(2)...hori et al., cell, 2008; amano et al., j. cell biol., 2009 nishino et al., embo j. 32:...
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![Page 1: (2)...Hori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009 Nishino et al., EMBO J. 32: 424-436, 2013 Hori et al., J. Cell Biol. 200: 45-60, 2013 DNA QTL Mollah et al](https://reader030.vdocuments.pub/reader030/viewer/2022040916/5e8e5be99457b342f62d7ad4/html5/thumbnails/1.jpg)
1 (1)
3
1
e-QTL
(2)
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(3)
multi-disciplinary
,
(4)
(5) 1
Huang, Kurata, , 2012; Shang,
., 2010 2008 7
2013 3 80 x 1012
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Hori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009
Nishino et al., EMBO J. 32: 424-436, 2013 Hori et al., J.
Cell Biol. 200: 45-60, 2013 DNA
QTL Mollah et al. Neural Processing Letters, 2007
Fujisawa & Eguchi, Journal of Multivariate Analysis, 2008
Ninomiya & Fujisawa, Biometrics, 2007
p
QTL 21
2008; Kuriki, Harushima, Fujisawa & Kurata, Annals of the Institute of Statistical
Mathematics, 2014
Fujisawa, H., Horiuchi, Y., Harushima, Y., Takada, T., Eguchi, S.,
Mochizuki, T., Sakaguchi, T., Shiroishi, T. and Kurata, N., BMC Bioinformatics, 2009
QTL Dou, Kuriki,
Maeno, Takada & Shiroishi, Biometrical Journal, 2014 P
P P
Fujisawa, H. and
Sakaguchi, T., TEST, 2012
(Dou, Kuriki, Lin & Richards, Computational
Statistics & Data Analysis, in press
1
1
1
II
I Takada
et al., Genome Res.,2013[ 2013.6.7 ]
Oka et al., PLos Genetics, 2014
Dou X et al., Biom. J.2014 2
Mamm. genome 2012; Exp. anim.2012 CT
Roy S et al. Med. Image Comput. Comput-Assist.
Interv. 2013 Tamura et al. Hum. Mol. Genet.,2013
DuoMouse
(Arakawa, Takahashi, Shiroishi, Tsuchiya, Koide Journal of Neuroscience Methods 2014)
http://www.nig.ac.jp/labs/MGRL/DuoMouse.html)
http://www.at-s.com/news/detail/1049459354.html
Kato, Kuriki, Koide Heredity,
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2014; Takahashi, Koide PLoS ONE 2014; Goto, Shiroishi, Koide Genes Brain Behav, 2013;
Umemori, Uno, Koide BMC Genomics, 2013
Takada et al., Genome Res.,2008, Oka et al., Genetics, 2007,
Amano et al.,Dev. Cell, 2009, Oka et al., PLos Genetics, 2013 CT
DuoMouse
DuoMouse
2013-2014 Takahashi
et al., Behav Genet.,2006, Mamm. Genome,2008, Behav. Genet.,2009, Umemori et al. BMC
Genetics, 2009 SNEP
Fujisawa et al., BMC Bioinfo.,2009 Mizuta et al., PNAS
2010 Huang, Kurata, Wang, Wei,et al.,
Nature,2012
GWAS genome-wide association study GWAS
e-QTL
Gal4
2013
Umeda et al., Neurosci Res, 2013; Wada et al., PNAS, 2013; Kishimoto et al., Nature Neurosci, 2013;
Asakawa et al., Frontiers in Neural Circuits, 2013; Muto et al., Frontiers in Neural Circuits, 2013;
Banjoet al. Nature Comm, 2013; Wada et al. Curr Biol, 2013; Satou et al. Development 2013; Kwon
et al. Development 2013; Nakayama et al. Mech Dev 2013; Sittaramane et al. Dev Biol, 2013
CRISPR/Cas9
Cas9 50
Kondo & Ueda, Genetics, 2013
(6)
1
4
LASSO
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2 (1)
3
DNA
DNA
4
3
(a)
(b) LASSO
(c)
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(a) 2
(b)
e-QTL
association
(c)
(d) RNAi knock-down
CRISPR/Cas9 -
(2) 25
3
25
1
3
LASSO QTL
GWAS
26
1 4 DNA
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H25
LASSO QTL
H25 3
2
e-QTL
27
Graphical LASSO
LASSO QTL
H22 26
Web
web Web
28
3
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Dou Xiaoling
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( ) Dou Xiaoling
4 3
1 1
22
Illumina HiSeq2000
c-BOT
BGI 1
100 1
200Gb
1
600Gb 24
HiSeq2500
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150bpx2 180Gb 40
DNA
4
DNA
HiSeq 5 MiSeq 3 PacBio RSII 1 ABI3730
6
/
180Gb/40hrs 150bp
112Tb
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