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Page 1: 2012 IBPhBME otchet for site - Институт по биофизика и ...biomed.bas.bg/bg/wp-content/uploads/2013/02/2012_IBPhBME... · 2013-02-09 · - Рамков договор

СОФИЯ 30.01.2013

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1. Научна проблематика на звеното

1.1. Преглед на изпълнението на целите /стратегически и оперативни/ и оценка на

постигнатите резултати в съответствие с мисията и приоритетите на звеното,

утвърдени от ОС на БАН при структурните промени през 2010 г.

Институтът по биофизика и биомедицинско инженерство (ИБФБМИ) е създаден с

решение на Общото събрание на БАН от 22.III.2010 г. чрез сливане и като правоприемник

на Института по биофизика и Централната лаборатория по биомедицинско инженерство в

съответствие с целите и задачите на структурната реформа на Академията. Съгласно

научната тематика на направление “Биомедицина и качество на живот” и националната и

международната разпознаваемост на Института като водещ в редица области на

фундаменталните и научно-приложните дисциплини, ОС на БАН утвърди за ИБФБМИ

следната МИСИЯ: Изучаване на структурно-функционалните взаимодействия на липиди

и белтъци в биологични мембрани, електро- и фотоиндуцирани явления в клетките,

биоелектрични процеси във възбудими клетки. Разкриване на механизмите, водещи до

възникване на мембранно-свързани патологични процеси. Моделиране на липид-

белтъчните, пигмент-липидните и междуклетъчните взаимодействия с помощта на

моделни мембрани, биофизични молекулни и математически модели. Създаване на

методи и средства за регистрация, обработка и анализ на електрофизиологични сигнали.

Регулация на двигателната дейност и биомеханика. Разработка на алгоритми, програмни и

апаратни средства за медицината, приложение на информационните технологии в

здравеопазването. Молекулно моделиране.

Въз основа на посочената мисия са конкретизирани следните ПРИОРИТЕТИ:

- Комплексни интердисциплинарни биофизични, биохимични и физиологични

изследвания на ролята на мембранната структура и свойства в регулацията на

клетъчни функции в норма и патология;

- Изучаване на ефектите на различни стресови фактори на околната среда върху

функционалната активност на клетките;

- Изследване на възбудимостта на невроните, мускулните влакна и двигателните

единици при физиологични и патологични състояния;

- Биофизика и фотобиологични процеси и създаване на биосензори;

- Изследване на взаимодействието на клетките с биоматериали и изучаване на

механизмите на клетъчната адхезия;

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- Методи за регистрация, обработка и анализ на електрофизиологични сигнали и данни

и реализацията им в диагностични и терапевтични устройства;

- Методи и алгоритми за разпознаване на образи, класификация и дискриминация;

- Моделиране и симулиране на биологични и медицински процеси и състояния;

- Проектиране на системи за компютърно подпомагане на решенията;

- Моделиране на зависимости между структура и активност на биологичноактивни

вещества.

След създаването на новото ПНЗ бе оптимизирана структурата на звеното – научна

- 9 секции на базата на предишните 11, и административна. При тази организация през

2012 г. от сътрудници на ИБФБМИ са публикували общо 168 и са подготвили за печат

19 публикации. Публикувани са 118 и са под печат 14 публикации, които са реферирани и

индексирани в световната система за рефериране, индексиране и оценяване. От тях

62 публикувани и 14 под печат са с импакт фактор, IF (Web of Science) или импакт ранг

SJR (SCOPUS). 41 публикувани и 2 под печат са публикациите без рефериране и

индексиране в световната система за рефериране, индексиране и оценяване. Излезли от

печат са 3 монографии 6 глави от книги, а са приети за печат 1 монография и 2 глави от

книги. През 2012 г. са забелязани 2142 цитирания на научни трудове на изследователи от

ИБФБМИ, с изключени самоцитати. Работено е по 81 теми, от които 54 с външно

финансиране: 32 от Фонд “Научни изследвания”, 3 проекта по 7FP и 9 по ОП "РЧР" и

4 теми по договори с чуждестранни фирми.

През 2012 г. един учен от ИБФБМИ беше удостоен с почетното академично звание

"член-кореспондент". Успешно са избрани за професори трима учени и за главни

асистенти - двама.

Приведените обобщени данни са основание за извод, че понастоящем ИБФБМИ е

водещ изследователски институт в България в областта на фундаменталните науки

биофизика, биохимия, клетъчна биология, физиология и в областта на научно-приложните

технологиии в електрофизиологията, двигателната механика, информационните

технологии и биологично активните вещества за нуждите на биомедицината и

практическото здравеопазване. Институтът е напълно конкурентен и разпознаваем в

международен план и постиженията на научния му състав получават високо национално и

международно признание.

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1.2. Връзка с политиките и програмите от приетите от ОС на БАН на 23.03.2009

г. ”Стратегически направления и приоритети на БАН през периода 2009-2013 г.”

Преди всичко мисията на ИБФБМИ е съществено обвързана с една от 4-те основни

задачи, поставени пред Академията – интердисциплинарността на изследванията. По

степента на този показател Институтът е уникално изследователско звено. Научните и

научно-приложните приоритетие на звеното се вписват в немалка част от политиките и

програмите на БАН, приети за посочените в двата документа периоди:

- Политика 1: Науката – основна двигателна сила за развитие на националната

икономика и общество, базирани на знания, в т.ч.:

Програма 1.1. – в развитие на биомедицината като част от социалните отношения и

социалната практика в страната, на нивото на страна-член на ЕС;

Програма 1.2. – в ефективното използване на природните ресурси, предимно на

естествените природни биологични суровини, за целите на биомедицината,

биотехнологиите и здравеопазването;

Програма 1.6. – в подготовката на високоспециализирани кадри в редица области на

биофизиката, биомедицинското инженерство, високите технологии в биомедицината;

- Политика 2: Научен потенциал и изследователска инфраструктура – част от

Европейското изследователско пространство, в т.ч.:

Програма 2.1. – в създаване на иновационни технологии, средства и продукти за нуждите

на здравеопазването, биомедицината, фармакологията, биотехнологиите;

Програма 2.3. – в подобряване качеството на живот чрез интердисциплинарни

изследвания в областта на изследователската и клиничната медицина, спорта, контрола

върху субстанции и фактори, вредящи на човека и живата природа.

1.3. Извършвани дейности във връзка с точка 1.2.

Изследванията, отразяващи съдържанието на приведените в горния раздел връзки,

през 2012 г. са конкретизирани в:

- изследвания върху фотосинтетичния апарат и неговата активност на представители от

растителния свят ;

- методи и алгоритми за регистриране, обработка, анализ и класификация на

биомедицински данни, сигнали и образи и реализацията им чрез програмни и схемни

решения в електронна клинична и животоспасяваща апаратура;

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- моделиране и експериментално изследване на двигателната активност при изпълнение

на различни двигателни задачи, включително и разработка на експериментални

устройства за превенция на скелетно-мускулни аномалии;

- скрининг на природни и синтетични биологично-активни съединения с използване на

молекулно моделиране;

- развитие и приложение на информационните технологии и математическите методи в

биомедицината;

- моделиране, оптимизация и управление на биопроцесни системи и апарати;

- многопосочни биофизични изследвания на невро-мускулни елементи в норма и

патология;

- разработка на биосензори;

- изследвания върху оксидативния стрес при здрави и онкогентрансформирани клетки;

- моделни изследвания върху клетъчни мембрани;

- изследване влиянието на физически фактори върху биоматериали, в т.ч. и

наноструктурирани;

- изследвания върху молекулярните механизми на паметта;

- подготовка на високоспециализирани кадри по биофизика за нуждите на медицината и

екологията (в обхвата на ОП “Човешки ресурси”), на магистри-инженери в областта на

информационните технологии в медицината, на докторанти по тематичните

направления на Института.

1.4. Полза/ефект за обществото от извършваните дейности по точка 1.3.

Здравен ефект и превенция при социално значими заболявания:

- за нуждите на клиничната медицина и спешната медицинска помощ са реализирани

разработки за подобряване точността на автоматичния анализ на

електрокардиографските сигнали в автоматични външни дефибрилатори и за

подобряване на енергетичните параметри на дефибрилацията;

- за нуждите на клиничната кардиология са проведени изследвания върху

приложимостта на електрокардиографски показатели за диагностика на трудни

диференциално-диагностични нозологични синдроми – кардиален Х синдром,

синдром на Brugada;

- разработено е пилотно устройство за превенция на гръбначни изкривявания при

подрастващи;

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- проучени са свойствата на нови антитуберколозни средства, на антиоксиданти и

токсични вещества;

- получени са оригинални резултати за изясняване механизмите на различни

невропатии;

- предложен е нов подход за изследване на множествена миелома;

- проучени са фактори, оказващи влияние върху фармакологичната активност на

антипсихотичните лекарства.

Разработки, свързани с възможности за внедряване на нови технологии, устройства и

материали:

- предложен е метод за разработване и приложение на нов клас биосензори;

- разработва се иновативна компютърно-подпомагаща технология за определяне

началото на отвикване от принудителна белодробна вентилация за нуждите на

интензивната медицина;

- разработен е клиничен апаратен комплекс за третиране на кожни тумори при пациенти

със сърдечни заболявания;

- получени са нови резултати върху повлияването на множествената лекарствена

резистентност в туморни клетки;

- разработена е серия устройства, в т.ч. и с безжичен интерфейс към пациента, за

високочестотно отвеждане на електро- и векторкардиограми с възможност за

синхронно осредняване, анализ, измерване на вариабилитета на сърдечния ритъм,

визуализация и организиране на пациентни бази данни.

Разработки, свързани с опазване на околната среда и подобряване качеството на

живот:

- предложен е високочувствителен метод за регистрация на ниски концентрации

хербициди, блокиращи функция на фотосинтетичния апарат;

- проучени са фактори, имащи влияние върху ежедневния оксидативен стрес в

съвременните условия на живот;

- с методите на компютърното моделиране на биологично-активни съединения са

анализирани данни за екотоксичност на седиментни замърсители във водни басейни.

Подготовка на високоспециализирани кадри в национален мащаб:

- създадена е и успешно се реализира система за обучение на кадри с биофизична

подготовка за нуждите на медицината и екологията в рамките на ОП “Човешки

ресурси” и с усвояване на средства по програмата;

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- провежда се непрекъснато обучение на докторанти за нуждите на висши медицински и

технически училища и водещи национални здравни звена.

1.5. Взаимоотношения с институциите

- Договор за съвместна дейност № 126/11 от 2001 с Университетска болница

“Александровска”

- Договор за съвместна дейност № 177 от 2008 г. с ФЕТТ, Техническия университет –

София

- Рамково споразумение от 31.01.2001 г. с Университетска МБАЛ “Св. Анна” – София

- Рамков договор за сътрудничество от 12.03.2004 г. с Нов български университет

- Рамков договор за съвместна дейност от 17.08.2006 г. с Националната кардиологична

болница

- Договор за сътрудничество от 26.03.2008 г. с Университет “Проф. Асен Златаров” –

Бургас

- Рамково споразумение от 14.10.2008 г. с УСБАЛ по неврология и психиатрия "Св.

Наум" – София

- Рамково споразумение от 12.10.2008 г. с Университетска СБАЛСМ “Н. Пирогов”

- Рамков договор от 2009 г. с Медицински Университет – Плевен

Споразумения с други национални научни организации или висши училища, със

съпътстващи научни програми с:

• Медицински Университет – Варна

• Физически факултет, СУ "Св. Кл. Охридски"

• Съвет по Медицинска Наука към МУ – София

• Медицински факултет на Тракийски Университет – Стара Загора

1.6. Общонационални и оперативни дейности, обслужващи държавата

1.6.1. Практически дейности, свързани с работата на национални правителствени и

държавни институции, индустрията, енергетиката, околната среда, селското

стопанство, национални културни институции и др. /относими към получаваната

субсидия/.

Учени от ИБФБМИ през изтеклата година са участвали в работата на следните

органи, извършващи общонационални и оперативни дейности, обслужващи държавата:

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Координационен съвет за електронно здравеопазване към Министерство на

здравеопазването; Национална агенция за оценяване и акредитация към Министерски

съвет; Държавната агенция за насърчаване на малки и средни предприятия; Държавна

агенция по метрология и технически надзор; Български институт за стандартизация.

1.6.2. Проекти, свързани с общонационални и оперативни дейности, обслужващи

държавата и обществото, финансирани от национални институции (без Фонд

“Научни изследвания”), програми, националната индустрия и пр. - до ТРИ най-

значими проекти

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2. Резултати от научната дейност през 2012 г.:

2.1. Най-важно и ярко научно постижение

Доказано е, че влиянието на електропорацията върху клетъчната адхезивност е клетъчно

специфично. Инвазивният клетъчен тип (MDA231) реагира с повишена адхезивност,

докато неинвазивният (MCF7) и соматичният тип клетки (MCF-10A) реагират с

намаляване на клетъчната адхезивност. Клетките от инвазивен тип под въздействие на

електрично поле оформят еднакво добре клетка-субстрат и клетка-клетка адхезиите, а

неинвазивният клетъчен тип увеличава образуването на междуклетъчни контакти.

Прилагането на електро(химио)терапия съчетава два ефекта на елeктричното поле:

намаляване на дозите прилагани цитостатици чрез повишаване на тяхната локална

концентрация (създаване на пори в мембраната) и адхезивен ефект, който води до промяна

на актиновия цитосклет, намалена подвижност и инвазивност на трансформираните

клетки. По такъв начин електропорацията придобива нов, допълнителен анти-туморен

ефект, който може да бъде наречен “адхезивен ефект”.

Ръководители на разработката: проф. дбн Яна Цонева и и доц. д-р Румяна Цонева

2.2. Най-важно и ярко научно-приложно постижение

Въз основа на междуакадемичен проект на БАН и CNR, Италия, и с участие на

водещи специалисти от Националната кардиологична болница, е разработен метод за

откриване и количествена оценка на визуално неразпознаваеми периодични промени в

камерната деполаризационна електрична активност на сърцето. Методът е базиран върху

оригинален алгоритъм за откриване и количествена оценка на периодични промени в Т-

вълната върху електрокардиограмата, отличен с първо място на IX ежегоден

международен конкурс на PhysioNet, 2008г. в Болоня, Италия. През 2012 г. методът е

внедрен в Националната кардиологична болница и в резултат от клинични

електрокардиографски изследвания с натоварване бе доказано статистически достоверно

наличие на периодични промени в камерната деполаризация (в QRS-комплекса на

електрокардиограмата) при пациенти с диабет, за разлика от деполаризационния процес

при пациенти без диабет. Този резултат е публикуван за първи път в научната литература.

Ръководител на разработката: проф. дтн Ивайло Христов.

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3. Международно научно сътрудничество на звеното

3.1. През годината служители на звеното работиха по следните теми в рамките на

договори и спогодби на ниво Академия:

3.1.1. Откриване и анализ на миниатюрни периодични промени на QRS комплекса и

Т вълната в електрокардиографски сигнали, Италиански национален съвет за

научни изследвания (ISIB-CNR), 2010-2012, ръководител проф. дтн Ивайло Христов.

3.1.2. Светлинно-индуцирано преобразуване на енергия и молекулна динамика в

ретинални белтъци. Приложение в биоелектрониката, Унгарска академия на

науките, 2010-2012, ръководител проф. дбн Стефка Танева

3.1.3. Създаване на модел на мускул на плъх съставен от реалистичен брой двигателни

единици и неговото експериментално и моделно изследване чрез прилагане на

различни серии от импулси за всяка двигателна единица, Полска академия на

науките, 2010-2012, ръководител проф. дтн Росица Райкова

3.1.4. Експериментално и моделно изследване на движенията на горния крайник на

човека в норма и при патологии чрез използване на повърхностна

електромиография и MOTCO софтуер, Полска академия на науките, 2012-2015,

доц. д-р Христо Аладжов

3.1.5. Състав и функции на каротеноиди в светосъбиращия комплекс на фотосистема 1,

Испания, Испания, 2011-2012, ръководител проф. д-р Мая Величкова

3.1.6. Роля на модифицирането на липидния, каротиноидния и белтъчен състав върху

структурната организация и функционална активност на фотосинтетичния апарат,

Унгарска академия на науките, 2010-2012, ръководител проф. д-р Емилия

Апостолова

3.1.7. Формиране на паметта: ефект на холинергичната система върху локалната

мозъчна протеинова синтеза, Италиански национален съвет за научни изследвания

(ISIB-CNR), 2010-2012, ръководител доц. д-р Полина Петкова-Кирова

3.1.8. Интуиционистки размити множества, интуиционистки размита оптимизация –

теория и приложения в медицината, екологията и други области, Полска академия

на науките, 2012-2014, ръководител чл. кор. дтн дмн Кр. Атанасов

3.1.9. Интуиционистки размити множества – теория и приложения, Словашка академия

на науките, 2012-2014, ръководител чл. кор. дтн дмн Кр. Атанасов

3.1.10. Геометрични аспекти на еластичните среди: от биомембрани до нанотубите,

Полска академия на науките, 2012-2014, ръководител доц. д-р И. Младенов

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3.1.11. Роля на супрамолекулярната организация на комплекса ФС2-ССК2 в изопрен-

отделящи растения и връзката й с термозащитата, Унгарска академия на науките,

2010-2012, ръководител доц. д-р Цонко Цонев, ИФРГ-БАН

3.2. През годината служители на звеното работиха по следните теми в рамките на

договори и спогодби на ниво сътрудничество между институти:

3.2.1. Анализ на цифрови електрокардиографски данни, рамков договор с ISIB-CNR,

Италия и St George’s University of London, ръководител проф. дтн Ивайло Христов.

3.2.2. Обобщеномрежови модели и интуиционистки размити множества в

интелигентните системи, Royal Society International Joint Project, Ref. №JP100372,

Westminster University, London, UK, ръководител чл. кор. дмн дтн Красимир

Атанасов.

3.2.3. Моделиране на АBC (АТФ-свързващи) транспортни протеини и техни субстрати и

инхибитори, участващи в множествената лекарствена резистентност и ADME

(Резорбция, Разпределение Метаболизъм, Екскреция), Университет Бон, Германия,

ръководител проф. дбн Илза Пъжева.

3.2.4. Моделиране, оптимизация и управление на ферментационни процеси, Рамково

споразумение с Институт по техническа химия – Университет Хановер,

Германия, ръководител проф. дтн Стоян Цонков

Най-значими международно финансирани проекти:

FP7-HEALTH-2010-Alternative-Testing-Strategies Collaborative project: “Integrated

in silico Models for the Prediction of Human Repeated Dose Toxicity of Cosmetics to Optimise

Safety”, Coordinator: Prof. Dr. M. Cronin, local coordinator: Assoc. Prof. Dr. I. Tsakovska.

4. Участие на звеното в подготовката на специалисти

Специалисти от звеното са чели лекции и водили упражнения в:

• Софийски Университет „Св. Климент Охридски”

• Химикотехнологичен и металургичен университет – София

• Медицински Университет – София

• Технически Университет – София

• Бургаски Технически Университет “Проф. А. Златаров”

• Бургаски Свободен Университет

• Пловдивски Университет

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Специалисти от звеното са провели и 5 докторантски курса.

Специалисти от звеното са чели лекции и водили упражнения и във връзка с изпълнение

на Lifelong Learning Programme: Higher Education (Erasmus) с:

• University Paris-Diderot – Paris VII

• Химикотехнологичен и металургичен университет – София

Образователната и научна степен “доктор” – защитили осем докторанти:

1. Цветан Николаев Мудров: Изследване и разработване на високоволтови генератори

за външна дефибрилация и електропорация, ръководител проф. дтн Иван Доцински,

консултант доц. д-р Весела Кръстева

2. д-р Светлин Недков Цонев: Кардиологичен синдром Х при жени - клинична,

инструментална и лабораторна характеристика, ръководител проф. д-р Михаил

Матвеев

3. Кристиян Иванов Тахтаков: Техническо устройство за превенция на сколиотични

деформации и експериментални изследвания на активността на мускулите на гърба,

ръководител проф. дтн Росица Райкова

4. Теодора Иванова Апостолова: Влияние на микровълново електромагнитно поле върху

електрическата, механичната и ензимна активност и конформация на белтъците в

скелетен мускул на жаба, ръководител доц. д-р Николина Радичева

5. Теодора Василева Лупанова: Структурна организация и функционална активност на

мембранните липиди в норма и в условия на оксидативен стрес, ръководител

проф. дбн Албена Момчилова.

6. Ивелина Миткова Вардева: Модели на процеси в мрежова сигурност чрез обобщени

мрежи, ръководители проф. дмн дтн Красимир Атанасов, ИБФБМИ, и доц. д-р Сотир

Сотиров, Университет “Проф. А. Златаров” – Бургас

7. Радослав Тодоров Цветков: Интуиционистки размити интеграли и тяхното

приложение при вземане на решения, ръководител проф. дмн дтн Красимир Атанасов,

ИБФБМИ, и доц. дтн Eulalia Szmidt, Institute of Systems Research, Polish Academy of

Sciences

8. Мариана Цветанова Хаджилазова: Геометрия на моделни биомембрани. Теория и

приложение, ръководител доц. д-р Ивайло Младенов.

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4.1. Получени през годината стипендии (брой, вид и размер на стипендията),

без стипендиите, получавани от докторантите по държавна поръчка:

а) от чужбина

• 4 стипендии /3-ма дипломанти и 1 редовен докторант/ по 480 евро по договор

COST - action DT1104, за участие в Международен курс “Electroporation for

Medicine, Basic Knowledge, Applications and Technologies”, October 25-27, 2012,

Bucharest, Romania.

• 1 стипендия за провеждане на научни изследвания на фондация "Александър фон

Хумболт" с продължителност 3 мес., 2450 Евро/месец

б) от България

5. Иновационна дейност на звеното

и анализ на нейната ефективност

5.1. Осъществяване на съвместна иновационна дейност с външни организации и

партньори, вкл. поръчана и договорирана с фирми от страната и чужбина;

През 2012 г. сътрудници на ИБФБМИ са работили с партньори по внедряване на

иновации, произтекли от съвместни разработки в Института:

- със Специализираната болница за активно лечение на онкологични заболявания –

Национална онкологична болница: модифицирана е методиката за електрохимиотерапия и

е създадена нова апаратура за електрохимиотерапия, която позволява да се третират

тумори при пациенти с кардиологични проблеми. Апаратурата е прилагана успешно през

2012 г. в Клиниката по дерматология на СБАЛО, София.

- с Университетска МБАЛ “Александровска” – за проучване на клиничните,

биохимичните и регулаторните характеристики при жени с кардиален Х-синдром;

- с Националната кардиологична болница – за оптимизиране енергията на

електрическите импулси при кардиоверсии;

- с Университетска МБАЛСМ “Н. И. Пирогов” – за внедряване на система за

компютърно подпомагане на решенията за отвикване от апаратна вентилация при

зависими от респиратора критично болни;

- с УМБАЛ "Св. Анна" - София - апаратура за безжично отвеждана високочестотна

електрокардиограма с възможност за Холтер изследване и анализ на ВСР;

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- с УМБАЛ "Св. Анна" - София и Университетска МБАЛ “Александровска” –

16-канална апаратура за отвеждане на електро- и вектор-кардиограма и дихателен сигнал с

висока разделителна способност.

5.2. Извършен трансфер на технологии и/или подготовка за трансфер на технологии

по договор с фирми; данни за полученото срещу това заплащане; данни за

реализираните икономически резултати във фирмите (работни места, печалба,

производителност, дял на новите продукти в общия обем на продажбите и т.н.);

През отчетната година продължиха дейности, свързани с трансфер на

инженерингови решения в областта на програмно-апаратното осигуряване на

електрокардиологията по договор с швейцарската фирма Schiller AG. За 2012 г.

трансферът е финансиран от фирмата в размер на 3 000 Евро.

6. Стопанска дейност на звеното за 2012 г.

6.1. Осъществяване на съвместна стопанска дейност с външни организации и

партньори /продукция, услуги и др., които не представляват научна дейност на

звеното/, вкл. поръчана и договорирана с фирми от страната и чужбина

6.2. Отдаване под наем на помещения и материална база;

Договорните отношения с фирмите ЕТ “Ласто-Лазар Стойчев”и “Шиллер –

Инженеринг София ЕООД продължават и през 2012 г. Отдадените под наем помещения и

материална база се поддържат в добро техническо състояние. Не са установени

закъснения в изплащането на наема и консумативните разходи.

6.3. Сведения за друга стопанска дейност;

Като форма на административно-стопанската дейност през 2012 г. могат да бъдат

определени такива дейности, като поддържане и ремонт на сградния фонд, поддържане на

прилежащите към него терени, изпълнението на мероприятия по безопасни и

здравословни условия на труд за работещите, противопожарна безопасност и др.

Ремонтните дейности, като ремонт на работни и санитарни помещения,

техническите съоръжения в отделните помещения, ВиК системата и абонатната станция за

топлоподаване се поддържат със средства и труд на института. През 2012 г. по нареждане

на ЦУ – БАН, бл.108 беше отписан от активите на ИБФБМИ и предаден на новите

собственици ИМБ- БАН и Институт по археология – БАН. С цел създаване на безопасни

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условия на труд за работещите, през 2012 г. се направи обследване на звеното по

отношение на противопожарна и аварийна безопасност, проведе се профилактичен

преглед на служителите в института.

Последното тримесечие се организира и проведе инвентаризация на всички

материални активи в института, съгласно закона за счетоводството. Специални комисии,

които отчетоха техническото състояние на отделните уреди, апарати и технически

средства, извършиха бракуване на негодната и морално остаряла техника и нейното

ликвидиране.

В рамките на възможностите и в зависимост от климатичните условия се правят

икономии на електрически ток, топлоенергия и вода, като заслугата за това се пада на

помощния персонал на института. С негова помощ се поддържа и районът около сградите

и зелените площи, особено през есенно-зимния сезон.

През 2012 г. бяха продължени договорите:

− с фирма “Агроинсект” ООД за борба с разни инсекти за обработки на работните места

по предварително изготвен и съгласуван график;

− с фирма ЕТ “ЕВРОШ-ВАНЬО НИКОЛОВ” за извозване на отпадъците на звеното;

− с охранителна фирма “3С СОТ” – АД.

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7. Кратък анализ на финансовото състояние на звеното за 2012 г.

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8. Издателска дейност

1. International Journal Bioautomation (ISSN 1314-2321 on-line), (ISSN 1314-1902 print)

Почетен главен редактор: Стоян Цонков

Главен редактор: Михаил Матвеев

Зам. гл. редактор: Таня Пенчева

През 2012 г. излязоха 3 броя, а 4-я е в процес на публикуване.

Списанието се реферира редица международни бази данни: Chemical Abstract

Service, Directory of Open Access Journals, Electronic Journals Library, Scopus, SCIRUS,

OhioLINK - Electronic Journal Finder, Electronic Journals by Publisher/University of

Saskatchewan Library, FHH - Bibliothek - Elektronische Zeitschriften, Elektronische

Zeitschriftenbibliothek, Universitätsbibliothek TU Berlin: E-Zeitschriften/EZB, Electronic

Journals, Medical informatics, bioinformatics, biomedical engineering: Free medical journals,

Google Scholar, Винити. Списанието е под наблюдение и в процес на оценяване от ISI Web

of Knowledge. От 2008 г. списанието е официално издание на БАН и периодично бе

подкрепяно финансово от Издателския съвет към Академията – през 2012 г. с 900 лв.

В края на 2011 г. Редакционния съвет спечели проект за подкрепа на научни списания от

Фонд “Научни изследвания”, така че издаването на Int J Bioautomation през 2012 г. беше

спонсорирано с 4 188 лв.

2. Notes on Intuitionistic Fuzzy Sets (ISSN-1310-4926)

Редактори Красимир Атанасов, Humberto Bustince (Испания) и Janusz Kacprzyk

(Полша)

Излезли от печат 4 книжки.

3. Notes on Number Theory and Discrete Mathematics (ISSN-1310-5132)

Редактори Aldo Peretti (Аржентина), Anthony Shannon (Австралия) и

Красимир Атанасов

Излезли от печат 4 книжки.

4. Proceedings of the Thirteenth International Conference on Geometry, Integrability and

Quantization, Avangard Prima, Sofia 2012, Eds. Mladenov I., A. Ludu,

A. Yoshioka, pp. 300, ISSN 1314-3247.

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9. ПРИЛОЖЕНИЯ

Списък на публикациите към Приложение 3:

3.1. Списък на публикациите, които са реферирани и индексирани в световната система за рефериране, индексиране и оценяване (в световни вторични литературни източници): - излезли от печат 1. Alzebdi M., P. Chountas, K. Atanassov. Approximate XML Query Matching and

Rewriting Using Intuitionistic Fuzzy Trees. Proc. of the 6th IEEE Int. Conf. “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 200-205, ISBN 978-1-4673-2277-5.

2. Andonov V., M. Stefanova-Pavlova, T. Stoyanov, M. Angelova, G. Cook, K. Klein, K. Atanassov, P. Vassilev. Generalized Net Model for Telehealth Services, Proc. of the 6th IEEE Conf. “Intelligent Systems”, Sofia, Bulgaria 6-8 September, 2012, Vol. 2, 221-224, ISBN 978-1-4673-2277-5.

3. Angelov B., A. Angelova, V. M. Garamus, M. Drechsler, R. Willumeit, R. Mutafchieva, P. Stepánek, S. Lesieur. Earliest Stage of the Tetrahedral Nanochannel Formation in Cubosome Particles from Unilamellar Nanovesicles. Langmuir, 28, 2012, 16647-16655, DOI: 10.1021/la302721n, ISSN 0743-7463.

4. Angelova M., K. Atanassov, T. Pencheva. Intuitionistic Fuzzy Estimations of Purposeful Model Parameters Genesis. Proc. of the 6th IEEE Conf. “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 206-211, ISBN 978-1-4673-2277-5.

5. Angelova M., K. Atanassov, T. Pencheva. Multi-population Genetic Algorithm Quality Assessment Implementing Intuitionistic Fuzzy Logic. Proceedings of Federated Conference on Computer Sciences and Information Systems (Workshop on Computational Optimization – WCO'2012), Wrocław, Poland, 9-12 September 2012, 365-370, ISBN 978-83-60810-51-4.

6. Angelova M., K. Atanassov, T. Pencheva. Purposeful Model Parameters Genesis in Simple Genetic Algorithms. Computers & Mathematics with Applications, 64, 2012, 221-228, ISSN 0898-1221.

7. Angelova M., K. Atanassov, T. Pencheva. Intuitionistic Fuzzy Logic based Quality Assessment of Simple Genetic Algorithm. Proceedings of the 16th International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania, 12-14 October 2012, ISBN 978-606-8348-48-3, Electronic edition.

8. Angelova M., P. Melo-Pinto, T. Pencheva. Modified Simple Genetic Algorithms Improving Convergence Time for the Purposes of Fermentation Process Parameter Identification. WSEAS Transactions on Systems, 11(7), 2012,256-267, E-ISSN 2224-2678.

9. Angelova M., T. Pencheva. Algorithms Improving Convergence Time in Parameter Identification of Fed-batch Cultivation. Comptes rendus de l'Académie bulgare des Sciences, 65(3), 2012, 299-306, ISSN 1310-1331.

10. Angelova M., T. Pencheva. Sensitivity Analysis for the Purposes of Parameter Identification of a S. cerevisiae Fed-batch Cultivation. Lecture Notes on Computer Science, 7116, 2012, 165-172, ISBN 978-3-642-29842-4.

11. Angelova P., A. Momchilova, D. Petkova, G. Staneva, R. Pankov, Z. Kamenov. Testosterone Replacement Therapy Improves Erythrocyte Membrane Lipid Composition in Hypogonadal Men. Aging Мale, 15(3), 2012, 173-179, ISSN 13685538.

12. Antonov A., S. Hadjitodorov. Concurrent Algorithm for Learning of Neural Networks, Proc. of the 6th IEEE Int. Conf. “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 225-228, ISBN 978-1-4673-2277-5.

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13. Atanassov K. A Modification of an Elementary Numerical Inequality. Notes on Number Theory and Discrete Mathematics, 18, No. 3, 2012, 5-7, ISSN 1310-5132.

14. Atanassov K. Note on ϕ, ψ and σ-functions. Part 5. Notes on Number Theory and Discrete Mathematics, Vol. 18, No. 1, 2012, 58-62, ISSN 1310-5132.

15. Atanassov K. On the Game Method for Modelling. Advanced Studies in Contemporary Mathematics, Vol. 22, No. 2, 2012, 189-207, ISSN 1229-3067.

16. Atanassov K. Remark on the Hollow Triangular and . Notes on Number Theory and Discrete Mathematics, Vol. 18, No. 4, 2012, 71-72, ISSN 1310-5132.

17. Atanassov K. Short Remarks on Jacobsthal Numbers. Notes on Number Theory and Discrete Mathematics, Vol. 18, No. 2, 2012, 63-64, ISSN 1310-5132.

18. Atanassov K. A Property of the Intuitionistic Fuzzy Implications. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 2, 2012, 1-12, ISSN 1310-4926.

19. Atanassov K. A Variant of Craig's Interpolation Theorem for Intuitionistic Fuzzy Formulas. Part 2. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 2, 2012, 51-52, ISSN 1310-4926.

20. Atanassov K. Intuitionistic Fuzzy Implication →C and Negation ¬C. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 4, 2012, 1-7, ISSN 1310-4926.

21. Atanassov K. On the Operators Partially Extending the Extended Intuitionistic Fuzzy Operators from Modal Type. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 3, 2012, 16-22, ISSN 1310-4926.

22. Atanassov K., S. Sotirov. Representation of the Neural Networks by the Game Method for Modeling. Advanced Studies in Contemporary Mathematics, Vol. 22, No. 3, 2012, 347-354, ISSN 1229-3067.

23. Atanassova L., K. Atanassov. On a Game-Method for Modelling with Intuitionistic Fuzzy Estimations: Part 1. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 7116, 2012, 182-189, ISSN 0302-9743.

24. Atanassova V. Generalized Nets with Volumetric Tokens. Comptes rendus de l’Academie bulgare des Sciences, 65(11), 2012, 1489-1498, ISSN 1310-1331.

25. Atanassova V. The Minimal Solution of a Problem in Generalized Nets. Proc. of the 6th IEEE Int. Conference on Intelligent Systems ‘2012, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 159-163, ISBN 978-1-4673-2277-5.

26. Atanassova V., S. Fidanova, P. Chountas, K. Atanassov. A Generalized Net with an ACO-Algorithm Optimization Component. Lecture Notes in Computer Science, Springer, Germany, 7116, 2012, 190-197, ISSN 0302-9743.

27. Atanassova V., S. Sotirov. A New Formula for De-i-fuzzification of Intuitionistic Fuzzy Sets. Notes on Intuitionistic Fuzzy Sets, 18(3), 2012, 49-51, ISSN 1310-4926.

28. Bortolan G., I. Christov, I. Simova, N. Dimitrov, I. Jekova, V. Krasteva. Clinical Characterization by Principal Component Analysis of ECG in Stress Test. Computing in Cardiology, 39, 2012, 613-616, ISSN 0276-6574.

29. Bortolan G., I. Christov, T-wave Alternans Detection by a Combined Method of Principal Component Analysis and T-wave Amplitude. Physiological Measurement, 33, 2012, 333-343, ISSN 0967-3334.

30. Bureva V., E. Sotirova, K. Atanassov. New operations over intuitionistic fuzzy index matrices. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 4, 2012, 12-18, ISSN 1310-4926.

31. Busheva M., I. Tzonova, K. Stoitchkova, A. Andreeva. Heat-induced Reorganization of the Structure of Photosystem II Membranes: Role of Oxygen Evolving Complex. J. Photochem. Photobiol. B: Biol., 117, 2012, 214-221, ISSN 1873-2682.

32. Cerbai F., D. Lana, D. Nosi, P. Petkova-Kirova, S. Zecchi, H. M. Brothers, G. L. Wenk, M. G. Giovannini. The Neuron-astrocyte-microglia Triad in Normal Brain Ageing and in a

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Model of Neuroinflammation in the Rat Hippocampus. PLoS One, 7(9):e45250. doi: 10.1371/journal.pone.0045250, 2012, eISSN-1932-6203.

33. Christov I., G. Bortolan, I. Simova, T. Katova, T Wave and QRS Complex Alternans during Stress ECG Testing according to the Presence or Absence of Diabetes Mellitus. Journal of Endocrinology and Metabolism, 2(1), 2012, 32-38, ISSN 1923-287X.

34. Çiçek N., I. Fedina, H. Çakırlar, K. Georgieva, M. Velitchkova. The Role of Short-term High Temperature Pre-treatment on UV-B Tolerance of Barley Cultivars. Turk. J. Agric. Forest, 36, 2012, 153-165, ISSN 1300-011X.

35. Dimitrov A. G., N. A. Dimitrova. A Possible Link of Oxaliplatin-Induced Neuropathy with Potassium Channel Deficit. Muscle Nerve, 45(3), 2012, 403-411, ISSN 0148-639X.

36. Dimitrov A. G., N. A. Dimitrova. Author Reply to: Wu SN, Lo YC, Chen BS, Cheung So E, Chen LT., Contribution of Blocked Potassium Current Conductance and Increased Conductance of Persistent Sodium Current to the Afterdischarge in Myelinated Neuron. Muscle Nerve, 46(2), 2012, 297-299, ISSN 0148-639X.

37. Dimitrov D. G., M. Marinov. On the Representation of Kahn Process Networks by a Generalized Net. Proc. of the 6th IEEE Int. Conference on Intelligent Systems ‘2012, Sofia, Bulgaria, 6-8 September 2012, 168-172, ISBN 978-1-4673-2277-5.

38. Dimitrov V. G., T. I. Arabadzhiev, N. A. Dimitrova, G. V. Dimitrov. The Spectral Changes In EMG During A Second Bout Eccentric Contraction Could Be Due To Adaptation In Muscle Fibres Themselves: A Simulation Study. European Journal of Applied Physiology, 112(4), 2012, 1399-1409, ISSN 1439-6319 (print), ISSN 1439-6327 (electronic).

39. Dimitrova D. Z., A. S. Alexandrov. Ghrelin: An Unique Functional System. Endokrinologya, 17(1), 2012, 13-25, ISSN 1310-8131.

40. Djondjorov P., V. Vassilev, I. Mladenov. Deformation of Injected Vesicles Adhering Onto Flat Rigid Substrates. Computers & Mathematics with Applications, 64, 2012, 214-220, ISSN 0898-1221.

41. Djondjorov P., V. Vassilev, M. Hadzhilazova, I. Mladenov. Analytic Description of the Viscous Fingering Interface in a Hele-Shaw Cell. Geometry, Integrability and Quantization, 13, 2012, 107-113, ISSN 1314-3247.

42. Dobrev D., T. Neycheva. Increased Power-line Interference Rejection by a Stray Capacitance Drive. Annual Journal of Electronics, 6(1), 2012, 12-15, ISSN 1314-0078.

43. Dobrev D., T. Neycheva. Simple Two-electrode Bootstrapped Non-differential Biopotential Amplifier. Annual Journal of Electronics, 6(1), 2012, 8-11, ISSN 1314-0078.

44. Dotsinsky I., B. Nikolova, E. Peycheva, I. Tsoneva. New Modality for Electrochemotherapy of Surface Tumors. Biotechnol. Biotechnolog. Eq., 26 (6), 2012, 3402-3406, ISSN 1310-2818.

45. Escoffre J-M., B. Nikolova, J. Henri, C. Favard, L. Mallet, J. Teissié, I. Tsoneva, M-P. Rols, New Sights in the Gene Electrotransfer Process: Evidence for Involvement of the Plasmid DNA Topology. Current Gene Therapy, 12(5), 2012, 417-422, ISSN 1666-5232

46. Fidanova S., O. Roeva, M. Ganzha. ACO for Parameter Settings of E. coli Cultivation Model. Proc. of the Federated Conference on Computer Science and Information Systems, WCO 2012, Wrocław, Poland, 9-12 September 2012, 407-414, ISBN 978-83-60810-51-4.

47. Georgieva N., R. Bryaskova, R. Tzoneva. New Polyvinyl Alcohol-Based Hybrid Materials For Biomedical Application. Materials Letters 88, 2012, 19-22, ISSN 2093-6788.

48. Hundertmark M., A. V. Popova, S. Rausch, R. Seckler, D. K. Hincha,. Influence of Drying on the Secondary Structure of Intrinsically Disordered and Globular Proteins. Biochem. Biophys. Res. Comm., 417, 2012, 122-128, ISSN 0006-291X.

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49. Iliev I., B. Nenova, I. Jekova, V. Krasteva. Algorithm for Real-time Pulse Wave Detection Dedicated to Non-invasive Pulse Sensing. Computing in Cardiology, 39, 2012, 777-780, ISSN 0276-6574.

50. Ilkova T., M. Petrov, O. Roeva. Optimization of a Whey Bioprocess Using Neuro-dynamic Programming Strategy. Biotechnology & Biotechnological Equipment, 26(5), 2012, 3249-3253, ISSN 1310-2818.

51. Ivanova P. I., V. Krasteva, E. L. Apostolova. Role of Organization of Photosynthetic Apparatus for its Sensitivity to Atrazine. Comp. rend. Acad. bulg. Sci., 65, 2012, 799-806, ISSN 1310-1331.

52. Jekova I., V. Krasteva, I. Christov, R. Abächerli. Threshold-based System for Noise Detection in Multilead ECG Recordings. Physiological Measurement, 33, 2012, 1473-1477, ISSN 0967-3334.

53. Jekova I., V. Krasteva, Z. Georgiev, L. Todorova, P. Vassilev, M. Matveev. Measurements of Ventilatory Signals during Volume Controlled and Pressure Support Ventilation to Predict the Weaning Outcome. Annual Journal of Electronics, 6(1), 2012, 27-30, ISSN 1314-0078.

54. Jereva D., I. Pajeva, T. Pencheva. Data Extraction Module – A Supplementary Tool for AMMOS_ProtLig Software Package. Comput. Math. Appl., 64(3), 2012, 266-271, ISSN 0898-1221.

55. Kosev K., O. Roeva. Generalized Net Model of the lac Operon in Bacterium E. coli. Proc. of 6th IEEE Conference on Intelligent Systems, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 237-241, ISBN 978-1-4673-2277-5.

56. Kosev K., T. Trenkova, O. Roeva. Tabu Search for Parameter Identification of an Fermentation Process Model. Journal of International Scientific Publication: Materials, Methods & Technologies, Vol. 6(2), 2012, 457-464, ISSN 1313-2539 (http://www.science-journals.eu/mmt/index.html).

57. Krasteva V., I. Jekova, E. Trendafilova, S. Ménétré, Ts. Mudrov, J. P. Didon. Study of Transthoracic Impedance Cardiogram for Assessment of Cardiac Hemodynamics in Atrial Fibrillation Patents. Int. J. Bioautomation, 16(3), 2012, 203-210, ISSN 1314-1902.

58. Krasteva V., I. Jekova, E. Trendafilova, T. Mudrov, S. Ménétré, J. P. Didon. Transthoracic Impedance Cardiogram Indicates for Compromised Cardiac Hemodynamics in Different Supraventricular and Ventricular Arrhythmias. Annual Journal of Electronics, 6(1), 2012, 23-26, ISSN 1314-0078.

59. Krutki P., J. Celichowski, R. Raikova. Motor Unit Contractions Evoked by Stimulation with Variable Interpulse Intervals. Biocybernetics and Biomedical Engineering, 32(3), 2012, 29-42, ISSN 0208-5216.

60. Lessigiarska I., I. Pajeva, P. Prodanova, M. Georgieva, A. Bijev. Structure-activity Relationships of Pyrrole Hydrazones as New Anti-tuberculosis Agents. Med. Chem., 8(3), 2012, 462-473, ISSN 1573-4064.

61. Lupanova T., D. Petkova, T. Markovska, G. Staneva, S. Chakarov, R. Skrobanska, R. Pankov, A. Momchilova. Effect of Cholesterol Modulation on the Antioxidant Potential of Quercetin in Rat Liver Plasma Membranes. Comptes Rendus de L’Academie Bulgare des Sciences, 65(5), 2012, 639-644, ISSN 13101331.

62. Marinov E., E. Szmidt, J. Kacprzyk, R. Tcvetkov. A Modified Weighted Hausdorff Distance Between Intuitionistic Fuzzy Sets. Proc. of the 6th IEEE Int. Conf. “Intelligent Systems”, Sofia, Bulgaria 6-8 September 2012, Vol. 2, 138-141, ISBN 978-1-4673-2277-5.

63. Marinov P., I. Mladenov. A Relation between the Cylindric Fluid Membranes and the Motions of Planar Curves. J. Geom. Symmetry Phys., 27, 2012, 93-102, ISSN 1312-5192.

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64. Matveev M, M. Milanova, K. Atanassov, V. Atanassova. Optimization of Emergency Management in Patients with Acute Coronary Syndromes in Big Urban District through Generalized Nets Model. J Clin Monit Comput, 26, 2012, 244-245, ISSN 1387-1307.

65. Matveev M., V. Krasteva, I. Jekova, G. Georgiev, S. Milanov, R. Prokopova, L. Todorova. Profile of the Autonomic Cardiac Control in Patients who are not Considered Ready for Weaning from Mechanical Ventilation. Computing in Cardiology, 39, 2012, 629-632, ISSN 0276-6574.

66. Matveev M., V. Krasteva, S. Tsonev, R. Prokopova, M. Milanova. Cardiac Syndrome X Electrocardiographic Patterns using Signal-averaged Orthogonal Leads and VCG Indices. Clinical Medicine and Diagnostics, 2(3), 2012, 15-19, ISSN 2163-1433.

67. Milanova M., M. Matveev, K. Atanassov, V. Atanassova, R. Prokopova. Optimization of Emergency Management in Patients with Acute Coronary Syndromes in Big Urban District. Intensive Care Medicine, 38, Suppl. 1, 2012, 155, ISSN 0342-4642.

68. Mladenov I., M. Hadzhilazova. Geometry of the Anisotropic Minimal Surfaces. An. St. Univ. Ovidius Constanta, 20, 2012, 79-88, ISSN 1224-1784.

69. Mladenov I., M.Hadzhilazova, P. Djondjorov, V. Vassilev. Serret’s Curves, Their Generalization and Explicit Parametrization. Geometric Methods in Physics, (Eds. P. Kielanowski, S. T. Ali, A. Odzijewicz, M. Schlichenmaier and Th. Voronov), Birkhauser, Basel, 2012, 383-390, ISBN 978-3-0348-0447-9.

70. Mladenova C., I. Mladenov. About Parametric Representations of SO(n) Matrices and Plane Rotations. AIP Conference Proceedings, 1487, 2012, 280-287, ISBN 978-0-7354-1099-2.

71. Mladenova C., I. Mladenov. An Approach for Decomposition of Finite Rotations. Proc. Appl. Math. Mech., 12, 2012, 45-46, ISSN 1617-7061.

72. Muradyan N., M. Klissurski, A. S. Alexandrov, B. Ishpekova. Repetitive Nerve Stimulation of Accessory Nerve in Diagnostic Assessment of Patients with Myasthenia Gravis. Comptes rendus de l'Academie bulgare des Sciences, 65(3), 2012, 411-418, ISSN 1310-1331.

73. Nikolova B., M. Georgieva, D. Savu, I. Tsoneva. Cell Membrane Alteration by Weak Alternating Electric Field at Low Frequency. Romanian Reports in Physics, 64(4), 2012, 1046-1052, ISSN 1221-1451.

74. Orozova D., K. Atanassov. Generalized Net Model of the Process of Selection and Usage of an Intelligent e-Learning System. Comptes Rendus de l'Academie bulgare des Sciences, 65, No. 5, 2012, 591-598, ISSN 1310-1331.

75. Parvathi R., V. Atanassova. Intuitionistic Fuzzy Statistical Tools for Filters in Image Processing. Proc. of the 6th IEEE Int. Conference on Intelligent Systems ‘2012, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 150-152, ISBN 978-1-4673-2277-5.

76. Pavlov Y., P. Vassilev. Preferences and Determination of the Nominal Growth Rate of Fed-batch Process: Control Design of Complex Processes. Biotechnology and Biotechnological Equipment, 26(5), 2012, 3254-3259, DOI: 10.5504/bbeq.2012.0064, ISSN 1310-2818.

77. Pehlivanova V., I. Tsoneva, R. Tzoneva. Multiple Effects of Electroporation on the Adhesive Behaviour of Breast Cancer Cells and Fibroblasts. Cancer Cell International, 12:9, 2012, art. no 9, ISSN 12211451.

78. Pencheva T., N. Novachev, D. Stratiev, K. Atanassov, Generalized Net Model of the Process of Evaluation of the Environmental Impact of Refinery Activity Using Intuitionistic Fuzzy Estimations. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 4, 2012, 32-39, ISSN 1310-4926.

79. Petkova D., G. Staneva, T. Markovska, I. Iliev, I. Ivanova, R. Pankov, S. Chakarov, A. Momchilova. Fructooligosaccharide Intake Alters the Phospholipid and Fatty Acid

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Composition of Liver Plasma Membranes. Biotechnology and Biotechnological Equipment, 26(2), 2012, 2904-2909, ISSN 13102818.

80. Petkova-Kirova P., M. G. Giovannini, R. Kalfin, A. Rakovska. Modulation of Acetylcholine Release by Cholecystokinin in Striatum: Receptor Specificity; Role of Dopaminergic Neuronal Activity. Brain Res Bull., 89(5-6), 2012, 177-184, ISSN 0361-9230.

81. Petrov M., T. Ilkova. Fuzzy-Decision-Making Problem of L-Lysine Production. Chemical and Biochemical Engineering Quarterly, 26(3), 2012, 257-265, ISSN 1846-5153.Online), ISSN 0352-

9568 (Print).

82. Pulov V., M. Hadzhilazova, K. Kardjilova, V. Lyutskanov, I. Mladenov. Helfrich’s Shape Model of Biological Membranes: Group Analysis, Determining System and Symmetries. Proceedings of the Third International Scientific Congress, TU Varna, Vol. 7, 2012, 271-275. ISBN 978-954-20-0556-8.

83. Rangasamy P., B. Riečan, K. Atanassov. Properties of Some Operations Defined over Intuitionistic Fuzzy Sets, Notes on Intuitionistic Fuzzy Sets. Vol. 18, No. 1, 2012, 1-4, ISSN 1310-4926.

84. Rangasamy P., S. Hadjitodorov, K. Atanassov, P. Vassilev. Generalized Net Model of an Intuitionistic Fuzzy Clustering Technique for Biomedical Data. Biotechnology and Biotechnological Equipment, 26(5), 2012, 3306-3309, DOI: 10.5504/bbeq.2012.0072, ISSN 1310-2818.

85. Rashkov G. R., A. G. Dobrikova, I. D. Pouneva, A. N. Misra, E. L. Apostolova. Sensitivity of Chlorella vulgaris to Herbicides. Possibility of using it as a Biological Receptor in Biosensors. Sensors & Actuators: B. Chemical, 161(1), 2012, 151-155, ISSN 0925-4005.

86. Ribagin S., V. Chakarov, K. Atanassov, Generalized Net Model of the Upper Limb Vascular System. Proc. of the 6th IEEE Int. Conf. “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, 229-232, ISBN 978-1-4673-2277-5.

87. Roeva O. A Hybrid Genetic Algorithm for Parameter Identification of Bioprocess Models. Lecture Notes on Computer Science, Springer, Germany, 7116, 2012, 247-255, ISSN 0302-9743.

88. Roeva O. Optimization of E. coli Cultivation Model Parameters Using Firefly Algorithm. Int. J. Bioautomation, 16(1), 2012, 23-32, ISSN 1314-2321 (on-line) 1314-1902 (print).

89. Roeva O., A. Shannon, T. Pencheva. Description of Simple Genetic Algorithm Modifications Using Generalized Nets. Proc. of IEEE 6th Conference on Intelligent Systems, , Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 178-183, ISBN 978-1-4673-2277-5.

90. Roeva O., T. Trenkova. Genetic Algorithms and Firefly Algorithms for Non-linear Bioprocess Model Parameters Identification. Proc. of the 4th International Joint Conference on Computational Intelligence (ECTA), Barcelona, Spain, 5-7 October 2012, 164-169, ISBN 978-989-8565-33-4.

91. Roeva O., T. Trenkova. Modelling of a Fed-batch Culture applying Simulated Annealing. BIOMATH, 1(2), 2012, 1-6, ISSN 1314-7218 (online), ISSN 1314-684X (print).

92. Roeva O., Ts. Slavov. Firefly Algorithm Tuning of PID Controller for Glucose Concentration Control during E. coli Fed-batch Cultivation Process. Proc. of the Federated Conference on Computer Science and Information Systems, WCO 2012, Wrocław, Poland, 9-12 September 2012, 455-462, ISBN 978-83-60810-51-4.

93. Roeva O., Ts. Slavov. PID Controller Tuning based on Metaheuristic Algorithms for Bioprocess Control. Biotechnology and Biotechnological Equipment, 26(5), 2012, 3267-3277, ISSN 1310-2818.

94. Shannon A., B. Riečan, D. Orozova, E. Sotirova, K. Atanassov, M. Krawczak, P. Melo-Pinto, R. Parvathi, T. Kim. Generalized Net Model of the Process of Selection and Usage

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of an Intelligent e-Learning System. Proc. of the 6th IEEE Int. Conf. “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 233-236, ISBN 978-1-4673-2277-5.

95. Shannon A., B. Riečan, E. Sotirova, G. Inovska, K. Atanassov, M. Krawczak, P. Melo-Pinto, T. Kim. A Generalized Net Model of University Subjects Rating with Intuitionistic Fuzzy Estimations, Notes on Intuitionistic Fuzzy Sets. Vol. 18, No. 3, 2012, 68-74, ISSN 1310-4926.

96. Slavov Ts., O. Roeva. Genetic Algorithm Tuning of PID Controller for Glucose Concentration Control using Software Sensor. WSEAS Transaction on Systems, 11(7), 2012, 223-233, E-ISSN 2224-2678.

97. Sotirova E., D. Dimitrov, K. Atanassov. On Some Applications of Game Method for Modeling. Part 1: Forest Dynamics. Proceedings of the Jangjeon Mathematical Society, Vol. 15, No. 2, 2012, 115-123, ISSN 1598-7264.

98. Sotirova E., N. Dobrinkova, K. Atanassov. On Some Applications of Game Method for Modeling. Part 2: Development of Forest Fire. Proceedings of the Jangjeon Mathematical Society, Vol. 15, No. 3, 2012, 335-342, ISSN 1598-7264.

99. Sotirova E., S. Sotirov, I. Vardeva, B. Riečan. Publication’s Assessment with Intuitionistic Fuzzy Estimations. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 4, 2012, 26-31, ISSN 1310-4926.

100. Stambolieva K., D. Diafas, V. Bachev, L..Christova, P.Gatev. Postural Stability of Canoeing and Kayaking Young Male Athletes during Quiet Stance. Eur. J. Appl. Physiology, 112, 2012, 1807-1815, ISSN 1439-6319.

101. Staneva G., N. Puff, M. Seigneuret, H. Conjeaud, M. I. Angelova, Segregative Clustering of Lo and Ld Membrane Microdomains Induced by Local pH Gradients in GM1-containing Giant Vesicles: A Lipid Model for Cellular Polarization. Langmuir, 28(47), 2012, 16327-16337, ISSN 07437463.

102. Stephanova D. I., S. M. Krustev, N. Negrev. Mechanisms Defining the Electrotonic Potential Abnormalities in Simulated Amyotrophic Lateral Sclerosis. J. Integr. Neurosci., 11(2), 2012, 155-167, ISSN 0219-6352.

103. Surchev J., L. Todorova, A. Hadjzhiyanev, K. Georgiev, A. William, M. Marinov. Mathematical Index for Comparing the Survival of Homogeneous Groups Ventricular Shunts. 23-th ESPN Congress, Amsterdam, The Netherlands, 1-5 May 2012, Child’s Nerv Syst, 28, No. 5, 803, ISSN 0256-7040 (Print) 1433-0350 (Online).

104. Surchev, J., L. Todorova, A. Hadjzhiyanev, K. Georgiev, A. William, M. Marinov. Correlation between the Types of Post-Shunt Complications and the Duration of the Interval to First Revision. 23-th ESPN Congress, Amsterdam, The Netherland, 1-5 May 2012, Child’s Nerv Syst, 28, No. 5, 803, ISSN 0256-7040 (Print) 1433-0350 (Online).

105. Tcheshmedjiev P. Practical Approach to Designing Processes with Generalized Nets and Linked Data Tokens. Proc. of 6th IEEE International Conference “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 164-167, ISBN 978-1-4673-2277-5.

106. Tcvetkov R., E. Szmidt, J. Kacprzyk, K. Atanassov. A Modified Hausdorff Distance between Intuitionistic Fuzzy Sets. Comptes Rendus de l'Academie bulgare des Sciences, Vol. 65, No. 8, 2012, 1035-1042, ISSN 1310-1331.

107. Todinova S., S. Krumova, P. Kurtev, V. Dimitrov, L. Djongov, Z. Dudunkov, S. G. Taneva. Calorimetry-based Profiling of Blood Plasma from Colorectal Cancer Patients. Biochimica et Biophysica Acta, 2012, Vol. 1820, 1879-1885, ISSN 0304-4165.

108. Todorova L., J. Surchev, P. Vassilev, P. Hadjistoykov. Application of Intuitionistic Fuzzy Sets for More Objective Comparison of Kaplan-Meier Curves. Proc. of IEEE 6th Conference on Intelligent Systems, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 212-215, ISBN 978-1-4673-2277-5.

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109. Todorova R., A. Atanasov. Diagnostic Strategies and Treatment for Ewing's Sarcoma. International Journal of Clinical Medicine, 3(6), 2012, 538-543, ISSN 2158-2882.

110. Todorova R. Disorder Structural Predictions of the Native EWS and its Oncogenic Fusion Proteins in Rapport with the Function. Advances in Bioscience and Biotechnology, 3(1), 2012, 25-34, ISSN 21568456.

111. Tzoneva R., B. Seifert, M. Behl, A. Lendlein. Elastic Multiblock Copolymers for Vascular Regeneration: Protein Adsorption And Hemocompatibility. Clinical Hemorheology and Microcirculation, 52 (2-4), 2012, 337-348, ISSN 1386-0291.

112. Vardeva I., K. Atanassov. Generalized Net Model for Protection of Patients’ Personal e-Data, Transmitted between Healthcare Information Systems over the Internet, Comptes Rendus de l'Academie bulgare des Sciences, Vol. 65, No. 3, 2012, 291-298, ISSN 1310-1331.

113. Vardeva I., V. Gochev. Calculation of Estimations of Messages by Generalized Nets and Intuitionistic Fuzzy Truth Values, Proc. of the 6th IEEE Int. Conf. “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 242-245, ISBN 978-1-4673-2277-5.

114. Vassilev P. Intuitionistic Fuzzy Sets with Membership and Non-membership Functions of Exponential Type. Proc. of IEEE 6th Conference on Intelligent Systems, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 145-149, ISBN 978-1-4673-2277-5.

115. Vassilev P. On the Intuitionistic fuzzy sets with Metric Type Relation between the Membership and Non-membership Functions. Proc. of 16th Int. Conf. on IFSs, Sofia, Bulgaria, 9-10 September 2012, Notes on Intuitionistic Fuzzy Sets, 18(3), 2012, 30-38, ISSN 1310-4926.

116. Vassilev P. Operators Similar to Operators Defined over Intuitionistic Fuzzy Sets. Notes on Intuitionistic Fuzzy Sets, Vol. 18, No. 4, 2012, 40-47, ISSN 1310-4926.

117. Vassilev V., P. Djondjorov, M. Hadzhilazova, I. Mladenov, J. Slawianowski, Equilibrium Shapes of Fluid Membranes and Carbon Nano-structures. Mechanics of Nanomaterials and Nanotechnology, Vol.3, IMECH, Sofia, Bulgaria, 2012, 153-154, ISSN 1314-3034.

118. Velizarova E., E. Sotirova, K. Atanassov, P. Vassilev, S. Fidanova. On the Game Method for the Forest Fire Spread Modelling with Considering the Wind Effect. Proc. of IEEE 6th Conference on Intelligent Systems, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 216-220, ISBN 978-1-4673-2277-5.

- приети за печат 1. Apostolova E. L. Effect of High-light on Photosynthetic Apparatus with Different Content

of Anionic Lipids and Organization of Light-harvesting Complex of Photosystem II. Acta Physiol. Plant., 2012, ISSN 0137-5881.

2. Arabadzhiev T. Peculiarities of Extracellular Potentials Produced by Deep Muscles. Part 1: Single Fibre Potential Fields. Medical and Biological Engineering and Computing, 2012, ISSN 0140-0118.

3. Arabadzhiev T., Peculiarities of Extracellular Potentials Produced by Deep Muscles. Part 2: Motor Unit Potentials. Medical and Biological Engineering and Computing, 2012, ISSN 0140-0118.

4. Dobrikova A. G., I. Domonkos, Ö. Sözer, H. Laczkó-Dobos, M. Kis, Á. Párduc, Z. Gombos, E. L. Apostolova. Effect of Partial or Complete Elimination of Light-harvesting Complexes on the Surface Electric Properties and the Functions of Cyanobacterial Photosynthetic Membranes. Physiol. Plantarum., 2012, doi: 10.1111/j.1399-3054.2012.01648.x, ISSN 1399-3054

5. Dobrikova A. G., V. Krasteva, E. L. Apostolova. Damage and Protection of the Photosynthetic Apparatus from UV-B radiation. I. Effect of Ascorbate. J. Plant Physiology, 2012, doi:10.1016/j.physletb.2003.10.071, ISSN 0176-1617.

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6. Dobrikova A., R. Vladkova, D. Stanoeva, A. Popova, M. Velitchkova. Effects of 24-epibrassinolide Pre-treatment on UV-B-induced Changes in the Pigment Content of Pea Leaves. Compt. rend. Acad. Bulg. Sci., 2012, ISSN 1310-1331.

7. Pechlivanova V., V. Usunova, I. Tsoneva, M. Berger, I. Ugrinova, R. Tsoneva. The Effect of Erufosine on Reorganization of Cytoskeleton and Cell Death in Adherent Tumor and Non-tumorigenic Cells. Biotechnol. Biotechnolog. Eq., ISSN 1310-2818.

8. Pencheva T., D. Jereva, M. Miteva, I. Pajeva. Post-docking Optimization and Analysis of Protein-Ligand Interactions of Estrogen Receptor Alpha using AMMOS Software. Curr. Comput. Aided Drug Des., 2012, ISSN 1573-4099.

9. Peshev R., L. Christova, New Data on Epidemiological Study of Bovine Herpesvirus 1 Strains. Comptes rendus de l'Academie bulgare des Sciences, 2012, ISSN 1310-1331.

10. Peshev R., L. Christova. Studies of Bovine Herpesvirus 1 Distribution in Bovine Population and Bulls from Artificially Insemination Centers and Private Farms in Bulgaria. Arhiv Veterinarske Medicine, 2012, ISSN, 1820-9955.

11. Peshev R., L. Christova. The Stress Provoked Infection with Bovine Herpesvirus 4 (BHV 4). Revue de Medecine Veterinaire, 2012, ISSN 0035-1555.

12. Petkova D., T. Markovska, G. Staneva, R. Scrobanska, A. Momchilova. Effect of Inulin Intake on the Content and Susceptibility to Oxidative Damage of Cholesterol in Liver Plasma Membranes. Comptes Rendus de L’Academie Bulgare des Sciences, 2012, ISSN 13101331.

13. Popova A. V., A. Andreeva. Carotenoid-lipid Interactions. Advances in Planar Lipid Bilayers and Liposomes, 15, 2012, ISBN 978-0-12-387720-8.

14. Zhelev Z., I. Aoki, V. Gadjeva, B. Nikolova, R. Bakalova, T. Saga. Tissue Redox Activity as a Sensing Platform for Imaging of Cancer Based on Nitroxide Redox Cycle. Eur. J. Cancer, ISSN 0959-8049.

3.2. Списък на публикациите, които са включени в издания с импакт фактор, IF (Web of Science) или импакт ранг SJR (SCOPUS) – те са част от горния списък (3.1.): - излезли от печат 1. Andonov V., M. Stefanova-Pavlova, T. Stoyanov, M. Angelova, G. Cook, K. Klein,

K. Atanassov, P. Vassilev. Generalized Net Model for Telehealth Services, Proc. of the 6th IEEE Conf. “Intelligent Systems”, Sofia, Bulgaria, 6-8 September 2012, Vol. 2, 221-224, ISSN 1025-8973.

2. Angelov B., A. Angelova, V. M. Garamus, M. Drechsler, R. Willumeit, R. Mutafchieva, P. Stepánek, S. Lesieur. Earliest Stage of the Tetrahedral Nanochannel Formation in Cubosome Particles from Unilamellar Nanovesicles. Langmuir, 28, 2012, 16647-16655, DOI: 10.1021/la302721n, ISSN 0743-7463.

3. Angelova M., K. Atanassov, T. Pencheva. Purposeful Model Parameters Genesis in Simple Genetic Algorithms. Computers & Mathematics with Applications, 64, 2012, 221-228, ISSN 0898-1221.

4. Angelova M., P. Melo-Pinto, T. Pencheva. Modified Simple Genetic Algorithms Improving Convergence Time for the Purposes of Fermentation Process Parameter Identification. WSEAS Transactions on Systems, 11(7), 2012, 256-267, E-ISSN 2224-2678.

5. Angelova M., T. Pencheva. Algorithms Improving Convergence Time in Parameter Identification of Fed-batch Cultivation. Comptes rendus de l'Académie bulgare des Sciences, 65(3), 2012,299-306, ISSN 1310-1331.

6. Angelova M., T. Pencheva. Sensitivity Analysis for the Purposes of Parameter Identification of a S. cerevisiae Fed-batch Cultivation. Lecture Notes on Computer Science, 7116, 2012, 165-172, ISBN 978-3-642-29842-4.

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7. Angelova P., A. Momchilova, D. Petkova, G. Staneva, R. Pankov, Z. Kamenov. Testosterone Replacement Therapy Improves Erythrocyte Membrane Lipid Composition in Hypogonadal Men. Aging Мale, 15(3), 2012, 173-179, ISSN 1368-5538.

8. Atanassov K. On the Game Method for Modelling. Advanced Studies in Contemporary Mathematics, Vol. 22, No. 2, 2012, 189-207, ISSN 1229-3067.

9. Atanassov K., S. Sotirov. Representation of the Neural Networks by the Game Method for Modeling. Advanced Studies in Contemporary Mathematics, Vol. 22, No. 3, 2012, 347-354, ISSN 1229-3067.

10. Atanassova L., K. Atanassov. On a Game-Method for Modelling with Intuitionistic Fuzzy Estimations: Part 1. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 7116, 2012, 182-189, ISSN 0302-9743.

11. Atanassova V. Generalized Nets with Volumetric Tokens. Comptes rendus de l’Academie bulgare des Sciences, 65(11), 2012, 1489-1498, ISSN 1310-1331.

12. Bortolan G., I. Christov, I. Simova, N. Dimitrov, I. Jekova, V. Krasteva. Clinical Characterization by Principal Component Analysis of ECG in Stress Test. Computing in Cardiology, 39, 2012, 613-616, ISSN 0276-6574.

13. Bortolan G., I. Christov. T-wave Alternans Detection by a Combined Method of Principal Component Analysis and T-wave Amplitude. Physiological Measurement, 33, 2012, 333-343, ISSN 0967-3334.

14. Busheva M., I. Tzonova, K. Stoitchkova, A. Andreeva. Heat-induced Reorganization of the Structure of Photosystem II Membranes: Role of Oxygen Evolving Complex. J. Photochem. Photobiol. B: Biol., 117, 2012, 214-221, ISSN 1873-2682.

15. Cerbai F., D. Lana, D. Nosi, P. Petkova-Kirova, S. Zecchi, H. M. Brothers, G. L. Wenk, M. G. Giovannini. The Neuron-astrocyte-microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus. PLoS One, 7(9):e45250. doi: 10.1371/journal.pone.0045250, 2012, eISSN-1932-6203.

16. Çiçek N., I. Fedina, H. Çakırlar, K. Georgieva, M. Velitchkova. The Role of Short-term High Temperature Pre-treatment on UV-B Tolerance of Barley Cultivars. Turk. J. Agric. Forest, 36, 2012, 153-165, ISSN 1300-011X.

17. Dimitrov A. G., N. A. Dimitrova. A Possible Link of Oxaliplatin-Induced Neuropathy with Potassium Channel Deficit. Muscle Nerve, 45(3), 2012, 403-411, ISSN 0148-639X.

18. Dimitrov A. G., N. A. Dimitrova. Author Reply to: Wu SN, Lo YC, Chen BS, Cheung So E, Chen LT., Contribution of Blocked Potassium Current Conductance and Increased Conductance of Persistent Sodium Current to the Afterdischarge in Myelinated Neuron. Muscle Nerve, 46(2), 2012, 297-299, ISSN 0148-639X.

19. Dimitrov V. G., T. I. Arabadzhiev, N. A. Dimitrova, G. V. Dimitrov. The Spectral Changes In EMG During A Second Bout Eccentric Contraction Could Be Due To Adaptation In Muscle Fibres Themselves: A Simulation Study. European Journal of Applied Physiology, 112(4), 2012, 1399-1409, ISSN 1439-6319 (print); ISSN 1439-6327 (online).

20. Djondjorov P., V. Vassilev, I. Mladenov. Deformation of Injected Vesicles Adhering Onto Flat Rigid Substrates. Computers & Mathematics with Applications, 64, 2012, 214-220, ISSN 0898-1221.

21. Dotsinsky I., B. Nikolova, E. Peycheva, I. Tsoneva. New Modality for Electrochemotherapy of Surface Tumors. Biotechnol. Biotechnolog. Eq., 26 (6), 2012, 3402-3406, ISSN 1310-2818.

22. Escoffre J-M., B. Nikolova, J. Henri, C. Favard, L. Mallet, J. Teissié, I. Tsoneva, M-P. Rols. New Sights in the Gene Electrotransfer Process: Evidence for Involvement of the Plasmid DNA Topology. Current Gene Therapy, 12(5), 2012, 417-422, ISSN 1666-5232.

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23. Georgieva N., R. Bryaskova, R. Tzoneva. New Polyvinyl Alcohol-Based Hybrid Materials For Biomedical Application. Materials Letters, 88, 2012, 19-22, ISSN 2093-6788.

24. Hundertmark M., A. V. Popova, S. Rausch, R. Seckler, D. K. Hincha. Influence of Drying on the Secondary Structure of Intrinsically Disordered and Globular Proteins. Biochem. Biophys. Res. Comm., 417, 2012, 122-128, ISSN 0006-291X.

25. Iliev I., B. Nenova, I. Jekova, V. Krasteva. Algorithm for Real-time Pulse Wave Detection Dedicated to Non-invasive Pulse Sensing. Computing in Cardiology, 39, 2012, 777-780, ISSN 0276-6574.

26. Ilkova T., M. Petrov, O. Roeva. Optimization of a Whey Bioprocess Using Neuro-dynamic Programming Strategy. Biotechnology & Biotechnological Equipment, 26(5), 2012, 3249-3253, ISSN 1310-2818.

27. Ivanova P. I., V. Krasteva, E. L. Apostolova. Role of Organization of Photosynthetic Apparatus for its Sensitivity to Atrazine. Comp. rend. Acad. bulg. Sci., 65, 2012, 799-806, ISSN 1310-1331.

28. Jekova I., V. Krasteva, I. Christov, R. Abächerli. Threshold-based System for Noise Detection in Multilead ECG Recordings. Physiological Measurement, 33, 2012, 1473-1477, ISSN 0967-3334.

29. Jereva D., I. Pajeva, T. Pencheva. Data Extraction Module – A Supplementary Tool for AMMOS_ProtLig Software Package. Comput. Math. Appl., 64(3), 2012, 266-271, ISSN 0898-1221.

30. Krutki P., J. Celichowski, R. Raikova. Motor Unit Contractions Evoked by Stimulation with Variable Interpulse Intervals. Biocybernetics and Biomedical Engineering, 32(3), 2012, 29-42, ISSN 0208-5216.

31. Lessigiarska I., I. Pajeva, P. Prodanova, M. Georgieva, A. Bijev. Structure-activity Relationships of Pyrrole Hydrazones as New Anti-tuberculosis Agents. Med. Chem., 8(3), 2012, 462-473, ISSN 1573-4064.

32. Lupanova T., D. Petkova, T. Markovska, G. Staneva, S. Chakarov, R. Skrobanska, R. Pankov, A. Momchilova. Effect of Cholesterol Modulation on the Antioxidant Potential of Quercetin in Rat Liver Plasma Membranes. Comptes Rendus de L’Academie Bulgare des Sciences, 65(5), 2012, 639-644, ISSN 13101331.

33. Matveev M., M. Milanova, K. Atanassov, V. Atanassova. Optimization of Emergency Management in Patients with Acute Coronary Syndromes in Big Urban District through Generalized Nets Model. J Clin Monit Comput, 26, 2012, 244-245, ISSN 1387-1307.

34. Matveev M., V. Krasteva, I. Jekova, G. Georgiev, S. Milanov, R. Prokopova, L. Todorova. Profile of the Autonomic Cardiac Control in Patients who are not Considered Ready for Weaning from Mechanical Ventilation. Computing in Cardiology, 39, 2012, 629-632, ISSN 0276-6574.

35. Milanova M., M. Matveev, K. Atanassov, V. Atanassova, R. Prokopova. Optimization of Emergency Management in Patients with Acute Coronary Syndromes in Big Urban District. Intensive Care Medicine, 38 (Suppl. 1), 2012, 155, ISSN 0342-4642.

36. Mladenov I., M. Hadzhilazova. Geometry of the Anisotropic Minimal Surfaces. An. St. Univ. Ovidius Constanta, 20, 2012, 79-88, ISSN 1224-1784.

37. Muradyan N., M. Klissurski, A. S. Alexandrov, B. Ishpekova. Repetitive Nerve Stimulation of Accessory Nerve in Diagnostic Assessment of Patients with Myasthenia Gravis. Comptes rendus de l'Academie bulgare des Sciences, 65(3), 2012, 411-418, ISSN 1310-1331.

38. Nikolova B., M. Georgieva, D. Savu, I. Tsoneva. Cell Membrane Alteration by Weak Alternating Electric Field at Low Frequency. Romanian Reports in Physics, 64(4), 2012, 1046-1052, ISSN 1221-1451.

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39. Orozova D., K. Atanassov. Generalized Net Model of the Process of Selection and Usage of an Intelligent e-Learning System, Comptes Rendus de l'Academie bulgare des Sciences, Vol. 65, No. 5, 2012, 591-598, ISSN 1310-1331.

40. Pavlov Y., P. Vassilev. Preferences and Determination of the Nominal Growth Rate of Fed-batch Process: Control Design of Complex Processes. Biotechnology and Biotechnological Equipment, 26(5), 2012, 3254-3259, DOI: 10.5504/bbeq.2012.0064, ISSN 1310-2818.

41. Pehlivanova V., I. Tsoneva, R. Tzoneva. Multiple Effects of Electroporation on the Adhesive Behaviour of Breast Cancer Cells and Fibroblasts. Cancer Cell International, 12:9, 2012, art. no 9, ISSN 12211451.

42. Petkova D., G. Staneva, T. Markovska, I. Iliev, I. Ivanova, R. Pankov, S. Chakarov, A. Momchilova. Fructooligosaccharide Intake Alters the Phospholipid and Fatty Acid Composition of Liver Plasma Membranes. Biotechnology and Biotechnological Equipment, 26(2), 2012, 2904-2909, ISSN 13102818.

43. Petkova-Kirova P., M. G. Giovannini, R. Kalfin, A. Rakovska. Modulation of Acetylcholine Release by Cholecystokinin in Striatum: Receptor Specificity; Role of Dopaminergic Neuronal Activity. Brain Res Bull., 89(5-6), 2012, 177-184, ISSN 0361-9230.

44. Petrov M., T. Ilkova. Fuzzy-Decision-Making Problem of L-Lysine Production. Chemical and Biochemical Engineering Quarterly, 26(3), 2012, 257-265, ISSN 1846-5153 (Online), ISSN 0352-9568 (Print).

45. Rangasamy P., S. Hadjitodorov, K. Atanassov, P. Vassilev. Generalized Net Model of an Intuitionistic Fuzzy Clustering Technique for Biomedical Data. Biotechnology and Biotechnological Equipment, 26(5), 2012, 3306-3309, DOI: 10.5504/bbeq.2012.0072, ISSN 1310-2818.

46. Rashkov G. R., A. G. Dobrikova, I. D. Pouneva, A. N. Misra, E. L. Apostolova. Sensitivity of Chlorella vulgaris to Herbicides. Possibility of using it as a Biological Receptor in Biosensors. Sensors & Actuators: B. Chemical, 161(1), 2012, 151-155, ISSN 0925-4005.

47. Roeva O. A Hybrid Genetic Algorithm for Parameter Identification of Bioprocess Models.

Lecture Notes on Computer Science, Springer, Germany, 7116, 2012, 247-255, ISSN 0302-9743.

48. Roeva O., Ts. Slavov. PID Controller Tuning based on Metaheuristic Algorithms for Bioprocess Control. Biotechnology and Biotechnological Equipment, 26(5), 2012, 3267-3277, ISSN 1310-2818.

49. Slavov Ts., O. Roeva. Genetic Algorithm Tuning of PID Controller for Glucose Concentration Control using Software Sensor. WSEAS Transaction on Systems, 11(7), 2012, 223-233, E-ISSN 2224-2678.

50. Sotirova E., D. Dimitrov, K. Atanassov. On Some Applications of Game Method for Modeling. Part 1: Forest Dynamics. Proceedings of the Jangjeon Mathematical Society, Vol. 15, No. 2, 2012, 115-123, ISSN 1598-7264.

51. Sotirova E., N. Dobrinkova, K. Atanassov. On Some Applications of Game Method for Modeling. Part 2: Development of Forest Fire. Proceedings of the Jangjeon Mathematical Society, Vol. 15, No. 3, 2012, 335-342, ISSN 1598-7264.

52. Stambolieva K., D. Diafas, V. Bachev, L..Christova, P.Gatev. Postural Stability of Canoeing and Kayaking Young Male Athletes during Quiet Stance. Eur. J. Appl. Physiology, 112, 2012, 1807-1815, ISSN 1439-6319.

53. Staneva G., N. Puff, M. Seigneuret, H. Conjeaud, M. I. Angelova. Segregative Clustering of Lo and Ld Membrane Microdomains Induced by Local pH Gradients in GM1-containing Giant Vesicles: A Lipid Model for Cellular Polarization. Langmuir, 28(47), 2012, 16327-37, ISSN 07437463.

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54. Stephanova D. I., S. M. Krustev, N. Negrev. Mechanisms Defining the Action Potential Abnormalities in Simulated Amyotrophic Lateral Sclerosis. J. Integr. Neurosci., 11(2), 2012, 137-154, ISSN 0219-6352.

55. Stephanova D. I., S. M. Krustev, N. Negrev. Mechanisms Defining the Electrotonic Potential Abnormalities in Simulated Amyotrophic Lateral Sclerosis. J. Integr. Neurosci., 11(2), 2012, 155-167, ISSN 0219-6352.

56. Surchev J., L. Todorova, A. Hadjzhiyanev, K. Georgiev, A. William, M. Marinov. Mathematical index for comparing the survival of homogeneous groups ventricular shunts. Proc. of 23-th ESPN Congress, Amsterdam, The Netherland, 1-5 May 2012, Child’s Nerv Syst, 28, No. 5, 803, ISSN 0256-7040 (Print) 1433-0350 (Online).

57. Tcvetkov R., E. Szmidt, J. Kacprzyk, K. Atanassov. A Modified Hausdorff Distance between Intuitionistic Fuzzy Sets. Comptes Rendus de l'Academie bulgare des Sciences, Vol. 65, No. 8, 2012, 1035-1042, ISSN 1310-1331.

58. Todinova S., S. Krumova, P. Kurtev, V. Dimitrov, L. Djongov, Z. Dudunkov, S. G. Taneva. Calorimetry-based Profiling of Blood Plasma from Colorectal Cancer Patients. Biochimica et Biophysica Acta, 1820, 2012,1879-1885, ISSN 0304-4165.

59. Todorova R., A. Atanasov. Diagnostic Strategies and Treatment for Ewing's Sarcoma. International Journal of Clinical Medicine, 3(6), 2012,538-543, ISSN 2158-2882.

60. Todorova R. Disorder Structural Predictions of the Native EWS and its Oncogenic Fusion Proteins in Rapport with the Function. Advances in Bioscience and Biotechnology, 3(1), 2012, 25-34, ISSN 21568456.

61. Tzoneva R., B. Seifert, M. Behl, A. Lendlein. Elastic Multiblock Copolymers for Vascular Regeneration: Protein Adsorption And Hemocompatibility. Clinical Hemorheology and Microcirculation, 52 (2-4), 2012, 337-348, ISSN 1386-0291.

62. Vardeva I., K. Atanassov. Generalized Net Model for Protection of Patients’ Personal e-Data, Transmitted between Healthcare Information Systems over the Internet. Comptes Rendus de l'Academie bulgare des Sciences, Vol. 65, No. 3, 2012, 291-298, ISSN 1310-1331.

- приети за печат 1. Apostolova E. L. Effect of High-light on Photosynthetic Apparatus with Different Content

of Anionic Lipids and Organization of Light-harvesting Complex of Photosystem II. Acta Physiol. Plant., 2012, ISSN 0137-5881.

2. Arabadzhiev T. Peculiarities of Extracellular Potentials Produced by Deep Muscles. Part 1: Single Fibre Potential Fields. Medical and Biological Engineering and Computing, 2012, ISSN 0140-0118.

3. Arabadzhiev T. Peculiarities of Extracellular Potentials Produced by Deep Muscles. Part 2: Motor Unit Potentials. Medical and Biological Engineering and Computing, 2012, ISSN 0140-0118.

4. Dobrikova A. G., I. Domonkos, Ö. Sözer, H. Laczkó-Dobos, M. Kis, Á. Párduc, Z. Gombos, E. L. Apostolova. Effect of Partial or Complete Elimination of Light-harvesting Complexes on the Surface Electric Properties and the Functions of Cyanobacterial Photosynthetic Membranes. Physiol. Plantarum., 2012, doi: 10.1111/j.1399-3054.2012.01648.x, ISSN 1399-3054

5. Dobrikova A. G., V. Krasteva, E. L. Apostolova. Damage and Protection of the Photosynthetic Apparatus from UV-B radiation. I. Effect of Ascorbate. J. Plant Physiology, 2012, doi:10.1016/j.physletb.2003.10.071, ISSN 0176-1617.

6. Dobrikova A., R. Vladkova, D. Stanoeva, A. Popova, M. Velitchkova. Effects of 24-epibrassinolide Pre-treatment on UV-B-induced Changes in the Pigment Content of Pea Leaves. Compt. rend. Acad. Bulg. Sci., 2012, ISSN 1310-1331.

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7. Pechlivanova V., V. Usunova, I. Tsoneva, M. Berger, I. Ugrinova, R. Tsoneva. The Effect of Erufosine on Reorganization of Cytoskeleton and Cell Death in Adherent Tumor and Non-tumorigenic Cells. Biotechnol. Biotechnolog. Eq., ISSN 1310-2818.

8. Pencheva T., D. Jereva, M. Miteva, I. Pajeva. Post-docking Optimization and Analysis of Protein-Ligand Interactions of Estrogen Receptor Alpha using AMMOS Software. Curr. Comput. Aided Drug Des., 2012, ISSN 1573-4099.

9. Peshev R., L. Christova. New Data on Epidemiological Study of Bovine Herpesvirus 1 Strains. Comptes rendus de l'Academie bulgare des Sciences, 2012, ISSN 1310-1331.

10. Peshev R., L. Christova. Studies of Bovine Herpesvirus 1 Distribution in Bovine Population and Bulls from Artificially Insemination Centers and Private Farms in Bulgaria. Arhiv Veterinarske Medicine, 2012, ISSN, 1820-9955.

11. Peshev R., L. Christova. The Stress Provoked Infection with Bovine Herpesvirus 4 (BHV 4). Revue de Medecine Veterinaire, 2012, ISSN 0035-1555.

12. Petkova D., T. Markovska, G. Staneva, R. Scrobanska, A. Momchilova. Effect of Inulin Intake on the Content and Susceptibility to Oxidative Damage of Cholesterol in Liver Plasma Membranes. Comptes Rendus de L’Academie Bulgare des Sciences, 2012, ISSN 1310-1331.

13. Popova A. V., A. Andreeva. Carotenoid-lipid Interactions. Advances in Planar Lipid Bilayers and Liposomes, 15, 2012, ISBN 978-0-12-387720-8.

14. Zhelev Z., I. Aoki, V. Gadjeva, B. Nikolova, R. Bakalova, T. Saga. Tissue Redox Activity as a Sensing Platform for Imaging of Cancer Based on Nitroxide Redox Cycle. Eur. J. Cancer, ISSN 0959-8049.

3.3. Списък на публикациите без рефериране и индексиране в световната система за рефериране, индексиране и оценяване (в световни вторични литературни източници): - излезли от печат 1. Andonov V., T. Stoyanov, K. Atanassov, P. Kovachev. Generalized Net Model for

Telecommunication Processes in Telecare Services. Proc. of the 1st Int. Conf. on Telecommunication and Remote Sensing, Sofia, Bulgaria, 29-30 August 2012, 158-162, ISBN 978-989-8565-28-0.

2. Atanassov K. On a New Approach towards Defining Intuitionistic Fuzzy Subtractions. New Developments in Fuzzy Sets, Intuitionisitc Fuzzy Sets, Generalized Nets and Related Topics, Vol. 1: Foundations (K. Atanassov, M. Baczynski, J. Drewniak, J. Kacprzyk, M. Krawczak, E. Szmidt, M. Wygralak, S. Zadrozny, Eds.),, SRI, Polish Academy of Sciences, Warsaw, Poland, 2012, 1-35, ISBN 9788389475404.

3. Atanassov K., S. Sotirov, A. Shannon. Generalized Net Model of Hierarchical Neural Networks. Proc. of 13th Int. Workshop on Generalized nets, London, UK, 29 October 2012, 8-14. ISSN 1313-6860.

4. Atanassova V. Generalized Net Model of an Online Submission System. Proc. of 13th Int. Workshop on Generalized nets London, UK, 29 October 2012, 24-33. ISSN 1313-6860.

5. Atanassova V. On Intuitionistic Fuzzy Approach to Generalized Net Prognostics, In: New Developments in Fuzzy Sets, Intuitionistic Fuzzy Sets, Generalized Nets and Related Topics. Volume II: Applications. (K. Atanassov, M. Baczynski, J. Drewniak, J. Kacprzyk, M. Krawczak, E. Szmidt, M. Wygralak, S. Zadrozny, Eds.), SRI, Polish Academy of Sciences, Warsaw, Poland, 2012, 1-12, ISBN 9788389475411.

6. Borisova E., E. Pavlova, P. Troyanova, B. Nikolova, I. Tsoneva. Optical Biopsy – Tool for Initial Cancer Diagnosis and Monitoring of Therapy. Еuropean Medical Physics and Engineering Conference, Sofia, Bulgaria, 18-20 October 2012, 172-179, ISBN 978-954-91589-3-9,

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7. Bortolan G., I. Christov, I. Simova, N. Dimitrov. Clinical Characterization of the QRS Complex and T Wave Heterogeniety during Stress Test ECG. Proc. European Medical Physics and Engineering Conference, Sofia, Bulgaria, 18-20 October 2012, 76-84, ISBN 978-954-91589-3-9 (Invited lecture).

8. Busheva M., S. Krumova, S. Stoichev, I. Tzonova, I. Karadjov, K. Stoitchkova, A. Andreeva. Effect of pH on the Aggregation of the Major Light Harvesting Complex of Photosystem II. Scientific Research of the Union of Scientists in Bulgaria – Plovdiv, series B. Natural Sciences and Humanities, XIII, 2012, 133-137, ISSN 1311-9192.

9. Dimitrov D., O. Roeva. Comparison of Different Mathematical Models of an E. coli Fed-batch Cultivation Process Using a Generalized Net Model. Proc. of 13th Int. Workshop on Generalized nets, London, UK, 29 October 2012, 15-23. ISSN 1313-6860.

10. Doukovska, L., K. Atanassov. Generalized Net Model Of Hydro Power Plants Load Distribution. Part 1. Proc. of 13th Int. Workshop on Generalized nets, London, UK, 29 October 2012, 83-90. ISSN 1313-6860.

11. Haralanov L., V. Ignatova, L. Todorova. Clinico-Electrophysiological and MRI Comparisons of Visual and Brainstem Audutory Evoked Potentials in Patientes with Multiple Sclerosis. Bulgarian Neurology, 12, Suppl. 1, 2012, 30-34, ISSN 1311-8641.

12. Ilkova T., O. Roeva, M. Petrov, J. Vanags. Generalized Net Model of Neuro-Dynamic Programming Algorithm. Proc. of 12th Int. Workshop on Generalized Nets, Burgas, Bulgaria, 17 June 2012, 17-26, ISSN 1313-6860.

13. Ilkova T., O. Roeva, M. Petrov. Multiple Objective Optimisation of Saccharomyces

cerevisiae Fermentation in Different Mixing Systems. Proc. of the International Conference Automatics and Informatics’12, Sofia, Bulgaria, 3-5 October 2012, 154-157, ISSN 1313-1869.

14. Jekova I., V. Krasteva, G. Georgiev, L. Todorova, P. Vassilev, M. Matveev. Measurements on Ventilatory Signals during Volume Controlled and Pressure Support Ventilation to Predict the Weaning Outcome. Annual Journal of Electronics, 6(1), 2012, 27-30, ISSN 1314-0078.

15. Kosev K., O. Roeva, K. Atanassov. Generalized Net Model Cyt/Aux Interactions for Plant’s Root Formation, New Developments in Fuzzy Sets. Intuitionistic Fuzzy Sets, Generalized Nets and Related Topics, Volume II: Applications, SRI, Polish Academy of Sciences, Warsaw, Poland, 2012, 91-99, ISBN 83-894-7541-3.

16. Kostadinova A., B. Nikolova. Differences in Adhesion Phenotype of Normal T Human Lymphocytes and Cells from High Methastatic Cell Line Jurkat up to Static and Dynamic Conditions. Science&Technology, II(1), 2012,5-9.

17. Krasteva V., I. Jekova, E. Trendafilova, S. Ménétré, J. P. Didon. Transthoracic Impedance Patterns during Systole Reveal an Improvement of Cardiac Hemodynamics after External Cardioversion of Atrial fibrillation. Proc. European Medical Physics and Engineering Conference, Sofia, Bulgaria, 18-20 October 2012, 92-98, ISBN 978-954-91589-3-9.

18. Krustev S. M., D. I. Stephanova. Abnormalities in the Recovery Cycles in Simulated Demyelinating Neuropathies and Neuronopathies. Scripta Scientifica Medica, 44(2), 2012, 59-63, ISSN 0582-3250.

19. Krustev S. M., D. I. Stephanova. Effect of the Myelin Sheath Aqueous Layers on the Action Potentials in Simulated Hereditary and Chronic Demyelinating Neuropathies. Scripta Scientifica Medica, 44(2), 2012, 53-57, ISSN 0582-3250.

20. Krustev S. M., D. I. Stephanova. Effect of the Myelin Sheath Aqueous Layers on the Electrotonic Potentials in Simulated Hereditary and Chronic Demyelinating Neuropathies. Archives of the Balkan Medical Union, 46(4), Suppl. 1, 2012, 241-245, ISSN 1584-9244.

21. Krutki P., J. Celichowski, R. Raikova. Motor Unit Contractions Evoked By Stimulation with Variable Interpulse Intervals. Lecture Notes of the ICB Seminar “The Motor Unit.

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Development, Disorders and Diagnosis”, Warsaw, Poland, 15-18 May 2011, (Eds. McComas, Hausmanova-Petrusewicz, Zalewska), Polish Academy of Sciences, International Centre of Sciences, Warsaw, Poland, 2012, 137-150.

22. Novachev N., I. Marinov, D. Stratiev, T. Pencheva, K. Atanassov. Generalized Net Model of the Process of Evaluation of the Environmental Impact of Refinery Activity. Proc. of 13th Int. Workshop on Generalized nets, London, UK, 29 October 2012, 56-61, ISSN 1313-6860.

23. Parvathi R., P. Vassilev, K. Atanassov. A Note on the Bijective Correspondence between Intuitionistic Fuzzy Sets and Intuitionistic Fuzzy Sets of p-th Type. New Developments in Fuzzy Sets, Intuitionistic Fuzzy Sets, Generalized Nets and Related Topics. Volume I: Foundations, SRI, Polish Academy of Sciences, Warsaw, Poland, 2012, 143-147, ISBN 83-894-7540-5

24. Petrov M., O. Roeva, J. Vanags, T. Ilkova. Neuro-dynamic Optimal Control Strategy of L-lysine Fermentation Process. Proc. of the 1st IFAC Workshop on DYCAF 2012, Plovdiv, Bulgaria, 13-16 June 2012, 207-212, ISBN 978-954-9641-53-0.

25. Raikova R., H. Aladjov, D. Lochynski, D. Kaczmarek. Muscle Model Composed by Motor Units and Simulation of Their Control by Using Hierarchical Genetic Algorithm, The Proceedings of the 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Berlin, Germany, 7-11 April 2012, electronic format 6 pp., ISBN 978-0-9562121-5-3.

26. Ribagin S., V. Chakarov, K. Atanassov. Generalized Net Model of the Upper Limb in Relaxed Position. New Developments in Fuzzy Sets, Intuitionisitc Fuzzy Sets, Generalized Nets and Related Topics, Vol. 2: Applications, SRI, Polish Academy of Sciences, Warsaw, Poland, 2012, 201-210, ISBN 83-894-7541-3.

27. Roeva O., T. Pencheva, K. Atanassov. Generalized Net of a Genetic Algorithm with Intuitionistic Fuzzy Selection Operator. New Developments in Fuzzy Sets, Intuitionistic Fuzzy Sets, Generalized Nets and Related Topics, Volume 1: Foundations, SRI, Polish Academy of Sciences, Warsaw, Poland, 2012, 167-178, ISBN 83-894-7540-5.

28. Roeva O., Ts. Slavov. Application of Simulated Annealing and Threshold Accepting for a Parameter Tuning Problem. Proc. of OMCONET, Southampton, England, 2012, 64-71, ISBN 978-0-9563140-4-8.

29. Roeva O., Ts. Slavov. PID Controller Tuning for Glucose Control Using Generalized Nets. New Developments in Fuzzy Sets, Intuitionistic Fuzzy Sets, Generalized Nets and Related Topics, Volume 2: Applications, SRI, Polish Academy of Sciences, Warsaw, Poland, 2012, 211-218, ISBN 83-894-7541-3.

30. Shannon A., E. Sotirova, K. Atanassov, M, Krawczak, P. Melo-Pinto, T. Kim, T. Lambova. Generalized Net Model of the Process of Applying to University. Proc. of 12th Int. Workshop on Generalized Nets, Burgas, Bulgaria, 17 June 2012, 27-31, ISSN 1313-6860.

31. Slavov Ts., О. Roeva. System for Real Time Optimal PID Control of Fed-batch Cultivation Process. Proc. of Technical University of Sofia, 62(2), 2012, 155-164, ISSN 1311-0829.

32. Sotirova E., K. Atanassov, S. Fidanova, E. Velizarova, P. Vassilev, A. Shannon. Application of the Game Method for Modelling the Forest Fire Perimeter Expansion. Part 1: A Model Fire Intensity without Effect of Wind. Proc. of the 1st IFAC Workshop on DYCAF 2012, Plovdiv, Bulgaria, 13-16 June 2012, 159-163, ISBN 978-954-9641-53-0.

33. Sotirova E., K. Atanassov, S. Fidanova, E. Velizarova, P. Vassilev, A. Shannon. Application of the Game Method for Modelling the Forest Fire Perimeter Expansion. Part 2: A Model Fire Intensity with Effect of Wind. Proc. of 4the 1st IFAC Workshop on DYCAF 2012, Plovdiv, Bulgaria, 13-16 June 2012, 165-169, ISBN 978-954-9641-53-0.

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34. Sotirova E., K. Atanassov, S. Fidanova, E. Velizarova, P. Vassilev, A. Shannon. Application of the Game Method for Modelling the Forest Fire Perimeter Expansion. Part 3: A Model of the Forest Fire Speed Propagation in Different Homogeneous Vegetation Types. Proc. of the 1st IFAC Workshop on DYCAF 2012, Plovdiv, Bulgaria, 13-16 June 2012, 171-174, ISBN 978-954-9641-53-0.

35. Stratiev D., I. Marinov, T. Pencheva, K. Atanassov. Generalized Net Model of an Oil Refinery. Proc. of 12th Int. Workshop on Generalized Nets, Burgas, Bulgaria, 17 June 2012, 10-16, ISSN 1313-6860 .

36. Todorova L., P. Vassilev, J. Surchev. Diagnostic Method before Implantation of Cerebrospinal Fluid Draining Shunt in Infants. A generalized net model. Proc. of 13th Int. Workshop on Generalized nets, London, UK, 29 October 2012, 77-82. ISSN 1313-6860.

37. Todorova L., V. Ignatova, L. Haralanov. Generalized Net Model for Diagnosis of Multiple Sclerosis. Proc. of 12th Int. Workshop on Generalized Nets, Burgas, Bulgaria, 17 June 2012, 32-38, ISSN 1313-6860.

38. Ангелова М., Т. Пенчева. Процедура за сравнение качеството на генетични алгоритми чрез приложение на интуиционистки размита логика. Десета национална младежка научно-практическа сесия, София, България, 23-24 aприл 2012, 244-249, ISBN 1314-0698.

39. Ангелова М., Т. Пенчева. Целенасочен параметричен генезис с многопопулационен генетичен алгоритъм, Десета национална младежка научно-практическа сесия, София, България, 23-24 aприл 2012, 250-254, ISBN 1314-0698.

40. Косев К., О. Роева. Метаевристични алгоритми за параметрична идентификация. Десета национална младежка научно-практическа сесия 2012, София, България, 23-24 април 2012, 255-260, ISSN 1314-0698.

41. Маринова М. Г. Митева, В. Атанасова. Онлайн тестове в уики-среда с разширението Quiz. Образование и технологии, 3, 2012, 60-61, ISSN 1314-1791.

- приети за печат 1. Пехливанова В., В. Узунова, Я. Цонева, М. Бергер, И. Угринова, Р. Цонева.

Изследване влиянието на Еруфозина върху адхерентни туморни и соматични клетки. Влияние на електропорацията върху клетъчната цитотоксичност. Доклади на XXII Mеждународна научна конференция на Съюза на ученитe в Стара Загора, България, 7-8 юни 2012.

2. Todorova R., A. Atanasov. Ewing’s Sarcoma Stem Cell. Trakia J Science, 10(5), 2012,.

3.4. Списък на монографиите: - излезли от печат 1. Atanassov, K. On Intuitionistic Fuzzy Sets Theory, Springer, Berlin, 2012, ISBN 978-

3642291265. 2. Sotirov, S., K. Atanassov, Generalized Nets in Artificial Intelligence, Vol. 6: Generalized

Nets and Neural Networks, Prof. M. Drinov Academic Publishing House, Sofia, 2012. 3. Косев А. Р., А. Александров, М. Даскалов, Транскраниална магнитна стимулация в

норма и патология, Академично издателство „Проф. Марин Дринов”, София, 2012, ISBN 978-954-322-516-3.

- приети за печат 1. Stephanova D. I., B. Dimitrov. Computational Neuroscience: Simulated Demyelinating

Neuropathies and Neuronopathies. Taylor and Francis Group, CRC Press Inc., USA, 2012.

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3.4.1. Списък на глави в книги: - излезли от печат 1. Bortolan G., I. Christov, W. Pedrycz. Hyperellipsoids for Beat Classification in

Electrocardiogram, 2012, 219-236, Chapter 10 in: ECG Signal Processing, Classification and Interpretation: A Comprehensive Framework of Computational Intelligence. Eds: Gacek A., W. Pedrycz, © Springer-Verlag, London, Dordrecht, Heidelberg, New York, 279 pages, ISBN 978-0-85729-867-6.

2. Dotsinsky I., N. Mudrov, T. Mudrov. Technical Aspects of the Electrochemotherapy. 2012, 45-62, Chapter 2 in: Electroporation in Laboratory and Clinical Investigations. Eds: Spugnini E., Baldi A, Nova Science Publishers, Inc. ISBN 978-1-61668-327-6.

3. Milanova M., M. Matveev. Risk Evaluation of Perioperative Acute Coronary Syndromes and Other Cardiovascular Complications during Emergency High Risky Noncardiac Surgery. 2012, 129-162, Chapter 10 in: Acute Coronary Syndromes. Ed: Brizzio M., © InTech, ISBN 978-953-307-827-4.

4. Pencheva T., D. Lagorce, I. Pajeva, B. O. Villoutreix, M. A. Miteva. AMMOS Software: Method and Application, in: Computational Drug Discovery and Design, Series: Methods in Molecular Biology, Vol. 819, Baron, R. (Ed.), Humana Press, 2012, 127-141, ISBN 978-1-61779-464-3.

5. Roeva O., S. Fidanova. A Comparison of Genetic Algorithms and Ant Colony Optimization for Modeling of E. coli Cultivation Process. Chapter 13 in: Real-World Application of Genetic Algorithms, InTech, 2012, 261-282, ISBN 978-953-51-0146-8

6. Taneva S. G., S. Bañuelos, M. A. Urbaneja. Thermodynamic Signatures of Macromolecular Complexes. Insights on the Stability and Interactions of Nucleoplasmin, a Nuclear Chaperone, Chapter 7 in: Applications of Calorimetry in a Wide Context - Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microcalorimetry, 153-182, InTech, Ed: Elkordy A. A., University of Sunderland, UK, 2012, ISBN 978-953-51-0947-1.

- приети за печат 1. Martiny V. Y., I. Pajeva, M. Wiese, A. M. Davis, M. A. Miteva. Chemoinformatic and

Chemogenomic Approach to ADMET, in: Predictive ADMET: Integrated approaches in Drug Discovery and Development, Chapter 5, Part II: Intelligent integration and extrapolation of ADMET data, J. Wang and L. Urban (Eds.), John Wiley & Sons, 2012.

2. Matveev M., S. Denchev. Impact of the Stenosis Geometry and the Haemdynamic Effect around the Obstructing Plaque in Coronary Vessels on the Acute Coronary Syndrome Genesis, 2012, chapter in: Acute Coronary Syndrome – Current Advances and Future Directions. Ed: Postadzhiyan A., © InTech, ISBN 980-953-307-902-3.

3.5. Списък на учебници, учебни помагала, публицистика, научно-популярни произведения, художествени творби от всякакъв вид: 1. ...

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Списък на цитиранията за 2012 г. Acebrón S.P., Fernández-Sáiz V., Taneva S.G., Moro F., Muga A., DnaJ recruits DnaK to protein aggregates, Journal of Biological Chemistry, 283(3), 2008, 1381-1390

1. Reidy M., Miot M., Masison D.C., Prokaryotic Chaperones Support Yeast Prions and Thermotolerance and Define Disaggregation Machinery Interactions, Genetics, 2012, 192(1), 185-193.

2. Winkler J., Tyedmers J., Bukau B., Mogk A., Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation, J. Cell. Biol., 198(3), 2012, 387-404.

3. Kumar M., Sourjik V., Physical map and dynamics of the chaperone network in Escherichia coli, Molecular Microbiology, 84(4), 2012, 736-747.

Aladjov H., K. Atanassov. A generalized net for genetic algorithms learning. In: Proc. of the XXX Spring Conf. of the Union of Bulgarin Mathematicians, Borovets, 8-11 April 2001, 242-248.

4. Roeva, O., T. Slavov, PID controller tuning of glucose control using generalized nets. New Developments in Fuzzy Sets, Intuitionisitc Fuzzy Sets, Generalized Nets and Related Topics, Vol. 2: Applications, SRI, Polish Academy of Sciences, 2012, 211-218.

Altankov G., Groth T., Krasteva N., Albrecht W., Paul D., Morphological evidence for a different fibronectin receptor organization and function during fibroblast adhesion on hydrophilic and hydrophobic glass substrata, Journal of Biomaterials Science, Polymer Edition 8 (9), 1997,721-740

5. Ballester-Beltrán J., Lebourg M., Rico P., Salmerón-Sánchez M., Dorsal and ventral stimuli in cell-material interactions: Effect on cell morphology, Biointerphases 7 (1-4), 2012, 1-9

6. Ribeiro C., Panadero J.A., Sencadas V., Lanceros-Méndez S., Tamaño M.N., Moratal D., Salmerón-Sánchez M., Gómez Ribelles J.L., Fibronectin adsorption and cell response on electroactive poly(vinylidene fluoride) films, Biomedical Materials 7 (3), 2012, art. no. 035004

Alves, I., G. Staneva, C. Tessier, G. F. Salgado, P. Nuss, The interaction of antipsychotic drugs with lipids and subsequent lipid reorganization investigated using biophysical methods, Biochimica and Biophysica Acta, 1808 (8), 2011, 2009-2018, ISSN: 00052736.

7. Smesny, S., K. Langbein, R. Rzanny, A. Gussew, H. P. Burmeister, J. R. Reichenbach, H. Sauer, Antipsychotic drug effects on left prefrontal phospholipid metabolism: A follow-up 31P-2D-CSI study of haloperidol and risperidone in acutely ill chronic schizophrenia patients, Schizophrenia Research, 138 (2-3), 2012, 164-170, ISSN: 09209964

8. Paul, B.K., N. Guchhait, Differential interactions of a biological photosensitizer with liposome membranes having varying surface charges, Photochemical and Photobiological Sciences, 11 (4), 2012, 661-673, ISSN: 1474905X

Andreeva A., Abarova S., Stoichkova K., Picorel R., Velitchkova M., Selective Photobleaching of Chlorophylls and Carotenoids in Photosystem I Particles under High-Light Treatment. Photochem. Photobiol.. 83, 2007, 1301-1307. ISSN 1751 1097

9. Cazzaniga S. , Li Z., Niyogi K. K., Bassi R., Dall 'Osto L., The Arabidopsis szl1 mutant reveals a Critical role of β-carotene in photosystem I photoprotection. Plant Physiol., 159, 2012, 1745-1758. doi: http://dx.doi.org/10.1104/pp.112.201137

Andreeva A., Stoitchkova K., Busheva M., Apostolova E., Changes in the energy distribution between chlorophyll-protein complexes of thylakoid membranes from pea

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165. Martinetti, D., Janiš, V., Montes, S., Cuts of IF-sets respecting fuzzy connectives, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Volume 6857 LNAI, 2011, Pages 33-40

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751. Wang, Yulan, Huayou Chen, Ligang Zhou, Logarithm Compatibility of Interval Multiplicative Preference Relations with an Application to Determining the Optimal Weights of Experts in the Group Decision Making, Group Decision and Negotiation, April 2012, DOI 10.1007/s10726-012-9291-9

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767. Wei, G., Zhao, X., Wang, H. An approach to multiple attribute group decision making with interval intuitionistic trapezoidal fuzzy information (2012) Technological and Economic Development of Economy, 18 (2), pp. 317-330.

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784. Xu, You-Hong, Wei-Zhi Wu, Intuitionistic Fuzzy Topologies in Crisp Approximation Spaces, Rough Sets and Knowledge Technology, Lecture Notes in Computer Science Volume 7414, 2012, pp 496-503

785. Xu Yejun; Wang Huimin, The induced generalized aggregation operators for intuitionistic fuzzy sets and their application in group decision making, Applied Soft Computing, Vol. 12, 2012, No. 3, 1168-1179.

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792. Xu, Y., Merigó, J.M., Wang, H. Linguistic power aggregation operators and their application to multiple attribute group decision making (2012) Applied Mathematical Modelling, 36 (11), pp. 5427-5444.

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794. Xu, Y.J., Wang, Y.T. A novel entropy for intutionistic fuzzy set (2012) 2012 International Conference on Systems and Informatics, ICSAI 2012, art. no. 6223624, pp. 26-29.

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797. Xu, Z. Fuzzy ordered distance measures (2012) Fuzzy Optimization and Decision Making, 11 (1), pp. 73-97.

798. Xu, Z., Xia, M. Hesitant fuzzy entropy and cross-entropy and their use in multiattribute decision-making (2012) International Journal of Intelligent Systems, 27 (9), pp. 799-822.

799. Xu, Zeshui, Intuitionistic Fuzzy Multiattribute Decision Making: An Interactive Method, IEEE TRANSACTIONS ON FUZZY SYSTEMS, 20(3), 514-525, JUN 2012

800. Xuechong, Guan, Yongming Li, Feng Feng, A new order relation on fuzzy soft sets and its application, Soft Computing, January 2013, Volume 17, Issue 1, pp 63-70

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802. Yan, X. An approach to evaluating the risk of marketing with hesitant fuzzy information (2012) International Journal of Advancements in Computing Technology, 4 (9), pp. 122-128.

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806. Yang, Weixu, Jiao, Zhenhua ; Zhang, Zhifeng ; Jin, Conghao, A Common Fixed Point Theorem in Intuitionistic Fuzzy Metric Spaces, Chaos-Fractals Theories and Applications (IWCFTA), 2012 Fifth International Workshop on, 18-21 Oct. 2012, 3 - 5

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818. Ye, J. Multicriteria group decision-making method using the distances-based similarity measures between intuitionistic trapezoidal fuzzy numbers (2012) International Journal of General Systems, 41 (7), pp. 729-739.

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830. Zhang, Ling, A Novel Segmentation Method for Breast Cancer Ultrasound CAD System, Advances in Intelligent and Soft Computing Volume 112, 2012, pp 307-313

831. Zhang, C., Li, W., Yang, H. A new drug risk assessment model of comprehensive hospitals (2012) Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012, art. no. 6245336, pp. 1165-1168.

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836. Zhang, Qiansheng, Yirong Huang, Intuitionistic fuzzy automata based on complete residuated lattice–valued logic, International Journal of Materials and Product Technology, Volume 45, Number 1–4/2012, 108-118

837. Zhang, L., Zhang, T., Zhang, C. Web service composition algorithm based on hybrid-QoS and pair-wise comparison matrix (2012) Journal of Information and Computational Science, 9 (1), pp. 135-142.

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840. Zhang, Q., Luo, S. Intuitionistic fuzzy reasoning under quotient space structure (2012) Lecture Notes in Electrical Engineering, 139 LNEE, pp. 239-244.

841. Zhang, Q., Xing, H., Wu, L. Entropy, Similarity Measure, Inclusion Measure of Intuitionistic Fuzzy Sets and Their Relationships (2012) International Journal of Computational Intelligence Systems, 5 (3), pp. 519-529.

842. Zhang, Q., Zhou, Y., Li, X., Huang, Y. The study of warning degree evaluation method for uncertain network public sentiment emergency (2012) Journal of Computational Information Systems, 8 (20), pp. 8581-8588.

843. Zhang, X., W. Xu, Ranking for Objects and Attribute Reductions in Intuitionistic Fuzzy Ordered Information Systems, Mathematical Problems in Engineering, Vol. 2012, Article ID 426901, 19 pages; doi:10.1155/2012/426901

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846. Zhang, Y., Ma, H., Liu, B., Liu, J. Group decision making with 2-tuple intuitionistic fuzzy linguistic preference relations (2012) Soft Computing, 16 (8), pp. 1439-1446.

847. Zhang, Y., Wang, Y. Ranking alternatives expressed with interval-valued intuitionistic fuzzy set (2012) 15th International Conference on Information Fusion, FUSION 2012, art. no. 6290586, pp. 2317-2322.

848. Zhang, Y., Yang, X. Intuitionistic fuzzy dominance-based rough set approach: Model and attribute reductions (2012) Journal of Software, 7 (3), pp. 551-563.

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850. Zhang, Z. A rough set approach to intuitionistic fuzzy soft set based decision making (2012) Applied Mathematical Modelling, 36 (10), pp. 4605-4633.

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1061. Mahapatra, G. S.; Mandal, T. K.; Samanta, G. P.An EPQ Model with Imprecise Space Constraint Based on Intuitionistic Fuzzy Optimization Technique , JOURNAL OF MULTIPLE VALUED LOGIC AND SOFT COMPUTING Volume: 19 Issue: 5 6 Pages: 409 423 Published: 2012

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1069. Ratchford D., Shafiei F., Gray S.K., Li X., Polarization properties of a CdSe/ZnS and Au nanoparticle dimer, ChemPhysChem 13 (10), 2012, 2522-2525

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1072. Tomczak N., Jańczewski D., Dorokhin, D., Han, M.-Y., Vancso, G.J. , Enabling biomedical research with designer quantum dots ,2012, Methods in Molecular Biology 811 , pp. 245-265

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1075. Olivero F., Renò F., Carniato F., Rizzi M., Cannas M., Marchese L.A., Novel luminescent bifunctional POSS as a molecular platform for biomedical applications, Dalton Transactions 41 (25), 2012, 7467-7473

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1077. Liu Q., Guan M., Xu L., Shu C., Jin C., Zheng J., Fang X., Wang C., Structural effect and mechanism of C 70-carboxyfullerenes as efficient sensitizers against cancer cells, Small 8 (13), 2012, 2070-2077

1078. Choi Y.J., Kim Y.J., Lee J.W., Lee Y., Lim Y.-B., Chung H.W.,Cyto-/genotoxic effect of CdSe/ZnS quantum dots in human lung adenocarcinoma cells for potential photodynamic UV therapy applications, Journal of Nanoscience and Nanotechnology 12 (3), 2012, 2160-2168

1079. Li Y., Zhang W., Niu J., Chen Y., Mechanism of photogenerated reactive oxygen species and correlation with the antibacterial properties of engineered metal-oxide nanoparticles, ACS Nano 6(6), 2012, 5164-5173

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1082. Yukawa H., Watanabe M., Kaji N., Okamoto Y., Tokeshi M., Miyamoto Y., Noguchi H., Hayashi S., Monitoring transplanted adipose tissue-derived stem cells combined with heparin in the liver by fluorescence imaging using quantum dots, Biomaterials 33 (7), 2012, 2177-2186

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1083. Ghosh-Mitra S., Diercks D.R., Mills N.C., Hynds D.L., Ghosh S., Role of engineered nanocarriers for axon regeneration and guidance: Current status and future trends, Advanced Drug Delivery Reviews 64(1), 2012, 110-125

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1090. Paudel, A; Van den Mooter, G. Influence of Solvent Composition on the Miscibility and Physical Stability of Naproxen/PVP K 25 Solid Dispersions Prepared by Cosolvent Spray-Drying. PHARMACEUTICAL RESEARCH, 29 (1):251-270, JAN 2012.

1091. Reddy, GVR; Vidyadhara, S; Anusha, C. Formulation and Evaluation of Simvastatin Fast Dissolving Tablets with Croscarmellose Sodium as Super Disintegrant. ASIAN JOURNAL OF CHEMISTRY, 24 (3):1082-1086; MAR 2012.

1092. Purohit, Nirav S.; Patel, Jayvadan K. Preparation, characterization and dissolution studies of inclusion complexes of Escitalopram oxalate , Journal of Pharmacy Research (2012), 5(4), 2259-2263.

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1358. de Olyveira GM., Costa LMM., Leão AL., Protein-based Polymer Nanocomposites for Regenerative Medicine, BM Cherian, Natural Polymers: Volume 2: Nanocomposites, 2012, 21-25

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Fernández-Higuero J.Á, Acebrón S.P, Taneva S.G, Del Castillo U., Moro F., Muga A., Allosteric Communication between the Nucleotide Binding Domains of Caseinolytic Peptidase B, Journal of Biological Chemistry, 286(29), 2011, 25547-25555.

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1379. Daligadu J. Cortical and cerebellar motor processing changes subsequent to motor training and cervical spine manipulation., University of Ontario Institute of Technology, Canada (Thesis), 2012

1380. Hadzi-Petrushev N., Jankulovski N., Milev M., Filipovska P., Gagov H., Gjorgievska E., Mitrov D., Sopi R., Hristov K., Mladenov M., l-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent peroxidation in rat's liver and kidney, J. Thermal Biol., 37(5), 2012, 361-365. ISSN: 0306-4565

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1384. Silva, L. C., O. B. David, Y. Pewzner-Jung, E. L. Laviad, J. Stiban, S. Bandyopadhyay, A. H. Merrill Jr., M. Prieto, A. H. Futerman, Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes, Journal of Lipid Research, 53 (3), 2012, 430-436, ISSN: 00222275.

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1387. Tamas Hegedus, Gergely Gyimesi, Merse E. Gaspar, Kristof Z. Szalay, Rajeev Gangal, Peter Csermely. Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters. QUANTITATIVE BIOLOGY (2012), 1-34, arXiv:1206.0123v1 [q-bio.MN]http://arxiv.org/abs/1206.0123v1

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1399. Madhavan, T., Gadhe, C., Kothandan, G., Cho, S. Enhancement of P-gylcoprotein modulators of arylmethylamine-phenyl derivatives: an integrative modeling approach. Medicinal Chemistry Research, 1-13.

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1425. Sibirev N., Nazarenko M. and Dubrovskii V.: Technical Physics Letters 38 (2012) 221-224.

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1780. Yuji Koseki, Tomohiro Kinjo, Maiko Kobayashi, Shunsuke Aoki, Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library, European Journal of Medicinal Chemistry, Available online 19 December 2012, ISSN 0223-5234, 10.1016/j.ejmech.2012.12.012

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1792. Andrade de Paula CA, Coulson-Thomas VJ, Ferreira JG, Maza PK, Suzuki E, Nakahata AM, Nader HB, Sampaio MU, Oliva ML. EcTI, a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src-FAK signaling pathways. J BIOL CHEM. 287 (1), 170-182, 2012.

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1793. Wu LX, Guo CX, Qu Q, Yu J, Chen WQ, Wang G, Fan L, Li Q, Zhang W, Zhou HH. Effects of natural products on the function of human organic anion transporting polypeptide 1B1. XENOBIOTICA, 42 (4):339-348; APR 2012

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1795. Valdameri, G; Genoux-Bastide, E; Peres, B; Gauthier, C; Guitton, J; Terreux, R; Winnischofer, SMB; Rocha, MEM; Boumendjel, A; Di Pietro, A. Substituted chromones as highly-potent nontoxic inhibitors, specific for the breast cancer resistance protein. JOURNAL OF MEDICINAL CHEMISTRY, 55 (2):966-970; JAN 26 2012.

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ПРИЛОЖЕНИЕ 43: Информация за Научния съвет на звеното

Списъчен състав на НС с посочени научни звания, степени и основна месторабота на

членовете на съвета

проф. дбн Албена Момчилова – Председател на НС

проф. дбн Диана Петкова – Зам.-прдседател на НС

доц. д-р Таня Пенчева – Секретар на НС

чл. кор. дбн Андон Косев

проф. дбн Диана Стефанова

проф. дтн Ивайло Христов

проф. дбн Илза Пъжева

чл. кор. дмн дтн Красимир Атанасов

проф. д-р Михаил Матвеев

проф. дтн Росица Райкова

проф. дтн Стефан Хаджитодоров

проф. дбн Стефка Танева

проф. дбн Яна Цонева

проф. д-р Емилия Апостолова

проф. д-р Мая Величкова

проф. д-р Мира Бушева

Външни членове:

акад. Александър Петров – ИФТТ-БАН

проф. Георги Михов – Технически Университет, София

чл. кор. Здравко Лалчев – Софийски Университет “Св. Климент Охридски”

проф. Христо Гагов – Софийски Университет “Св. Климент Охридски”

Дата на избиране на съвета и сведения за промени в състава му след избора

НС на ИБФБМИ е избран на ОС на ИБФБМИ на 8.XII.2010 г., Протокол №2