10
(14)
18.
2%
6 (6
) 10
.9%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
6 (4
2) 4
8.1%
27
(42)
50.
0% 1
9 (3
3) 3
4.5%
14
(21)
25.
5%
19
(28)
35.
2% 2
3 (3
4) 4
2.6%
17
(27)
30.
9% 1
0 (1
2) 1
8.2%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 34 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.6%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
3 (3
) 5.
6%
3 (3
) 5.
6%
3 (3
) 5.
5%
1 (1
) 1.
8%
3
(3)
5.6%
3
(3)
5.6%
3
(3)
5.5%
1
(1)
1.8%
2
(2)
3.7%
4
(4)
7.4%
3
(3)
5.5%
5
(5)
9.1%
2 (2
) 3.
7%
3 (3
) 5.
6%
3 (3
) 5.
5%
4 (4
) 7.
3%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5 (5
) 9.
3%
7 (7
) 13
.0%
6
(6)
10.9
%
6 (6
) 10
.9%
5 (5
) 9.
3%
6 (6
) 11
.1%
6
(6)
10.9
%
5 (5
) 9.
1%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
5 (5
) 9.
3%
3 (7
) 5.
6%
1 (1
) 1.
8%
0 (0
) 0.
0%
4
(4)
7.4%
3
(7)
5.6%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
1
(2)
1.8%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (6
) 11
.1%
3
(7)
5.6%
2
(2)
3.6%
1
(2)
1.8%
5 (5
) 9.
3%
3 (7
) 5.
6%
2 (2
) 3.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
1
(2)
1.8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (2
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (2
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
2 (4
) 3.
6%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
2
(3)
3.6%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 35 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
9
(10)
16.
7% 1
1 (1
2) 2
0.4%
4
(5)
7.3%
3
(3)
5.5%
7 (8
) 13
.0%
11
(12)
20.
4%
4 (4
) 7.
3%
2 (2
) 3.
6%
5 (5
) 9.
3%
6 (6
) 11
.1%
7
(7)
12.7
%
2 (2
) 3.
6%
4
(4)
7.4%
4
(4)
7.4%
6
(6)
10.9
%
1 (1
) 1.
8%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
5 (1
6) 2
7.8%
16
(18)
29.
6% 1
0 (1
2) 1
8.2%
5
(5)
9.1%
1
2 (1
3) 2
2.2%
15
(16)
27.
8%
9 (1
0) 1
6.4%
3
(3)
5.5%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.7%
1
(2)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
2 (2
) 3.
7%
1 (2
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
3 (3
) 5.
6%
1 (2
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
2
(2)
3.7%
1
(2)
1.8%
0
(0)
0.0%
- 36 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
2 (2
) 3.
7%
0 (0
) 0.
0%
2 (2
) 3.
6%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
4
(4)
7.4%
2
(2)
3.7%
1
(1)
1.8%
0
(0)
0.0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (6
) 11
.1%
2
(2)
3.7%
3
(3)
5.5%
1
(1)
1.8%
3 (3
) 5.
6%
1 (1
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
1
2 (1
6) 2
2.2%
8
(9)
14.8
%
7 (9
) 12
.7%
5
(7)
9.1%
8 (1
0) 1
4.8%
5
(5)
9.3%
5
(6)
9.1%
2
(3)
3.6%
3
(3)
5.6%
7
(9)
13.0
%
4 (8
) 7.
3%
1 (3
) 1.
8%
3
(3)
5.6%
5
(6)
9.3%
3
(3)
5.5%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
4 (1
9) 2
5.9%
12
(18)
22.
2% 1
0 (1
7) 1
8.2%
6
(10)
10.
9%
10
(13)
18.
5%
8 (1
1) 1
4.8%
7
(9)
12.7
%
2 (3
) 3.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
3 (3
) 5.
6%
0 (0
) 0.
0%
1 (1
) 1.
8%
1
(1)
1.9%
2
(2)
3.7%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
3 (3
) 5.
6%
0 (0
) 0.
0%
1 (1
) 1.
8%
1
(1)
1.9%
2
(2)
3.7%
0
(0)
0.0%
1
(1)
1.8%
- 37 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
4
(4)
7.4%
1
(1)
1.9%
4
(4)
7.3%
3
(3)
5.5%
2 (2
) 3.
7%
0 (0
) 0.
0%
3 (3
) 5.
5%
1 (1
) 1.
8%
0 (0
) 0.
0%
3 (3
) 5.
6%
3 (3
) 5.
5%
0 (0
) 0.
0%
0
(0)
0.0%
3
(3)
5.6%
3
(3)
5.5%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
4 (4
) 7.
4%
4 (4
) 7.
4%
7 (7
) 12
.7%
3
(3)
5.5%
2 (2
) 3.
7%
3 (3
) 5.
6%
6 (6
) 10
.9%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.9%
1
(1)
1.8%
1
(1)
1.8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (2
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
1 (1
) 1.
9%
1 (1
) 1.
8%
2 (3
) 3.
6%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(2)
1.9%
1
(5)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
2 (3
) 3.
7%
1 (5
) 1.
8%
0 (0
) 0.
0%
- -
- -
5 (5
) 9.
3%
2 (2
) 3.
7%
3 (3
) 5.
5%
2 (2
) 3.
6%
5
(5)
9.3%
2
(2)
3.7%
2
(2)
3.6%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5 (5
) 9.
3%
3 (3
) 5.
6%
3 (3
) 5.
5%
2 (2
) 3.
6%
5
(5)
9.3%
3
(3)
5.6%
2
(2)
3.6%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
- 38 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
2
(2)
3.7%
6
(7)
11.1
%
4 (4
) 7.
3%
5 (6
) 9.
1%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
11
(14)
20.
4%
8 (1
1) 1
4.8%
11
(14)
20.
0% 1
3 (1
5) 2
3.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (3
) 3.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
2 (1
6) 2
2.2%
14
(18)
25.
9% 1
4 (1
8) 2
5.5%
19
(22)
34.
5%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(3)
3.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 39 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
2 (2
) 3.
7%
4 (5
) 7.
4%
2 (2
) 3.
6%
2 (3
) 3.
6%
- -
- -
4 (5
) 7.
4%
1 (1
) 1.
9%
5 (6
) 9.
1%
6 (6
) 10
.9%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
6 (7
) 11
.1%
5
(6)
9.3%
7
(8)
12.7
%
8 (9
) 14
.5%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
- -
- -
- 40 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(2)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (2
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
2
(2)
3.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
2 (2
) 3.
6%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 41 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (2
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (2
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (2
) 1.
8%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (3
) 1.
8%
1 (1
) 1.
8%
- -
- -
3 (4
) 5.
6%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
1 (1
) 1.
9%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
4 (5
) 7.
4%
3 (3
) 5.
6%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
3 (3
) 5.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
4 (4
) 7.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 42 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1
7 (3
6) 3
1.5%
16
(46)
29.
6% 2
1 (4
4) 3
8.2%
13
(19)
23.
6%
14
(31)
25.
9%
8 (1
6) 1
4.8%
12
(17)
21.
8%
6 (9
) 10
.9%
6
(13)
11.
1%
7 (1
2) 1
3.0%
1
(1)
1.8%
3
(10)
5.
5%
3
(8)
5.6%
2
(4)
3.7%
0
(0)
0.0%
2
(4)
3.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
0 (4
9) 3
7.0%
20
(58)
37.
0% 2
1 (4
5) 3
8.2%
15
(29)
27.
3%
15
(39)
27.
8%
9 (2
0) 1
6.7%
12
(17)
21.
8%
7 (1
3) 1
2.7%
4
(4)
7.4%
4
(4)
7.4%
2
(2)
3.6%
2
(2)
3.6%
4 (4
) 7.
4%
2 (2
) 3.
7%
1 (1
) 1.
8%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
ALT
4 (4
) 7.
4%
4 (4
) 7.
4%
2 (2
) 3.
6%
3 (3
) 5.
5%
4
(4)
7.4%
2
(2)
3.7%
1
(1)
1.8%
2
(2)
3.6%
2
(2)
3.7%
4
(4)
7.4%
1
(1)
1.8%
2
(2)
3.6%
2 (2
) 3.
7%
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
AST
2 (2
) 3.
7%
4 (4
) 7.
4%
1 (1
) 1.
8%
3 (3
) 5.
5%
2
(2)
3.7%
2
(2)
3.7%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
- -
- -
- 43 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5
(6)
9.3%
3
(3)
5.6%
2
(2)
3.6%
2
(2)
3.6%
2 (2
) 3.
7%
2 (2
) 3.
7%
0 (0
) 0.
0%
2 (2
) 3.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
CK
5 (6
) 9.
3%
3 (3
) 5.
6%
2 (2
) 3.
6%
2 (2
) 3.
6%
2
(2)
3.7%
2
(2)
3.7%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
2
(2)
3.7%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
3 (3
) 5.
6%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.9%
3
(3)
5.5%
1
(1)
1.8%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
3 (5
) 5.
6%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
4 (6
) 7.
4%
2 (2
) 3.
7%
3 (3
) 5.
5%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
1
(1)
1.8%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
2
(2)
3.7%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
LDH
2 (2
) 3.
7%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
2
(2)
3.7%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
- 44 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
3
(3)
5.6%
1
(1)
1.8%
2
(2)
3.6%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
3 (3
) 5.
6%
1 (1
) 1.
8%
2 (2
) 3.
6%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.9%
3
(3)
5.5%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
BU
N
1 (1
) 1.
9%
1 (1
) 1.
9%
3 (3
) 5.
5%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
1
(1)
1.8%
2
(2)
3.6%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
1 (1
) 1.
9%
1 (1
) 1.
8%
2 (2
) 3.
6%
3
(3)
5.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
C
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
- 45 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
2
(2)
3.7%
6
(6)
11.1
%
4 (4
) 7.
3%
0 (0
) 0.
0%
2
(2)
3.7%
3
(3)
5.6%
3
(3)
5.5%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-GTP
2 (2
) 3.
7%
6 (6
) 11
.1%
4
(4)
7.3%
1
(1)
1.8%
2 (2
) 3.
7%
3 (3
) 5.
6%
3 (3
) 5.
5%
1 (1
) 1.
8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
HbA
1c
0 (0
) 0.
0%
4 (4
) 7.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
3
(3)
5.6%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.7%
1
(1)
1.8%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
7%
1 (1
) 1.
8%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
3
(3)
5.6%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.7%
1
(1)
1.8%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
7%
1 (1
) 1.
8%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
- -
- -
- 46 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.6%
1
(1)
1.9%
2
(2)
3.7%
1
(1)
1.8%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
7%
1 (1
) 1.
8%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
6%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
- 47 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
3 (3
) 5.
6%
0 (0
) 0.
0%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
T
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
1
(1)
1.9%
0
(0)
0.0%
3
(3)
5.5%
1
(1)
1.8%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
0 (0
) 0.
0%
3 (3
) 5.
5%
1 (1
) 1.
8%
3
(3)
5.6%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
2
(2)
3.7%
1
(1)
1.9%
3
(3)
5.5%
0
(0)
0.0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
/
3 (3
) 5.
6%
1 (1
) 1.
9%
3 (3
) 5.
5%
0 (0
) 0.
0%
3
(3)
5.6%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
U
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.9%
3
(3)
5.5%
0
(0)
0.0%
1 (1
) 1.
9%
1 (1
) 1.
9%
3 (3
) 5.
5%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
ALP
1 (1
) 1.
9%
1 (1
) 1.
9%
3 (3
) 5.
5%
0 (0
) 0.
0%
1
(1)
1.9%
1
(1)
1.9%
3
(3)
5.5%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
1 (1
) 1.
9%
2 (2
) 3.
7%
4 (4
) 7.
3%
1 (4
) 1.
8%
0
(0)
0.0%
2
(2)
3.7%
3
(3)
5.5%
0
(0)
0.0%
1
(1)
1.9%
4
(4)
7.4%
1
(1)
1.8%
3
(4)
5.5%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1 (2
) 1.
9%
7 (7
) 13
.0%
5
(5)
9.1%
4
(8)
7.3%
0 (0
) 0.
0%
5 (5
) 9.
3%
3 (3
) 5.
5%
1 (1
) 1.
8%
- 48 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.6%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
2 (2
) 3.
6%
1 (1
) 1.
8%
0
(0)
0.0%
3
(3)
5.6%
2
(2)
3.6%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (4
) 1.
8%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
1 (1
) 1.
8%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (2
) 1.
9%
1 (1
) 1.
9%
2 (2
) 3.
6%
2 (5
) 3.
6%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
7
(8)
13.0
%
6 (6
) 11
.1%
3
(3)
5.5%
5
(5)
9.1%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
5 (7
) 9.
3%
4 (5
) 7.
4%
2 (2
) 3.
6%
5 (7
) 9.
1%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
1 (1
5) 2
0.4%
9
(11)
16.
7%
5 (5
) 9.
1% 1
0 (1
2) 1
8.2%
2 (2
) 3.
7%
1 (1
) 1.
9%
1 (1
) 1.
8%
1 (1
) 1.
8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 49 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
2
(2)
3.7%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
2 (2
) 3.
7%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 50 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
3 (3
) 5.
6%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
- 51 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(2)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
1 (2
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
5%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
( )
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
1
1 (1
1) 2
0.4%
20
(28)
37.
0% 2
1 (2
8) 3
8.2%
9
(10)
16.
4%
10
(10)
18.
5% 1
9 (2
5) 3
5.2%
19
(24)
34.
5%
7 (8
) 12
.7%
3
(4)
5.6%
6
(7)
11.1
%
4 (4
) 7.
3%
2 (2
) 3.
6%
1
(2)
1.9%
4
(5)
7.4%
3
(3)
5.5%
1
(1)
1.8%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
4 (1
6) 2
5.9%
26
(35)
48.
1% 2
4 (3
2) 4
3.6%
11
(12)
20.
0%
11
(12)
20.
4% 2
3 (3
0) 4
2.6%
21
(27)
38.
2%
8 (9
) 14
.5%
- 52 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
4 (6
) 7.
4%
3 (3
) 5.
5%
0 (0
) 0.
0%
0
(0)
0.0%
3
(5)
5.6%
2
(2)
3.6%
0
(0)
0.0%
0
(0)
0.0%
3
(3)
5.6%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
3 (3
) 5.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
7 (9
) 13
.0%
4
(4)
7.3%
0
(0)
0.0%
0 (0
) 0.
0%
6 (8
) 11
.1%
2
(2)
3.6%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.6%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.6%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
5
(5)
9.3%
4
(4)
7.3%
2
(2)
3.6%
2 (2
) 3.
7%
4 (4
) 7.
4%
4 (4
) 7.
3%
1 (1
) 1.
8%
3 (4
) 5.
6%
2 (2
) 3.
7%
0 (0
) 0.
0%
1 (1
) 1.
8%
1
(2)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
5 (6
) 9.
3%
7 (7
) 13
.0%
4
(4)
7.3%
3
(3)
5.5%
3 (4
) 5.
6%
5 (5
) 9.
3%
4 (4
) 7.
3%
1 (1
) 1.
8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
8 (8
) 14
.8%
14
(14)
25.
9% 1
6 (1
7) 2
9.1%
7
(8)
12.7
%
8
(8)
14.8
% 1
4 (1
4) 2
5.9%
16
(16)
29.
1%
6 (7
) 10
.9%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.6%
1
(1)
1.8%
0 (0
) 0.
0%
1 (1
) 1.
9%
2 (2
) 3.
6%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
8 (8
) 14
.8%
15
(15)
27.
8% 1
7 (1
9) 3
0.9%
8
(9)
14.5
%
8
(8)
14.8
% 1
5 (1
5) 2
7.8%
17
(18)
30.
9%
7 (8
) 12
.7%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
6%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
- 53 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
2 (2
) 3.
7%
2 (2
) 3.
6%
2 (2
) 3.
6%
0
(0)
0.0%
1
(1)
1.9%
2
(2)
3.6%
1
(1)
1.8%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
2 (2
) 3.
7%
2 (2
) 3.
6%
2 (2
) 3.
6%
1
(1)
1.9%
1
(1)
1.9%
2
(2)
3.6%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
9%
1 (1
) 1.
8%
1 (1
) 1.
8%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
1
(1)
1.8%
0
(0)
0.0%
3
(3)
5.6%
1
(1)
1.9%
2
(2)
3.6%
0
(0)
0.0%
2 (2
) 3.
7%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (2
) 1.
9%
2 (2
) 3.
6%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
4 (4
) 7.
4%
2 (3
) 3.
7%
4 (4
) 7.
3%
0 (0
) 0.
0%
2
(2)
3.7%
1
(1)
1.9%
2
(2)
3.6%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
- 54 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
- 55 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
2 (2
) 3.
7%
3 (3
) 5.
6%
2 (2
) 3.
6%
0 (0
) 0.
0%
2
(2)
3.7%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
3
(3)
5.6%
3
(3)
5.6%
4
(6)
7.3%
1
(2)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (6
) 11
.1%
6
(6)
11.1
%
6 (8
) 10
.9%
1
(2)
1.8%
2 (2
) 3.
7%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3 (3
) 5.
6%
1 (1
) 1.
9%
1 (1
) 1.
8%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
- 56 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
3
(5)
5.5%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
1 (1
) 1.
9%
3 (5
) 5.
5%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
5 (5
) 9.
3%
2 (2
) 3.
7%
4 (4
) 7.
3%
5 (6
) 9.
1%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
4
(4)
7.3%
3
(3)
5.6%
4
(4)
7.4%
7
(9)
12.7
%
5 (5
) 9.
1%
1
(1)
1.9%
3
(3)
5.6%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
7 (8
) 13
.0%
6
(6)
11.1
% 1
0 (1
3) 1
8.2%
9
(11)
16.
4%
2
(2)
3.7%
3
(3)
5.6%
1
(1)
1.8%
5
(6)
9.1%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
2
(3)
3.6%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (4
) 3.
6%
1 (1
) 1.
8%
- -
- -
- 57 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
1 (1
) 1.
9%
0 (0
) 0.
0%
2 (2
) 3.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.6%
1
(1)
1.9%
2
(2)
3.7%
2
(2)
3.6%
1
(1)
1.8%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 3.
7%
3 (3
) 5.
6%
2 (2
) 3.
6%
3 (3
) 5.
5%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
2
(2)
3.6%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
1 (1
) 1.
8%
1 (2
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(2)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
- 58 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
1
(1)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
1 (1
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
4 (5
) 7.
4%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
3
(4)
5.6%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (7
) 11
.1%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
5 (6
) 9.
3%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
3.7%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 5.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3
(3)
5.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
-
- -
-
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
- -
- -
- 59 -
2.7
.6.1
.1-1
8 (
)
20
mg
(5
4)
40 m
g
(54
) 60
mg
(5
5)
(5
5)
20 m
g
(54
) 40
mg
(5
4)
60 m
g
(55
)
(55
)
2
(2)
3.7%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 3.
7%
1 (1
) 1.
9%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
3.7%
1
(1)
1.9%
0
(0)
0.0%
0
(0)
0.0%
(
)
[5.
3.5.
1-01
14
.3-9
14
.3-1
0 ]
- 60 -
(B)
2.7.6.1.1-19
1 20 mg 196 44
40 mg 226 71 60 mg 189 42 140 21
2 1
2.7.6.1.1-19
( )
(%) (%)
20 mg 54 47 196 87.0 32 109 59.3 0 1 54 22 44 40.7 19 38 35.2 1 2 52 9 12 17.3 3 4 5.8 2 4 50 16 28 32.0 9 16 18.0 4 8 50 26 58 52.0 13 27 26.0 8 12 46 19 26 41.3 5 6 10.9 12 45 14 28 31.1 7 18 15.6
40 mg 54 47 226 87.0 42 118 77.8 0 1 54 32 71 59.3 30 59 55.6 1 2 50 12 13 24.0 7 7 14.0 2 4 49 19 31 38.8 11 15 22.4 4 8 47 24 53 51.1 8 17 17.0 8 12 45 16 30 35.6 7 10 15.6 12 43 15 28 34.9 8 10 18.6
60 mg 55 47 189 85.5 38 92 69.1 0 1 55 23 42 41.8 21 38 38.2 1 2 53 12 17 22.6 7 10 13.2 2 4 49 19 28 38.8 11 16 22.4 4 8 47 27 68 57.4 11 17 23.4 8 12 45 15 20 33.3 6 7 13.3 12 44 10 14 22.7 4 4 9.1
55 44 140 80.0 24 52 43.6 0 1 55 12 21 21.8 9 15 16.4 1 2 53 6 8 11.3 3 3 5.7 2 4 53 17 30 32.1 9 14 17.0 4 8 52 28 48 53.8 8 9 15.4 8 12 48 16 21 33.3 5 6 10.4 12 46 11 12 23.9 4 5 8.7
0 1 7 1 2 8 14 2 4 15 28 4 8 29 568 12 57 84 12 85
[ 5.3.5.1-01 14.3-21 14.3-22 ]
(C)
2.7.6.1.1-20
20 mg 14/54 (25.9%) 21 40 mg 11/54
(20.4%) 16 60 mg 8/55 (14.5%) 12 11/55 (20.0%)
11 20 mg 4/54 (7.4%) 8 40 mg
6/54 (11.1%) 6 60 mg 3/55 (5.5%) 3 4/55 (7.3%)
4
- 61 -
(F)
20 mg 3 4 40 mg 7 13 60 mg 9 15
2 3
(G) ( )
( ) ±
LDH 20 mg
( )
60 mg 4
1+ 7 8 2
( ) ±
20 mg 1 (250 mmHg)
2.7.6.1.1.3
20 mg 40 mg 60 mg
20 60 mg
(LOCF) 20 mg 40 mg 60 mg
(LOCF)
12
20 mg 40 mg 60 mg
1 (20 mg ) 11 (20 mg 4
40 mg 3 4 ) 20 mg 87.0% (47/54
) 40 mg 87.0% (47/54 ) 60 mg 85.5% (47/55 ) 80.0% (44/55 )
10% 20 mg
- 74 -
40 mg -GTP
60 mg
20 mg 40 mg 60 mg
- 75 -
2.7.6.1.2
2.7.6.1.2.1
2.7.6.1.2-1
2.7.6.1.2-1
[ 5.3.5.1-02 ] 15N0831
( )
40 60 mg1 1 12 40 mg60 mg ( )
15 16 1 2 12 11 4 12
14 24 ( )
1 140 mg 20 mg 1 40 mg 60 mg
20 mg 1 40 mg 1 60 mg
20 mg40 mg
20 mg
40 mg60 mg
40 mg 20 mg
Visit
0 1 2 3 4 6 8 10 12 13
2 ( )
31 4 5 6 7
40 mg
60 mg 20 mg
-2 -1
a)
14
a) 3
- 76 -
1) 20 802) 1 2 *1
6*2
()
( ) (
) ( )
*12
*2 ( )
2 1 2
3 2 1 2 3
1
1) 2) *2
2
2 3 C128 10 4
[ (distal symmetric polyneuropathy) ( 2002 1 18 ) ]
3)
1) Visit1 HbA1c
*1 9.0% *1
2) Visit1 42 70 HbA1c Visit1*2 ±1.0%
*2 Visit1 42 70Visit1 42 70
3) Visit2 7 24
( ) 4 4) Visit1 Visit2 80%
- 77 -
1) *
* ( 4 6 29 80 )
3 2) 3) Visit1 70 (
) 4) 5)
6) 1
7)
() (
) ( )
8) 9) Visit1 42 70 HbA1c 10) ( ) 11) Visit1 90 12) 1 ( )
13) ( )
1) Visit2 14 Monoamine oxidase (MAO)
Visit2 14
2) ( 180 mmHg110 mmHg )
3) Visit1 ALT* AST* 100 U/L 4) Visit1 * 1.5 mg/dL 5) Visit1 * 2.0 mg/dL
* 6) Visit1
7) Visit1
8) Visit1 55 Visit1
9) Visit2 7 4 10) Visit2 1 Beck
-II (BDI-II) 20 2
1. 2 1
2. 2
( M.I.N.I. (Mini international neuropsychiatric interview) )11) ( )
- 78 -
300 (40 mg 75 60 mg 75 150 )
339 (40 mg 86 60 mg 86 167 )
Full Analysis Set (FAS) 338 (40 mg 85 60 mg 86 167 )
Per Protocol Set (PPS) 278 (40 mg 68 60 mg 70 140 )
338 (40 mg 85 60 mg 86 167 )
412 40 mg
2.07 1.41 -0.7140 mg 0.33 (0.7/2.1)
60 mg 40 mg 40 mg60 mg
0.33 0.025 t 20.80 1 143 286
150 (40 mg 7560 mg 75 ) 150 300
1 20 mg
1 1 3 1 1 1 2
C
A B C BC1 C2
1 2 3 12 3 3 4 40 mg 20 mg 40 mg 40 mg 20 mg 20 mg 0 mg 60 mg 20 mg 40 mg 60 mg 20 mg 40 mg 20 mg 0 mg 0 mg 0 mg 0 mg 0 mg 0 mg
A B B 3 C C 1
13 ( 12 1 )
Visit1 Visit7
1) [
( ) 1 1.5 g Visit2
Visit6 7 4]
2) ( ®) 3)
- 79 -
4) 5) 6) ( ) 7) (
) 8) ( ) 9) [
( ) ] 10) ( )11) [ (
) ] 12) 13) 14) 15) /
( ® ) (
®) ( ® ) 5-HT3 (® ) 5-HT4 ( ® ) 5-HT1B/1D (
® ) ( ® ) 16) 17) MAO ( ®) 18) ( ®) 19)
Visit1 Visit7
1) 2) 3) 4) 5) 6) 7)
Visit1 Visit7 Visit156 Visit1
1) 2) ( ) 3) ( ® ) 4) ( ® ) 5) E1 6) ( ® ) 7) ( ® ®
)
( ® ) 1 1.5 g
Visit2 Visit6 7 4
- 80 -
Visit1 Visit7
Visit1 Visit7
Visit1 Visit7
1) 16)
(BPI)
(PGI- ) BDI-II
24 24 BPI-
PGI- BDI-II
(FAS)
(PPS) 1 ( )
0.15 Fisher Wilcoxon
2
12 ( 12
- ) 0.025Last
Observation Carried Forward (LOCF)
95%
Fisher (0.05)
73
20 20
- 81 -
Visit 1 2 - 3 - 4 5 6 7 - -2 -1 0 1 2 3 4 8 12
13/ 14
BPI PGI- BDI-II
a)
a)
a) BPI PGI- BDI Beck a)
2.7.6.1.2.2
(1)
2.7.6.1.2-1
448 339 (40 mg 86 60 mg 86
167 ) 338 293 (40 mg
73 60 mg 70 150 ) 46 (40 mg 13 60 mg
16 17 )
( ) 448
109
( ) 339 40 mg 86
60 mg 86 167
293 46 a) 40 mg 73 60 mg 70
150
40 mg 13 60 mg 16
17
a) ( 1 )
2.7.6.1.2-1 ( )
[ 5.3.5.1-02 10-1 ]
- 82 -
2.7.6.1.2-2
28 (40 mg 9 60 mg 10
9 ) 5 (40 mg 2 60 mg 1 2 )
3 (60 mg 1 2 ) 2 (40 mg 1
1 ) 1 (60 mg 1 ) 5 (40 mg 1 60 mg 1
3 )
2.7.6.1.2-2
40 mg 60 mg
% % % % 172 100.0 86 100.0 86 100.0 167 100.0
122 70.9 61 70.9 61 70.9 136 81.4 50 29.1 25 29.1 25 29.1 31 18.6
1 0.6 0 0.0 1 1.2 2 1.2
19 11.0 9 10.5 10 11.6 9 5.4 3 1.7 2 2.3 1 1.2 2 1.2
1 0.6 0 0.0 1 1.2 0 0.0 1 0.6 1 1.2 0 0.0 1 0.6 2 1.2 1 1.2 1 1.2 3 1.8
27 15.7 13 15.1 14 16.3 17 10.2 a)
1 0 0.0 0 0.0 0 0.0 0 0.0 1 2 0 0.0 0 0.0 0 0.0 0 0.0 2 6 1 0.6 0 0.0 1 1.2 1 0.6 6 12 0 0.0 0 0.0 0 0.0 1 0.6 12 0 0.0 0 0.0 0 0.0 0 0.0
1 4 2.3 3 3.5 1 1.2 1 0.6 1 2 2 1.2 2 2.3 0 0.0 2 1.2 2 6 8 4.7 3 3.5 5 5.8 3 1.8 6 12 5 2.9 1 1.2 4 4.7 3 1.8 12 0 0.0 0 0.0 0 0.0 0 0.0
1 0 0.0 0 0.0 0 0.0 0 0.0 1 2 0 0.0 0 0.0 0 0.0 0 0.0
2 6 0 0.0 0 0.0 0 0.0 0 0.0 6 12 0 0.0 0 0.0 0 0.0 0 0.0 12 0 0.0 0 0.0 0 0.0 0 0.0
1 0 0.0 0 0.0 0 0.0 0 0.0 1 2 0 0.0 0 0.0 0 0.0 1 0.6
2 6 0 0.0 0 0.0 0 0.0 0 0.0 6 12 3 1.7 2 2.3 1 1.2 1 0.6 12 0 0.0 0 0.0 0 0.0 0 0.0
1 0 0.0 0 0.0 0 0.0 0 0.0 1 2 0 0.0 0 0.0 0 0.0 0 0.0 2 6 1 0.6 0 0.0 1 1.2 0 0.0 6 12 0 0.0 0 0.0 0 0.0 0 0.0 12 0 0.0 0 0.0 0 0.0 0 0.0
- 83 -
2.7.6.1.2-2 ( )
40 mg 60 mg
% % % % 1 1 0.6 1 1.2 0 0.0 0 0.0
1 2 0 0.0 0 0.0 0 0.0 0 0.0 2 6 0 0.0 0 0.0 0 0.0 1 0.6 6 12 0 0.0 0 0.0 0 0.0 0 0.0 12 0 0.0 0 0.0 0 0.0 0 0.0
1 0 0.0 0 0.0 0 0.0 0 0.0 1 2 1 0.6 0 0.0 1 1.2 1 0.6 2 6 1 0.6 1 1.2 0 0.0 0 0.0 6 12 0 0.0 0 0.0 0 0.0 2 1.2 12 0 0.0 0 0.0 0 0.0 0 0.0
0 0.0 0 0.0 0 0.0 0 0.0
2 1.2 0 0.0 2 2.3 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0
1 0.6 1 b) 1.2 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 0.6 1 b) 1.2 0 0.0 0 0.0
4 2.3 2 2.3 2 2.3 0 0.0 a) 1 1 7 1 2 8 14 2 6 15 42 6 12
43 84 12 85 b)
[ 5.3.5.1-02 10-1 10-2 ]
(2)
2.7.6.1.2-2 2.7.6.1.2-3
339 (40 mg 86 60 mg 86
167 ) FAS (
) 1 (40 mg ) 338 (40 mg 85 60 mg 86
167 ) PPS FAS 5 (60 mg 1 4 )
55 (40 mg 17 60 mg 15 23 ) 278 (40 mg
68 60 mg 70 140 ) FAS
PPS
1 (40 mg ) 338
(40 mg 85 60 mg 86 167 )
- 84 -
[ ] ( ) 339
40 mg 86 60 mg 86 167
GCP 0 1
40 mg 1 60 mg 0 0 FAS 338
40 mg 85 60 mg 86 167
5
40 mg 0 60 mg 1 4 0 55
40 mg 17 60 mg 15 23 PPS 278
40 mg 68 60 mg 70 140
[ ] ( ) 339
40 mg 86 60 mg 86 167
GCP 0
40 mg 0 60 mg 0 0 1
40 mg 1 60 mg 0 0
338 40 mg 85 60 mg 86 167
2.7.6.1.2-2
[ 5.3.5.1-02 11-1 12-1 ]
2.7.6.1.2-3 a)
FAS PPS
40 mg 0073 0453 0523 80% 0554 0863 0953 1052 1063 1103 1123 1173 80% 1321 1363
- 85 -
2.7.6.1.2-3 ( ) a)
FAS PPS
40 mg 1422 ( ) 1503
1542 b) c)
[ ] [ ]
1571 1631
60 mg 0442 0522 0533 0561 0602
0753 Visit2 [ ] Visit2 [ ]
0861 0881 1163 1192 1211 1223 1282 1484 1533 80% 1641
0214 0361
0424 ( ) 0472
0482 Visit2 [ ] Visit2 [ ] Visit2 [ ]
0512 80% 0571 0574 0713
0751 Visit2 [ ] Visit2 [ ]
0883 Visit2 [ ] Visit2 [ ]
[ ]
0884 0934 0971 0972 1003 1071 1114 1152 1202 1214
- 86 -
2.7.6.1.2-3 ( ) a)
FAS PPS
1262 1292
( ) 1293 1334 1442 1611
a) b) c)
[ 5.3.5.1-02 10-3 11-2 ]
(3)
FAS 2.7.6.1.2-4
75.7% (256/338 ) 24.3% (82/338 ) ( ±
) 60.8±10.0 4.29±4.11
BMI
3 (p=0.1218 p=0.0708 p=0.1229)
2.7.6.1.2-4 (FAS)
a)
338
171 167 b)40 mg
85 60 mg
86 256 (75.7%) 127 (74.3%) 129 (77.2%) Pe=0.5291 65 (76.5%) 62 (72.1%)
82 (24.3%) 44 (25.7%) 38 (22.8%) 20 (23.5%) 24 (27.9%) ( ) 20 30 2 (0.6%) 1 (0.6%) 1 (0.6%) Pk=0.5212 0 (0.0%) 1 (1.2%)
30 40 12 (3.6%) 8 (4.7%) 4 (2.4%) 2 (2.4%) 6 (7.0%) 40 50 28 (8.3%) 16 (9.4%) 12 (7.2%) 4 (4.7%) 12 (14.0%) 50 65 162 (47.9%) 72 (42.1%) 90 (53.9%) 44 (51.8%) 28 (32.6%) 65 80 134 (39.6%) 74 (43.3%) 60 (35.9%) 35 (41.2%) 39 (45.3%) 60.8 60.9 60.8 62.1 59.7 10.0 10.8 9.2 9.3 12.1 22 22 28 35 22 62.0 63.0 62.0 62.0 63.0 79 79 76 79 79
(cm) 150 21 (6.2%) 10 (5.8%) 11 (6.6%) Pk=0.9537 7 (8.2%) 3 (3.5%) 150 160 78 (23.1%) 42 (24.6%) 36 (21.6%) 23 (27.1%) 19 (22.1%) 160 170 148 (43.8%) 71 (41.5%) 77 (46.1%) 29 (34.1%) 42 (48.8%) 170 91 (26.9%) 48 (28.1%) 43 (25.7%) 26 (30.6%) 22 (25.6%) 163.98 163.83 164.13 163.63 164.02 8.34 8.06 8.65 8.78 7.32 144.0 145.3 144.0 145.3 148.2 164.20 164.00 164.20 163.10 164.35 184.2 180.3 184.2 178.8 180.3
- 87 -
2.7.6.1.2-4 (FAS)( )
a)
338
171 167 b)40 mg
85 60 mg
86 (kg) 50 29 (8.6%) 15 (8.8%) 14 (8.4%) Pk=0.8699 10 (11.8%) 5 (5.8%)
50 60 104 (30.8%) 51 (29.8%) 53 (31.7%) 30 (35.3%) 21 (24.4%) 60 70 115 (34.0%) 62 (36.3%) 53 (31.7%) 24 (28.2%) 38 (44.2%) 70 90 (26.6%) 43 (25.1%) 47 (28.1%) 21 (24.7%) 22 (25.6%) 64.21 63.91 64.52 62.72 65.08 11.90 11.90 11.93 13.35 10.23 38.3 38.3 40.6 38.3 43.6 63.70 63.70 63.70 60.30 65.45 108.4 105.6 108.4 105.6 95.6 BMI (kg/m2) 18.5 17 (5.0%) 9 (5.3%) 8 (4.8%) Pk=0.1218* 5 (5.9%) 4 (4.7%) 18.5 25.0 209 (61.8%) 112 (65.5%) 97 (58.1%) 59 (69.4%) 53 (61.6%) 25.0 30.0 88 (26.0%) 41 (24.0%) 47 (28.1%) 17 (20.0%) 24 (27.9%) 30.0 35.0 21 (6.2%) 7 (4.1%) 14 (8.4%) 3 (3.5%) 4 (4.7%) 35.0 40.0 3 (0.9%) 2 (1.2%) 1 (0.6%) 1 (1.2%) 1 (1.2%) 40.0 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 23.82 23.74 23.90 23.27 24.20 3.65 3.60 3.70 3.67 3.50 16.0 16.5 16.0 16.8 16.5 23.45 23.40 23.50 23.10 23.65 37.4 35.5 37.4 35.5 35.5
6 187 (55.3%) 96 (56.1%) 91 (54.5%) Pe=0.8269 49 (57.6%) 47 (54.7%) 6 151 (44.7%) 75 (43.9%) 76 (45.5%) 36 (42.4%) 39 (45.3%)
1 17 (5.0%) 9 (5.3%) 8 (4.8%) Pe=1.0000 5 (5.9%) 4 (4.7%) 2 321 (95.0%) 162 (94.7%) 159 (95.2%) 80 (94.1%) 82 (95.3%)
5 69 (20.4%) 36 (21.1%) 33 (19.8%) Pk=0.9984 20 (23.5%) 16 (18.6%) ( ) 5 10 64 (18.9%) 32 (18.7%) 32 (19.2%) 18 (21.2%) 14 (16.3%) 10 200 (59.2%) 103 (60.2%) 97 (58.1%) 47 (55.3%) 56 (65.1%) 5 (1.5%) 0 (0.0%) 5 (3.0%) 0 (0.0%) 0 (0.0%)
2 104 (30.8%) 53 (31.0%) 51 (30.5%) Pe=1.0000 26 (30.6%) 27 (31.4%) ( ) 2 234 (69.2%) 118 (69.0%) 116 (69.5%) 59 (69.4%) 59 (68.6%)
4.29 4.37 4.21 4.58 4.16 4.11 3.78 4.44 3.90 3.67 0.3 0.3 0.6 0.3 0.6 3.30 3.30 3.20 3.50 3.15 41.3 23.1 41.3 17.8 23.1
295 (87.3%) 144 (84.2%) 151 (90.4%) Pe=0.1791 69 (81.2%) 75 (87.2%) 30 (8.9%) 20 (11.7%) 10 (6.0%) 9 (10.6%) 11 (12.8%) 13 (3.8%) 7 (4.1%) 6 (3.6%) 7 (8.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
0 316 (93.5%) 163 (95.3%) 153 (91.6%) Pk=0.1620 80 (94.1%) 83 (96.5%)1 2 8 (2.4%) 3 (1.8%) 5 (3.0%) 3 (3.5%) 0 (0.0%)
( ) 3 5 3 (0.9%) 2 (1.2%) 1 (0.6%) 1 (1.2%) 1 (1.2%) 6 10 7 (2.1%) 2 (1.2%) 5 (3.0%) 1 (1.2%) 1 (1.2%) 11 4 (1.2%) 1 (0.6%) 3 (1.8%) 0 (0.0%) 1 (1.2%) 0.4 0.3 0.6 0.2 0.4 2.1 1.9 2.4 0.9 2.5 0 0 0 0 0 0.0 0.0 0.0 0.0 0.0 22 22 17 7 22
- 88 -
2.7.6.1.2-4 (FAS)( )
a)
338
171 167 b)40 mg
85 60 mg
86 123 (36.4%) 54 (31.6%) 69 (41.3%) Pe=0.0708* 29 (34.1%) 25 (29.1%)
215 (63.6%) 117 (68.4%) 98 (58.7%) 56 (65.9%) 61 (70.9%) 4 (1.2%) 1 (0.6%) 3 (1.8%) Pe=0.3669 1 (1.2%) 0 (0.0%)
334 (98.8%) 170 (99.4%) 164 (98.2%) 84 (98.8%) 86 (100.0%) 3 (0.9%) 2 (1.2%) 1 (0.6%) Pe=1.0000 2 (2.4%) 0 (0.0%)
335 (99.1%) 169 (98.8%) 166 (99.4%) 83 (97.6%) 86 (100.0%) 198 (58.6%) 93 (54.4%) 105 (62.9%) Pe=0.1229* 41 (48.2%) 52 (60.5%)
140 (41.4%) 78 (45.6%) 62 (37.1%) 44 (51.8%) 34 (39.5%) 62 (18.3%) 29 (17.0%) 33 (19.8%) Pe=0.5745 17 (20.0%) 12 (14.0%)
276 (81.7%) 142 (83.0%) 134 (80.2%) 68 (80.0%) 74 (86.0%) 338 (100.0%) 171 (100.0%) 167 (100.0%) - 85 (100.0%) 86 (100.0%)
0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 186 (55.0%) 95 (55.6%) 91 (54.5%) Pe=0.8176 45 (52.9%) 50 (58.1%)
( ) 78 (23.1%) 37 (21.6%) 41 (24.6%) 23 (27.1%) 14 (16.3%)
74 (21.9%) 39 (22.8%) 35 (21.0%) 17 (20.0%) 22 (25.6%) 113 (33.4%) 57 (33.3%) 56 (33.5%) Pe=0.9525 25 (29.4%) 32 (37.2%)
( ) 114 (33.7%) 59 (34.5%) 55 (32.9%) 33 (38.8%) 26 (30.2%)
111 (32.8%) 55 (32.2%) 56 (33.5%) 27 (31.8%) 28 (32.6%)90 186 (55.0%) 95 (55.6%) 91 (54.5%) Pe=0.9130 54 (63.5%) 41 (47.7%)90 152 (45.0%) 76 (44.4%) 76 (45.5%) 31 (36.5%) 45 (52.3%)
(mL/min) 92.26 91.70 92.84 86.61 96.73 32.81 33.40 32.29 32.28 33.92 32.9 32.9 37.6 32.9 33.5 86.55 87.00 85.90 82.20 91.30 220.4 220.4 203.6 197.4 220.4
(%) * (p<0.15) a) X Y X Y b) Pe Fisher Freeman-Halton p Pk Wilcoxon p
[ 5.3.5.1-02 11-4 ]
(4)
(A)
FAS 12
2.7.6.1.2-5 40 mg 60 mg
2.7.6.1.2-6
×
12 ( ± )
-2.47±0.18 -1.61±0.18
(p<0.0001)
- 89 -
(p=0.0001) 12
40 mg 60 mg 12 -2.41±0.21 -2.53±0.21
-1.61±0.19 40 mg 60 mg [
95% (-1.18 -0.43) (-1.30 -0.56)]
(p=0.0001)
2.7.6.1.2-5 12 (FAS)
95% ( )
t p a) 145 -2.47 0.18 -2.83 -2.11 - - -
150 -1.61 0.18 -1.97 -1.24 - - - - - -0.87 0.15 -1.17 -0.56 3412 -5.59 <0.0001*
[ ]
t p a)
-0.230 0.0596 3412 -3.86 0.0001* 1 -0.418 0.3162 3412 -1.32 0.1858
2 0.000 2 -0.289 0.1509 3412 -1.92 0.0554
2 0.000 * (p<0.05) a) p
×
[ 5.3.5.1-02 11-7 ]
- 90 -
2.7.6.1.2-6 12 (FAS)
95%
40 mg 73 -2.41 0.21 -2.83 -2.00 60 mg 72 -2.53 0.21 -2.95 -2.11
150 -1.61 0.19 -1.97 -1.24 40 mg- - -0.81 0.19 -1.18 -0.43 60 mg- - -0.93 0.19 -1.30 -0.56
[ ]
t p a)
-0.230 0.0597 3401 -3.85 0.0001* 1 -0.419 0.3168 3401 -1.32 0.1855
2 0.000 2 -0.289 0.1511 3401 -1.91 0.0561
2 0.000 * (p<0.05) a) p
×
[ 5.3.5.1-02 11-10 ]
(LOCF)
2.7.6.1.2-7 40 mg 60 mg
2.7.6.1.2-8
LOCF
(LOCF)( ± )
-2.38±0.24 -1.56±0.24
(p<0.0001)
2 ( p=0.0009 p=0.0355)
2
40 mg 60 mg (LOCF) -2.34±0.27 -2.43±0.27
40 mg 60 mg [ 95%
(-1.23 -0.33) (-1.31 -0.43)]
- 91 -
2.7.6.1.2-7 (LOCF)(FAS)
95%
a) ( )
171 -2.38 0.24 -2.85 -1.91 - 167 -1.56 0.24 -2.03 -1.08 -
- - -0.82 0.18 -1.19 -0.46 <0.0001*
[ ]
t p a)
0.416 0.4920 70 0.84 0.4012 -0.825 0.1846 263 -4.47 <0.0001*
0.000 -0.270 0.0805 263 -3.35 0.0009*
1 -0.395 0.4298 263 -0.92 0.3587 2 0.000
2 -0.432 0.2045 263 -2.11 0.0355* 2 0.000 * (p<0.05) a) p
[ 5.3.5.1-02 11-8 ]
2.7.6.1.2-8 (LOCF)(FAS)
95%
40 mg 85 -2.34 0.27 -2.87 -1.81 60 mg 86 -2.43 0.27 -2.96 -1.89
167 -1.56 0.24 -2.03 -1.09 40 mg- - -0.78 0.23 -1.23 -0.33 60 mg- - -0.87 0.23 -1.31 -0.43
[ 5.3.5.1-02 11-9 ]
40 mg 60 mg
2.7.6.1.2-9
( ± )
1 40 mg 2
60 mg 1
- 92 -
2.7.6.1.2-9 (FAS)
1 2 3 4 5 6 7 8 9 10 11 12
171 171 167 164 163 159 156 153 153 152 151 147 145
a)
5.77 ±1.20
5.22 ±1.33
4.80 ±1.50
4.50 ±1.61
4.23±1.60
4.08±1.63
3.98±1.66
3.80±1.69
3.74±1.82
3.68 ±1.78
3.68 ±1.78
3.58±1.74
3.48 ±1.81
b) -
-0.78 ±0.18
-1.20 ±0.18
-1.49 ±0.18
-1.74±0.18
-1.89±0.18
-1.97±0.18
-2.16±0.18
-2.21±0.18
-2.28 ±0.18
-2.28 ±0.18
-2.38±0.18
-2.47±0.18
p c) - 0.0299* 0.0003* 0.0001* <0.0001*<0.0001* 0.0001* <0.0001*<0.0001*<0.0001*<0.0001*<0.0001*<0.0001*40 mg
85 85 82 80 80 79 78 76 76 75 75 73 73
a) 5.79
±1.23 5.27
±1.39 4.80
±1.57 4.54
±1.75 4.26
±1.734.11
±1.814.02
±1.853.83
±1.853.80
±1.933.72
±1.83 3.73
±1.87 3.60
±1.773.54
±1.86 b)
- -0.74 ±0.21
-1.22 ±0.21
-1.49 ±0.21
-1.77±0.21
-1.92±0.21
-1.99±0.21
-2.17±0.21
-2.20±0.21
-2.28 ±0.21
-2.26 ±0.21
-2.36±0.21
-2.41±0.21
95% d) -
(-0.650.08)
(-0.93-0.20)
(-0.96-0.22)
(-1.10-0.36)
(-1.09-0.36)
(-0.98-0.24)
(-1.11-0.37)
(-1.09-0.34)
(-1.16-0.42)
(-1.10-0.36)
(-1.17-0.42)
(-1.18-0.43)
60 mg 86 86 85 84 83 80 78 77 77 77 76 74 72
a)
5.76 ±1.17
5.17 ±1.28
4.79 ±1.44
4.46 ±1.47
4.20±1.46
4.04±1.44
3.94±1.47
3.76±1.52
3.68±1.72
3.63 ±1.73
3.63 ±1.70
3.56±1.72
3.41 ±1.77
b) -
-0.83 ±0.21
-1.20 ±0.21
-1.50 ±0.21
-1.72±0.21
-1.87±0.21
-1.96±0.21
-2.15±0.21
-2.23±0.21
-2.28 ±0.21
-2.31 ±0.21
-2.41±0.21
-2.53±0.21
95% d) -
(-0.74-0.01)
(-0.91-0.18)
(-0.97-0.24)
(-1.05-0.32)
(-1.05-0.31)
(-0.95-0.22)
(-1.09-0.35)
(-1.11-0.37)
(-1.16-0.42)
(-1.14-0.40)
(-1.22-0.48)
(-1.30-0.56)
167 167 166 162 161 159 157 157 155 153 153 152 150
a)
5.78 ±1.17
5.56 ±1.28
5.35 ±1.41
5.11 ±1.46
4.98±1.59
4.83±1.69
4.64±1.77
4.58±1.81
4.53±1.91
4.52 ±1.92
4.47 ±1.92
4.44±1.95
4.38 ±1.99
b) -
-0.45 ±0.18
-0.65 ±0.18
-0.90 ±0.18
-1.03±0.18
-1.19±0.18
-1.38±0.18
-1.43±0.18
-1.48±0.18
-1.49 ±0.18
-1.54 ±0.18
-1.56±0.18
-1.61±0.18
* (p<0.05) a) ± b) ± c) p d) 40 mg 60 mg 95%
[ 5.3.5.1-02 11-11 11-12 14.2-1 ]
2.7.6.1.2-10 2.7.6.1.2-11
30% 30%
30% 30% (50% 75% 100%
) 30%
2 30% 2
20%
Fisher
30% 57.3% 35.3%
- 93 -
(p<0.0001) 50%
39.2% 19.8% 30%
(p=0.0001)
48.5% 32.3%
(p=0.0028)
40 mg 60 mg 30% 55.3% 59.3% 40 mg 60 mg
[ 95% (7.1 32.8) (11.3
36.6)] 50% 40 mg 60 mg 37.6% 40.7% 30%
40 mg 60 mg [ 95%
(5.9 29.8) (8.9 32.9)] 40 mg 60 mg 48.2%
48.8% 40 mg 60 mg [
95% (3.1 28.7) (3.8 29.2)]
2.7.6.1.2-10 (FAS) a)
40 mg 60 mg 40 mg 60 mg
171 85 86 167 30% 98 47 51 59 30% (%) 57.3 55.3 59.3 35.3 <0.0001* (7.1, 32.8) (11.3, 36.6)50% 67 32 35 33 50% (%) 39.2 37.6 40.7 19.8 0.0001* (5.9, 29.8) (8.9, 32.9)75% 21 11 10 16 75% (%) 12.3 12.9 11.6 9.6 0.4876 (-5.1, 11.8) (-6.1, 10.2)100% 5 2 3 0 100% (%) 2.9 2.4 3.5 0.0 0.0607 (-0.9, 5.6) (-0.4, 7.4)* (p<0.05) a) Fisher p 40 mg 60 mg 95%
[ 5.3.5.1-02 11-13 14.2-3 ]
2.7.6.1.2-11 (FAS) a)
40 mg 60 mg 40 mg 60 mg
171 85 86 167 83 41 42 54 (%) 48.5 48.2 48.8 32.3 Pe=0.0028* (3.1, 28.7) (3.8, 29.2)
* (p<0.05) a) Fisher p 40 mg 60 mg 95%
[ 5.3.5.1-02 11-14 14.2-4 ]
30% 2.7.6.1.2-12
2.7.6.1.2-13
30% 30%
- 94 -
40 mg 60 mg
30%
(p<0.0001) 40 mg 60 mg (
p=0.0011 p=0.0003)
(p=0.0006) 40 mg 60 mg
( p=0.0044 p=0.0030)
2.7.6.1.2-12 30% (FAS)
30% ( ) ( ) a)( ) 171 104 67 1 3.0 <0.0001*
40 mg 85 50 35 1 3.0 0.0011* 60 mg 86 54 32 1 4.0 0.0003*
167 67 100 1 4.0 - * (p<0.05) a) p
[ 5.3.5.1-02 11-15 ]
2.7.6.1.2-13 (FAS)
( ) ( ) a)( ) 171 83 88 1 3.0 0.0006*
40 mg 85 41 44 1 3.0 0.0044* 60 mg 86 42 44 1 3.0 0.0030*
167 54 113 1 4.0 - * (p<0.05) a) p
[ 5.3.5.1-02 11-16 ]
2.7.6.1.2-14
( )
( ) 2
1 (LOCF)
BDI-II (LOCF) 2
BDI-II (LOCF)
1 ( p<0.0001 p<0.0001)
(LOCF)
2 (p<0.0001)
99.982% 0.018%
- 95 -
2.7.6.1.2-14 (FAS)
[ ] t a)
1 -1.3396 0.1392 331 -9.63 <0.0001* -0.0157 0.0037 331 -4.23 <0.0001* BDI-II 0.0034 0.0156 331 0.22 0.8294
2 -2.2335 0.4739 332 -4.71 <0.0001* -0.0008 0.0131 332 -0.06 0.9495 * (p<0.05) a) p
[ ]
99.982% 0.018%
[ 5.3.5.1-02 11-17 ]
(B)
12
2.7.6.1.2-15 40 mg 60 mg 2.7.6.1.2-16
12
40 mg 60 mg
24 ( ) 12 (
± ) -2.51±0.19 -1.55±0.19
(p<0.0001)
( ) 12 ( ± )
-2.39±0.19 -1.56±0.19
(p<0.0001) BPI- (
) BPI- (
7 ) PGI- 10
( p<0.0001 p<0.0001 p<0.0001 p<0.0001
p=0.0228 p=0.0076 p=0.0378 p=0.0089 p=0.0095 p<0.0001)
40 mg BPI- (
) BPI- ( )
PGI- 9 [ 95%
(-1.26 -0.49) (-1.17 -0.39) (-1.34 -0.44) (-1.23 -0.33) (-1.39 -0.58)
(-1.35 -0.41) (-1.14 -0.06) (-1.11 -0.03) (-0.90 -0.39)] 60 mg
BPI- ( ) BPI-
( 7 ) PGI- 10
[ 95% (-1.43
- 96 -
-0.66) (-1.28 -0.50) (-1.51 -0.62) (-1.36 -0.46) (-1.41 -0.61) (-1.41 -0.48) (-1.21
-0.22) (-1.27 -0.24) (-0.97 -0.07) (-0.91 -0.40)]
2.7.6.1.2-15 12 (FAS)
95%
a)
()
145 -2.51 0.19 -0.96 -1.27 -0.64 <0.0001* 150 -1.55 0.19 -
145 -2.39 0.19 -0.83 -1.15 -0.51 <0.0001* 150 -1.56 0.19 - BPI- 142 -2.59 0.21 -0.98 -1.34 -0.61 <0.0001*
150 -1.62 0.21 - BPI- 142 -1.98 0.21 -0.85 -1.21 -0.48 <0.0001*
150 -1.13 0.21 - BPI- 142 -2.54 0.20 -1.00 -1.33 -0.67 <0.0001*
150 -1.54 0.20 - BPI- 142 -2.59 0.22 -0.92 -1.29 -0.54 <0.0001*
150 -1.67 0.22 - BPI- 142 -2.29 0.24 -0.41 -0.85 0.03 0.0676
150 -1.88 0.24 - BPI- 142 -2.28 0.24 -0.37 -0.80 0.06 0.0933
150 -1.91 0.24 - BPI- 142 -2.31 0.23 -0.49 -0.91 -0.07 0.0228*
150 -1.82 0.23 - BPI- 142 -1.86 0.23 -0.38 -0.80 0.04 0.0783
150 -1.49 0.23 - BPI- 142 -1.32 0.23 -0.55 -0.96 -0.15 0.0076*
150 -0.77 0.23 - BPI- 142 -2.15 0.24 -0.46 -0.90 -0.03 0.0378*
150 -1.69 0.24 - BPI- 142 -2.15 0.23 -0.56 -0.98 -0.14 0.0089*
150 -1.59 0.23 - BPI- 142 -2.04 0.20 -0.48 -0.85 -0.12 0.0095*7 150 -1.56 0.20 - BDI-II 142 -3.37 0.64 -0.11 -1.22 1.01 0.8517 150 -3.27 0.64 - PGI- 142 2.53 0.12 -0.65 -0.85 -0.44 <0.0001* 150 3.18 0.12 - * (p<0.05) BPI PGI- BDI Beck
- a) p
(PGI- )
× [ 5.3.5.1-02 11-18 ]
- 97 -
2.7.6.1.2-16 12 (FAS)
95%
40 mg 73 -2.42 0.22 -0.87 -1.26 -0.49 60 mg 72 -2.59 0.22 -1.05 -1.43 -0.66 150 -1.55 0.19
40 mg 73 -2.33 0.22 -0.78 -1.17 -0.39 60 mg 72 -2.45 0.23 -0.89 -1.28 -0.50 150 -1.56 0.19 BPI- 40 mg 72 -2.51 0.25 -0.89 -1.34 -0.44
60 mg 70 -2.68 0.25 -1.06 -1.51 -0.62 150 -1.62 0.21 BPI- 40 mg 72 -1.92 0.25 -0.78 -1.23 -0.33
60 mg 70 -2.04 0.25 -0.91 -1.36 -0.46 150 -1.13 0.21 BPI- 40 mg 72 -2.53 0.23 -0.98 -1.39 -0.58
60 mg 70 -2.56 0.23 -1.01 -1.41 -0.61 150 -1.55 0.20 BPI- 40 mg 72 -2.55 0.25 -0.88 -1.35 -0.41
60 mg 70 -2.62 0.26 -0.95 -1.41 -0.48 150 -1.67 0.22 BPI- 40 mg 72 -2.48 0.29 -0.60 -1.14 -0.06
60 mg 70 -2.10 0.29 -0.23 -0.77 0.32 150 -1.88 0.24 BPI- 40 mg 72 -2.18 0.29 -0.27 -0.80 0.27
60 mg 70 -2.39 0.29 -0.48 -1.01 0.05 150 -1.91 0.24 BPI- 40 mg 72 -2.32 0.28 -0.50 -1.02 0.02
60 mg 70 -2.31 0.28 -0.49 -1.01 0.03 150 -1.82 0.23 BPI- 40 mg 72 -1.84 0.28 -0.35 -0.86 0.16
60 mg 70 -1.90 0.28 -0.41 -0.92 0.11 150 -1.49 0.23 BPI- 40 mg 72 -1.16 0.27 -0.39 -0.89 0.11
60 mg 70 -1.49 0.27 -0.71 -1.21 -0.22 150 -0.77 0.23 BPI- 40 mg 72 -2.26 0.29 -0.57 -1.11 -0.03
60 mg 70 -2.05 0.29 -0.36 -0.90 0.18 150 -1.69 0.24 BPI- 40 mg 72 -1.96 0.28 -0.37 -0.88 0.15
60 mg 70 -2.35 0.28 -0.76 -1.27 -0.24 150 -1.59 0.23 BPI- 40 mg 72 -2.00 0.24 -0.45 -0.90 0.00 7 60 mg 70 -2.08 0.24 -0.52 -0.97 -0.07 150 -1.56 0.20
- 98 -
2.7.6.1.2-16 12 (FAS)( )
95%
BDI-II 40 mg 72 -2.94 0.76 0.34 -1.03 1.71 60 mg 70 -3.83 0.77 -0.55 -1.92 0.81 150 -3.28 0.65 PGI- 40 mg 72 2.53 0.14 -0.65 -0.90 -0.39 60 mg 70 2.52 0.14 -0.65 -0.91 -0.40 150 3.18 0.12 BPI PGI- BDI Beck
40 mg ( 60 mg)- (PGI- )
×
[ 5.3.5.1-02 11-19 ]
(LOCF)
2.7.6.1.2-17 40 mg 60 mg
2.7.6.1.2-18
(LOCF)( ± )
-2.39±0.25 -1.46±0.25
(p<0.0001) (LOCF)
-2.31±0.25 -1.52±0.25
(p<0.0001) BPI- (
) BPI- ( )
PGI- 7
( p<0.0001 p<0.0001 p<0.0001 p<0.0001 p=0.0496 p=0.0464 p<0.0001)
40 mg BPI- (
) PGI- 7
[ 95% (-1.32 -0.39) (-1.22 -0.29) (-1.38
-0.36) (-1.25 -0.30) (-1.38 -0.47) (-1.34 -0.33) (-0.90 -0.36)] 60 mg
BPI- (
) BPI- ( ) PGI- 9
[ 95% (-1.47
-0.55) (-1.29 -0.36) (-1.53 -0.51) (-1.41 -0.46) (-1.42 -0.52) (-1.38 -0.38) (-1.05
-0.05) (-1.12 -0.08) (-0.90 -0.37)]
- 99 -
2.7.6.1.2-17 (LOCF)(FAS)
95%
a)
( ) 171 -2.39 0.25 -0.93 -1.31 -0.55 <0.0001*
167 -1.46 0.25 - 171 -2.31 0.25 -0.79 -1.17 -0.41 <0.0001*
167 -1.52 0.25 - BPI- 169 -2.67 0.27 -0.94 -1.36 -0.53 <0.0001*
165 -1.72 0.27 - BPI- 169 -2.02 0.25 -0.85 -1.24 -0.47 <0.0001*
165 -1.17 0.25 - BPI- 169 -2.51 0.24 -0.94 -1.31 -0.57 <0.0001*
165 -1.56 0.25 - BPI- 169 -2.52 0.26 -0.86 -1.27 -0.45 <0.0001*
165 -1.66 0.26 - BPI- 169 -2.18 0.28 -0.33 -0.79 0.12 0.1448
165 -1.84 0.29 - BPI- 169 -2.23 0.28 -0.35 -0.79 0.08 0.1108
165 -1.88 0.28 - BPI- 169 -2.29 0.26 -0.41 -0.83 0.00 0.0496*
165 -1.88 0.26 - BPI- 169 -1.74 0.27 -0.20 -0.62 0.23 0.3600
165 -1.54 0.27 - BPI- 169 -1.30 0.26 -0.38 -0.79 0.03 0.0720
165 -0.92 0.27 - BPI- 169 -2.28 0.28 -0.42 -0.87 0.02 0.0607
165 -1.85 0.28 - BPI- 169 -2.15 0.27 -0.43 -0.86 -0.01 0.0464*
165 -1.72 0.27 - BPI- 169 -2.01 0.24 -0.38 -0.75 0.00 0.0516 7 165 -1.63 0.24 - BDI-II 169 -3.40 0.71 0.39 -0.74 1.52 0.4956 165 -3.79 0.72 - PGI- 169 2.45 0.15 -0.63 -0.85 -0.41 <0.0001* 165 3.08 0.15 - * (p<0.05) BPI PGI- BDI Beck
- a) p
(PGI- )
[ 5.3.5.1-02 11-20 ]
- 100 -
2.7.6.1.2-18 (LOCF)(FAS)
95%
40 mg 85 -2.31 0.28 -0.85 -1.32 -0.39
60 mg 86 -2.47 0.29 -1.01 -1.47 -0.55 167 -1.46 0.25
40 mg 85 -2.28 0.28 -0.75 -1.22 -0.29 60 mg 86 -2.35 0.28 -0.83 -1.29 -0.36 167 -1.52 0.25 BPI- 40 mg 84 -2.59 0.31 -0.87 -1.38 -0.36
60 mg 85 -2.75 0.31 -1.02 -1.53 -0.51 165 -1.73 0.27 BPI- 40 mg 84 -1.94 0.28 -0.77 -1.25 -0.30
60 mg 85 -2.10 0.28 -0.93 -1.41 -0.46 165 -1.17 0.25 BPI- 40 mg 84 -2.48 0.28 -0.92 -1.38 -0.47
60 mg 85 -2.53 0.28 -0.97 -1.42 -0.52 165 -1.56 0.25 BPI- 40 mg 84 -2.49 0.30 -0.83 -1.34 -0.33
60 mg 85 -2.54 0.30 -0.88 -1.38 -0.38 165 -1.66 0.26 BPI- 40 mg 84 -2.37 0.32 -0.53 -1.08 0.02
60 mg 85 -1.98 0.33 -0.14 -0.69 0.41 165 -1.84 0.29 BPI- 40 mg 84 -2.12 0.32 -0.24 -0.77 0.29
60 mg 85 -2.34 0.32 -0.47 -1.00 0.07 165 -1.88 0.28 BPI- 40 mg 84 -2.31 0.30 -0.43 -0.93 0.08
60 mg 85 -2.28 0.30 -0.40 -0.90 0.10 165 -1.88 0.26 BPI- 40 mg 84 -1.75 0.31 -0.21 -0.73 0.31
60 mg 85 -1.73 0.31 -0.19 -0.71 0.33 165 -1.54 0.27 BPI- 40 mg 84 -1.13 0.30 -0.20 -0.71 0.30
60 mg 85 -1.47 0.30 -0.55 -1.05 -0.05 165 -0.93 0.27 BPI- 40 mg 84 -2.39 0.32 -0.54 -1.08 0.01
60 mg 85 -2.16 0.32 -0.31 -0.85 0.23 165 -1.85 0.28 BPI- 40 mg 84 -1.99 0.31 -0.26 -0.78 0.26
60 mg 85 -2.32 0.31 -0.60 -1.12 -0.08 165 -1.73 0.27 BPI- 40 mg 84 -1.99 0.27 -0.35 -0.82 0.11 7 60 mg 85 -2.03 0.28 -0.40 -0.86 0.06 165 -1.63 0.24
- 101 -
2.7.6.1.2-18 (LOCF)(FAS)( )
95%
BDI-II 40 mg 84 -3.01 0.81 0.79 -0.58 2.17 60 mg 85 -3.81 0.82 -0.01 -1.38 1.36 165 -3.80 0.72 PGI- 40 mg 84 2.45 0.16 -0.63 -0.90 -0.36 60 mg 85 2.44 0.17 -0.64 -0.90 -0.37 165 3.08 0.15 BPI PGI- BDI Beck
40 mg ( 60 mg)- (PGI- )
[ 5.3.5.1-02 11-21 ]
(5)
(A)
2.7.6.1.2-19
( ) 145/171 (84.8%) 534 40 mg
72/85 (84.7%) 256 60 mg 73/86 (84.9%) 278 123/167
(73.7%) 373 (
) (p=0.0153) 40 mg 60 mg
( )
( ) (p<0.0001) 40 mg 60 mg
(p=0.0021 p=0.0009)
( ) 138/171 (80.7%) 40 mg 69/85
(81.2%) 60 mg 69/86 (80.2%) 114/167 (68.3%)
( )
(p=0.0090) 40 mg (p=0.0362) 60 mg
( )
( ) (p=0.0005)
40 mg 60 mg (p=0.0047 p=0.0046)
( ) 56/171 (32.7%) 40 mg
29/85 (34.1%) 60 mg 27/86 (31.4%) 39/167 (23.4%)
(
) 40 mg 60 mg
( ) (
)
- 102 -
2.7.6.1.2-19
40 mg 60 mg 40 mg 60 mg 171 85 86 167 171 85 86 167
145 72 73 123 106 52 54 67 534 256 278 373 287 132 155 149 (%) 84.8 84.7 84.9 73.7 62.0 61.2 62.8 40.1 95% 78.5 75.3 75.5 66.3 54.3 50.0 51.7 32.6 95% 89.8 91.6 91.7 80.2 69.3 71.6 73.0 48.0 a) 0.0153* 0.0560 0.0560 <0.0001* 0.0021* 0.0009*
138 69 69 114 93 46 47 59 415 190 225 244 233 105 128 92 (%) 80.7 81.2 80.2 68.3 54.4 54.1 54.7 35.3 95% 74.0 71.2 70.2 60.6 46.6 43.0 43.5 28.1 95% 86.3 88.8 88.0 75.2 62.0 65.0 65.4 43.1 a) 0.0090* 0.0362* 0.0536 0.0005* 0.0047* 0.0046*
56 29 27 39 29 15 14 25 119 66 53 129 54 27 27 57 (%) 32.7 34.1 31.4 23.4 17.0 17.6 16.3 15.0 95% 25.8 24.2 21.8 17.2 11.7 10.2 9.2 9.9 95% 40.3 45.2 42.3 30.5 23.4 27.4 25.8 21.3 a) 0.0692 0.0736 0.1766 0.6578 0.5884 0.8546 * (p<0.05) a) Fisher p
[ 5.3.5.1-02 12-3 12-4 ]
(MedDRA )
2.7.6.1.2-20
5% 37 (21.6%) 39
24 (14.0%) 28 24 (14.0%) 27 AST 13 (7.6%) 13
11 (6.4%) 12 10 (5.8%) 12 ALT 10 (5.8%)
10 9 (5.3%) 12 9 (5.3%) 10 9 (5.3%) 9
40 mg 16 (18.8%) 16 10 (11.8%) 11
6 (7.1%) 8 CK 6 (7.1%) 6 AST ALT
5 (5.9%) 5 60 mg 21 (24.4%) 23 14
(16.3%) 17 14 (16.3%) 16 AST 8 (9.3%) 8 7 (8.1%)
7 6 (7.0%) 7 5 (5.8%) 7 5 (5.8%) 6 ALT
-GTP LDH HbA1c 5 (5.8%) 5
24 (14.4%) 24 14 (8.4%) 14 9 (5.4%) 9
( p<0.0001 p=0.0007 p=0.0354)
127 (74.3%) 362
- 103 -
90 (52.6%) 162 4 (2.3%) 10 40 mg 66 (77.6%)
180 39 (45.9%) 71 3 (3.5%) 5 60 mg
61 (70.9%) 182 51 (59.3%) 91 1 (1.2%) 5
83 (49.7%) 200 81 (48.5%) 164 4 (2.4%)
9
171 118 (69.0%) 356
17 (9.9%) 29 40 mg 85 60 (70.6%) 172 9 (10.6%)
16 60 mg 86 58 (67.4%) 184 8 (9.3%) 13
167 86 (51.5%) 202 8 (4.8%) 17
907 267 640
604
5% 37 (21.6%) 39
24 (14.0%) 27 9 (5.3%) 10 40 mg
16 (18.8%) 16 10 (11.8%) 11 5 (5.9%) 5 60 mg
21 (24.4%) 23 14 (16.3%) 16 6 (7.0%) 7
13 (7.8%) 13
( p<0.0001 p=0.0004)
97 (56.7%) 221 37
(21.6%) 63 2 (1.2%) 3 40 mg 51 (60.0%) 105
16 (18.8%) 26 1 (1.2%) 1 60 mg
46 (53.5%) 116 21 (24.4%) 37 1 (1.2%) 2
51 (30.5%) 100 28 (16.8%) 48 1 (0.6%)
1
171 80 (46.8%) 195
9 (5.3%) 15 40 mg 85 38 (44.7%) 89 5 (5.9%) 6
60 mg 86 42 (48.8%) 106 4 (4.7%) 9 167
36 (21.6%) 61 2 (1.2%) 6 436
145 291 277
- 104 -
2.7
.6.1
.2-2
0
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
127
(362
) 74
.3%
66
(180
) 77
.6%
61
(182
) 70
.9%
83
(200
) 49
.7%
97
(221
) 56
.7%
51
(105
) 60
.0%
46
(116
) 53
.5%
51
(100
) 30
.5%
90
(162
) 52
.6%
39
(71)
45.
9% 5
1 (9
1) 5
9.3%
81
(164
) 48
.5%
37
(63)
21.
6% 1
6 (2
6) 1
8.8%
21
(37)
24.
4% 2
8 (4
8) 1
6.8%
4 (1
0)
2.3%
3
(5)
3.5%
1
(5)
1.2%
4
(9)
2.4%
2
(3)
1.2%
1
(1)
1.2%
1
(2)
1.2%
1
(1)
0.6%
14
5 (5
34)
84.8
% 7
2 (2
56)
84.7
% 7
3 (2
78)
84.9
%12
3 (3
73)
73.7
%10
6 (2
87)
62.0
% 5
2 (1
32)
61.2
% 5
4 (1
55)
62.8
% 6
7 (1
49)
40.1
%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
5
(5)
2.9%
1
(1)
1.2%
4
(4)
4.7%
4
(4)
2.4%
3
(3)
1.8%
0
(0)
0.0%
3
(3)
3.5%
4
(4)
2.4%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (6
) 3.
5%
1 (1
) 1.
2%
5 (5
) 5.
8%
4 (4
) 2.
4%
4 (4
) 2.
3%
0 (0
) 0.
0%
4 (4
) 4.
7%
4 (4
) 2.
4%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
2
(2)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
- 105 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
7
(7)
4.1%
4
(4)
4.7%
3
(3)
3.5%
1
(1)
0.6%
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
1
(1)
0.6%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
9 (9
) 5.
3%
5 (5
) 5.
9%
4 (4
) 4.
7%
1 (1
) 0.
6%
4 (4
) 2.
3%
2 (2
) 2.
4%
2 (2
) 2.
3%
1 (1
) 0.
6%
4
(4)
2.3%
3
(3)
3.5%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5 (5
) 2.
9%
4 (4
) 4.
7%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
1 (1
) 0.
6%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
1
(1)
0.6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
5 (6
) 2.
9%
2 (2
) 2.
4%
3 (4
) 3.
5%
8 (9
) 4.
8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
8 (9
) 4.
7%
4 (4
) 4.
7%
4 (5
) 4.
7%
9 (1
0)
5.4%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
- 106 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(2)
0.6%
0
(0)
0.0%
1
(2)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(2)
0.6%
0
(0)
0.0%
1
(2)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
- 107 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
41
(62)
24.
0% 2
3 (2
9) 2
7.1%
18
(33)
20.
9% 1
4 (1
9)
8.4%
32
(48)
18.
7% 1
7 (2
3) 2
0.0%
15
(25)
17.
4%
9 (1
2)
5.4%
2
7 (3
1) 1
5.8%
11
(11)
12.
9% 1
6 (2
0) 1
8.6%
22
(25)
13.
2% 1
9 (2
3) 1
1.1%
8
(8)
9.4%
11
(15)
12.
8% 1
2 (1
2)
7.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
61
(93)
35.
7% 3
0 (4
0) 3
5.3%
31
(53)
36.
0% 3
3 (4
4) 1
9.8%
46
(71)
26.
9% 2
2 (3
1) 2
5.9%
24
(40)
27.
9% 2
0 (2
4) 1
2.0%
1
7 (2
0)
9.9%
7
(7)
8.2%
10
(13)
11.
6%
1 (1
) 0.
6% 1
7 (1
9)
9.9%
7
(7)
8.2%
10
(12)
11.
6%
1 (1
) 0.
6%
8
(8)
4.7%
4
(4)
4.7%
4
(4)
4.7%
2
(2)
1.2%
8
(8)
4.7%
4
(4)
4.7%
4
(4)
4.7%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
24
(28)
14.
0% 1
0 (1
1) 1
1.8%
14
(17)
16.
3%
3 (3
) 1.
8% 2
4 (2
7) 1
4.0%
10
(11)
11.
8% 1
4 (1
6) 1
6.3%
3
(3)
1.8%
4 (5
) 2.
3%
3 (3
) 3.
5%
1 (2
) 1.
2%
1 (1
) 0.
6%
3 (4
) 1.
8%
2 (2
) 2.
4%
1 (2
) 1.
2%
1 (1
) 0.
6%
7
(7)
4.1%
3
(3)
3.5%
4
(4)
4.7%
8
(8)
4.8%
6
(6)
3.5%
3
(3)
3.5%
3
(3)
3.5%
5
(5)
3.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
11
(12)
6.
4%
6 (6
) 7.
1%
5 (6
) 5.
8%
9 (9
) 5.
4%
9 (1
0)
5.3%
5
(5)
5.9%
4
(5)
4.7%
6
(6)
3.6%
- 108 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
10
(11)
5.
8%
4 (5
) 4.
7%
6 (6
) 7.
0%
3 (3
) 1.
8%
7 (8
) 4.
1%
4 (5
) 4.
7%
3 (3
) 3.
5%
2 (2
) 1.
2%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
3
(3)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
11
(12)
6.
4%
4 (5
) 4.
7%
7 (7
) 8.
1%
6 (6
) 3.
6%
7 (8
) 4.
1%
4 (5
) 4.
7%
3 (3
) 3.
5%
3 (3
) 1.
8%
5
(5)
2.9%
3
(3)
3.5%
2
(2)
2.3%
2
(2)
1.2%
4
(4)
2.3%
2
(2)
2.4%
2
(2)
2.3%
1
(1)
0.6%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
2 (2
) 1.
2%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
7 (8
) 4.
1%
3 (4
) 3.
5%
4 (4
) 4.
7%
4 (4
) 2.
4%
6 (7
) 3.
5%
2 (3
) 2.
4%
4 (4
) 4.
7%
1 (1
) 0.
6%
7
(9)
4.1%
4
(5)
4.7%
3
(4)
3.5%
2
(2)
1.2%
6
(7)
3.5%
4
(5)
4.7%
2
(2)
2.3%
1
(1)
0.6%
2 (3
) 1.
2%
0 (0
) 0.
0%
2 (3
) 2.
3%
0 (0
) 0.
0%
2 (3
) 1.
2%
0 (0
) 0.
0%
2 (3
) 2.
3%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
9 (1
2)
5.3%
4
(5)
4.7%
5
(7)
5.8%
2
(2)
1.2%
8
(10)
4.
7%
4 (5
) 4.
7%
4 (5
) 4.
7%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
3 (3
) 1.
8%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
3 (3
) 1.
8%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
4
(4)
2.4%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
3 (3
) 1.
8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
3 (3
) 1.
8%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
- 109 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
- -
- -
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(2)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(2)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (2
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (2
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
- 110 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
- 111 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
22
(26)
12.
9% 1
3 (1
3) 1
5.3%
9
(13)
10.
5%
7 (8
) 4.
2% 2
0 (2
3) 1
1.7%
12
(12)
14.
1%
8 (1
1)
9.3%
5
(5)
3.0%
4 (4
) 2.
3%
3 (3
) 3.
5%
1 (1
) 1.
2%
4 (4
) 2.
4%
3 (3
) 1.
8%
2 (2
) 2.
4%
1 (1
) 1.
2%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
5 (3
0) 1
4.6%
15
(16)
17.
6% 1
0 (1
4) 1
1.6%
11
(12)
6.
6% 2
2 (2
6) 1
2.9%
13
(14)
15.
3%
9 (1
2) 1
0.5%
7
(7)
4.2%
7 (8
) 4.
1%
2 (2
) 2.
4%
5 (6
) 5.
8%
3 (3
) 1.
8%
7 (8
) 4.
1%
2 (2
) 2.
4%
5 (6
) 5.
8%
3 (3
) 1.
8%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
9
(10)
5.
3%
3 (3
) 3.
5%
6 (7
) 7.
0%
3 (3
) 1.
8%
9 (1
0)
5.3%
3
(3)
3.5%
6
(7)
7.0%
3
(3)
1.8%
8 (8
) 4.
7%
4 (4
) 4.
7%
4 (4
) 4.
7%
3 (3
) 1.
8%
7 (7
) 4.
1%
4 (4
) 4.
7%
3 (3
) 3.
5%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
8
(8)
4.7%
4
(4)
4.7%
4
(4)
4.7%
3
(3)
1.8%
7
(7)
4.1%
4
(4)
4.7%
3
(3)
3.5%
2
(2)
1.2%
3 (3
) 1.
8%
3 (3
) 3.
5%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3
(3)
1.8%
3
(3)
3.5%
0
(0)
0.0%
1
(1)
0.6%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
1
(1)
0.6%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
0
(0)
0.0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
- 112 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
- 113 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
8
(9)
4.7%
2
(2)
2.4%
6
(7)
7.0%
10
(10)
6.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
30
(36)
17.
5% 1
2 (1
4) 1
4.1%
18
(22)
20.
9% 3
1 (3
6) 1
8.6%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
3
(3)
1.8%
1 (2
) 0.
6%
1 (2
) 1.
2%
0 (0
) 0.
0%
2 (4
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
38
(47)
22.
2% 1
5 (1
8) 1
7.6%
23
(29)
26.
7% 4
2 (5
0) 2
5.1%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
3
(3)
1.8%
7 (7
) 4.
1%
2 (2
) 2.
4%
5 (5
) 5.
8%
6 (6
) 3.
6%-
- -
-
1
8 (2
0) 1
0.5%
8
(9)
9.4%
10
(11)
11.
6% 1
8 (1
8) 1
0.8%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
24
(27)
14.
0% 1
0 (1
1) 1
1.8%
14
(16)
16.
3% 2
4 (2
4) 1
4.4%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
3
(3)
1.8%
- -
- -
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
3
(3)
1.8%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
4
(4)
2.3%
1
(1)
1.2%
3
(3)
3.5%
6
(6)
3.6%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(2)
0.6%
1
(2)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
4 (5
) 2.
3%
2 (3
) 2.
4%
2 (2
) 2.
3%
1 (1
) 0.
6%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
- 114 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
- 115 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
- 116 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
- 117 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
9
(9)
5.3%
5
(5)
5.9%
4
(4)
4.7%
4
(5)
2.4%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
1
2 (1
3)
7.0%
6
(7)
7.1%
6
(6)
7.0%
5
(6)
3.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
3 (4
) 1.
8%
2 (2
) 2.
4%
1 (2
) 1.
2%
1 (1
) 0.
6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
20
(26)
11.
7% 1
2 (1
4) 1
4.1%
8
(12)
9.
3% 1
0 (1
2)
6.0%
2
(4)
1.2%
1
(1)
1.2%
1
(3)
1.2%
0
(0)
0.0%
3 (3
) 1.
8%
0 (0
) 0.
0%
3 (3
) 3.
5%
3 (3
) 1.
8%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
5
(5)
2.9%
2
(2)
2.4%
3
(3)
3.5%
3
(3)
1.8%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
2 (3
) 1.
2%
2 (3
) 2.
4%
0 (0
) 0.
0%
1 (1
) 0.
6%-
- -
-
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%-
- -
-
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
1 (1
) 0.
6%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%-
- -
-
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- 118 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
- 119 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
55
(114
) 32
.2%
28
(58)
32.
9% 2
7 (5
6) 3
1.4%
39
(97)
23.
4% 2
7 (5
0) 1
5.8%
14
(22)
16.
5% 1
3 (2
8) 1
5.1%
24
(50)
14.
4%
9
(16)
5.
3%
6 (1
2)
7.1%
3
(4)
3.5%
9
(40)
5.
4%
7 (1
0)
4.1%
4
(6)
4.7%
3
(4)
3.5%
5
(12)
3.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6
0 (1
30)
35.1
% 3
1 (7
0) 3
6.5%
29
(60)
33.
7% 4
4 (1
37)
26.3
% 3
1 (6
0) 1
8.1%
16
(28)
18.
8% 1
5 (3
2) 1
7.4%
28
(62)
16.
8%
AST
13
(13)
7.
6%
5 (5
) 5.
9%
8 (8
) 9.
3%
3 (3
) 1.
8%
7 (7
) 4.
1%
3 (3
) 3.
5%
4 (4
) 4.
7%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3
(3)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
13
(13)
7.
6%
5 (5
) 5.
9%
8 (8
) 9.
3%
6 (6
) 3.
6%
7 (7
) 4.
1%
3 (3
) 3.
5%
4 (4
) 4.
7%
4 (4
) 2.
4%
ALT
9
(9)
5.3%
4
(4)
4.7%
5
(5)
5.8%
4
(4)
2.4%
5
(5)
2.9%
2
(2)
2.4%
3
(3)
3.5%
3
(3)
1.8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
0 (1
0)
5.8%
5
(5)
5.9%
5
(5)
5.8%
6
(6)
3.6%
6
(6)
3.5%
3
(3)
3.5%
3
(3)
3.5%
4
(4)
2.4%
- 120 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
8
(8)
4.7%
3
(3)
3.5%
5
(5)
5.8%
3
(3)
1.8%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
9 (9
) 5.
3%
4 (4
) 4.
7%
5 (5
) 5.
8%
4 (4
) 2.
4%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
CK
6
(6)
3.5%
6
(6)
7.1%
0
(0)
0.0%
5
(5)
3.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (6
) 3.
5%
6 (6
) 7.
1%
0 (0
) 0.
0%
6 (6
) 3.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
3 (3
) 1.
8%
-GTP
6
(6)
3.5%
1
(1)
1.2%
5
(5)
5.8%
3
(3)
1.8%
3
(3)
1.8%
0
(0)
0.0%
3
(3)
3.5%
2
(2)
1.2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
7 (7
) 4.
1%
2 (2
) 2.
4%
5 (5
) 5.
8%
5 (5
) 3.
0%
4 (4
) 2.
3%
1 (1
) 1.
2%
3 (3
) 3.
5%
2 (2
) 1.
2%
3
(5)
1.8%
2
(4)
2.4%
1
(1)
1.2%
5
(13)
3.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
2
(2)
1.2%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
4
(6)
2.3%
2
(4)
2.4%
2
(2)
2.3%
7
(15)
4.
2%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%
LDH
7
(7)
4.1%
2
(2)
2.4%
5
(5)
5.8%
2
(2)
1.2%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
7 (7
) 4.
1%
2 (2
) 2.
4%
5 (5
) 5.
8%
4 (4
) 2.
4%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
3 (3
) 1.
8%
/
5 (5
) 2.
9%
2 (2
) 2.
4%
3 (3
) 3.
5%
5 (5
) 3.
0%
4 (4
) 2.
3%
2 (2
) 2.
4%
2 (2
) 2.
3%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
5
(5)
2.9%
2
(2)
2.4%
3
(3)
3.5%
6
(6)
3.6%
4
(4)
2.3%
2
(2)
2.4%
2
(2)
2.3%
2
(2)
1.2%
H
bA1c
5
(5)
2.9%
1
(1)
1.2%
4
(4)
4.7%
2
(2)
1.2%
3
(3)
1.8%
0
(0)
0.0%
3
(3)
3.5%
2
(2)
1.2%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (6
) 3.
5%
1 (1
) 1.
2%
5 (5
) 5.
8%
4 (4
) 2.
4%
4 (4
) 2.
3%
0 (0
) 0.
0%
4 (4
) 4.
7%
3 (3
) 1.
8%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
5
(5)
3.0%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
2
(2)
1.2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
4 (4
) 2.
3%
2 (2
) 2.
4%
2 (2
) 2.
3%
5 (5
) 3.
0%
4 (4
) 2.
3%
2 (2
) 2.
4%
2 (2
) 2.
3%
2 (2
) 1.
2%
- 121 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
BU
N
5 (5
) 2.
9%
2 (2
) 2.
4%
3 (3
) 3.
5%
3 (3
) 1.
8%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
5
(5)
2.9%
2
(2)
2.4%
3
(3)
3.5%
4
(4)
2.4%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
A
LP
5 (5
) 2.
9%
3 (3
) 3.
5%
2 (2
) 2.
3%
1 (1
) 0.
6%
4 (4
) 2.
3%
3 (3
) 3.
5%
1 (1
) 1.
2%
1 (1
) 0.
6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
6
(6)
3.5%
4
(4)
4.7%
2
(2)
2.3%
2
(2)
1.2%
5
(5)
2.9%
4
(4)
4.7%
1
(1)
1.2%
1
(1)
0.6%
3 (3
) 1.
8%
2 (2
) 2.
4%
1 (1
) 1.
2%
2 (2
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
3
(3)
1.8%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
3 (3
) 1.
8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
4
(4)
2.4%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
3 (3
) 1.
8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
4
(4)
2.4%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
3 (3
) 1.
8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
4
(4)
2.4%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
4 (4
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
4
(4)
2.4%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
4 (4
) 2.
3%
2 (2
) 2.
4%
2 (2
) 2.
3%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
4
(4)
2.3%
2
(2)
2.4%
2
(2)
2.3%
1
(1)
0.6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
- 122 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
4
(4)
2.4%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
5 (5
) 3.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
4
(4)
2.3%
2
(2)
2.4%
2
(2)
2.3%
1
(1)
0.6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
4 (4
) 2.
3%
2 (2
) 2.
4%
2 (2
) 2.
3%
1 (1
) 0.
6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
2
(2)
1.2%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
3 (3
) 1.
8%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
3 (3
) 1.
8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3
(3)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
4 (4
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3
(3)
1.8%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
4 (4
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 1.
8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3 (3
) 1.
8%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
- 123 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
C-
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(2)
0.6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (3
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
0
(0)
0.0%
2
(2)
2.3%
0
(0)
0.0%
2
(2)
1.2%
0
(0)
0.0%
2
(2)
2.3%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
1 (1
) 0.
6%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
- 124 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
T
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
ST
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
ST
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- 125 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
- 126 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(2)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(2)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
- 127 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
CK
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
11
(13)
6.
4%
4 (6
) 4.
7%
7 (7
) 8.
1%
1 (1
) 0.
6% 1
0 (1
0)
5.8%
3
(3)
3.5%
7
(7)
8.1%
1
(1)
0.6%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
1 (2
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
4 (1
7)
8.2%
6
(8)
7.1%
8
(9)
9.3%
2
(3)
1.2%
12
(12)
7.
0%
5 (5
) 5.
9%
7 (7
) 8.
1%
1 (1
) 0.
6%
4
(4)
2.3%
0
(0)
0.0%
4
(4)
4.7%
0
(0)
0.0%
4
(4)
2.3%
0
(0)
0.0%
4
(4)
4.7%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5 (5
) 2.
9%
1 (1
) 1.
2%
4 (4
) 4.
7%
0 (0
) 0.
0%
5 (5
) 2.
9%
1 (1
) 1.
2%
4 (4
) 4.
7%
0 (0
) 0.
0%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
1
(1)
0.6%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
1 (1
) 0.
6%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
1 (1
) 0.
6%
1
(3)
0.6%
1
(3)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (2
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
3 (5
) 1.
8%
2 (4
) 2.
4%
1 (1
) 1.
2%
1 (2
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
- 128 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
10
(12)
5.
8%
3 (4
) 3.
5%
7 (8
) 8.
1% 1
0 (1
1)
6.0%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
0
(0)
0.0%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
8 (9
) 4.
8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
2 (1
6)
7.0%
3
(5)
3.5%
9
(11)
10.
5% 1
8 (2
1) 1
0.8%
4
(4)
2.3%
2
(2)
2.4%
2
(2)
2.3%
1
(1)
0.6%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
2
(2)
1.2%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
0
(0)
0.0%
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%-
- -
-
- 129 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
(2)
1.2%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
- 130 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
(
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
- )
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%-
- -
-
4
7 (5
9) 2
7.5%
23
(32)
27.
1% 2
4 (2
7) 2
7.9%
22
(23)
13.
2% 4
4 (5
3) 2
5.7%
22
(28)
25.
9% 2
2 (2
5) 2
5.6%
17
(17)
10.
2%
6
(10)
3.
5%
2 (3
) 2.
4%
4 (7
) 4.
7% 1
0 (1
2)
6.0%
5
(9)
2.9%
1
(2)
1.2%
4
(7)
4.7%
5
(7)
3.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (2
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
52
(70)
30.
4% 2
5 (3
5) 2
9.4%
27
(35)
31.
4% 2
9 (3
7) 1
7.4%
48
(62)
28.
1% 2
3 (3
0) 2
7.1%
25
(32)
29.
1% 2
1 (2
5) 1
2.6%
- 131 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
35
(37)
20.
5% 1
5 (1
5) 1
7.6%
20
(22)
23.
3% 1
4 (1
4)
8.4%
35
(37)
20.
5% 1
5 (1
5) 1
7.6%
20
(22)
23.
3% 1
3 (1
3)
7.8%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3
7 (3
9) 2
1.6%
16
(16)
18.
8% 2
1 (2
3) 2
4.4%
14
(14)
8.
4% 3
7 (3
9) 2
1.6%
16
(16)
18.
8% 2
1 (2
3) 2
4.4%
13
(13)
7.
8%
8
(10)
4.
7%
5 (7
) 5.
9%
3 (3
) 3.
5%
1 (1
) 0.
6%
5 (6
) 2.
9%
3 (4
) 3.
5%
2 (2
) 2.
3%
1 (1
) 0.
6%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
2
(2)
1.2%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
10
(12)
5.
8%
6 (8
) 7.
1%
4 (4
) 4.
7%
2 (3
) 1.
2%
7 (8
) 4.
1%
4 (5
) 4.
7%
3 (3
) 3.
5%
2 (2
) 1.
2%
5
(5)
2.9%
4
(4)
4.7%
1
(1)
1.2%
2
(2)
1.2%
3
(3)
1.8%
3
(3)
3.5%
0
(0)
0.0%
1
(1)
0.6%
1 (2
) 0.
6%
0 (0
) 0.
0%
1 (2
) 1.
2%
5 (7
) 3.
0%
1 (2
) 0.
6%
0 (0
) 0.
0%
1 (2
) 1.
2%
1 (3
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
6 (7
) 3.
5%
4 (4
) 4.
7%
2 (3
) 2.
3%
6 (9
) 3.
6%
4 (5
) 2.
3%
3 (3
) 3.
5%
1 (2
) 1.
2%
1 (4
) 0.
6%
2
(3)
1.2%
2
(3)
2.4%
0
(0)
0.0%
0
(0)
0.0%
2
(3)
1.2%
2
(3)
2.4%
0
(0)
0.0%
0
(0)
0.0%
1 (2
) 0.
6%
0 (0
) 0.
0%
1 (2
) 1.
2%
0 (0
) 0.
0%
1 (2
) 0.
6%
0 (0
) 0.
0%
1 (2
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3 (5
) 1.
8%
2 (3
) 2.
4%
1 (2
) 1.
2%
0 (0
) 0.
0%
3 (5
) 1.
8%
2 (3
) 2.
4%
1 (2
) 1.
2%
0 (0
) 0.
0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
- 132 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
3
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%-
- -
-
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%-
- -
-
- 133 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
6
(6)
3.5%
5
(5)
5.9%
1
(1)
1.2%
2
(2)
1.2%
5
(5)
2.9%
5
(5)
5.9%
0
(0)
0.0%
1
(1)
0.6%
4 (4
) 2.
3%
2 (2
) 2.
4%
2 (2
) 2.
3%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
1 (1
1)
6.4%
7
(7)
8.2%
4
(4)
4.7%
2
(2)
1.2%
7
(7)
4.1%
5
(5)
5.9%
2
(2)
2.3%
1
(1)
0.6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
1
(1)
0.6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- 134 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
8
(8)
4.7%
2
(2)
2.4%
6
(6)
7.0%
5
(5)
3.0%
7
(7)
4.1%
2
(2)
2.4%
5
(5)
5.8%
3
(3)
1.8%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
8 (8
) 4.
7%
2 (2
) 2.
4%
6 (6
) 7.
0%
7 (7
) 4.
2%
7 (7
) 4.
1%
2 (2
) 2.
4%
5 (5
) 5.
8%
4 (4
) 2.
4%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
1
(1)
0.6%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
2 (2
) 1.
2%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
2 (2
) 1.
2%
- 135 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
2
(2)
1.2%
0
(0)
0.0%
2
(2)
2.3%
2
(2)
1.2%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
2 (2
) 1.
2%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
4
(4)
2.3%
3
(3)
3.5%
1
(1)
1.2%
1
(1)
0.6%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
8 (9
) 4.
7%
4 (4
) 4.
7%
4 (5
) 4.
7%
3 (3
) 1.
8%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
2 (1
3)
7.0%
7
(7)
8.2%
5
(6)
5.8%
4
(4)
2.4%
4
(4)
2.3%
1
(1)
1.2%
3
(3)
3.5%
1
(1)
0.6%
- 136 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
1
(1)
0.6%
- -
- -
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
- 137 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
12
(13)
7.
0%
8 (8
) 9.
4%
4 (5
) 4.
7%
6 (6
) 3.
6%
5 (5
) 2.
9%
2 (2
) 2.
4%
3 (3
) 3.
5%
1 (1
) 0.
6%
14
(15)
8.
2%
5 (5
) 5.
9%
9 (1
0) 1
0.5%
11
(11)
6.
6%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
7 (7
) 4.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2
4 (2
8) 1
4.0%
12
(13)
14.
1% 1
2 (1
5) 1
4.0%
16
(17)
9.
6%
8 (8
) 4.
7%
3 (3
) 3.
5%
5 (5
) 5.
8%
7 (8
) 4.
2%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
2
(2)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
3 (3
) 1.
8%
2 (2
) 2.
4%
1 (1
) 1.
2%
3 (3
) 1.
8%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5 (5
) 2.
9%
4 (4
) 4.
7%
1 (1
) 1.
2%
5 (5
) 3.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
3 (3
) 1.
8%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
0
(0)
0.0%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
4 (4
) 2.
3%
1 (1
) 1.
2%
3 (3
) 3.
5%
1 (1
) 0.
6%
4 (4
) 2.
3%
1 (1
) 1.
2%
3 (3
) 3.
5%
1 (1
) 0.
6%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
2
(2)
1.2%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (2
) 1.
2%
2 (2
) 2.
4%
0 (0
) 0.
0%
2 (2
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
2 (2
) 1.
2%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
1 (1
) 0.
6%
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
2
(2)
1.2%
2
(2)
2.4%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
- 138 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
2 (2
) 1.
2%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
- 139 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(2)
0.6%
0
(0)
0.0%
1
(2)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(2)
0.6%
0
(0)
0.0%
1
(2)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
- 140 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
9
(10)
5.
3%
4 (5
) 4.
7%
5 (5
) 5.
8%
5 (5
) 3.
0%
5 (5
) 2.
9%
2 (2
) 2.
4%
3 (3
) 3.
5%
3 (3
) 1.
8%
7
(7)
4.1%
4
(4)
4.7%
3
(3)
3.5%
2
(3)
1.2%
3
(3)
1.8%
2
(2)
2.4%
1
(1)
1.2%
1
(1)
0.6%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
16
(17)
9.
4%
8 (9
) 9.
4%
8 (8
) 9.
3%
7 (8
) 4.
2%
8 (8
) 4.
7%
4 (4
) 4.
7%
4 (4
) 4.
7%
4 (4
) 2.
4%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
2
(2)
1.2%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
2
(2)
1.2%
4 (4
) 2.
3%
3 (3
) 3.
5%
1 (1
) 1.
2%
2 (3
) 1.
2%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5 (5
) 2.
9%
3 (3
) 3.
5%
2 (2
) 2.
3%
4 (5
) 2.
4%
2 (2
) 1.
2%
1 (1
) 1.
2%
1 (1
) 1.
2%
3 (3
) 1.
8%
3
(3)
1.8%
1
(1)
1.2%
2
(2)
2.3%
1
(1)
0.6%
2
(2)
1.2%
1
(1)
1.2%
1
(1)
1.2%
1
(1)
0.6%
2 (2
) 1.
2%
0 (0
) 0.
0%
2 (2
) 2.
3%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
5 (5
) 2.
9%
1 (1
) 1.
2%
4 (4
) 4.
7%
1 (1
) 0.
6%
3 (3
) 1.
8%
1 (1
) 1.
2%
2 (2
) 2.
3%
1 (1
) 0.
6%
1
(2)
0.6%
1
(2)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
2 (3
) 1.
2%
2 (3
) 2.
4%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1 (1
) 0.
6%
1 (1
) 1.
2%
0 (0
) 0.
0%
0 (0
) 0.
0%
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
1
(1)
1.2%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
- -
- -
- 141 -
2.7
.6.1
.2-2
0 (
)
(SO
C)
(PT
)
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
N
=171
40
mg
N=8
5 60
mg
N=8
6
N=1
67
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
1
(1)
0.6%
0
(0)
0.0%
1
(1)
1.2%
0
(0)
0.0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
1 (1
) 0.
6%
0 (0
) 0.
0%
1 (1
) 1.
2%
0 (0
) 0.
0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
- -
- -
0
(0)
0.0%
0
(0)
0.0%
0
(0)
0.0%
1
(1)
0.6%
- -
- -
()
(%
) [
5.3.
5.1-
02
14.3
-5
14.3
-14 ]
- 142 -
(B)
2.7.6.1.2-21
1
1
40 mg 60 mg
2.7.6.1.2-21
a)
171 40 mg 85
60 mg 86
167
0 1 171 85 86 167 1 2 167 82 85 166 2 4 165 80 85 162 4 8 161 80 81 161 8 12 153 76 77 155 12 144 73 71 150 171 85 86 167
0 1 64 (121) 37.4% 31 (59) 36.5% 33 (62) 38.4% 27 (33) 16.2%
1 2 31 (41) 18.6% 17 (25) 20.7% 14 (16) 16.5% 24 (34) 14.5% 2 4 55 (99) 33.3% 24 (47) 30.0% 31 (52) 36.5% 46 (71) 28.4% 4 8 57 (117) 35.4% 26 (49) 32.5% 31 (68) 38.3% 47 (83) 29.2% 8 12 49 (85) 32.0% 23 (34) 30.3% 26 (51) 33.8% 45 (88) 29.0% 12 43 (71) 29.9% 23 (42) 31.5% 20 (29) 28.2% 33 (64) 22.0% 145 (534) 84.8% 72 (256) 84.7% 73 (278) 84.9% 123 (373) 73.7%
0 1 53 (103) 31.0% 25 (49) 29.4% 28 (54) 32.6% 17 (22) 10.2%
1 2 19 (26) 11.4% 8 (13) 9.8% 11 (13) 12.9% 10 (16) 6.0% 2 4 34 (48) 20.6% 15 (24) 18.8% 19 (24) 22.4% 21 (26) 13.0% 4 8 27 (50) 16.8% 11 (16) 13.8% 16 (34) 19.8% 25 (42) 15.5% 8 12 19 (32) 12.4% 7 (11) 9.2% 12 (21) 15.6% 12 (18) 7.7% 12 21 (28) 14.6% 14 (19) 19.2% 7 (9) 9.9% 15 (25) 10.0% 106 (287) 62.0% 52 (132) 61.2% 54 (155) 62.8% 67 (149) 40.1%
( ) (%) a) 0 1 7 1 2 8 14 2 4 15 28 4 8 29 56
8 12 57 84 12 85 [ 5.3.5.1-02 12-11 14.3-19 ]
(C)
2.7.6.1.2-22
31/171 (18.1%) 43 40 mg
16/85 (18.8%) 22 60 mg 15/86 (17.4%) 21 23/167
(13.8%) 26 12/171
(7.0%) 14 40 mg 9/85 (10.6%) 11 60 mg 3/86 (3.5%) 3
8/167 (4.8%) 10
- 143 -
40 mg 60 mg
2 4 (2.3%) 4
3 (1.8%) 3 2 (1.2%) 2 40 mg
2 (2.4%) 2 60 mg 3 (3.5%) 3 2 (2.3%) 2
3 (1.8%) 3 2 (1.2%) 2
2.7.6.1.2-22
171 40 mg 85
60 mg 86
167
a) ( ) 31 (43) 18.1% 16 (22) 18.8% 15 (21) 17.4% 23 (26) 13.8% 95% (12.7, 24.7) (11.2, 28.8) (10.1, 27.1) (8.9, 19.9)
b) 0.3009 0.3571 0.4608 a) ( ) 12 (14) 7.0% 9 (11) 10.6% 3 (3) 3.5% 8 (10) 4.8% 95% (3.7, 11.9) (5.0, 19.2) (0.7, 9.9) (2.1, 9.2)
b) 0.4908 0.1098 0.7540 ( ) (%)
a) b) Fisher p
[ 5.3.5.1-02 12-3 12-4 ]
(D)
(E)
2.7.6.1.2-23
5 (2.9%) 7 40 mg 3 (3.5%) 4
60 mg 2 (2.3%) 3 6 (3.6%) 18
40 mg
60 mg
40 mg 60 mg
60 mg 2 1 ( 0824)
- 144 -