1. imunologi dasar new
TRANSCRIPT
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Rita Evalina Rusli
Basic Immunology
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Sejarah Imunologi
Awalnya : cabang mikrobiologiRespons tubuh terutama respons kekebalan
terhadap agen penyebab infeksi dansubstansi asing dari lingkungan
Yunani, 430 SM, wabah sembuh tidakmenderita kedua kalinya
acar : pertama tercatat di hina
!000 SM, tabib hina menghirup puyeryang terbuat dari krusta lesi cacar
"arum#pocking de$ice kekulit %$ariolasi& 'urki dan Asia tengah
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!()* : +dward enner cowpo- $accination%$acca . sapi&
!**0 : /ouis asteur : attenuated $accines
Robert 1och : 2ypersensiti$ity !)00 : bukti bahwa tubuh memiliki
pertahanan komprehensi terhadap ineksidengan memproduksi antibodi
!)0 : Rodney Robert orter dan 5erald+delman struktur imunoglobulin
!)60 : renaisance imunologi selular masuk
era modern
Sejarah ……………
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Sejarah ……………
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Figure 1-33Figure 1-33
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6
COMPONENTS OF THE IMMUNE RESPONSE
TYPETYPE LOCATIONLOCATION FUNCTIONFUNCTION
B-LymphocyteB-Lymphocyte Lymph nodesLymph nodes
SpleenSpleen
Pe!phe"lPe!phe"l
Re"cts #!th spec!$!c "nt!%ens &Re"cts #!th spec!$!c "nt!%ens &
d!$$eent!"tes !nto pl"sm" cell o memoyd!$$eent!"tes !nto pl"sm" cell o memoy
cellcell
Respons!'le $o "nt!'ody-med!"tedRespons!'le $o "nt!'ody-med!"ted
!mm(n!ty!mm(n!ty
T-lymphocyteT-lymphocyte Lymph nodesLymph nodes
SpleenSpleen
Pe!phe"lPe!phe"l
T!ss(e $l(!dsT!ss(e $l(!ds
Spec!$!c "nt!%en eco%n!t!on to t!%%e cellSpec!$!c "nt!%en eco%n!t!on to t!%%e cell
med!"ted !mm(n!tymed!"ted !mm(n!ty
Mo'!l!)es othe cells tom p"t!c!p"te !n cellMo'!l!)es othe cells tom p"t!c!p"te !n cell
med!"ted !mm(n!tymed!"ted !mm(n!tyHelps e%(l"te !mm(ne esponseHelps e%(l"te !mm(ne esponse
Pl"sm" cellsPl"sm" cells Lymph nodes* SpleenLymph nodes* Spleen
+"sto!ntest!n"l Assoc!"ted+"sto!ntest!n"l Assoc!"ted
Lympho!d T!ss(e ,+ALTLympho!d T!ss(e ,+ALT
Pod(ces "nt!'od!es I%+* I%A* I%E I%M* I%./Pod(ces "nt!'od!es I%+* I%A* I%E I%M* I%./
M"coph"%eM"coph"%e Pe!phe"lPe!phe"lAll t!ss(esAll t!ss(es
00Pesents1 "nt!%ens to B & T lymphocytesPesents1 "nt!%ens to B & T lymphocytesEn%(l$ opson!)ed '"cte!" En%(l$ opson!)ed '"cte!"
ComplementComplement Blood ,pl"sm" pote!nsBlood ,pl"sm" pote!ns Foms cytolyt!c "nd to2!c comple2es toFoms cytolyt!c "nd to2!c comple2es to
"nt!%en"nt!%en
Med!"tos o$Med!"tos o$
!n$l"mm"t!on!n$l"mm"t!on
−Ne(toph!lsNe(toph!ls−Eos!noph!lsEos!noph!ls
BloodBlood
T!ss(e !n$l"mm"t!onT!ss(e !n$l"mm"t!on
En%(l$ !mm(ne comple2esEn%(l$ !mm(ne comple2es
Ph"%ocytos!sPh"%ocytos!s
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Origin, differentiation & main function in immunity of hagocytes
7
Bone Marrow stem cells
Lymphoid progenitors Myeloid progenitors Erythroid progenitors Platelet progenitors
Erythrocytes PlateletsT Lymphocyte B Lymphocyte
Granulocytes (In Blood Tissues! Monocytes ( In Blood !
"eutrophils Eosinophils Basophils
Micro#icidalpresentearly inin$lamm
response
%estroyparasitesproducemediators o$
inlammation
&eleasehistamine heparin inanaphylactic
reaction
Macrophages 'leolar Splenic lymph node
Lier )up$$er
cells Peritoneal *ther tissues(#rain+ synoia+,idney!
Present late in in$lammresponse
Micro#icidalInitiate immune response
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Figure 1-3Figure 1-3
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Figure 1-3 part 1 of 4Figure 1-3 part 1 of 4
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Figure 1-3 part 2 of 4Figure 1-3 part 2 of 4
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Figure 1-3 part 3 of 4Figure 1-3 part 3 of 4
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Figure 1-3 part 4 of 4Figure 1-3 part 4 of 4
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Elements of the immune systemElements of the immune system
%-
B
-TL
")T
")
M.PM"
nonspeci$ic(innate!
immunityspeci$ic(adaptie!immunity
"*
IgG
IgM
Ig'
IgE
-hemo,ines
Gran/yme
-
T0
s1&eceptors
E*-yto,ines
P&&
Treg
!"#OR$% E%%"%$R
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'o discriminate self from non(self
'o recognise non(self
'o react to non(self )immunodeficiency*
+unctions of the immune system
'o recognise self
'o recognise and resond to altered self
)cancer*
'o avoid reacting to harmless antigens )allergy*
'o maintain tolerance to self )autoimmunity*
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Immune system is really a-net .ork/
that involves many differentlayers .hich interact .ith each
other
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+I%O0E1I SIS'E# I#"1 +I%O0E1I SIS'E# I#"1
77 Evolusi perkembangan sistem imun : suatu seri respons adatif terhadap lingkungan yang
berubah dan otensial ra.an
7 +$olusi perkembangan sistem imun ditin"au dari
sudut keragaman berbagai macam spesies%paling primiti paling kompleks : manusia&
7 Seleksi spesies yang paling dapat beradaptasi
terhadap lingkungan proses adaptasi : dasar
ilogeni respons imun
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+I%O0E1I I#"1I'$S 1O1 S2ESI+I3
77 8entuk paling primiti : fagositosis
( Organisme uniseluler, fagositosis
berfungsi nutriti
7 9rganisme lebih tinggi, agositosis
berungsi pertahanan
7 ada manusia, 3 dari lekosit yang beredar )monosit, 2#1 dan eosinofil* berperan
sebagai agosit
7 Respons inlamasi, pertahanan non spesiik yang sudah terlihat pada invertebrata
rimitif
7 engan e$olusi, bentuk pertahanan
dipertahankan dan ditambah bentuk lain
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+I%O0E1I I#"1I'$S S2ESI+I3
7 Sudah terlihat pada in$ertebrata primiti
%hagish& berbentuk sistem limfoid yang tersebar; Antibodi yang terbentuk
analog dengan Ig#
7 <ertebrata yang tinggi, struktur limoid
tersendiri
7 <ertebrata yang lebih rendah Ab yang
dibentuk mempunyai 8M tinggi %analog dg
=gM&, pada yang lebih tinggi timbul Ab kedua yang analog dengan =g5, diikuti
antibodi yang analog dengan =gA
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+I%O0E1I I#"1I'$S S2ESI+I3…………
7 =munitas seluler sudah terlihat padain$ertebrata dan $ertebrata berupa enolakanterhada jaringan translantasi
7 pada in$ertebrata belum terlihat antibodi yanganalog dengan =g
7 ada manusia : terdapat kelas Ab %=gM, =g5,=gA, =g dan =g+& dengan masing7masingsubkelas
7 Selama e$olusi ter"adi spesialisasi sel yang
berperan spesiik7 >rutan e$olusi kelas imunoglobulin paralel
dengan proses pematangan pada indi$idu
7 Respons imun yang berkembang sempurna
dengan sesifisitas dan memori imunologik
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+I%O0E1I
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O1'O0E1I SIS'E# I#"1
roses perkembangan sistem imun ditin"au
dari indi$idu yang sedang berkembang : darisel pendahulu sel matur ada manusia : maturasi respons imun mulai
pd etus ?73 bulan
ierensiasi ungsi imunologik sel nonspesiikdan spesiik %keduanya dari populasi selasal#stem cell&
Stem cell pada embrio : pada "aringan
hematopoietik yolksac1ehamilan 6 minggu : hatiMulai kehamilan ? bulan dan selan"utnya :
sumsum tulang
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1ehamilan 37 bln limpa "g berperan sbg
"aringan hematopoietik Stlh lahir, sumsum tulang satu7satunya
hematopoietik Sumsum tulang gagal diambil alih oleh hati
dan limpa 8ergantung pada lingkungan mikro sel akanberkembang melalui "alur hematopoietik danlimopoietik
alur hematopoietik : eritrosit, granulosit,trombosit dan monosit
alur limopoeitik : sel limosit9ntogeni berkaitan dengan patogenesis
penyakit deisiensi imun terutama deisiensi
imun kongenital
O1'O0E1I ………4
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ONTOGENIONTOGENI
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SPESIFI3NONSPESIFI3
FISI3 LARUT SELULAR HUMORAL SELULAR
• 3ULIT
• SELAPUT
LEN.IR• SILIA• BATU3• BERSIN
• BIO3IMIA 4 LISO5IM*
SEBASEOUS*
ASAM LAMBUN+*
LA3TOFERIN* ASAM
NEURAMINI3• HUMORAL 4
3OMPLEMEN* INTER
FERON* CRP
• FA+OSIT 4
MN* PMN
• SEL N3• SEL MAST• BASOFIL
SEL B 4• I%+
• I%A• I%M• I%.• I%E
SEL T 4• Th6• Th7• Ts8T8Th9• Tdth• CTL8Tc
SISTEM IMUN
INNATE A.APTI:E
MemoryNo memory
First line of defence Second line of defence
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-omponent o$ innate immunity
-omponent Principal $unction
Epithelial layersEpithelial layers
Mucosal layersMucosal layers Chemicals (enzymeChemicals (enzyme
gastric aci!s"gastric aci!s"
Mechanicals (gutMechanicals (gut
peristaltic mucosalperistaltic mucosal
cilliary"cilliary"
#re$ent micro%ial entry
#re$ent micro%ial entry #re$ent micro%ial entry
#re$ent micro%ial entry
&on circulating
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-omponent o$…………………
-omponent Principal $unction
&eutrophyls&eutrophyls
MacrophagesMacrophages
&' cells&' cells
Early phagocytes an! illing of
micro%es Efficient phagocytosis an!
illing of micro%es secretion
cytoines that stimulate
inflamation
)ysis of infecte! cells acti$ation
of macrophages
Circulating effectors cells
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-omponent o$…………………
Circulating effectors proteins
Complement
Manose-%in!inglectin (collectin"
C-reacti$e protein
(penta*in"
Coagulation factors
'illing of micro%es opsonization of
micro%es acti$ation of leucocytes
+psonization of micro%es acti$ation of complement (lectin path,ays"
+psonization of micro%es acti$ation
of complement
alling off of infecte! tissue
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-omponent o$…………………Cytoines
.&F /)-1 chemoines
/F&-0
/)-12
/)-1
/)-1 .F-
/nflamation
5esistance to $iral infection
Macrophage acti$ation /F&- pro!uction %y &'
cells an! . cells
#roliferation of &' cells
Control of inflamation
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Innate Immunity 2 in#orn
"on1spesi$ic de$ense against in$ection
Macrophages+ "eutrophils
Its action does not depend on prior
e3posure to a particular pathogens Phagocytosis
Basic concepts
Innate Immunity in pathogen elimination
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Innate Immunity in pathogen elimination1 8ateri ulit langsung !iserang oleh omplemen eliminasi
2 9e%agian resisten th! er:a omplemen ati$asi marofag %eri sinyal e hepar
3 9inyal imia !ari marofag in!usi hepar untu pro!usi ;## iat %ateri
4 /atan ;## th! %ateri
ati$asi omplemen eliminasi %ateri !an meningatan !aya eliminasi oleh marofag
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Innate Immunity……4
;cti$ate Complement system an! they,ill !estroy the pathogen
;cute phase proteins pro!uce! %y the
li$er stimulate the macrophage functionagainst infection
.hose protein %in!s to %acterial surface
an! acti$ates complement system toeliminate %acteria !irectly an! enhance
their elimination %y macrophages
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Innate Immunity………
9ecrete! /)6 %y the macrophage ,ill
stimulate the li$er to pro!uce
<acute phase proteins= ie >
- C-reacti$e protein
- 9erum amyloi! protein
- Mannose %in!ing protein
- Fi%rinogen
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-1reactie protein
C-reacti$e protein %in!s to
#hosphorylcholine on %acterial surfaces
Mannose %in!ing protein %in!s Mannosa
resi!u on %acterial surfaces
C-reacti$e protein an! Mannose %in!ing
protein respons lie anti%o!y
+psonisation an! acti$ates the
complement casca!e
1 8 t i i ! i i t
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1 8ateri in!usi sintesa
/)-6 oleh marofag
2 /)-6 %ereasi !engan
sel hepatosit in!usi
sintesa ;## termasu
M8#
1 C5# iat phosphorylcholine pa!a permuaan %ateri
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1 C5# iat phosphorylcholine pa!a permuaan %ateri
2 Manose %in!ing protein iat resi!u manose pa!a permuaan %ateri
saat sel host eurangan manose ar%ohi!rat
3 C5# %ersama M8# ati$asi omplemen untu lisisan %ateri !an
langsung opsonisasi %ateri
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In$lammatory response
/nfection %acteria trigger macrophagesto release inflammatory me!iators
?aso!ilatation an! increase! $ascular
permea%ility cause re!ness an! heat (ru%or!an calor")eaage of cells an! flui!s cause s,elling
an! pain (tumor !an !olor" 8loo! $essel ,alls %ecome sticy allo,ing
%loo! cells to migrate into tissue.-cells acti$ate! %y macrophages may
sustain chronic inflammation
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IMUNITAS BA;AAN .AN IMUNITAS .I.APATIMUNITAS BA;AAN .AN IMUNITAS .I.APAT
IMUNITAS BA;AAN
@ Pertahanan lini pertama
@ Ada sejak lahir
@ Non-spes!$!<
IMUNITAS .I.APAT
@ Setelah infeksi/
aksinasi/dipelajari
@ Sel memori
• Spes!$!<
@ Pertahanan lini ked!a
PERBE.AAN SISTEM IMUN NONSPESIFI3 .AN SPESIFI3
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PERBE.AAN SISTEM IMUN NONSPESIFI3 .AN SPESIFI3
NONSPESIFI3
POSITIF 4 SELALU
SIAP* RESPONS
CEPAT* TI.A3 PERLU
PA=ANAN
SEBELUMNYA
NE+ATIF 4 .APAT
BER >>* MEMORI ??
SPESIFI3
NE+ATIF 4 TI.A3 SIAP
SAMPAI TERPA=AN ALER+EN *
RESPONS LAMBAT
POSITIF 4 RESPONS INTENS*
PERLIN.UN+AN LEBIH BAI3 PA.A
PA=ANAN BERI3UT
PRESENTASI ANTI+EN
SITO3IN
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SISTEM IM"N NON SPESI#I$SISTEM IM"N NON SPESI#I$
Terse%ar disel!r!h t!%!h
&alam s!ms!m t!lan'( tim!s( darah( $G)(
limpa( sal nafas( sal *erna( sal kemih dan
jarin'an
)erasal dari sel prek!rsor m!ltipoten dalam
s!ms!m t!lan'
SISTEM IMUN
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FA+OSITBASOFIL .AN
SEL MAST
SISTEM IMUN
NONSPESIFI3
NULL CELL* SEL 3
.AN SEL N3
PMNMN
MONOSIT
MA3ROFA+
FA+OSITOSIS
NETROFIL
EOSINOFIL
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Me<"n!sme espons !m(n '"#""n
Innate immunity
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Im(n!t"s l"h!!"hIm(n!t"s l"h!!"hTop!<
• Pertahanan fisis( kimia+i dan %iolo'is
• ,at-.at anti-infektif alamiah
• #a'ositosis
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Pet"h"n"n $!s!s* <!m!"#! d"n '!olo%!sPet"h"n"n $!s!s* <!m!"#! d"n '!olo%!s
@8arier fisis
@8arier imia,i@Flora %aterial
)ulit@ 8arier fisis
@ 8arier imia,i
Mem#ran mu,osa
@ Mem%ran muosa
@ ;sam !an %asa
@ Flora %aterial
Saluran cerna
@ Mem%ran muosa
@ Epitel %ersilia
Saluran respiratori
Me<"n!sme espons !m(n '"#""n Innate immunity
5 t t! ! $ <t!$ l ! h5"t "nt! !n$e<t!$ "l"m!"h
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5"t "nt! !n$e<t!$ "l"m!"h5"t "nt! !n$e<t!$ "l"m!"h
• Anti-bacterial agentsLyso)yme
Ada dalam air mata( salia(makrofa'(limpa Men'han*!rkan dindin' %akteri sel
• Anti-viral agents
Inte$eon &isintesis %ila ada infeksi ir!s Men'ham%at replikasi ir!s
3omplemen
Men'han*!rkan dindin' %akteri sel Mem%ant! destr!ksi pato'en
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.he specificity of innate immunity an! a!apti$e immunity.he specificity of innate immunity an! a!apti$e immunity
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Functions of epithelia in innate immunityFunctions of epithelia in innate immunity
Th $ t ! th ! t! $ 'l d l < t t !t $ ! $ t!
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The se@(ence o$ eents !n the m!%"t!on o$ 'lood le(<ocytes to s!tes o$ !n$ect!on
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Functions of natural iller (&'" cellsFunctions of natural iller (&'" cells
Innate Immunity in pathogen elimination
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Innate Immunity in pathogen elimination
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Resepto d"n $(n%s! espons $"%os!tos!s m"<o$"%
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Resepto d"n $(n%s! espons $"%os!tos!s m"<o$"%
Adhesipd endotel
Migrasike jaringan
Mikrobadimusnahkan
Mikrobadimusnahkan
Reseptor Transmembran
Seven α-helical
Reseptor Toll-like Reseptor
fagositik
AviditasIntegrin
Perubahansitoskeletal
Respiratory burst
FagositosisMikroba pd fagosom
Reactive oxygenIntermediate (ROIs)
LPS
CD 14
Mediatorlipid
Kemokin
PeptidaN-orm!lmethion!l
Sel sel y% 'epe"n p"d" s!stem <e<e'"l"n t('(hSel-sel y% 'epe"n p"d" s!stem <e<e'"l"n t('(h
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Sel-sel y%/ 'epe"n p"d" s!stem <e<e'"l"n t('(hSel-sel y%/ 'epe"n p"d" s!stem <e<e'"l"n t('(h
6/ Sel l!m$os!t 4 Sel T d"n Sel B6/ Sel l!m$os!t 4 Sel T d"n Sel B
Sel T 0 Sel T 0 - Sel T- Sel T helperhelper 1 sel T231 sel T23 - Sel T- Sel T supressorsupressor 1 sel T4 31 sel T4 3
Sel limfosit non T( non )0 sel Nat!ral $iller 1 N$ 3 Sel limfosit non T( non )0 sel Nat!ral $iller 1 N$ 3
7/ Sel $"%os!t , sel pen%h"nc( m!<o'"7/ Sel $"%os!t , sel pen%h"nc( m!<o'"
- Sel ne!trofil 1le!kosit %erinti %anyak3- Sel ne!trofil 1le!kosit %erinti %anyak3
- Sel eosinofil 0 %erperan pada inf5 parasit serta- Sel eosinofil 0 %erperan pada inf5 parasit sertapada reaksi aler'ipada reaksi aler'i
- Sel monosit/makrofa' 0 %erinti sat! - Sel monosit/makrofa' 0 %erinti sat!
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Poses $"%os!tos!s 9 t"h"pa5 Per'erakan le!kosit ke tempat k!man %erada
%5 Pen'ikatan k!man oleh anti%odi 1opsonisasi3*5 Pen'el!aran en.im oleh le!kosit !tk5 men'han*!rkan k!man y' s!dah ditelan
9/ Sel '"so$!l d"n sel m"st9/ Sel '"so$!l d"n sel m"st - Men'and!n' .at histamin dll5- Men'and!n' .at histamin dll5
- )erperan pd reaksi peradan'an 6 reaksi aler'i - )erperan pd reaksi peradan'an 6 reaksi aler'i
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F"%os!tos!sF"%os!tos!s
F"%os!tP"tho%en F"%os!t-hemota3isAtt"chment)illing.!%est!on
Imunitas alami (Innate immunity)
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F"%os!tos!s 4 Sel netrofil( makrofa'( PMN menelan pato'en
!nt!k *e'ah infeksi5 7 89 j!ta sel %erada di sirk!lasi 6 jarin'anyan' melapisi pem%!l!h darah par!( hati( $G) 6 limpa5
Poses $"%os!tos!s mel!'"t<"n4
$emotaksisMakrofa' kontak d'n pato'en menelan m!snahkan
Mem!snahkan j!taan pato'en di jarin'an dlm %%rp menit
)erperan se%a'ai jem%atan antara im!nitas alami dan
im!nitas didapat den'an memproses dan
mempresentasikan pato'en pada sel limfosit T
Imunitas alami (Innate immunity)
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Ant!%enAnt!%en
Ant!%en "d"l"h 4
• S!%stansi yan' memi*! respon im!n 1im!no'en3
• :non-self’
• )iasanya molek!l %esar( *omple;
• Serin' terdiri dari protein ata! polisakarida
ata! kom%inasi ked!anya den'an lipidir!s dan %akteri
< ! !S < A ! !
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St(<t( Ant!%en ep!topeSt(<t( Ant!%en ep!tope
0epatitis B irus
S($"ce "nt!%en ,HBsA%
Pe-S6 "nd pe-S7 "nt!%en
eD "nt!%en ,HBeA%
Coe "nt!%en ,HBcA%
Bordetella
pertussis
Pet(ss!s to2!n
F!l"mento(s h"em"%%l(t!n!n
Pet"ct!n
F!m'!"l "nt!%ens
3ESIMPULAN IMUNITAS BA;AAN
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3ESIMPULAN IMUNITAS BA;AAN
<5<5 #aktor fisik( %iokimia#aktor fisik( %iokimia
=5=5 #a'ositosis( sel dendrit( netrofil#a'ositosis( sel dendrit( netrofil
>5>5
InterferonInterferon
2525 ?y.osim?y.osim
8585 $omplemen$omplemen
@5@5 Sifat tidak spesifikSifat tidak spesifik
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)ellanti A5 Imm!nolo'y III
Stites &P( Terr AI( Parslo+ TG5 Medi*al Imm!nolo'y
A%%as A$( ?i*htman A5)asi* Imm!nolo'y
Boitt I( )rostof C( Male &5 Imm!nolo'y
REFERENSI
Me<"n!sme espon !m(n d!d"p"tMe<"n!sme espon !m(n d!d"p"t
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Me<"n!sme espon !m(n d!d"p"tMe<"n!sme espon !m(n d!d"p"t
Cell-med!"ted
,Sel(l"
@ Mempol!$e"s! sel-sel•<h(s(s
.!t((<"n teh"d"p "nt!%en
d! d"l"m sel
@ .!-med!"s! oleh l!m$os!t T @ .!med!"s! oleh l!m$os!t B
,L!m$os!t-T (%" tel!'"t
Ant!'ody-med!"ted
,H(mo"l
@ Men%h"s!l<"n pote!n
<h(s(s ,"nt!'od!
@ .!t((<"n teh"d"p "nt!%en
s!<(l"s!
S"t( t!l!(n sel l!m$os!t tet"p 'e"d" d! s!<(l"s!
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S(ms(m t(l"n%
Sel Stem
Pem"t"n%"n
d! Thym(s
Pem"t"n%"n d! S/S/TL
Sel l!m$os!t TSel l!m$os!t B
p
S!<(l"s! l!m$os!tS!<(l"s! l!m$os!t
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S!<(l"s! l!m$os!tS!<(l"s! l!m$os!t
Limpa)elenjar
lim$e
Sumsum tulang
Thymus
Blood stream
$lon ekspansi
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Pool l!m$os!t !m"t(
M"s!n%-m"s!n% 'e'ed"
."p"t men%en"l 6 (t" A%
:!(s
A% spes!$!<
menst!m(l"s!l!m$os!t
3lon l!m$os!t
Sem(" l!m$os!t s"m"
$lon ekspansi
Respons !m(n p!me d"n se<(nde
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Respons !m(n p!me d"n se<(nde
Ap"<"h espons !m(n p!me d"n espons !m(n se<(ndeG
1 ! " # $
3ont"< pet"m" 3ont"< <ed("
%ali
Intens!t"sespons
!m(n I%M
I%+
Respons !m(n p!me d"n se<(nde
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p p
Paparan Ag
Pertama kali
Paparan Ag
%edua kali
Sel &aktif
Sekresi Abdr sel plasma
Responsprimer
'ong livedPlasma cell
(in &M)
Sel &memori
Sel & aktif
Responsprimer
Responssekunder
*ari setelah paparan Ag *ari setelah paparan Ag
'ong livedPlasma cell
(in &M)
Sel &memori
+ u m l a h a n t i b o d i
SekresiAb dari
Sel plasma
$omponen sistem keke%alan t!%!h$omponen sistem keke%alan t!%!h
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$omponen sistem keke%alan t!%!ho po e s ste e e%a a t!%!
S!stem <e<e'"l"n h(mo"l ,I%M* I%+* I%A* I%E* I%.S!stem <e<e'"l"n h(mo"l ,I%M* I%+* I%A* I%E* I%.
Im(no%lo'(l!n M 4- )erperan pada reaksi keke%alan a+al mis5 Infeksi- )erperan pada reaksi keke%alan a+al mis5 Infeksi
tahap a+al5tahap a+al5
- Tidak dapat melal!i plasenta- Tidak dapat melal!i plasenta Im(no%lo'(l!n +4
- )erperan pada reaksi keke%alan sek!nder 1lanj!tan3- )erperan pada reaksi keke%alan sek!nder 1lanj!tan3
Im(no%lo'(l!n A 4 - Pada perm5 sel5 lendir mis5sal5 *erna 1I'A sekretorik3 ata!- Pada perm5 sel5 lendir mis5sal5 *erna 1I'A sekretorik3 ata!
sal5 napassal5 napas
Im(no%lo'(l!n E4- Menempel p"d" sel m"st ,'epe"n p"d" e"<s! pe"d"n%"n8
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- Menempel p"d" sel m"st ,'epe"n p"d" e"<s! pe"d"n%"n8
"le%! * 'e<e" s"m" den%"n sel eos!no$!l men%h"nc(<"n
p""s!t
Im(no%lo'(l!n . 4- 3"d"ny" s"n%"t <ec!l* $(n%s! 'el(m el"s
S!stem <e<e'"l"n sel(l" ,Cell Mediated Immunity/ CMI 4
.!pe"n<"n oleh sel T d"n monos!t8m"<o$"% 3ont"< "nt" sel mel"l(! s!to<!n Bepe"n p"d" !n$e<s! <on!< te(t"m" !n$e<s! <(m"n d"l"m sel
m!s/ T'c* !(s set" "m(
S!stem <omplemen Mempe<("t pet"h"n"n t('(h spes!$!< d"n non spes!$!</ .!"<t!$<"n mel"l(! "l( <l"s!< d"n "l( "lten"t!$/