Ｃａｆｅ回⑥rｙＹ－ＫＵＮＩＮＯＢＵ.＊Ｔ－ＩＷＡＮＡＧＡｏＴ－ＯＭＵＲＡｐＫ－ＴＡＫＡＩ＊（ＯＫＡＹＡＭＡＵＮＩＶＥＲＳＩＴＹＡＮＤＴＨＥ

ＵＮＩＶＥＲＳＩＴＹＯｒＴＯＫＹＱＪＡＰＡＮ）

Palladium-Qktalyzedo諭o-SeiectiveC-HBoEylationof2-PhenylpyridmeandltsDerivatives薊tRoomTmnpemtur已

且"geMKC?ie腕嶬mfEti201aJ2,“31-4434

Me2aK-WIed胞廿②H

SynthesIs

Ｋ⑧ｙｗｃｒ衝＆

Pd-Catalyzedortho-SelectiveＣ－ＨＢｏｒｙｌａｔｉｏｎ

ｏｆ２－Ｐｈｅｎｙ１ｐｙｒｉｄineDerivatives

orrho･seIectiveC-H

borylati、刑

PITenylpWidmederiVatlveS

paHadmm

ｒ、

薊C〔ｉ７鰍′Ａ

ｕｐｔｏ９７９６ｙｌｅｌｄ

儒０９卦圖《:､譽笹蝋!:蝋［、

〈1equiv）（1.4equiv）

X=･N

Y=ＱＯ

Ｒ＝４０Ｍe鞭４.ＣＦ⑧02-Ｍe`ｃｃ両dei.i量鐘壼aromaMcs

ＳＧＩ⑨Cted己Xa

局Ｃ

Ａ83％ｙｌｅｌｄ

－人一|人

！'

41％ylel仕 93％yield

法 法50％yleld77％yjeld １９％yieId

c〔震八89％yleld

lハ’97％yield 27％yieId

Significance:AnelficientPd-catalyzedborylation

of2-pheny}pyIidinederivativeshasbeendis-

ＣＩＣ雲蓮.Theregiose{ectMty訂i尊塞fromLewis

acid-baseinteractiorlbetweenthenitrogenand

boron重tDrTis,fumishingthecorrespondingprod-

uctsingoodyields

sYNFAc加sccnMbuto麺:P31J1ZE二cEhE1ChristophS語台詫，Synfn亡循2013,,(7)?O775PubHshedmIine:17-062013

DOI：10-1055/3-0033-1338900:馳殴No.:PO6813SrDP｡｡■□■巳｡■■｡■■Ｂ■■ｂｄｂ■凸■■印可凸■B■Ｇ■ＢＯＯ■ウ咀凸■■5口■■■■■凸■■■■００.■■－■わ■●凸■q●、■■中▲で□守らP｡■■ｑＤＳｂｏ■､■■■企靱｡ごSPB■▲■｡①P上｡■ＢＵＳ■し■■■■■ロム■Ｌ可ｇｃ

ＺＯＸ３ＣＴＨＩＥＭＥＳＴＵＴＴＧＡＲＴ･ＮＥＷＹＯＲＫ

Comme8nt:Thereactionproceedsatroomtem‐

pe虚turebutcarlalsobeconductedwithoutthe

paMadiumcatalystathighertemperatures・Fw-

thenTldc1theauthorshaveshownthatthereac-

tioncanalsobereadilyperformedong旧ｍｓｃａｌｅ

7７５