Æ&É Û'¨ m¹³成24年度24naika_1.pdf · huang y, yamamoto t, misaki t, suzuki h,...
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25 3 31 1
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H11.10.1 H19.3.31 H19.4.1 H22.6.30 H22.7.1
H8.8.1 H19.3.31 H19.4.1 H22.12.31 H23.1.1
H20.6.1 H23.1.31 23.2.1
H18.10.1 H19.3.31 H19.4.1 H24.3.31 H24.4.1
H18.4.1 H18.10.1 H19.12.16
H18.4.1 H19.3.31 H19.4.1 H20.1.15 ; H21.10.1~H23.3.31
; H23.4.1
H24.4.1
H23.4.1
H23.6.1
H23.4.1 H24.5.31
H24.6.1
H24.4.1
24
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16.5
1. Konishi T, Kono S, Fujimoto M, Terada T, Matsushita K, Ouchi Y, Miyajima H:Benign hereditary
chorea: dopaminergic brain imaging in patients with a novel intronic NKX2.1 gene mutation, J Neurol,
260(1):207-13, 2013.
2. Sugimoto M, Watada M, Jung SW, Graham DY, Yamaoka Y:Role of Helicobacter pylori plasticity
region genes for development of gastroduodenal diseases, J Clin Microbiol, 50:441-448, 2012 .
3. Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Furuta T:Impact of acid inhibition
on esophageal mucosal injury induced by low-dose aspirin. Digestion, 85:9-17, 2012.
4. Sugimoto M, Shirai N, Nishino M, Kodaira C, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K,
Miyajima H, Furuta T:Rabeprazole 10mg qds deceases 24-hour intragastric acidity significantly more
than rabeprazole 20mg bd or 40mg om overcoming CYP2C19 genotype, Aliment Pharmacol Ther,
36:627-634, 2012.
5. Kodaira C, Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida
A, Furuta T:Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by
[13C]-aminopyrine breath test, J Clin Pharmacol, 52:432-439, 2012.
6. Yamade M, Sugimoto M, Nishino M, Uotani T, Sahara S, Iwaizumi M, Yamada T, Osawa S, Sugimoto
K, Miyajima H, Furuta T:Trastuzumab Has Opposing Effects on SN-38-induced Double-strand Breaks
and Cytotoxicity in HER2-positive Gastric Cancer Cells Depending on Administration Sequence,
Anticancer Res, 32:105-112, 2012.
7. Takayanagi Y, Osawa S, Ikuma M, Takagaki K, Zhang J, Hamaya Y, Yamada T, Sugimoto M, Furuta T,
Miyajima H, Sugimoto K:Norepinephrine suppresses IFN- and TNF- production by murine intestinal
intraepithelial lymphocytes via the (1) adrenoceptor, J Neuroimmunol, 245:66-74, 2012.
8. Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K,
Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T: Ability of Rabeprazole to Prevent Gastric
Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype, Clin
185
Gastroenterol Hepatol, 10: 879-885, 2012.
9. Sahara S, Sugimoto M, Vilaichone RK, Mahachai V, Miyajima H, Furuta T, Yamaoka Y:Role of
Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal
diseases in Southeast Asian countries: a meta-analysis, BMC Infect Dis, 12:223, 2012.
10. Zhang J, Osawa S, Takayanagi Y, Ikuma M, Yamada T, Sugimoto M, Furuta T, Miyajima H, Sugimoto
K: Statins directly suppress cytokine production in murine intraepithelial lymphocytes, Cytokine,
61:540-545, 2013.
11. Ohashi N, Tsuji N, Naito Y, Iwakura T, Isobe S, Ono M, Fujikura T, Tsuji T, Sakao Y, Yasuda H,
Kawamura K, Sakaguchi T, Kato A, Fujigaki Y:Relationship between urinary fractional excretion of
sodium and life prognosis in liver cirrhosis patients. Hepatol Res. 2013 Jan 14. doi: 10.1111/hepr.12068
35.01
1. Suzuki S, Fukasawa H, Misaki T, Togawa A, Ohashi N, Kitagawa K, Kotake Y, Liu N, Niida H,
Nakayama K, Nakayama KI, Yamamoto T, Kitagawa M:The amelioration of renal damage in
Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice, PLoS One, 7: e36249,
2012.
2. Hamaya Y, Kuriyama S, Takai T, Yoshida K, Yamada T, Sugimoto M, Osawa S, Sugimoto K, Miyajima
H, Kanaoka S:A Distinct Expression Pattern of the Long 30-Untranslated Region Dicer mRNA and Its
Implications for Posttranscriptional Regulation in Colorectal Cancer, Clinl Translational
Gastroenterology , 3:e17, 2012.
3. Kato A, Takita T, Furuhashi M, Maruyama Y, Miyajima H, Kumagai H: Brachial-ankle pulse wave
velocity and the cardio-ankle vascular index as a predictor of cardiovascular outcomes in patients on
regular hemodialysis, Ther Apher Dial, 16(3): 232-241, 2012.
4. Kato A, Takita T, Furuhashi M, Fujimoto T, Suzuki H, Maruyama Y, Sakao Y, Miyajima H:Association
of HCV core antigen seropositivity with long-term mortality in patients on regular hemodialysis,
Nephron Extra, 2(1): 76-86, 2012. 5.48
1. Shimatani T, Sugimoto M, Nishino M, Adachi K, Furuta K, Ito M, Kurosawa S, Manabe N, Mannen K,
Hongo M, Chiba T, Kinoshita Y:Predicting the efficacy of proton pump inhibitors in patients with
non-erosive reflux disease before therapy using dualchannel 24-h esophageal pH monitoring, J
186
Gastroenterol Hepetol, 27:899-906, 2012.
2. Jung SW, Sugimoto M, Shiota S, Graham DY, Yamaoka Y:The intact dupA cluster-forming type IV
secretion system is a more reliable Helicobacter pylori virulence marker than dupA alone, Infect Immun,
80:381-387, 2012.
3. Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A,
Nishiyama A, Senbonmatsu T, Ikegaya N, Hishida A:Enhanced intrarenal receptor-mediated prorenin
activation in chronic progressive anti-thymocyte serum nephritis rats on high salt intake, Am J Physiol
Renal Physiol, 303:F130-138, 2012.
4. Hanai H, Iida T, Takeuchi K, Arai H, Arai O, Abe J, Tanaka T, Maruyama Y, Ikeya K, Sugimoto K,
Nakamura T, Nakamura K, Watanabe F:Nutritional therapy versus 6-mercaptopurine as maintenance
therapy in patients with Crohn's disease, Dig Liver Dis, 44(8):649-54, 2012.
13.87
1. Ohashi N, Sakao Y, Fujikura T, Yasuda Y, Kato A, Fujigaki Y:Relationship between urinary fractional
excretion of sodium and life prognosis in liver cirrhosis patients, J Am Soc Nephrol, 23:903A, 2012.
1. Kato A, Sakao Y, Tsuji T, Ohashi N, Yasuda H, Fujigaki Y:Arterial Stiffening is related to changes in
body composition in patients on regular hemodialysis, J Am Soc Nephrol, 23:774A , 2012.
1. Kono S:Aceruloplasminemia, Curr Drug Targets, 13(9):1190-9, 2012.
2. , : , , 109:992-993, 2012.
3. Sugimoto M, Yamaoka Y, Shirai N, Furuta T:The role of the renin-angiotensin system in gastric
oncogenesis, J Gastroenterol Hepetol, 27:442-451, 2012.
4. Sugimoto M, Furuta T:Efficacy of Esomeprazole in treating acid-related diseases in Japanese
populations: A review, Clil Experimental Gastroenterol, 5:49-59, 2012.
5. Sugimoto M, Jang JS, Yoshizawa Y, Osawa S, Sugimoto K, Sato Y, Furuta T:Proton pump inhibitor
therapy before and after endoscopic submucosal dissection: A review, Diag Ther Endoscopy, 1-11,
2012.
6. , , , , , : GERD
, 21:445-452, 2012.
187
7. , , , , , :
, , 15:129-136, 2012.
8. , , , , , , , :
, Therapeutic Research, 33:293-301, 2012.
9. , , : Helicobacter
pylori , , 55:287-291, 2012.
10. , , : pH
, , 243:945-951, 2012.
11. Ohashi N, Sakao Y, Yasuda H, Kato A, Fujigaki Y:Methoxy polyethyleneglycol-epoetin beta for
anemia with chronic kidney disease, Int J Nephrol Renovasc Dis, 5:53-60, 2012.
12. Miyajima H:Editorial: neurodegeneration with brain iron accumulation. Curr Drug Targets 13(9):1181,
2012.
13. , , 43(2):123-124, 2012.
14. , , 44(6): 5-7, 2012.
15. , , 29(2):155-159, 2012.
16. , , Wernicke Thiamine transporter gene mutation I
Vitamin B1 , , 76(3): 248-254, 2012.
17. B1 .
Wernicke , Vitamins (Japan), 86(11): 625-629, 2012.
18. , :ALS2(alsin). II ALS, , 76(5): 472-476,
2012.
19. , : 1 2012-13,
,72 , 597-601, 2012.
20. , :AKI , AKI Q A, • , 24:
298- 303, 2012.
21. , : , ,
19:17-18, 2013.
22. : • 2
, Nutrition Care, 72-75,2012
23. : • 3
, Nutrition Care, 168-173,2012
9.97
1. Furuta T, Sugimoto M, Shirai N:Individualized Therapy for Gastrointestinal Reflux Disease: Potential
Impact of Pharmacogenetic Testing based on CYP2C19, Mol Diag Ther, 16:223-234, 2012.
188
2. , :
, 28:1695-1700, 2012.
1.71
1. , : AKI ,
AKI , Q A , , 97-98, 2012.
2. , :
, Q A , , 97-98, 2012.
3. :
AKI Q A , 88-90, 2012.
4. : AKI AKI
, , 134-141, 2012
5. :AKI ARF , Medical Practice , , , 685 , 2012.
6. , , , , 25-32,
2012.
7. , : , , , , ,
, Annual Review 2013 , , , 196-203, 2012.
8. , : , , , , , ,
, 2 , , , 752-757, 2012.
9. 2 , , ,
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10. , 13.
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11. : , , ,
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12. , : .
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14. :Wernicke , ,
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189
1. Kono S, Bunai T, Terada T, Shimoyama K, Konishi T, Shirakawa K, Miyajima H:Subacute progressive
ophthalmoplegia associated with dermatomyositis, J Neurol, 259(9):1982-1984, 2012.
2. Kono S, Ouchi Y, Terada T, Suzuki M, Yagi S, Miyajima H: Combined FDG and raclopride PET study
in a case of ALS with the R521C FUS gene mutation, J Neurol, 259(2): 367-369, 2012.
3. Terai T, Sugimoto M, Uozaki H, Kitagawa T, Kinoshita M, Baba S, Yamada T, Osawa S, Sugimoto
K:Lymphomatoidgastropathy mimicking extranodal NK/T cell lymphoma, nasal type: a case report,
World J Gastroenterol, 18:2140-2144, 2112.
4. Ikeya K, Osawa S, Kuriyama S, Hamaya S, Yamada T, Sugimoto M, Furuta T, Sugimoto
K:Decompression side tube-equipped double-balloon enteroscopy extends intubation depth and reduces
patient discomfort, Endoscopy , 44 supple 2:E256-7, 2012.
5. Iwakura T, Fujigaki Y, Matsuyama T, Fujikura T, Ohashi N, Yasuda H, Kato A, Baba
S:Tubulointerstitial Nephritis and Primary Biliary Cirrhosis with a T Cell-dominant Profile of
Infiltrating Cells and Granulomas in Both Organs, Intern Med, 52: 467-471, 2013.
15.56
1. Uyama S, Ohashi N, Iwakura T, Ono M, Fujikura T, Sakao Y, Yasuda H, Kato A, Fujigaki Y:A case
presenting with the possible relationship between myeloperoxidase-antineutrophil cytoplasmic
antibody-associated glomerulonephritis and membranous changes of glomerular basement membrane,
CEN Case Rep DOI 10.1007/s13730-012-0039-9.
2. Miwa M, Sakao Y, Ishigaki S, Ono M, Fujikura T, Yasuda H, Suzuki H, Kato A, Nagata Y, Shigeno K,
Nakamura S, Ohnishi K, Fujigaki Y:Recovery of kidney function by rituximab-based therapy in a
patient with Waldenstrom's macroglobulinemia-related nephropathy presenting cast nephropathy and
interstitial lymphocytic infiltration, Intern Med, 51(13):1725-30, 2012.
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1. Sugimoto M:The new trend of H. pylori eradication treatments including third-line therapy,
sequential therapy and concomitant therapy in Japan, 18 ,
, 2012 6 , ( )
1. Sugimoto M:Efficacy of frequent PPI dosing for potent acid inhibition over 24 hours,
, 2012 5 , San Diego( )
2. Sugimoto M:Antiplatelet drugs are a risk factor for esophageal mucosal injury, APDW, 2012 12
,
3. Konishi T:Genetic features and dopaminergic imaging in benign hereditary chorea, Meeting Of
European Neurological Society, 2012 9 , ( )
4. Yamada T:Guggulsterone, a plant sterol inhibitor of NF- B, suppresses CDX2 and COX-2
overexpression and reduces proliferation of esophageal adenocarcinoma cells, ,
2012 5 , ( )
5. Yamade M: Trastuzumab has opposing effects on SN-38-induced double strand breaks and
192
cytotoxicity in HER2-positive gastric cancer cells depending on administration sequence,
, 2012 5 , San Diego( )
6. Uotani T: Role of clopidogrel and rabeprazole in low-dose aspirin-induced gastric mucosal injury in
relation to CYP2C19 genotype, , 2012 5 , San Diego( ), Poster of
Distinction
7. Uotani T: The role of rabeprazole and famotidine for low-dose aspirin-induced gastric mucosal
injury with clopidogrel, APDW, 2012 12 , ( )
8. Sahara S: Association of Helicobacter pylori-related gastroduodenal diseases with vacA and cagA
genotypes in Southeast Asia, , 2012 5 , San Diego( )
9. Sahara S: Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for peptic ulcer in the
Southeast Asia, APDW, 2012 12 , ( )
10. Tsuji T: Partial recovery from AKI, followed by sepsis, worsens kidney injury and mortality, bur
protects other organs, ASN Kidney Week, 2012 11 , San Diego( )
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1. :The Open Pathology Journal, Editorial Advisory Board, ,
2. :World Journal of Nephrology, Editorial Board Member, ,
3. :Case Reports in Nephrology Editorial Board Member, ,
4. :Open Journal of Nephrology Editorial Board Member, ,
5. :World Journal of Gastrointestinal Oncology Editorial Board, ,
6. World Journal of Pharmacology Editorial Board, ,
7. World Journal of Clinical Case Conference Editorial Board, ,
8. : World Journal of Nephrology Editorial Board Member
9. Case Report in Nephrology Editorial Board Member
1. 1 Neurology (USA)
2. 1 J Neurol Sci (USA)
3. 1 Neurobiology (USA)
4. 1 Hepatol Res (USA)
5. 2 ISRN Neurology (Korea)
6. 1 PLOS ONE (USA)
7. Kidney Int (USA) 1
8. : Ther Apher Dialysis (Japan) 1
9. : Clinical and Experimental Nephrology (Japan) 3
10. : CEN case reports (Japan) 1
11. : Intern Med (Japan) 1
12. : 4 J Gastroenterology (Japan)
13. : 2 J Med Microbiol (England)
195
14. : 1 Expert Review of Clinical Pharmacology (USA)
15. : 6 Pros One (USA)
16. : 2 Helicobacter (USA)
17. : 4 World J Gastroenterol (China)
18. : 1 Dig Dis Sci (USA)
19. : 1 Digestion (Greece)
20. : 1 Current Microbiology (USA)
21. Clinical Experimental Nephrology (Japan) 2
22. International Journal of Nephrology and Renovascular Disease (USA) 2
23. BMC Nephrology (USA) 1
24. Tohoku Journal of Experimental Medicine (Japan) 1
25. Journal of Public Health and Epidemiology (Republic of Kenya) 1
26. Medical Science Monitor (USA) 1
27. International Journal of Clinical Medicine (USA) 1
28. British Journal of Medicine and Medical Research (UK) 1
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8. H.pylori esomeprazole omeprazole CYP2C19
PPI CYP2C19 CYP2C19
omeprazole OPZ S
esomeprazole EPZ OPZ CYP2C19
PPI H.pylori
EPZ OPZ CYP2C19 EPZ
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metabolizer [IM] 15 poor metabolizer [PM] 10 rabeprazole RPZ
lansoplazole LPZ 4 esomeprazole
CYP2C19 RM PPI
, , , ,
9. IL-12 B
IL-12 B (Breg) IL-12 Breg
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