高雄醫學大學雲鵬樟芝子實體化學圖資與 ...產學合作第一季季報.pdf ·...

: S099009

99 10 01 100 09 30

: S099009

------------------------------------------------------ 1

------------------------------------------------------------------ 2

------------------------------------------------------------------------ 3

1. --------------------------------------------------------------------------- 3

2. --------------------------------------------------------------------------- 3

3. --------------------------------------------------------------------------- 4

4. --------------------------------------------------- 4

--------------------------------------------------------------------- 5

1. --------------------------------------------------------------------------- 5

2. ------------------------------------------------------------------------ 5

3. ------------------------------------------ 7

4. --------------------------------- 8

5. ------------------------------- 12

6. ------------------------- 14

7. ------- 16

8. (2.0 kg) ---------------------- 18

---------------------------------------------------------------------- 19

: S099009

1 ------------- 7

2YP-100817AYP-100817B --------------------- 9

3YP-100817A ----------- 10

4YP-100817B ----------- 12

5YP-101019 -

-----------------------------------------------------------------------------------------14

6 ------------------------------------ 15

7YP-101019

--------------------------------------------------------------------------------- 16

8YP-101019

------------------------------------------------------------------ 18

: S099009

1 ------------------------------------- 7

2 ------------------------------------------------------- 8

3 ---------------------------------------------- 8

4YP-100817A ----------------------------- 10

5YP-100817A() ------------------- 10

6YP-100817B ----------------------------- 11

7YP-100817B() ------------------- 11

8YP-101019 ------------------------------------- 12

9YP-101019 ---------------------------- 13

10YP-101019 --------------- 13

11 -------------------------------------- 14

12YP-101019 ------ 15

13YP-101019()

------------------------------------------------------------------------------------ 16

14YP-101019

() ------------------------------------------------------------------ 17

15YP-110105 ------------------------------------ 18

: S099009 : 3

()

1.

(Androdia cinnamomea)

(Cinnamomum kanehirai)

(YUNG PENG BIOTECHNOLOGY. CO., LTD)

(biomass)

2.

/

98

(translational research)

: S099009 : 4

3.

2009

4.

99 100 10 11 12 1 2 3 4 5 6 7 8 9

1

2

3

4

5

6 (2.5 Kg)

4

1 2

3 6

: S099009 : 5

1.

antcin Kantcin Czhankuic acid Czhankuic acid Adehydrosulphurenic

acid dehydroeburicoic acid YP-

100817AYP-100817BYP-101019 YP-110105

(TW 098104772US 12/538,549TW 098107047 US 12/552,115)

2.

2010 08 17 YP-100817A 3 kg 2010 08 17 YP-100817B 3 kg 2010 10 19 YP-101019 2.5 kg 2011 01 05 YP-110105 2 kg

TW 098104772

US 12/538,549 TW 098107047

US 12/552,115

: S099009 : 6

O

HO OHHO

COOH

H

H

H

OH

O

O

COOH

H

H

H

antcin K antcin C

COOH

O

O

HO

OH

H

H

H

COOH

O

O

OH

H

H

zhankuic acid C zhankuic acid A

HO

HOOC

OH

H

H HO

HOOC

H

H

dehydrosulphurenic acid dehydroeburicoic acid

: S099009 : 7

3.

(ergostane)

(lanostane) 20.4%

1 antcin K ( 1a 1b)

antcin C ( 2a 2b)zhankuic acid C ( 3a 3b) zhankuic acid A

( 5a 5b) dehydrosulphurenic acid (

4) dehydroeburicoic acid ( 6) 1 5

89.9% 92.17%

1

1

(min) (%) (%)

antcin K 1a 1b 5.783 5.929

4.12 7.55

11.87 19.84

antcin C 2a 2b 22.703 24.741

5.86 5.66

4.53 4.31

zhankuic acid C 3a 3b 25.348 26.512

5.04 6.78

3.89 4.60

dehydrosulphurenic acid 4 39.849 16.41 11.95

zhankuic acid A 5a 5b 46.025 46.721

15.94 12.70

11.88 9.72

dehydroeburicoic acid 6 79.119 9.84 9.58 10.1 7.83 100.00 100.00

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

0

10

20

30

40

1: 254 nm, 8 nmAC-FEA-2-0106 \AC-FEA-2-0106

1a

1b

2a 2b 3b

3a

4 5a

5b 6

: S099009 : 8

4.

2010 08 17

2 3 YP-100817A 3

kg YP-100817B 3 kg YP-100817B

dehydrosulphurenic acid

() dehydroeburicoic acid (YP01)

2

( YP-100817A YP-100817B)

3

( YP-100817A YP-100817B)

: S099009 : 9

2 YP-

100817A 3 22.67%22.50% 23.16%

YP-100817B 2 24.66% 22.80%

YP-100817A YP-100817B

2 YP-100817A YP-100817B

(g) (%)

(g)

(mL)

YP-100817-A ( 1) 25.14 250 4.14 1.11 0.45 5.70 16.47 4.42 1.79 22.67

YP-100817-A ( 2) 25.08 250 4.16 1.13 0.39 5.68 16.60 4.50 1.40 22.50

YP-100817-A ( 3) 25.00 250 4.20 1.22 0.37 5.79 16.80 4.88 1.48 23.16

YP-100817-B ( 1) 25.10 250 4.61 1.08 0.50 6.19 18.37 4.30 1.99 24.66

YP-100817-B ( 2) 25.04 250 4.23 1.13 0.35 5.71 16.90 4.50 1.40 22.80

( YP-100817A YP-100817B)

YP-100817A YP-100817B

YP-

100817A 54.06% 4 5

3 YP-100817A antcin Kantcin C

zhankuic acid C zhankuic acid A


3

: S099009 : 10

4 YP-100817A

5 YP-100817A ()

3 YP-100817A

(min) (%) (%)

antcin K 1a 1b 5.692 5.824

10.21 13.37

23.51 31.63

antcin C 2a 2b 22.305 24.348

7.75 5.19

3.60 2.58


6.57 8.00

3.29 3.83



4.15 2.78

2.22 1.53


Minutes

10 20 30 40 50 60 70 80 90 100

mA

U

0

20

40

60

1: 254 nm, 8 nmCLOUD-FEA-0106 \CLOUD-FEA-0106

1a

1b

2a 2b

3a 3b 5a 5b

4

6

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

0

5

10

15

1: 254 nm, 8 nmCLOUD-FEA-0106 \CLOUD-FEA-0106

1a

1b

2a

2b

3a 3b

5a

5b

4

6

: S099009 : 11

YP-100817B 42.20%

6 7 4 YP-100817B antcin K

antcin Czhankuic acid C zhankuic acid A


4

6 YP-100817B

7 YP-100817B ()

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

-10

0

10

20

30

1: 254 nm, 8 nmYP-FEA-0106 \YP-FEA-0106

1a

1b

2a 2b 3a

3b 5a 5b

4

6

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

0.0

2.5

5.0

7.5

10.0

12.5

15.0

1: 254 nm, 8 nmYP-FEA-0106 \YP-FEA-01061a 1b

2a 2b

3a 3b

5a 5b

4 6

: S099009 : 12

4 YP-100817B

(min) (%) (%)

antcin K 1a 1b 5.713 5.849

4.18 6.04

10.71 12.63

antcin C 2a 2b 22.583 24.655

1.79 1.29

1.08 0.71


0.69 1.12

0.46 0.59



0.69 0.27

0.37 0.15


5.

2010 10 19

8 YP-101019 2.5 kg

8 YP-101019

YP-101019

9 25.10 g 1 cm2

34.46%

: S099009 : 13

9 YP-101019

YP-101019 56.55%

10 5 YP-101019

antcin Kantcin Czhankuic acid C zhankuic acid A


dehydroeburicoic acid

5

10 YP-101019

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

0

5

10

15

20

25

1a

1b

2a 2b

3a 3b 5a

4 6

5b

: S099009 : 14

5 YP-101019

antcin K 1a 1b 6.490 6.797

8.58 11.80

16.49 21.93

antcin C 2a 2b 25.017 27.080

5.48 4.57

3.81 2.59


4.83 5.53

3.29 3.56



4.54 3.26

3.26 2.33


6.

YP-101019

11

11

()

6 2

28.73% 28.27%

: S099009 : 15

6

(g) (%)

(g)

(mL)

YP-101019-FB-1 ()

10.20 500 1.90 0.81 0.22 2.93 18.63 7.94 2.16 28.73

YP-101019-FB-2 ()

10.08 500 1.90 0.75 0.20 2.85 18.85 7.44 1.98 28.27

YP-101019 ()

58.08% 12 13 7




7

12 YP-101019

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

0

20

40

60

801: 254 nm, 8 nmYPFB-FEA-0106-1 \YPFB-FEA-0106-1

1a

1b

2a 2b

3a 3b 5a 5b 4

6

: S099009 : 16

13 YP-101019

()

7 YP-101019

(min) (%) (%)

antcin K 1a 1b 6.341 6.636

13.34 16.27

22.76 27.25

antcin C 2a 2b 24.024 26.002

9.71 7.19

6.23 4.01


5.89 7.18

3.76 4.33



5.44 3.62

3.66 2.53


7.

YP-101019 250 g

57.18g

22.87%

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

0

5

10

15

20

25

1: 254 nm, 8 nmYPFB-FEA-0106-1 \YPFB-FEA-0106-1

1a

1b

2a

2b 3a

3b 5a

5b

4

6

: S099009 : 17

1 g

1 g 54.06% 14

8 YP-101019




8

14 YP-101019

Minutes

0 10 20 30 40 50 60 70 80 90 100

mA

U

0

10

20

30

40

50

1a

1b

2a 2b

3a 3b 5a 5b

4 6

: S099009 : 18

8 YP-101019

antcin K 1a 1b 5.952 6.111

9.60 13.05

22.98 29.46

antcin C 2a 2b 24.032 26.170

6.49 5.03

3.46 2.39


5.25 6.01

2.79 3.04



4.58 3.15

2.60 1.89


8. (2.0 kg)

2011 01 05

15 YP-110105 2.0 kg

15 YP-110105

YP-110105 2.0 kg

435.78 g

21.79%

: S099009 : 19

1 g

(TW 098104772US

12/538,549TW 098107047 US 12/552,115)

1.

2.

高雄醫學大學 雲鵬樟芝子實體化學圖資與 ...產學合作第一季季報.pdf ·...

Documents

高雄醫學大學雲鵬樟芝子實體化學圖資與 ...產學合作第一季季報.pdf ·...