0-123 - lww journalsjournals.lww.com/anesthesia-analgesia/documents... · %’...
TRANSCRIPT
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!"#!!!
!"#$%&
!"#$%&'()*+,-./0-123
!"#$ %$&'($
!
)**+
!
),
!
)-.(
!
/01230
!
4
5"6' +7 )8'$&
!
)**+
!
),
!
)59
!
/01230
!
/30:+3;
!
/:30
!
!
)"##<$= >7 ?7 3<"@
!
)**+
!
/01230
!
"
0@AB$= /CBD$&
!
)+E
!
5<,
!
#
)(E<"$' F7 5"$E<
!
)**+
!
,)
!
,:3GH
!
/:30
!
/01230
!
//5)01230
!
/:0123GH
"
9C@
#!
!
5<('(. 5$8#C@
!
)**+
!
),
!
/01230
!
"
*B$@A"@ +7 +('D$B#
!
)**+
!
/01230
!
I
"@A -'(J"D$#< K(''("L&C@
!
5<,
4 4
4
,$."B#L$@# CM 0@"$&#<$&(" "@A 5"(@ )"@"N$L$@#O :C8"' )$'DC6B@$ 9C&.(#"'O )$'DC6B@$O
06&#B"'("O "@A ,$."B#L$@# CM 5<"BL"EC'CN8O P@(Q$B&(#8 CM )$'DC6B@$O )$'DC6B@$O 06&#B"'("R
!
,$."B#L$@# CM 0@"$&#<$&(" "@A 5$B(C.$B"#(Q$ )$A(E(@$O 0'MB$A 9C&.(#"'O )$'DC6B@$O 06&#B"'("O
"@A 0E"A$L(E *C"BA CM 0@"$&#<$&(" "@A 5$B(C.$B"#(Q$ )$A(E(@$O )C@"&< P@(Q$B&(#8O )$'DC6B@$O
06&#B"'("R
"
,$."B#L$@# CM 0@"$&#<$&("O 5B(@E$ CM K"'$& 9C&.(#"'O 9C@N !C@NO 5$C.'$
$
& :$.6D'(E
CM 3<(@"O "@A ,$."B#L$@# CM 0@"$&#<$&("O 3<(@$&$ P@(Q$B&(#8 CM 9C@N !C@NO 5$C.'$
$
& :$.6D'(E
CM 3<(@"R
#
,$."B#L$@# CM -.(A$L(C'CN8 "@A 5B$Q$@#(Q$ )$A(E(@$O )C@"&< P@(Q$B&(#8O
)$'DC6B@$O 06&#B"'("R
!
+E<CC' CM )$A(E(@$ "@A 5<"BL"EC'CN8O P@(Q$B&(#8 CM K$&#$B@ 06&#B"'("O
5$B#< 06&#B"'("O "@A ,$."B#L$@# CM 0@"$&#<$&(" "@A 5"(@ )$A(E(@$O !(@N -A="BA )$LCB("'
9C&.(#"' MCB KCL$@O 5$B#<O 06&#B"'("R
"
,$."B#L$@# CM 0@"$&#<$&("O 06&#(@ 9C&.(#"'O
)$'DC6B@$O 06&#B"'("O "@A ,$.# CM +6BN$B8O 06&#(@ 9C&.(#"' "@A P@(Q$B&(#8 CM )$'DC6B@$O
)$'DC6B@$O 06&#B"'("R
I
,$."B#L$@# CM 0@"$&#<$&(" +#O ?(@E$@#
$
& 9C&.(#"'O )$'DC6B@$O 06&#B"'("R
,$."B#L$@# CM +6BN$B8O P@(Q$B&(#8 CM )$'DC6B@$O )$'DC6B@$O 06&#B"'("R
4 4
,$."B#L$@# CM
-.(A$L(C'CN8 "@A 5B$Q$@#(Q$ )$A(E(@$O )C@"&< P@(Q$B&(#8O )$'DC6B@$O 06&#B"'("7
./
%
01
%
!!"#"#$%$%&&''(())**+,+,+
!
--.*./.)./01
"
20
!
1234
5364%56)77
"
%&'()* 889 !"+" 9:: ! ;<='>;<$%
!
=>?@A?@AB?!!"#@B5B?!!
"#@
"
CDE %&'()* $%AF=CGH
!
IDE''(())&&JK
"
23
%
FGL.GH*9)HI,MJKN
#
L
M+,*9)N&,OO
$
'PQ+BRP()*/+
!
ES9$%AFTU=C
"
GH)VQWXR/S+
"
45
%
PY=
C<6R $
&
+ T
%
Z6
&
" , +
&
- T
'"
$." 9
%
#/
''
$%;<U+,
!
=C&6
!
/# 9
%
0
&
+
''
*/'PQ+
!
00 9
%
!
&
!
''
*
/RP
"
!!"#-5V[$%+,)JK 1JK\ 2 "
&
/.
(
/+
'
"]Z6
%
3456789539 75:9;<=>? @'
'&
"
&
." , #
&
!"
)
A
#
! 2
B "
&
.!
'"
B?!!"#)$%^$'PQ+)_`\a\W #
&
+/
%
/+
'
@'
&
#
&
"# , !
&
+#
#
! 2 "
&
"0
'$
RP)_`\a\W #
&
"#
B
%
/+
'
@'
&
"
&
++ , #
&
.-
#
! 2"
&
/-
'"
46
%
!!"#X&&'PQ+)JK$%.7
!
YX+,BRPb7
"
!!"#XEZ&
B cd[\U])77
!
^Qe_`.)abc=>EfGHde3
"
!"#$%&'$
%
(!)*+,-./01
><$B$ (& " .'"6&(D'$ ."#<C.<8&(C'CN(E B"#(C@"'$ MCB (@EB$"&$A 'C@N
(
#$BL
S E"BA(CQ"&E6'"B LCBD(A(#8 "@A LCB#"'(#8 (@ ."#($@#& B$E$(Q(@N &(N@(M(E"@# $T.C&6B$ #C @(#BC6& CT(A$7 9C=$Q$BO #<(&
B$'"#(C@&<(. <"& @C# D$$@ $&#"D'(&<$A E'(@(E"''87 ><$ -1;H)0 #B("' B"@ACL(J$A UVWV ."#($@#& <"Q(@N @C@E"BA("E &6BN$B8
'"&#(@N LCB$ #<"@ U <C6B& #C @(#BC6& CT(A$
(
D"&$A CB @(#BC6& CT(A$
(
MB$$ "@$&#<$&("7 K$ EC@A6E#$A " MC''C=
(
6. A8 CM
#<$ -1;H)0 ."#($@#& #C $Q"'6"#$ #<$ B(&X CM E"BA(CQ"&E6'"B $Q$@#& (@ #<$ 'C@N$B #$BL7
2345-061
><$ #B("' E"&$
S B$.CB# MCBL& "@A L$A(E"' B$ECBA& CM "'' A8 ."#($@#& =$B$ B$Q($=$A7 ><$ A"#$ "@A E"6&$ CM A$"#< "@A CEE6BB$@E$ CM
L8CE"BA("' (@M"BE#(C@ CB &#BCX$ =$B$ B$ECBA$A7 0 #$'$.<C@$ (@#$BQ($= ="& #<$@ EC@A6E#$A =(#< "'' &6BQ(Q(@N ."#($@#& 7 ><$
"$!!!!
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!"#$%"& '()!*#(+ *, +-' .+/)& 0%. ./"1#1%23
!"#$%&#'
4-' $')#%( ,*22*0
(
/! +#$' 0%. 5
&
6 7"%(8'9 : +* 6
&
;< &'%". 3
= 4-"'' -/()"') '#8-+&!%+#'(+. 7>?
'
< -%) )#') .#(@' +-' #()'A ./"8'"&B ?> 7C
&
6
'
< 0'"' "'@*")') %. -%1#(8 $&*@%")#%2
#(,%"@+#*(B %() CC 7D
&
D
'
< -%) % .+"*E' )/"#(8 +-' '(+#"' ,*22*0
(
/! !'"#*)3 F#+"*/. *A#)' )#) (*+ .#8(#,#@%(+2& #(@"'%.'
+-' "#.E *, )'%+-
!
-%G%") "%+#* H:
&
?I 7?6
'
@*(,#)'(@' #(+'"1%2B JK9 :
&
I: +* >
&
D:L ! H:
&
ID<
"
3 4-' %)M/.+') *)). "%+#*
,*" $&*@%")#%2 #(,%"@+#*( #( !%+#'(+. %)$#(#.+'"') (#+"*/. *A#)' 0%. >
&
6? 7?6
'
JK9 >
&
:> +* D
&
6>L ! H :
&
:C< %() ,*"
N .+"*E' 0%. >
&
:> 7?6
'
JK9 :
&
66 +* >
&
I;L ! H :
&
?;<3
()*(%$#+)*#'
4-' %)$#(#.+"%+#*( *, (#+"*/. *A#)' 0%.
= %..*@#%+') 0#+- #(@"'%.') 2*(8
(
+'"$ "#.E *, $&*@%")#%2 #(,%"@+#*(B O/+ (*+ *, )'%+- *" .+"*E' #( !%+#'(+. '("*22') #( +-'
PFKQRS +"#%23 4-' 'A%@+ "'2%+#*(.-#! O'+0''( (#+"*/. *A#)' %)$#(#.+"%+#*( %() .'"#*/. 2*(8
(
+'"$ %)1'".' */+@*$'. 0#22
"'T/#"' @*(,#"$%+#*( O& %( %!!"*!"#%+'2& )'.#8(') 2%"8' "%()*$#G') @*(+"*22') +"#%23
#
"#$%&' "#()* +,--. --+/ 012
)
30
$
!!""!#"#$%!&#$$'%()&
*+,-*
%
."!#/&010(02%'
!
#
)
!
"
&
!!""#!!31( %
#!
4("&$
%
#%$)*
'5+
%
6789:(;(&)<=,>?$%@
-&')*(.)A
!
$
)
&
"
&
(.*B)AC/+$$
?,0#
!
'
"
%
&)!!D-
!
(
"
%
*.+1/01E
',
!
)
"
&
23
%
/45FG$%(-!!""= *)
6.?
!
+
"
#2)$+ $" >?
!
&
"
(#$$'%"#
&
B2
%
!!""H!&#$$'%()&*+,-
*7I(JK3L8/
&
MNOP(!&9=*0
:;
!
#"
"
%
/1Q2RS3T45
&
,-./01 4<56-= !"&" U>V ! 6.?#
6W<$%
%
X@S-<4YA(-!!""=Z
L(-!!""$%=
!
##
"
&
<= $" >?
!
#'
"
%
#' U
$%,-
#
!!""= + U
%
[7= $ U
'
! 2
3 "
&
#"
$&
8V#79:++#2+B)A/;
%
!!
""= #$ U+[7= ( U)1#28,
#
456789:;8<
;=>897?;6=
%
0.
$#
! 2"
&
!"
$&
@.
%
!!""= $" U
3 +[7= #" U&UC<(#79Z#2+B)A=
> 0.
#
! 2 "
&
""!
$
!
#!
"
&
!!""=$%<=$%@
3 -&')*(.\)
%
]8!!""+ 0. 7I/&
010(02DK
!
&
%
#$
"
&
.?@A/ENS3T
45
&
^R
%
BC[ ,-./01 4<$%S_5F45
&
DG?#6W<$%(-!!""
%
<=,`)1
,-
(
0. +94(aHaL(-!!""OP($
%QE
&
.
!!
/
bI( ,-./01 Gc4
%
!"&" U`J #) ,Z
#) ,6\(W<$%056X-F=
%
3=G ("
'
!!""-' $"
'
!K=
%
3=G )"
'
!K-'
!"
'
"K=
&
de;H
%
I<&fJMOPghK
i
&
45(LQMjklm>
&
8Vlm&I
(
<
= $" >(gnC<+7:5FNopQ(q)
L
!
##
"
&
M@NrO$%$s
%
qXP<Q+<=R
3>$%@-&')*+;*(.
!
&
"
&
"#
.0
Rt=A45MO0SuCTU
&
bIv@N
-=45($%
%
!6./V#=A45
%
w60
6PQWXYZ<[H@N
&
G/\45xR
%
]
^w/$%(45&UF_+gnC<
&
C<,-
(>&+&^
(
#28,Z94'%
&
5=[w/
($%S_@P!(7:5F
&
=`$%a&W<
=kb)1 0. +947Q
%
WSc$%(1d@
N
&
yA$%v,-
%
5Fd>TZpzgh
%
1
d@N=
%
r{@s(@P!`2=`
&
Ue45
&3F_+gmfg$0K|=V(DK;(}~
44H$%?8 $ Y
&
yA�@
%
}~44Hd5
T
(
pzghZF%?8 $ Y
&
Rt45pQ(xRk1�hi
%
C<$%b
=3Y5F/W.IZ,-.I
&
dYxRG 0. +
94
%
6&M$%�A
(
d5T
(
pzghZ&3
/;
&
0. 8V#2+B
#
2B$CZ @A
(
0%
$
D-
(1X+!
%
q3}~��YZ3tL+;[
%
L
+��D-)$j�
%
���(&0� B \Z CD ]
:+
%
./7�Z 0. (&0ke
&
940,8G�
)^MK|L+YA !* 6.Z6\
%
8V^M?�
ghE[�c_6[`F�ZGaH5I;[
&
$#
1234
6Y<Q+<4(fg{N��9lm-
)
`
9
(
�@
(
b�
(
1C1 Nn
(
.#&&:
(
J$
(
;;W<:
(
<oW<:
(
pqr
(
K)�OP�
(
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!"%!!!
!!""
!
!"!!#$#$%&%"'
"
#()
$%*+,&"#$'-$%./($
#
0)1%
& ' * 2 3 + % & $ '
$
%&'&%(% )*+,-*).
/-'/,'0.)0&-'
#
123
%
,
"
4-5(.)#/,#16+789
#
0:5
0;<=>$*+
"
1?2 3-4 3$@ABC,4
:D - % E C @ # 56
'
. / 5 '
$
/-'7&8,'/,
&'0,.+)*9
#
3:9
%"
F?2 3-4 @ABC,46GH
7
&
I&&J
$
<'
!
)8
!
9K
!
2;2 :0
!
';
<<(
!
(=
!
)1LI#*2LI(
%#
#&J+
M,3
"
!!""
!
456
!
!"!!#$NI&
&JM+,3
"
#()$%*"# < "
&
=6123 +O
P$'
$
QR"#$%S&+,& 123 ,$'
%
T
U&%"'NI&&J
!
!!""
!
!"!!#$
M+,3
$
VWX456
#
?7 !>= AY:456S
&$%+QR"#$%*+$8-Z
#
[\9&J
V]^#,4
%#
_`:]3;<'>a./
'
#?
(
#
^
bEC)$@A+:c
"
dF<A
#
1: e*,(<fg($Vh=
$
H
#
?($(<<>
%
e-Z
#
iTY: *-@&90&/ 3$4
-?@g' 1: #*,+@,@# 56
'
./5'
"
F
&J,4Hj6G
"
k3$,4,
#
lm!!""
Nno&J'p+q:@rp+s^b:c
"
I&
A)QR=+O4,-AB+$'
#
BnC 5" 01
&$-%7ItuO4,-AB=D
'
#6
(
#
_sCD
0v^EwY=
"
Y:Ex ! AFe !
!
AF^b
A y4
"
7z:c-Z+?@$8+q:
#
FG{:H
I|G)1%
"
JH*,# 1: $8-Z1?K)
#
}kFI3J1L+MKj~2FK.2
'
#>
(
"
xD
781%
#
Y: *-@&90&/ ,4c4/09NZLK
#
0BnK�O# 3-4 3$,4FP
'
#?
(
"
QRkHI
1%`:,MS&
"
Y: ;0)0)#"
&
"
$
;0)0) 3-.B-.)0&-'
#
3-**,@, ;0)0&-'
#
CD
#
E;2
%
^b$81%
"
" ,!1
#
" <"
&
"6 3ly
A 4�T%
"
.
!!
/
!""$ < ? U� !""? < ## U^b FG:H12 VF
<A#N
"
!"#! AQR^#T4)��1%
"
!""=
< # U� !""I < ## Ug'^b5g?@
#
?@,&
$7 $
&
6 <
$
5'
&
" J 6
&
= <
%"
-D,;;�V6
#
!!= AIt78O $" f+QRv]?@
)
##$ AQR
?@"v]P��QR
)
Wl ! A78^EwXNC
D+QR
"
ilTjQR+?@"'Q($7 $" f
)
QRY1778
!
$" f�(7 1: #*, $ N^#1
%
"
?@$8- #>>" A
$
I$
'%
<AZR
$
[ #
%"
0
"!
FG:H12 t%5g?@CD+9<[
$
G
!
K L!!""
%
$I" AQR
$
#5
'%
LIt=>
$
#! AD $" f�
=>
#
$>I A $" ft=>
%"
=>\?72D
$
=>
'%#
1:
$
6
'%#
*,
$
#
'%#
no;=]�S
$
!
'%#
:"34
$
#
'%#
5=D
$
>
'%#
no\?
$
>
'%#
v�\?
$
$
'%"
?@k #!5" AQR
$
>6
'%
,~2
"
;(?@g'
#
5# A
$
?
&
6
'%
QR�� 1:
#
?? A
$
!
&
!
'%
QR��*,
"
!!""v^_=>+EC
$
EC@ "
&
5I
)
56
'
3:
&
"
&
I" J #
&
!"
)
" L "
&
I!
% $
* #
%"
u'
!
<)
!
A *2LI(
!
456
!
< "
&
=6123 +OP"#$
'
!
$%&%"'=5�=>+��.)#/
"
!
!""+`:N*2LIT'labp+q:
$
c9
" L"
&
"!I
%"
*2LI,
#
"#!!""+=>EC
A @7 #
&
"!
$
56
'
3:
&
"
&
66 J #
&
5"
)
" L"
&
56
%#
U*2
A LI,
#
=>EC@7 "
&
>?
$
56
'
3:
&
"
&
?$ J "
&
5>
)
" L"
&
"$
%$
U*2LI,
#
v"#!!""QR+=
A >97� $>
'#
�*2LI,v(�=>97�
%"
"&!!!!
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
.
"!
!"#$%&'()*
!
! %!"#!
"
!+
&',
!
&'
'
()
"
!-" *+
!
&'
'
()
"
" #
.-" *+
!
&'
'
()
"
" #
/"
!
#
"
,
%
-.& '"
!
." / 0!
"
%
.& / 0. 0$
!
'$ / 10
"
#
&
!0
!
"
&
&' / #
&
00
"
#
&
"0
!
"
&
2" / #
&
.#
"
%
#0' &#
!
12 / #"'
"
#
&
1&
!
#
&
$& / !
&
$!
"
-"
&
"""# #
&
.'
!
#
&
"& / #
&
&#
"
"
&
"#
0$
,
%
$0 10
!
01 / 21
"
%
%0 0"
!
'# / 1"
"
"
&
12
!
"
&
0. / "
&
&0
"
"
&
"! "
&
11
!
"
&
0! / "
&
&'
"
"
&
"!
%1
!
34
"
,
%
-0" 2!
!
1" / &0
"
%
0# / 1. 00
!
'' / 1&
"
"
&
2"
!
"
&
0$ / #
&
"#
"
"
&
2$
!
"
&
0' / #
&
"0
"
%
#1' '2
!
.2 / 1"
"
"
&
1#
!
"
&
'' / "
&
&"
"
"
&
"! "
&
2$
!
"
&
0. / #
&
"2
"
"
&
!$
565 &!
,
%
# / ! 0$
!
'0 / 1!
"
%
$ / . 2.
!
1" / #""
"
#
&
$#
!
#
&
"0 / #
&
0$
"
"
&
"# #
&
#!
!
"
&
21 / #
&
.'
"
"
&
$0
!'(
,
%
) 00
!
'& / 1.
"
%
" 21
!
01 / ##$
"
#
&
$#
!
"
&
&& / #
&
1.
"
"
&
"0 #
&
#"
!
"
&
2" / #
&
'$
"
"
&
''
"*
,
%
" 0.
!
'1 / 1!
"
%
) #".
!
2! / #$$
"
#
&
0#
!
#
&
!$ / !
&
#"
"
"
&
"""' #
&
!!
!
"
&
&! / #
&
0$
"
"
&
#0
&"23
,
%
) 01
!
0# / 1'
"
%
" &"
!
'2 / #."
"
#
&
$#
!
"
&
2$ / !
&
"'
"
"
&
!. #
&
!1
!
"
&
2" / !
&
"#
"
"
&
$#
'#23
,
%
) .#
!
$. / '"
"
%
" &"
!
2" / #"!
"
!
&
#'
!
#
&
1# / !
&
1"
"
-"
&
"""# !
&
".
!
#
&
0" / !
&
'&
"
-"
&
"""#
7)6 4$
8
%
) 0!
!
'' / 1"
"
%
" &$
!
11 / ##!
"
#
&
.1
!
#
&
#2 / #
&
2.
"
"
&
""# #
&
!"
!
"
&
&' / #
&
'#
"
"
&
#$
+56,
8
%
(% 1!
!
0$ / 2$
"
%
7(% 0'
!
'0 / 1'
"
"
&
&#
!
"
&
1. / #
&
##
"
"
&
$. "
&
&2
!
"
&
2" / #
&
!"
"
"
&
2!
&'(89
8
%
) 0$
!
'0 / 1#
"
%
" #"!
!
2! / #!1
"
#
&
'&
!
#
&
!. / !
&
"$
"
-"
&
"""# #
&
0"
!
#
&
!$ / !
&
"1
"
"
&
""".
95( #
:
%
#"
&
1' .'
!
$1 / ''
"
%
-"
&
1' 2"
!
1" / &!
"
#
&
11
!
#
&
$& / !
&
!.
"
-"
&
"""# #
&
'&
!
#
&
!! / !
&
"2
"
"
&
"""1
:;9-)<
!
.)
"
:
%
-!
&
' $1
!
!2 / .1
"
%
!
&
' / $
&
& 0$
!
'$ / 1'
"
#
&
1$
!
#
&
!0 / !
&
$0
"
#
&
.$
!
#
&
"# / !
&
"!
"
%
#.
&
" &1
!
20 / ##.
"
!
&
0'
!
#
&
&1 / $
&
'1
"
-"
&
"""# !
&
"$
!
#
&
.. / !
&
21
"
"
&
"""#
%%
/
#
() %*+0<
$
*+ %()*
!
=>1%(),?2=>1%()
%
()3@AB4%#,
"
565 %CD:;EFGH
$
7)6 %$%)-35
$
95( %I.&'(6
,!+<*.
8 !+<?J!"7" ,%!+*.
:!+<?J!"7" ,K 8 %!+*.
%
,L&'(
!
!01 M#$ 95( #+N
"
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!"'!!!
!!!!""#$% %& &'("")#)#
#
&
'(
!
('
'
)&
"
#
&
"# * !
&
'#
#
! + "
&
",
$ !
$ !
$%
#
- *
&
+$
'
./. $," * #%
'
-&'(!%&&
%
'
"'.&(/01234() %& $%('5
%
'5/)*+678
%
"")#)9:;<(),
=>*-*?(@A
(
#
&
'0
!
('
'
)&
"
"
&
(( * !
&
,0
#
! +"
&
"'
$)%
!!""BC./#DEF
(
)#)# #
&
"#
!
('
'
)&
"
"
&
'' * #
&
12
#
! + "
&
(2
$)%
+$4;'5
- 0+D$1G+()#D$%('5
!
23C,H
$&
'5I() %& $%('56J
%
"")#)9:;
<(),=>*-*?(@A
(
#
&
"#
!
('
'
)&
"
"
&
'' * #
&
12
#
! +"
&
(1
$)%
IK4'%J+&'-..(.)/6)
&
%&
&'K#5'('%)/*+*+
!
$ $
$%
#*
&
%& &'K#+J+&'-.'6()LM+
%
'%
&'-..(.)/6)
&
C$N%O'.PQ'
0/OR17
%
.
!!
/
!!""I&S %& $%(EF./T7
&
UI
PQV#D)7
%
34&5%. 82!3(&'C9:
;
&
$" WX.&SY4$%ZM[
&
\]<G9,
=<^&>!!!!""(&'$% %& EF
*
5
_
+
`*(a>b/
(
#2
)
%
?@`
&
c1de#3(
$%Z`*.6fAT<G
&
g^Be+!,-
%
\]
&
CDh1i!: 2""" L,T.&*'8%/
&EFV-.&*'8%/&(7%/jK&'
&
EF,#!!"" 3 . k G 3 l h 1 i 8 9
!
34&5%.
(
$89
&
-0 666789:;<=!7>?;7=@
$
(
#!
)
%
CD&SE:(23I 34&5%. 82( $" WX
%&
!
"
&
'
'$
.#D
!
"
&
#
'$
$%(236H
%
:;!
3&'B7Im%'J.&(EF
"
; ##
'
&'T
!%&&%
&
,
'
&'T#D&%
%
CD(23Jn
I7:;jK&'( %& .#D$%(236
H
(
#1
)
#(
)
&
B71++EF&'(M+$&Z
(
!"
)
%
&SE:S/
&
##
'
7 %& &'. ,0
'
%& &'
KB+J+&'-.'6
%
_2o89$<J+&
'-.,T/h23.'4=p(qr
%
0l&s
'
56s.I\89$<+&'-.'6&'%'J
Y4($&ZM+
(
#'
)
%
t>
&
u78CL_)1(
.
!
23"M('%J+&'-.)/
$
(
!#
)
!$
)
.9r
!!""01<^?v %& $%
%
cNABeOP0
EF89h1iL_
(
#!
&
!!
)
%
!!""<G94Qw+J+&'-.'6F
x
&
>4QwyzFx@A23
%
{|R@2x
'
93:%p?v
'
/h;9<.!![!)/
(
#
)
!
)
%
Y_`
&
34&5%. &'RK#S1T $" WX$%=
4A>
'
$?
'
;UB$6(EF/O
(
##
)
%
t>
&
E:89BCL_!!""./7%/jK&'(
&SPQZ
%
E:89S/
&
};IVBCWX#4()9
@23(D~'5
%
-��({|+$
(
$,
)
$0
)
'
./.
$%" *#%
(
!,
&
!0
)
!2
)
^�&(/jK
(
!'
)
%
YJCD
CGEZ&'58AB[F
&
U46UjK&'(
PQZ`*<GI&'�:C6��67
%
JnG
&
!![)/D$801�013&'(PQ
&
<G
\]BO�<.&.kD$801�7^'0H�
s'!([E:8
%
34&5%. 828R(IJ8453!!(!)
/9J
!
!!""3!)/# $"
' &
kG3!)/
# 1"
'$%
�]K>HmWM019qLM
&
BG_
&'�`)!!""!!(N�
!
{|!!+)/
!
$
(
##
)
%
]*
&
CD89!Oq#D~\P(qr
&
U�T$N17
%
E:89(#1IJ4K# %& .
#D(�)�&'(d���a�
&
CD^&'E
:(��EZ&b89(Q�
%
�mcNc\
&
E
:89D��( %& .#D$%Z<GW[=
%
�
#
&
CD�TdeKD'0H�sV01+/(*
-
&
]5'I9@(#OR678
%
f0
&
!!""I %& $%(&SEFT7
&
U
89*]IPQZ�#D)7
%
!!""I�<(
&S9@(#(&R7�Beh1iK>K�(O
P0EFkG89^L_
(
#!
)
%
"(!!!!
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
.
$!
!"#$%!!"&'()*"*
!
! %!"#!
"
!+
!
!
&'
'
()
"
#,$ *+
!
&'
'
()
"
" "
-,$ *+
!
&'
'
()
"
" "
."
!
#
"
,
%
-.& /
!
#
"
%
.& 0 1. !/
!
.
"
.
&
!1
!
#
&
2. 0 &
&
2.
"
$
&
!'
!
#
&
$2 0 /
&
1/
"
%
#1' '/
!
&
"
&
&
.#
!
.
&
!1 0 !"
&
#2
"
-"
&
"""# .
&
./
!
#
&
&$ 0 #"
&
$'
"
"
&
""!
/%
,
%
$/ '/
!
'
"
%
%/ $.
!
.
"
"
&
1.
!
"
&
.! 0 "
&
&&
"
"
&
"' "
&
/$
!
"
&
.1 0 #
&
#1
"
"
&
#&
&0
!
34
"
,
%
-1" $1
!
1
"
%
1# 0 /. $'
!
'
"
"
&
&"
!
"
&
'1 0 #
&
.'
"
"
&
&/
!
"
&
'2 0 #
&
1"
"
%
#/' !"
!
$
"
"
&
'"
!
"
&
!2 0 "
&
2/
"
"
&
". "
&
'1
!
"
&
$# 0 #
&
"$
"
"
&
#$
565 '!
,
%
# 0 ! $#
!
!
"
%
$ 0 . 1"
!
#!
"
1
&
1/
!
.
&
!/ 0 #"
&
.$
"
-"
&
"""# $
&
'"
!
!
&
"2 0 '
&
21
"
-"
&
"""#
#!(
,
%
) '/
!
$
"
%
" $.
!
#'
"
'
&
./
!
$
&
.2 0 2
&
'2
"
-"
&
"""# #
&
/#
!
#
&
"# 0 !
&
&!
"
"
&
".2
$*
,
%
) 1/
!
.
"
%
" !.
!
#"
"
!
&
&2
!
#
&
2$ 0 .
&
21
"
-"
&
"""# #
&
2'
!
#
&
"1 0 $
&
!'
"
"
&
"$
&"12
,
%
) 2.
!
.
"
%
" /
!
&
"
!
&
"2
!
"
&
&$ 0 .
&
1'
"
"
&
"2 #
&
"!
!
"
&
.! 0 !
&
'"
"
"
&
&1
'#12
,
%
) .#
!
'
"
%
" '"
!
.
"
"
&
&$
!
"
&
1# 0 #
&
.!
"
"
&
/. "
&
/2
!
"
&
.& 0 #
&
!1
"
"
&
$#
7)6 3$
8
%
) 1&
!
.
"
%
" !!
!
'
"
#
&
!!
!
"
&
/' 0 !
&
""
"
"
&
.! #
&
#1
!
"
&
12 0 #
&
&/
"
"
&
'2
+45,
8
%
(% $/
!
.
"
%
6(% '.
!
'
"
#
&
.1
!
"
&
&' 0 !
&
!.
"
"
&
"2 #
&
'&
!
#
&
"# 0 !
&
'#
"
"
&
".
&'(78
8
%
) &2
!
.
"
%
" #$
!
'
"
#
&
"&
!
"
&
1" 0 !
&
""
"
"
&
// #
&
$1
!
"
&
/# 0 !
&
'&
"
"
&
$'
95( "
:
%
#"
&
/' !&
!
$
"
%
-"
&
/' .&
!
1
"
#
&
/'
!
#
&
#" 0 !
&
&"
"
"
&
"! "
&
2.
!
"
&
.2 0 #
&
.1
"
"
&
'$
9:8-);
!
.)
"
:
%
-!
&
' #&
!
$
"
%
!
&
' 0 $
&
& !$
!
$
"
#
&
"'
!
"
&
'/ 0 #
&
&'
"
"
&
2#
!
"
&
." 0 #
&
1$
"
%
#.
&
" .&
!
/
"
!
&
$1
!
#
&
$2 0 .
&
"1
"
"
&
"""1 #
&
&$
!
#
&
"" 0 $
&
/!
"
"
&
""&
%%
/
#
*+ %*"*
!
(<0=>?@1A2>?@1%*"*BC+0=>?@1A2>?@1%*"
"
*+,
,-3;
$ -.-,
DE9:FGHI
$ /+. ,
%&).41
$ 0-*,
J.'()5
1
!+;*/
2
!+;BK!"6"
1
%!+*/
3
!+;BK!"6"
1
L
2
%!+*/
%
*&'(M
!456
<#$
0-*
"+N
"
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!")!!!
.
%!
!!!""##$"$$%%
#! $% ! &
&!
%
!""##$
!
%%&'()
"
*
&
$
7
+
&
" *
&
,
7
+
&
"
#
%!
" -$,.
"
%
$$
!
%%&'()
"
!$
&
/
7
0
&
" !$
&
,
7
0
&
"
#
%!
" -$,/
"
&'
%
!""##$
!
%%&'()
"
*
&
*
7
/
&
" #"
&
/
7
+
&
"
"
&
,,$#
1
%!
" -$."
"
%
$$
!
%%&'()
"
!+
&
$
7
/
&
" !0
&
0
7
/
&
"
"
&
!++!
1
%!
" -$."
"
%
!""##$##$
&
0
!
%%&'()
"
$!
!
#!
"
!"
!
#,
"
"
&
#0#
%!
" -0!
"
()'&'$ '&'$ ! &
&!
%
!""##$
!
%%&'()
"
*
&
!
7
+
&
# ##
&
*
7
+
&
#
#
%!
" -$,.
"
%
$$
!
%%&'()
"
!$
&
,
7
0
&
! !!
&
,
7
0
&
,
#
%!
" -$,/
"
&'
%
!""##$
!
%%&'()
"
*
&
.
7
0
&
, #$
&
*
7
0
&
#
"
&
"++.
1
%!
" -$."
"
%
$$
!
%%&'()
"
!+
&
/
7
/
&
! !0
&
"
7
0
&
.
"
&
"!,/
1
%!
" -$."
"
%
!""##$##$
&
0
!
%%&'()
"
$/
!
##
"
#/
!
+/
"
2"
&
"""#
%!
" -0!
"
%%
(
$
)"*#*&
7
+$,+)"
!
#,)
"
%&
%
-!""##$!'($)&!!!!""##$
8
* *" #,-&
!
#$
&
0%%&'()
"
1+&!&%,'
!
!
%
"
%
#
%%
$%&
%
'
"
!
()*+
%
,-.
%
/
%
0
"
#*!!!!
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
.
!
/
!
'
!
0