1 cortex technology denmark. 2 to obtain objective data to visualize invisible changes and...

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DermaScan® C USBHigh Resolution Ultrasound

CORTEX TECHNOLOGY DENMARK

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DermaScan® CHigh Resolution Ultrasound

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To obtain objective data

To visualize invisible changes and conditions

To learn more - faster

To help improve treatment and life quality for patients

To improve quality of products

To lower cost of product development


Ultrasound Measurements - Why?

Ultrasound Measurements - When?

Prior to therapy (e.g. tumors, port wine stains)

Follow-up (e.g. wound healing, tumors, port wine stains, aging)

To document product claims (cosmetics, pharma.)

To obtain accurate and reproducible data for basic research


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Ultrasound Measurements - Who?

In dermatology & plastic surgery (clinically, research)

Pharmaceutical industry

Cosmetic and aesthetic industry

Others - neuro medicine, wound healing, paediatrics, occupational medicine etc.


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Ultrasound Applications include … Scientific skin research Irritancy/allergy testing Wound healing Collagen (photo damage, skin aging, skin rejuvenation) Cellulite (efficiency of treatment) Scleroderma, Psoriasis Tumors (basal cell, squamous cell, malignant melanoma …) Vascular lesions (port wine stains, hemangioma) Claims substantiation (cosmetics and pharma.)


Definition of Ultrasound

Frequency 20.000 Hz (20 kHz)

UltrasoundEchograpySonography


Conventional Ultrasound

Conventional ultrasound: fmax < 10 MHz

+ High penetration+ Wide application range+ Wide price range


- Low resolution

High Resolution Ultrasoundfor Skin Measurement

High resolution ultrasound: f = 20 MHz or higher

+ High resolution+ High definition


- Low penetration- Limited to skin / subcutis

Send Ultrasound Pulse and listen for Echo

skin boundaries


Skin

The basic Echo A-Scan

CORTEX TECHNOLOGY DENMARK 11

Transmitted pulse of ultrasound

Received signal (A-scan)

B-Scan image = 224 lines of A-Scan


Prob

e

One image consists of 224 lines of ultrasound A-scan

The B-Scan Image

Normal face scan, young lady, near eye


Epidermis Dermis Subcutis

Prob

e

Water Film Gel

In-depth penetration

Beam Focus is important for high Resolution

Sound beam Focal zone

Active element (x-tal)

Transducer housing

Skin surface

Water/gel path


Skin

Resolution of B-Scan Image

Axial resolution (Rax) is determined by the sound velocity (v) and the system bandwidth (BW)

where BW ~ 75% of Fcrystal

E.g. 20MHz: v ~ 1580 m/s, BW ~ 0,75 * 20 MHz => Rax ~ 60 µm

50MHz: v ~ 1580 m/s, BW ~ 0,75 * 50 MHz => Rax ~20 µm

Lateral resolution is determined by the beam diameter (diameter determined by acoustic focusing)

typically 150 µm

BW

vRax

2


Higher ultrasound frequency higher band-width higher resolution

Penetration in to the Skin

Determined by focal distance (water/gel path)

Determined by attenuation (1 dB / MHz / cm)


Higher ultrasound frequency lower penetration into the skin

Selection of ultrasound frequency is a trade-off between resolution and penetration

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Nail foil – 20 MHz and 50 MHzNotice the higher resolution but lower penetration

in the 50 MHz image


DermaScan® C20 MHz <–> 50 MHz

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DermaScan® C USB


2-D Ultrasound Imaging

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DermaScan® C USB2-D Ultrasound Imaging


Prob

e

Normal skin

Mal

igna

nt

Mel

anom

aTh

in a

nd p

hoto

-age

d(S

tero

id a

trop

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Scar

tiss

ue

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DermaScan® C Compact3-D Ultrasound Imgaging


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DermaScan® C Compact3-D Ultrasound Imaging


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Some examples of Images


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DermaScan® C2-D sample Images

Normal photo-aged skinNotice : The Collagen structure changes over time

(colors disappear over time)

20 years 30 years 40 years 50 years


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Cellulite After AHA peeling

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Hemangioma in the face


DermaScan® C2-D sample Image

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Scar tissue


DermaScan® C2-D sample Image

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BCC, various body sites



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Measurements


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Ultrasound BasicsMeasurement modes

Distance (A-scan, arbitrary, B-scan edge/peak detect.) Intensity (B-scan edge/peak detection, Region of Interest) Area (B-scan edge/peak detection, Region of Interest) Volume (3D-scan only)


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DermaScan® CDistance Measurements

Insect bite


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DermaScan® CIntensity Measurement

Insect bite


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DermaScan® CArea Measurement


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Thank You

for Your Attention


1 cortex technology denmark. 2 to obtain objective data to visualize invisible changes and...

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