016_20160722 molecular circuits for dynamic noise filtering
TRANSCRIPT
Molecular Circuits for Dynamic Noise Filtering
Tran Quoc Hoan
@k09ht haduonght.wordpress.com/
Paper Alert 2016-07-22, Hasegawa lab., Tokyo
The University of Tokyo
PNAS(2016-04), vol. 113 no. 17, Christoph Zechner, 4729–4734, doi: 10.1073/pnas.1517109113
Findings
Molecular Circuits for Dynamic Noise Filtering 2
• Developed the Possion noise filter by biochemical reactions as a molecular analog of the Kalman filter applied for molecular systems.
• Potential to improve the reliability of synthetic biological circuits and plan an important role in the development of new medical therapies.
Background
Molecular Circuits for Dynamic Noise Filtering 3
Electrical circuits Biological circuits
• Robust with noise and changing environmental conditions
• Context-dependency (Ex. hot cells)
• Noise-filter: build a circuit that evaluates what the noise looks like (Ex. Kalman filter)
• Noise-filter: cancel out the effects of molecular environment
Poisson filter
Optimal Signal Estimation
Molecular Circuits for Dynamic Noise Filtering 4
Kinetic model driven by an external input dY(t)
Optimal Signal Estimation
Molecular Circuits for Dynamic Noise Filtering 5
• When cYZ(t) is large, we have Gamma Filter
• When cY is small (V(t) = M(t)), we have Posson filter
Poison filter can be implemented by below reactions
General Filtering Circuits
6Molecular Circuits for Dynamic Noise Filtering
In Vitro Estimation of Dynamic Signals
7Molecular Circuits for Dynamic Noise Filtering
Others
8
• Ensemble Averaging
Molecular Circuits for Dynamic Noise Filtering
• Adaptive System Identification
• Extinct Noise Cancellation