Æ&É Û'¨ m¹³成24年度24naika_1.pdf · huang y, yamamoto t, misaki t, suzuki h,...

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Page 1: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

25 3 31 1

1 2 0 5 3

2 0

5 0

0 13 0

0 0

0 4

33

H11.10.1 H19.3.31 H19.4.1 H22.6.30 H22.7.1

H8.8.1 H19.3.31 H19.4.1 H22.12.31 H23.1.1

H20.6.1 H23.1.31 23.2.1

H18.10.1 H19.3.31 H19.4.1 H24.3.31 H24.4.1

H18.4.1 H18.10.1 H19.12.16

H18.4.1 H19.3.31 H19.4.1 H20.1.15 ; H21.10.1~H23.3.31

; H23.4.1

H24.4.1

H23.4.1

H23.6.1

H23.4.1 H24.5.31

H24.6.1

H24.4.1

24

19 0

54.36

184

Page 2: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

2

0.00

25 18

11.68

14 14

7 0

16.5

1. Konishi T, Kono S, Fujimoto M, Terada T, Matsushita K, Ouchi Y, Miyajima H:Benign hereditary

chorea: dopaminergic brain imaging in patients with a novel intronic NKX2.1 gene mutation, J Neurol,

260(1):207-13, 2013.

2. Sugimoto M, Watada M, Jung SW, Graham DY, Yamaoka Y:Role of Helicobacter pylori plasticity

region genes for development of gastroduodenal diseases, J Clin Microbiol, 50:441-448, 2012 .

3. Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Furuta T:Impact of acid inhibition

on esophageal mucosal injury induced by low-dose aspirin. Digestion, 85:9-17, 2012.

4. Sugimoto M, Shirai N, Nishino M, Kodaira C, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K,

Miyajima H, Furuta T:Rabeprazole 10mg qds deceases 24-hour intragastric acidity significantly more

than rabeprazole 20mg bd or 40mg om overcoming CYP2C19 genotype, Aliment Pharmacol Ther,

36:627-634, 2012.

5. Kodaira C, Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida

A, Furuta T:Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by

[13C]-aminopyrine breath test, J Clin Pharmacol, 52:432-439, 2012.

6. Yamade M, Sugimoto M, Nishino M, Uotani T, Sahara S, Iwaizumi M, Yamada T, Osawa S, Sugimoto

K, Miyajima H, Furuta T:Trastuzumab Has Opposing Effects on SN-38-induced Double-strand Breaks

and Cytotoxicity in HER2-positive Gastric Cancer Cells Depending on Administration Sequence,

Anticancer Res, 32:105-112, 2012.

7. Takayanagi Y, Osawa S, Ikuma M, Takagaki K, Zhang J, Hamaya Y, Yamada T, Sugimoto M, Furuta T,

Miyajima H, Sugimoto K:Norepinephrine suppresses IFN- and TNF- production by murine intestinal

intraepithelial lymphocytes via the (1) adrenoceptor, J Neuroimmunol, 245:66-74, 2012.

8. Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K,

Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T: Ability of Rabeprazole to Prevent Gastric

Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype, Clin

185

Page 3: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

Gastroenterol Hepatol, 10: 879-885, 2012.

9. Sahara S, Sugimoto M, Vilaichone RK, Mahachai V, Miyajima H, Furuta T, Yamaoka Y:Role of

Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal

diseases in Southeast Asian countries: a meta-analysis, BMC Infect Dis, 12:223, 2012.

10. Zhang J, Osawa S, Takayanagi Y, Ikuma M, Yamada T, Sugimoto M, Furuta T, Miyajima H, Sugimoto

K: Statins directly suppress cytokine production in murine intraepithelial lymphocytes, Cytokine,

61:540-545, 2013.

11. Ohashi N, Tsuji N, Naito Y, Iwakura T, Isobe S, Ono M, Fujikura T, Tsuji T, Sakao Y, Yasuda H,

Kawamura K, Sakaguchi T, Kato A, Fujigaki Y:Relationship between urinary fractional excretion of

sodium and life prognosis in liver cirrhosis patients. Hepatol Res. 2013 Jan 14. doi: 10.1111/hepr.12068

35.01

1. Suzuki S, Fukasawa H, Misaki T, Togawa A, Ohashi N, Kitagawa K, Kotake Y, Liu N, Niida H,

Nakayama K, Nakayama KI, Yamamoto T, Kitagawa M:The amelioration of renal damage in

Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice, PLoS One, 7: e36249,

2012.

2. Hamaya Y, Kuriyama S, Takai T, Yoshida K, Yamada T, Sugimoto M, Osawa S, Sugimoto K, Miyajima

H, Kanaoka S:A Distinct Expression Pattern of the Long 30-Untranslated Region Dicer mRNA and Its

Implications for Posttranscriptional Regulation in Colorectal Cancer, Clinl Translational

Gastroenterology , 3:e17, 2012.

3. Kato A, Takita T, Furuhashi M, Maruyama Y, Miyajima H, Kumagai H: Brachial-ankle pulse wave

velocity and the cardio-ankle vascular index as a predictor of cardiovascular outcomes in patients on

regular hemodialysis, Ther Apher Dial, 16(3): 232-241, 2012.

4. Kato A, Takita T, Furuhashi M, Fujimoto T, Suzuki H, Maruyama Y, Sakao Y, Miyajima H:Association

of HCV core antigen seropositivity with long-term mortality in patients on regular hemodialysis,

Nephron Extra, 2(1): 76-86, 2012. 5.48

1. Shimatani T, Sugimoto M, Nishino M, Adachi K, Furuta K, Ito M, Kurosawa S, Manabe N, Mannen K,

Hongo M, Chiba T, Kinoshita Y:Predicting the efficacy of proton pump inhibitors in patients with

non-erosive reflux disease before therapy using dualchannel 24-h esophageal pH monitoring, J

186

Page 4: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

Gastroenterol Hepetol, 27:899-906, 2012.

2. Jung SW, Sugimoto M, Shiota S, Graham DY, Yamaoka Y:The intact dupA cluster-forming type IV

secretion system is a more reliable Helicobacter pylori virulence marker than dupA alone, Infect Immun,

80:381-387, 2012.

3. Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A,

Nishiyama A, Senbonmatsu T, Ikegaya N, Hishida A:Enhanced intrarenal receptor-mediated prorenin

activation in chronic progressive anti-thymocyte serum nephritis rats on high salt intake, Am J Physiol

Renal Physiol, 303:F130-138, 2012.

4. Hanai H, Iida T, Takeuchi K, Arai H, Arai O, Abe J, Tanaka T, Maruyama Y, Ikeya K, Sugimoto K,

Nakamura T, Nakamura K, Watanabe F:Nutritional therapy versus 6-mercaptopurine as maintenance

therapy in patients with Crohn's disease, Dig Liver Dis, 44(8):649-54, 2012.

13.87

1. Ohashi N, Sakao Y, Fujikura T, Yasuda Y, Kato A, Fujigaki Y:Relationship between urinary fractional

excretion of sodium and life prognosis in liver cirrhosis patients, J Am Soc Nephrol, 23:903A, 2012.

1. Kato A, Sakao Y, Tsuji T, Ohashi N, Yasuda H, Fujigaki Y:Arterial Stiffening is related to changes in

body composition in patients on regular hemodialysis, J Am Soc Nephrol, 23:774A , 2012.

1. Kono S:Aceruloplasminemia, Curr Drug Targets, 13(9):1190-9, 2012.

2. , : , , 109:992-993, 2012.

3. Sugimoto M, Yamaoka Y, Shirai N, Furuta T:The role of the renin-angiotensin system in gastric

oncogenesis, J Gastroenterol Hepetol, 27:442-451, 2012.

4. Sugimoto M, Furuta T:Efficacy of Esomeprazole in treating acid-related diseases in Japanese

populations: A review, Clil Experimental Gastroenterol, 5:49-59, 2012.

5. Sugimoto M, Jang JS, Yoshizawa Y, Osawa S, Sugimoto K, Sato Y, Furuta T:Proton pump inhibitor

therapy before and after endoscopic submucosal dissection: A review, Diag Ther Endoscopy, 1-11,

2012.

6. , , , , , : GERD

, 21:445-452, 2012.

187

Page 5: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

7. , , , , , :

, , 15:129-136, 2012.

8. , , , , , , , :

, Therapeutic Research, 33:293-301, 2012.

9. , , : Helicobacter

pylori , , 55:287-291, 2012.

10. , , : pH

, , 243:945-951, 2012.

11. Ohashi N, Sakao Y, Yasuda H, Kato A, Fujigaki Y:Methoxy polyethyleneglycol-epoetin beta for

anemia with chronic kidney disease, Int J Nephrol Renovasc Dis, 5:53-60, 2012.

12. Miyajima H:Editorial: neurodegeneration with brain iron accumulation. Curr Drug Targets 13(9):1181,

2012.

13. , , 43(2):123-124, 2012.

14. , , 44(6): 5-7, 2012.

15. , , 29(2):155-159, 2012.

16. , , Wernicke Thiamine transporter gene mutation I

Vitamin B1 , , 76(3): 248-254, 2012.

17. B1 .

Wernicke , Vitamins (Japan), 86(11): 625-629, 2012.

18. , :ALS2(alsin). II ALS, , 76(5): 472-476,

2012.

19. , : 1 2012-13,

,72 , 597-601, 2012.

20. , :AKI , AKI Q A, • , 24:

298- 303, 2012.

21. , : , ,

19:17-18, 2013.

22. : • 2

, Nutrition Care, 72-75,2012

23. : • 3

, Nutrition Care, 168-173,2012

9.97

1. Furuta T, Sugimoto M, Shirai N:Individualized Therapy for Gastrointestinal Reflux Disease: Potential

Impact of Pharmacogenetic Testing based on CYP2C19, Mol Diag Ther, 16:223-234, 2012.

188

Page 6: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

2. , :

, 28:1695-1700, 2012.

1.71

1. , : AKI ,

AKI , Q A , , 97-98, 2012.

2. , :

, Q A , , 97-98, 2012.

3. :

AKI Q A , 88-90, 2012.

4. : AKI AKI

, , 134-141, 2012

5. :AKI ARF , Medical Practice , , , 685 , 2012.

6. , , , , 25-32,

2012.

7. , : , , , , ,

, Annual Review 2013 , , , 196-203, 2012.

8. , : , , , , , ,

, 2 , , , 752-757, 2012.

9. 2 , , ,

3 , , , 226-244, 2012.

10. , 13.

, 131-135.

11. : , , ,

2012-2014, , 366-369, 2012.

12. , : .

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2012.

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, , 322-325, 2012.

14. :Wernicke , ,

, , 326-329, 2012.

189

Page 7: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

1. Kono S, Bunai T, Terada T, Shimoyama K, Konishi T, Shirakawa K, Miyajima H:Subacute progressive

ophthalmoplegia associated with dermatomyositis, J Neurol, 259(9):1982-1984, 2012.

2. Kono S, Ouchi Y, Terada T, Suzuki M, Yagi S, Miyajima H: Combined FDG and raclopride PET study

in a case of ALS with the R521C FUS gene mutation, J Neurol, 259(2): 367-369, 2012.

3. Terai T, Sugimoto M, Uozaki H, Kitagawa T, Kinoshita M, Baba S, Yamada T, Osawa S, Sugimoto

K:Lymphomatoidgastropathy mimicking extranodal NK/T cell lymphoma, nasal type: a case report,

World J Gastroenterol, 18:2140-2144, 2112.

4. Ikeya K, Osawa S, Kuriyama S, Hamaya S, Yamada T, Sugimoto M, Furuta T, Sugimoto

K:Decompression side tube-equipped double-balloon enteroscopy extends intubation depth and reduces

patient discomfort, Endoscopy , 44 supple 2:E256-7, 2012.

5. Iwakura T, Fujigaki Y, Matsuyama T, Fujikura T, Ohashi N, Yasuda H, Kato A, Baba

S:Tubulointerstitial Nephritis and Primary Biliary Cirrhosis with a T Cell-dominant Profile of

Infiltrating Cells and Granulomas in Both Organs, Intern Med, 52: 467-471, 2013.

15.56

1. Uyama S, Ohashi N, Iwakura T, Ono M, Fujikura T, Sakao Y, Yasuda H, Kato A, Fujigaki Y:A case

presenting with the possible relationship between myeloperoxidase-antineutrophil cytoplasmic

antibody-associated glomerulonephritis and membranous changes of glomerular basement membrane,

CEN Case Rep DOI 10.1007/s13730-012-0039-9.

2. Miwa M, Sakao Y, Ishigaki S, Ono M, Fujikura T, Yasuda H, Suzuki H, Kato A, Nagata Y, Shigeno K,

Nakamura S, Ohnishi K, Fujigaki Y:Recovery of kidney function by rituximab-based therapy in a

patient with Waldenstrom's macroglobulinemia-related nephropathy presenting cast nephropathy and

interstitial lymphocytic infiltration, Intern Med, 51(13):1725-30, 2012.

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Page 8: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

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Page 9: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

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sequential therapy and concomitant therapy in Japan, 18 ,

, 2012 6 , ( )

1. Sugimoto M:Efficacy of frequent PPI dosing for potent acid inhibition over 24 hours,

, 2012 5 , San Diego( )

2. Sugimoto M:Antiplatelet drugs are a risk factor for esophageal mucosal injury, APDW, 2012 12

,

3. Konishi T:Genetic features and dopaminergic imaging in benign hereditary chorea, Meeting Of

European Neurological Society, 2012 9 , ( )

4. Yamada T:Guggulsterone, a plant sterol inhibitor of NF- B, suppresses CDX2 and COX-2

overexpression and reduces proliferation of esophageal adenocarcinoma cells, ,

2012 5 , ( )

5. Yamade M: Trastuzumab has opposing effects on SN-38-induced double strand breaks and

192

Page 10: Æ&É Û'¨ M¹³成24年度24naika_1.pdf · Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya

cytotoxicity in HER2-positive gastric cancer cells depending on administration sequence,

, 2012 5 , San Diego( )

6. Uotani T: Role of clopidogrel and rabeprazole in low-dose aspirin-induced gastric mucosal injury in

relation to CYP2C19 genotype, , 2012 5 , San Diego( ), Poster of

Distinction

7. Uotani T: The role of rabeprazole and famotidine for low-dose aspirin-induced gastric mucosal

injury with clopidogrel, APDW, 2012 12 , ( )

8. Sahara S: Association of Helicobacter pylori-related gastroduodenal diseases with vacA and cagA

genotypes in Southeast Asia, , 2012 5 , San Diego( )

9. Sahara S: Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for peptic ulcer in the

Southeast Asia, APDW, 2012 12 , ( )

10. Tsuji T: Partial recovery from AKI, followed by sepsis, worsens kidney injury and mortality, bur

protects other organs, ASN Kidney Week, 2012 11 , San Diego( )

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194

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18.

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1. :The Open Pathology Journal, Editorial Advisory Board, ,

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3. :Case Reports in Nephrology Editorial Board Member, ,

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5. :World Journal of Gastrointestinal Oncology Editorial Board, ,

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7. World Journal of Clinical Case Conference Editorial Board, ,

8. : World Journal of Nephrology Editorial Board Member

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1. 1 Neurology (USA)

2. 1 J Neurol Sci (USA)

3. 1 Neurobiology (USA)

4. 1 Hepatol Res (USA)

5. 2 ISRN Neurology (Korea)

6. 1 PLOS ONE (USA)

7. Kidney Int (USA) 1

8. : Ther Apher Dialysis (Japan) 1

9. : Clinical and Experimental Nephrology (Japan) 3

10. : CEN case reports (Japan) 1

11. : Intern Med (Japan) 1

12. : 4 J Gastroenterology (Japan)

13. : 2 J Med Microbiol (England)

195

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14. : 1 Expert Review of Clinical Pharmacology (USA)

15. : 6 Pros One (USA)

16. : 2 Helicobacter (USA)

17. : 4 World J Gastroenterol (China)

18. : 1 Dig Dis Sci (USA)

19. : 1 Digestion (Greece)

20. : 1 Current Microbiology (USA)

21. Clinical Experimental Nephrology (Japan) 2

22. International Journal of Nephrology and Renovascular Disease (USA) 2

23. BMC Nephrology (USA) 1

24. Tohoku Journal of Experimental Medicine (Japan) 1

25. Journal of Public Health and Epidemiology (Republic of Kenya) 1

26. Medical Science Monitor (USA) 1

27. International Journal of Clinical Medicine (USA) 1

28. British Journal of Medicine and Medical Research (UK) 1

24

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2. 17 2012 6

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4. 117 2012 11

196

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,

197

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4. PET

PET

PET

2013

J neurology

PET ,

,

5. - (RAS) 24

RAS

RAS RAS

RAS

RAS (AGT)

(CKD)

RAS CKD RAS

(UAE)

CKD Riser

(CKD-R) (CKD-NR) CKD-NR RAS UAE

CKD CKD-R RAS UAE

CKD-R RAS

RAS RAS

, ,

6.

S

G1

Flow cytometry Cdt1

G1 G0:G1 3:2 G0:G1

6 1 G1

lead acetate G1

S

G1

, , , ,

198

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7.

(P)RR -

RAS RAS

AKI AKI

AKI RAS

AKI PRR

AKI AKI (P)RR RAS

SD 8 45

AKI AKI

24~48 (P)RR AKI

1 ERK1/2 (P)RR

(P)RR AKI ,

, , ,

8. H.pylori esomeprazole omeprazole CYP2C19

PPI CYP2C19 CYP2C19

omeprazole OPZ S

esomeprazole EPZ OPZ CYP2C19

PPI H.pylori

EPZ OPZ CYP2C19 EPZ

40 CYP2C19 rapid metabolizer [RM] 15 intermediated

metabolizer [IM] 15 poor metabolizer [PM] 10 rabeprazole RPZ

lansoplazole LPZ 4 esomeprazole

CYP2C19 RM PPI

, , , ,

9. IL-12 B

IL-12 B (Breg) IL-12 Breg

wild type Th17 IL-17

(Sugimoto et al.Gastroenterology 133,124-136,2007) Breg

Breg

Resting

Treg Activated Treg IL-12 Breg

, , ,

199

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10. Sevoflurane TNBS

TNBS Th1

Sevoflurane TNBS

, , ,

1. 2013

1 24

2. 2013 1 25

3. , , 20 2013 3 14

200