012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+,...
TRANSCRIPT
![Page 1: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/1.jpg)
!"#$%&'()*(+,-./012
34 5678
! '9,7:(+,);<=>?@ABCDEF5:+,"G9HI7JKLF1@M(NOF1@
M)PQFR8ST@S@:;<H'UV<:(V');<%'%W('X)9FL=SS@YHZ[=H
5:M1\M]^@_=`abc8S&'d:efg
h4 ijkl%mnoIpq
! #$rs 100tnu vw0xyz
{4 ef%!"
! Z|%+,"G=}~�S��(Z���)9�6Jb�%+,"G9��@S@:�0(�B�
�A�)�H��������@_=`:�&'���%ef=`:��@��%;<=�%+,
"G9��=��J:�09H&'%!"0@:��9 M0xykJ:g'%,7:¡kU¢£
:¤¥¦@§¨(PTHaPTT@_%+,©ª)%«9-.F5:��1¬"H�"+,"G%®
¯/F5Y°±9²³F5:9H´.F5:��1�Jv�%+,"G%®¯/(µ XIII/13"G�
¶·B¸¹º»¼B½"G@_)U¾¿=ÀÁ=Âç¨d:>?95YHÄÅ°±1ÆÇF5:g
È4 /É
! &'%ÊËÌ�ÍÎÌÏ@SH'U,<:Ðk@'Ñ('ÐÒ)%mÏÓabM@M%=ÏÔ6
ÕHÖ[&'d:g�%×6�MØ|F5:ÙÚ�ÛÜ%&'9 M9HÝ�%_%ØÞ=FÏ&
'd:ßà(95:gá=��=&'8;YHâã¦5:M1äo(=&'d:%Få'=@YH
æçèDÉéUê�d�0Ï5:g
ë4 �%ef=ìabêL:/É
! &'d:ØÞ=`ab1íî@/É9��kabê�:(�ï/)ßà(95:gð=ñUòóô
õ¬%&'F1ñö÷=Høù�ú95:ûü¬%&'F1ýþ=ÿM!"Uê�8H#$¦
0@:��Ï5:g7;H��&'F�'%d:�0Ï5:g
&4 '()
! &'UV<:;<=�J*J%"G+,U-.d:�09>?F5:9H/{4!"0=1M;
Z���=`:�B��A�%2F1H-.8;+,"G3,94�@S@:;<H�J56F&
'UV<:�01Ç8Mg�J*J%+,"G=78bH9:U;<:3(9:<=3)U-.8b
Z���U�6>@M`?=d:>?95:g�J*J%"G+,9@á=A�FL@M��1H
7Õ'X9B6=SS@:3(�CB3)UDEd:0H5:FqV'=G4F5:0HIkJ:g
J4 KLM
°±ÆÇ@r!"#$%z&'()*(+,-./%N�¦°(OP%�Q KLM
![Page 2: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/2.jpg)
!!"#$"#
%&'$(!"#$)*+,#-./%&0'(*)*+,-$&&!.1/2$30+12$#3 ! ! 4&566678429:5;678<9= %>'?@:A5BC8"#$;D5E+"#FG$<H9IJ=>:A$<H9$?@KA,8L ! ! B5;678<9= %M'"#$)*+NC./OPQR8ST$URV4;6WEXY78<9=
Z[978F\$]^$D_ (V 1)` ! EF-GH-$a VIII/8bI(F8)cdJ+a IX/9bI(F9)cdJ+a XI/11bI(F11)cdJ+a VII/7bI(F7)cdJ+a X/10 bI(F10)cdJ+a V/5 bI(F5)cdJ+efKfghg(PT)cdJ+Li
jklmg(Fbg)cdJ+aXIII/13bI(F13)cdJ+von WillebrandbI(vWF)cdJ+alpha2-plasmin inhibitor (alpha2-PI)cdJ+plasminogen activator inhibitor-1 (PAI-1)cdJ+)n )*9%&`
! op$qrM9N5stuvvw8EF-GH-xyz{J (OPz{J4|})E+Q~xy�R2S�kT�g�K��)�$(����U)9+S�kT�g���)�$(����U)5A�QR+����UE��*��5��VW2w8K+����UEXYZ;2E�b��$EF9QR��=�<2+
[����U$\]4��\^R+_��)�R9��$���k�`4��+ab]^U$cD*�
���9�� ¡4¢d78<9Kb"#$)*2w8=
! b"#E+��CKz)8£bIcdJ$FG4Z[9u+cD*)�� ¡$¤e4) 7*+¥
¦*5§�T�2w8*+¨5\fuCGH-©ª«¬-F®g XIII(13)$¯"#$dT°hSi`
4±²78*)nK%&2w8= OPQR8ST` ! b"#2b]^U$\]4�-,5u+cD*)�� ¡4¢d78<92+<R12�b��9Q
R\³CEFJj$�b5´kCµ¶)��K2³8LB5)8=dTE+·G$¥¸$¹º©]g»
^¼½5´kCf¤4lm*¾¿5�À�\¢d78C�$�ÁÂTÃ9)8=1C+b]^U%z*
)�RÄn+�RC+��n+��CKopQR8$2+?qÅ> $ÆÇÈ�Ér5ÊK8=Ë5+b
]^U4��5��+��78<95LÌ+�,#)�R°��4ÍÎQÏ+��C4Ðsu+EFÑ
4Òt78$2+u�È�4ÉrQÏ89N5u�vw$µxM5�ÓÔu+¥¸$u�+Õyf¤5
Z78zÖ4s7Q{9)8= "#<H`
! b"#¯E+|}~ 1D+A�~ 4D+×Ø~ 27D,-)8=F¥^R$\f4Ù�u\+b]^UÚ�Jj$�Û4��+%��Ü�R4�Ýu+AIg]m*�R4\f78=�RÞT4��5�ß
u+àe��+�µ)��4\f78=^Rá419�\b]^U$�� ��9��âã�äãg4¢
d78=100 D4:�)åJj@9u\+£"#~K^R78K+"#�æc�9&JjICÌ$�#
ç�%�è�é�'$êägS4ëì\+%5����U$VW-$q�Jj4íîu\�Ü�R4ï
)B=����U5v�\E+ðñò+óð+ðôõN$"#~Kqöu\±÷u\�8ð�bGH-
F®gøùK�T�qú�%û_'5�ßu\!�4à"78= ! &:)5E^R±÷$o#4Ù�u+F¥�g!TK^R2Jj$p$©%&4o#u\+�Á]^
$�e+'G$�E+¢²�($�e+)u�xybI'G�RC$op*4ï+C=>:)E+Ù�
$,-4.�u\Ë5/0$Jj4%&u+Jj195�R+��+��$�µM4Äì8= �$¦+
EFS2�43²u\+J¼$45-+��5L8Ðs$6A47878= 1C+)9opuCã`l
�f:K'G�EC$;A0%z-+�fTê�'OPW�R$�²-4�<78="#��=5+>
&uCv�9%&uCÂTÃ4?5+�R+��+��5?78 ¡4¢d78= ! )�+Õy@A�9B�lm�$qö=>2w8$]^%z* iPS �C4±²uC�g"#+=>5Z´u\DE�FG5;HuC iPS�C4²�8\�E, 2E)�$2+IJuC= .1/2$30` ! ¡¢�mum�.1�£�$¤K4L\+¥�uKJj°MN,-�OBG4L\\f78=
![Page 3: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/3.jpg)
!
!
![Page 4: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/4.jpg)
(!"#$)*+,#-./%&0'(*)*
%&'"#$)*+,#-./%&0'(*)*5v�\E+µPBÔ4Q²uvv+&56667 ! ! 842RG*,v�à5;678<9= %>'IJ"#<H5?u\Z¦125ï+C"#*+"#$��*))å4Sd78$5,#)ü ! ! $"#<H9+IJ"#<H$?@4�à578<9= %M'"#O�45T4n<12�-,578,+£:A$)å4�à5uCr2;678<9= %ý'IJ"#$%&0'(*)*5v�\E+¥40¥U$ü$"#2n<12�-,5)+\� ! ! Ì+n$LB)�AKVQR\�8$,4W1X\;678<9=
!"#$%&'()*+,-./01234567
489:,;<=>?@A&BC>?@A&,DEFGH
! IJ,;<FKLMN)*+LOP7
"#QR'(/0STUVWXYZ[\];<4^_`ab7
! "7$%&cde'()*+
! ! 4"7f VIII/8dg(F8)hi+
! ! 4j7f IX/9dg(F9)hi+
! ! 4k7f XI/11dg(F11)hi+
! j7$%&lde'()*+
! ! 4"7f VII/7dg(F7)hi+
! k7$%&mnop'()*+
! ! 4"7f X/10dg(F10)hi+
! ! 4j7f V/5dg(F5)hi+
! ! 4k7qrsrYtY(PT)hi+
! ! 4u7vwxVyzY(Fbg)hi+{
j#QR'(/0STUVWXYZ|}];<4^_|}b7
! "7$%&vwxVY~��)*+
! ! 4"7f XIII/13dg(F13)hi+
! ! 4j7vwxVyzY(Fbg)hi+{
! j7$%&��&'()*+
! ! 4"7von Willebranddg(vWF)hi+{
! k7$%&��)*+
! ! 4"7alpha2-plasmin inhibitor (alpha2-PI)hi+
! ! 4j7plasminogen activator inhibitor-1 (PAI-1)hi+
! u7�,�4Q�1]���)*+��,�������
! ! ! ! ! ! ! ],S�l7
{ ��,�1�����ON)]�/0������L�� :
�!
!
!"! ¡;<b,234567
!j! ¡;<b,¢£!
!k! ¡;<,��+¤¥¦§
"#$)*`
! EF-GH-xyz{J(¥5cdJYV2Z, V3)E+Q~xy�R2S�kT�g�KVW)�$(����U)9��)�$(����U+V 1)5A�QR+����UE��*��5��VW2w8=b"
#2E+XYZ;2E�b��$EF9QR\[\QR������U$\]4��\^R+,v%�
�R9�Ü�R5LÌ��5��u+*à)��4o#78�� �k�`4��u\+b]^UFG$
cD*����9�� ¡4¢d78<94)*978= "#$,#-` ! MN]+¨^]$§�EF-GH-xyz{JE_`a2w+CK+b:$op$qrM5c�¨a5sXvvwÌ+d©*);D�w8$2eO��+eO��K�Vc2w8=<R-$4+ª«¬-F8cdJ%GH-F®gA; Green, 1981'E+fAKq�%1.5o©géo©:; Collins, 2007'$2+¨5¥4U2âã�äãgK¢dQR\�8(Collins, 2008; hi, 2011)=ª«¬-F5, F13, vWFcdJKGH-F®gA5E�\/�9jeQR8K+1k�$\]E�-,2)0+âã�äãg�)�= ! 1C+lª«¬-$£bIcdJ(V1, 2)Eª«¬-$�$8r5/0pJu\�Ì+m~E��CKz)8$2+eO$àe��K�Vc2w8=�<2+cD*)��0��hSi`4��u\+b]^U$��4�µM78,#Kw8=
![Page 5: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/5.jpg)
!
%&0'(*)*` &'<R12+Q~xy�R2S�kT�g���)EF-GH-xyz{JE+[\QR8<9K/,+C=b"#2E+b]^U4nªuCcD*)�� ¡4��78=
>'op2�+b]^U$«q*)"#E)�= M'b]^U$cD*rs5L+\Ek�\+GH-OPz{J (V 1)$�§K�-,5)8= ý'¨5\fuCGH-F®g XIII(13)$¯"#$dT°hSi`4±²u+ptQÏ8= Z¦125ï+C"#` ! b�F~E+�d 21-23 :A5BC8$GH-F®g XIII(13)$\]^R+pJ�($r�9��NC$op+"#2+uv2��\Q¥$FG^R4\fu+dT4¬�pzuC(Ichinose, 2011a,b)=�$ÞT+/@$ª«¬-w8�Elª«¬- F13cdJ4àe��+��+w©78<9K2³CK+F13 cd8U$�bKw89xBR8JjKw8<9��-,5)+C=_+\+cD*)�� ¡4¢d78,#KwÌ+yz$Õ@l""#2L-RCdT4Ë5ptQÏ+®*0G«*5j{789�B|})*5Dd78= �d 25 :A4$)å` &'b]^U4Q~xy�R2S�kT�g�K��)]^9��)]^5A�u+ àe��5~S78���k�`4¢d78=
>'op2�¥42��0ß-R\�)�b]^U$\]4�-,578= M'EF-GH-xyz{J$cD*����9�� ¡4¢d78=
!
!
�!OPQR8dT!
%&'OPQR8dT5v�\E�Õy@Aï�$f¤*2$±²$VW-%f¤2$�¯°�$VW-+�¤¢d$y6*5��8��9u\�¯*5±²QR8VW-+�¯*)�.ST*%¸�2$±±²%�BQ²*'+ÆÇÈ�$Ér+ü$�¤r�O)"#2$pt-)n'KOP2³8,'4i�5²667842;678<9�!
%>'IJ"#Kn$LB)Õy@Aï�$��5Zu+n$LB5ÓÔ78$,*5v�\+�$RG*)4�°j4�Ø�à578<9=
�!�F"#��=$dT`
&'EF-GH-xyz{J5Z78�� ¡�L/cD*5ë���78���k�`4¢d78
<99cD*����9�� ¡4¢d78<9K+b"#4\f78<95LÌVW5)8$
2+�K¥$u�È�4Ér78<9K2³8= >'b"#2F¥^R4\f78<95LÌ+��\EF-GH-xyz{J$ \]4xà,vnª
*5��78<9K2³8$2+¥¸$¹º©]g»^¼½5´kCf¤4¢d78�ÁÂTÃK
L-R8=
�!XYum+u�2 $ÓÔ` ! �R�R$EF-GH-xyz{J$��5�Vc)�RC4opuCÌ+�R�R5Z78%z*)��n+��C4opuCÌ78VW-Kq�$2+Än+�Ý�R+�nA³)n$?q78¸�Å>$ÆÇÈ�Ér2$�¯*�.STKOPQR8=
�!Õy@Aï�$f¤*2$±²$VW-`
&'EF-GH-xyz{J$)u��Rn+�RC+��n+��C)nKopQR+lm*¾¿
5�À0µ¶)��478<9K2³8=
>'ª«¬-GH-xyz{J$�n5E¬���CK�Vc2w8K+aQíînK�Su)
�;D5E+k�´h:j4��78<9K,#2w89��QR8=<$nEZ¦" µ´U9
)+\�Ì+¥�uK3²4¡¢u\�8¼½2w8K+b"#5LÌ �n$ª«¬]^5��
83²$£I-K�-,5)89OPQR8=
![Page 6: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/6.jpg)
&6!"#<H0NC!!
%&'"#)*4Sd78C�$RG*)"#<H./NC4&5²667842;678<9= %>'"#<H4¤ï78C�$"#G�5v�\+"#|}~+"#A�~./"#×Ø~$RG ! ! *)¥¦4�à578<9= %M'?@:A5BC8"#$;D5E+"#FG$<H9:¨<H9$?@KB,8LB5;67 ! ! 8<9= %ý'IJ:A$"#<H0NC4�à5;678<9= %�'b"#4\f78C�53²78"#f§0"#¨©0"#LiT��$à"*+Z¦$"# ! ! µª$¼½4W1X\;678<9= %²'XY0m"#5��\E+�b«ãg+)åJj0Ä©@./78NC*4�à5;67 ! ! 8<9= "#G�` ! "#|}~ 1D+"#A�~ 4D+"#×Ø~ 27D,-)8= �b«ãg` ! F¥^R$\f4Ù�u\+¥�u,-$�Û4��+%��Ü�R4�Ýu+AIg]m*�R
4\f78(V 4)=ÞT4��5�ßu+��+��78=^Rá419�\ ¡¢d$�ÁÂTÃ978=100 D4:�)åJj@9u\+£"#~K^R78K+"#�æc�9&JjICÌ$�#
ç�%�è�é�'$êägS4ëì\+%5����U$VW-$q�Jj4íîu\�Ü�R4
ï)B=����U5v�\E+ðñò+óð+ðôõN$"#~Kqöu\±÷u\�8ð�bG
H-F®gøùK�T�qú�%û_'5�ßu\!�4à"78= �d>�:A"#<H
&'^RÙ�`¡¢ �m$¥¶2\f ! ¬:A5¢duCb]^U5?78Ù�äh4Ð�u+�b��$EFJj5��5®¯78w°�+±¢Ul+²³l+´:l9+�$�Û4��8�Rl+F·4l5µYuCÌ+�R-$mÇ%�23¶u\+Ù�,-53¶u\Ë5·ß4V8=b]^U5?78�g!TK4Ð�u+\]419�8=¥4U$m�°£¸$"#�°mǹº2"#dT4p}u\¬�pzu+b]^U$��5ÓÔ78=
>'F¸tFm*XY"#`¥5"#×Ø~K\f`EFS2�2+45-9ÐsA4787
8= %&'Jj$S�kT� g�G�$»M `¹º¼½+õ1*õ½4.�u\qöef�ä`4Ð�
u+LÌ/0$Jj4p$78= %>'��C$Ð� `Jj+¹{Z¾+�R-$ 1:1¿DFÀ$ PT, aPTT° F13, vWF, F8)n$
±-9'�Á)n$»e5+alpha2-plasmin inhibitor°+plasminogen activator inhibitor-1)n$%��R¼)4Âtu+LÌnª*+*à)��0��4VW578=
%M'tF�C$Ð� Ã̀u�ĽKK�-RCIJbI4|}FÀ�Å4V.*�°,5��u\+
tFST4àK78=àe��¬G$tF�C4�µMu\+���k�`4¢du+)u�J
j5µ²78= %ý'¬���C$Ð� `TR,$xybI5Z78ãgÆhÃT$ǦKÚBRC;DE+V
.*�°,5��4o#u\+þȲÉSifã�+h�fL¾SLÊË�9k�´h:j$ã
gÆhÃTÌÍST4��78=
%�'|Î*tF�C$�Ï` àe��KY012$O�°cduCxybI4|}FÀ�ÅK6
Ð2³812$�E+KägÑËg°±-ÒxybI�Å4��u+tFST4ÓÔ78= M'AIg]m*"#`¥5¡ ¢�m9D¿À�m$"#A�~K\f %&'ãgÆhÃT$xybIÕÖ�($�e`xybI$ãgÆhÃT4¬m*)»eC2�
Eu+'G$xybI$ÕÖ×Ø)n4rs78=
%>'��ãgÆhÃT�R$op `ÕÖ�(4�à5uC'G4²�\+£bI5Z78'G$
ã`ljfùKC�L/ã`l�f:KC5L8�ENC4Ùdu+\õ5IJu\+�$;
A0%z-4�Ú78=
![Page 7: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/7.jpg)
%M''OP°´$�fTê�)�RC$µ² `)u�NC2+<R12[\QR\�CVW-$
q�'OPbIcdJ4�Û78= ! )�+Õy@A�9B�lm�$qö=>2w8$]^%z* iPS�C4±²uC�g"#+=>5
Z´u\DE�FG5;HuC iPS�C4²�8\�E, 2E)�$2+IJuC= ý'����+�� ¡$¢d ! )u�ãgÆhÃT�R4|�C�R9��$���k�`+�R5´kC��$âã�äãg
4¢d78=
!u! $%&'()*+,¨J,PM,/0,©ª«V¬4567!
!
!
!
!
!
!
!
![Page 8: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/8.jpg)
!
!
! ®^_|}]4¯d°±,7��&$%&'()*+,
! ! ²³1^´µ¶,·¸¹º»,�¼½¾¿À
! fQÁÂÃĸjuBjÅÆÇ4jÆÈ7ÃÉÊË0�� &'EF-GH-xyz{J4����)]^9����)]^5A�u+àe��5Ü8��
�k�`4¢d78=
>'EF-GH-xyz{J$\]4�-,578=
M'EF-GH-xyz{J$cD*����9�� ¡4¢d78=
ý'cD*����9�� ¡4F¥5pzu+Jj$p[4Ý{78=
! f�ÁÂÃĸjÌÍjÎÆÇ4kÆÈ7ïdϱ�� &'EF-GH-xyz{J$py4Þ:ß�Ãkg�u\+�Á]^$�§+¸�2A�u+
pJ�b4àÛ78=
>'ãgÆhÃTK�b2w8Jj2E+ãgÆhÃT$å*Ãgá�É%xya VIII/8, V/5,
XIII/13, vWbI)n'âãI$/Ò-4rs78=
M'ª«'GK�b2w8Jj2E+ª«'G4yk8äGå$�b+%5¬«°xy«bI
$âãI/Ò°;æçi�SÒ)n4rs78=
ý'8r$ÞT419�\+�b�$)u�]^A�9����4¢d78=
�'�b�$)u�]^A�9����4F¥5pzu+Jj$àe��4Ý{78=
! fÐÁÂÃĸjÑÍkkÆÇ4ÅÆÈ7ÃÒÓÔÕ�� &'EF-GH-xyz{J$py4Þ:ß�Ãkg�u\+)u�JjÞ5�b�$)u�]
^A�9����4µ²u+�S-°zÖ-)n4�<78=
>'EF-GH-xyz{J$�b5´kC+ä�$)u��RNC4op78=
M'EF-GH-xyz{J$�b5´kC+ä�$)u���NC4op78=
ý'8r$ÞT419�\+�R+��+��%+�Ò'NC4|})u�cD*��âã�ä
ãg4¢d78=
�')u���âã�äãg4F¥5pzu+Jj$��9��4�µM+è\èM78=
!
![Page 9: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/9.jpg)
!
&&!.1/2$30
0"#Z[~5Z78o!"#r$30+�±Á0$ -$%J°&�9�O%ãgL¾T`�02 gégK'2$Z´¼½./\�÷Â5Z78÷Â'#r$30*4;678<9=
! b"#2E+45)EFJ¼4(78Jj$�G43²u\+âãI/Ò4|}£¸$�R°Ã
gá�ÉMm*\�4ïB$2+21:A5¡¢�mum�$.1�£�$¤K 4L\�Ì+£¥
�uKJjw8�E�$MN,-BG5L8�O4L8=
! 1C+)`+£¸$xybIlù��çK:çS)n43²u\g]$rs478;DE+bm
$âãI*X\�+F�£�$,V 4L8=
.19e$-.`) GCP$.19e%1997'4-.u\fï78=¢dQRCqQ$"#<HG$4�5?u£f§192.1�£�$¤K4L8=
XY"#�t5��8ÃO-$à"` bXYÄ�2$ªp*O/5�À³�OKL-RCJj$
ì4Z[978=)�+"#y6$0T)8=*5��812�,�QR+�$<95LÌ��r
�±Á4��8=$§�3�;78=
äo¬�345Z78Òê` L-RC¬�EA�ÄÅ4Yu\äoK%eQR)�LB5uQO
$~K545¶178=
�G3²)*5?78�6`�G$78w8�E�G$b"#)*8U$3²EQ¶ï)B)�=
äo¬�9:$�"` b"#2L-RCdT$;Ì<�Eäo¬�"#C5�¿78=
¬�oÚ=Æ`b"#2L-RC¬�EZ[~K>?78;D+ÞTKL-R\�8�$5v�\
Eß[r@4|�\�AF/oÚ978=
\�÷Â$;Ì<�` ÷Â\�4;Ì<B;DE+$÷Â$'#./¶15?78CB+./$C�ÃDEFeGG3+5�¿78=
-.7H³"#5?@78 ¡* %"#$4�5¾-u+-.u)�RI)-)� ¡*5v�\E+JI78 ¡*$$J+$K 45$Ç+4;678<9%?@$ ¡*KJI78;DE+�R�R$K45$Ç+4;678 <9=''=
Ç !ÆKml`0âãIrs"#5?78.1 ¡ !m"#5?78.1 ¡
!âãI��XY"#5?78 ¡ Ç !XY"#5?78.1 ¡
!ÆKL�C4²�8XY"#5?78 ¡
Ç !Õy@A�$�¶78\f�?5��8÷Â\�*$\f5?78�b ¡
!�$ü$ ¡*% ¡*$D_`! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! '
m0yÂq<m$¹ºM$?�$� !§ �! 0! ǧ ! 0! �$ü%! ! ! ! ! ! ! ! ! '
!X Y " # MN�e$�§ �! 0! §! 0Ç�$ü%"#{O¼½5L8'
![Page 10: 012 - 日本血栓止血学会€¦ · !fi^_|}]4fld°–,7ž⁄&$%&’()*+, !!†‡1^·µ¶,•‚„”»,‚…‰¾¿À!fQ`´ˆ˜‚juBj¯˘˙4j˘¨7ˆÉ˚¸0‰„ &’EF-GH-xyz{J4ƒ⁄…—)]^9ƒ](https://reader030.vdocuments.pub/reader030/viewer/2022040412/5edd1d1aad6a402d6668155b/html5/thumbnails/10.jpg)
!"#$%&'()*+,-./012345'(678./01245'(679
'(:;<
=>?@A BCD&E&F-GHIJ& K-L MNOPNQRSTUVWXNWXYMUMZM[M\]XMOX^_
'(G`<
abcde BCD&E&F-GHIJ& fKL USR]gNTUVWXNWXYMUMZM[M\]XMOX^_
hi-j BCD&E&F-GHIJ& +-K [RSMkNTUVWXNWXYMUMZM[M\]XMOX^_
lm?no pqE%D&-E"r& K-L ]gMQR[TPMUM\UVWXMOX^_
qs-d tuvD&E&FwxIy-z{F K-L [UM[S]TUVWXQMZRYM\]XMOX^_
'(|}<
~H?d� ���E�D&�&F-�%& K-L NVkRUTPRk]\NgYR\]XMOX^_
��?�H ��D&E&FwxIy-z{F �-� Y[MUMNTOOXPNgRSMkN\]XMOX^_
��?�� ��Iy��?��E�����-{��% E-� [RSPN�N[R�N[RTYMPRRXORX^_
��?,� BCD&E&F- ¡%& ¢£KL kkM¤MUMVTUVWXNWXYMUMZM[M\]XMOX^_
B¥?d¦ §¨D&©&F-"ª& fKL Q\YMUMUR[RT_PMXRP]\]XMOX^_
«¬?/®/E%D&?GHIJ/�'(����GHIJ'(F
�-� UMWROPMQT^NOPNXMOX^_
¯°?±² ³|E%D&-´µ%& fKL PNWVk]gRTWRkkYRUVWXMOX^_
´�?¶�·¸D&D&yE&¹'(%-"º»¼�%½{��%¾
+-K YR\RZM¤MTUVWXZ]QUM\]XMOX^_
¿À?-� ÁÂD&E&FwxIy-ÃÄF K-L YM[RY][M\[kYT]UNQXMOX^_
ÅÆ?ÇÈ ÁÂD&E&FwxIy-{�ɪ�ÊF �-� PMQMË]SM\[kYT]UNQXMOX^_
�Ì?ÍÎ AÂD&E&F-�%& K-L kMÏTUVWX[VNkYR\]XMOX^_
ÐÑ?ÒÓ ÔÕD&E&F-�%&Ö× fKL Ë]UNSPNTSPNQSP]\]XMOX^_
�Ø???ÙÚBD&D&yE&©&'(FÛÜGHIJÃÄ&�Ý
K-L kN[M^NUMTUVWX]\[RYMUMXMOX^_
Þß?àá ,âD&wxIy??ãäåæç/�F fKL PMSMk]gMTS[MËËXkMQMÏM¤M\]XMOX^_
èméêH ë�D&E&FwxIy-{�ìí�% +-K PRSRQRT]\Ë]k]NXMOX^_
îc?-ï �ðñ�òóIy67ôr<8y�9
URPgNPTPRS_N[MõXË]^NVWMXSPNÏ]RkMX^_
´ö?÷Î pqE����� y-� [kRøMTPUVWOXRgX^_
ÍÑ?àÎ ùúD&D&yE&¹'(%-ÃÄE& fKL ¤MWMPNWVTOõNQXUVWNOXUNV\]XMOX^_
ûÑ?üý ��þÿ!I'(����-z{ôr" E-� SUNYM[MTPS_XQO#OXZRX^_
$%?&ÍD'D&D&yE&¹'(%{�(ìí�%
�-� kMSPNTP_\øõRRWXUVWXRSMkM\]XMOX^_
)Ñ?d* ��Iy��?D'E�����-+% E-� UNkVWMTRQPXZRX^_
,�?-" ./D&E&Fé0Iy-+% fKL Y]kM¤MTQMgMXUVWXkNQWMNXMOX^_
12?-3 45E%D&-{��% �-� _MgMSRõTU]MXøNZõRøVXQVX^_
¨�?ã678D&E&FwxIyz{(è9/�F
IyKL [MkMPM[RTUXVPNUV\]XMOX^_
:¥?;j�<Õñ�=>Iy?ª!(@AI����-+%
�����B+%¢£F�
kRP^NXRkMUR[TZUMNõXORU
:C?-*DEFD&E&F-�%&�Ý{�(ìí�%
K-L RkMU]gMTUVWXk]g]UV\]XMOX^_
�G?²&H¥D&E&FwxIyz{(è9/�F
+-K UN[]PNgR\]OPNøMTËOXk]PXk]UMUR[R\]XMOX^_
IJ?KLMµØD&D&yE�&òó'(%{ô:NIJOP&
K-L [Vg][RPMTUQXk]ËUXkMZRSPNUM\]XMOX^_
RB?STMµØD&D&yE�&òó'(%UVWX{YZ¼&
[£KL gNQkVQTUQXk]ËUXkMZRSPNUM\]XMOX^_
\]^_.`8abc6d9e{0fg0hijkldòóm]�nodpqr?'(s---