01 aula patologia_necrose 2
TRANSCRIPT
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PATOLOGIA CELULAR 1
Patologia Celular 1
Lesão celular reversível e
irreversível, e
adaptações celulares
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Etapas Evolutivas da Agressão Celular
Homeostasia
Mudanças do meio externo
Adaptações
Lesão celular reversível
Lesão celular irreversível
Morte celular
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Hipóxia / Isquemia:Obstrução do fluxo,
↓ oxigenação, ↓ transporte de O2
Agentes físicos: Trauma,
temperatura, radiação.
Agentes químicos: Sal,
glicose, oxigênio, drogas.
Causas de lesão celular
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Agentes infecciosos:Vírus, bactérias, fungos.
Anormalidades
Genéticas: Sínd. de Down,
Anemia Falciforme.
Anormalidades metabólicas: Desnutrição,
Dislipidemia.
Causas de lesão celular
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Determinantes da lesão celular
Agente agressor:- tipo
- duração
- intensidade
Célula lesada- tipo celular
- idade
- adaptabilidade
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Sistemas sub-celulares vulneráveis
Membranas celulares (manutenção da integridade)
Mitocôndria (respiração aeróbica e produção de ATP)
Síntese protéica (proteínas enzimáticas e estruturais)
Integridade do genoma
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Lesão e morte celular
● Depleção de ATP.
● Oxigênio e radicais livres derivados.
● Aumento de Cálcio intracelular e perda de
homeostasia de cálcio.
● Alterações na permeabilidade da membrana.
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Depleção de ATP
ATP-ase de
sódio e potássio
Síntese
de proteínas
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Radicais livres do oxigênio
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Lesão de reperfusão
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Acúmulo intracelular de cálcio
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Alteração da permeabilidade da
membrana
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Homeostasia
Mudanças do meio externo
Adaptações
Lesão celular reversível
Lesão celular irreversível
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Adaptação dos tecidos
1) Hipertrofia
2) Hiperplasia
3) Atrofia
4) Metaplasia
5) Acúmulos Intracelulares
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Coração normal
ADAE
VE
VD
Septo IV
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Coração hipertrófica /
Hipertensão arterial
VE
VD
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Hipertrofia: Hipertrofia cardíaca
VD
VE
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Hipertrofia: Hipertrofia cardíaca (micro)
normal hipertrofia
200x
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Hipertrofia: Hipertrofia cardíaca (micro)
normal hipertrofia
400x
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Endométrio
proliferativo
Endométrio
secretor
Endométrio
hiperplásico
Hiperplasia
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Hiperplasia endometrial
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Tireóide normal
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Hiperplasia da tireóide: doença de Graves
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Tireóide normal Hiperplasia (Graves)
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Atrofia
Testículo
normal Testículo
atrófico
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Atrofia
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Metaplasia
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Metaplasia
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Metaplasia