(2017 mass spectrometry for clinical diagnosis symposium) · 病理學系的timothy...

科技部化學推動中心補助學術研討會成果報告表

會議名稱：2017 質譜分析技術在臨床醫學檢測研討會

(2017 Mass Spectrometry for Clinical Diagnosis Symposium)

舉辦日期：民國 106 年 10 月 12 日至民國 106 年 10 月 14 日

主辦機構：國立中山大學科技醫學中心主持人：謝建台

舉辦地點：國立中山大學國際研究大樓聯絡電話： 07-5252000#5833

出席人數：工業界 56 人、學術界(含學生) 244 人共 300 人

會議重要成果： (如篇幅不足,另以A4白紙填寫)

1.會議經過及議程

繼這幾年我們在高雄西子灣國立中山大學成功舉辦第一至三屆“質譜分析技術在

臨床醫學檢測研討會＂，此項會議獲得國內生醫質譜界及相關業界一致肯定及讚

譽，因此今年持續以“質譜分析技術在臨床醫學檢測＂為主題，舉辦第五屆(2017)

研討會。承蒙科技部化學研究推動中心、國立中山大學科技醫學中心、台灣質譜學

會、國立中山大學理學院及化學系、美國 MSACL 學會以及世界各大質譜儀器廠商(包

括 Bruker Daltonics, Shimadzu,Applied Biosystem, Agilent, Thermo Fisher,

Sciex 等)的經費贊助，本研討會得以於 10 月 12 日至 14 日三天，假高雄西子灣國

立中山大學國際研究大樓華立廳、光中廳及階梯教室順利召開，此次會議共邀請到

來自美國猶他大學病理學系的 Alan Rockwood 教授、日本大阪大學和田芳直

(Yoshinao Wada)教授、澳洲昆士蘭科技大學 Stephen J. Blanksby 教授、德州大

學聖安東尼奧醫學中心韓賢林教授、韓國科學技術研究院 Man-Ho Choi 教授、韓國

國家標準與科學研究院 Tae Geol Lee 教授、美國佛羅里達大學病理學系的 Timothy

Garrett 教授、加拿大亞伯達大學化學系的厲良教授、加拿大英屬哥倫比亞大學的

史俊艷博士、美國德州大學奧斯汀分校的張佳玲博士、香港大學化學系的 Ivan K.

Chu 教授、香港理工大學化學系的姚鍾平教授等 12 位國外學者。國內演講者則是

分別來自包括國立清華大學、高雄醫學大學、國立中山大學、台北醫學大學、慈濟

大學、國立台灣大學、國立成功大學、長庚大學、輔仁大學、基隆長庚醫院、林口

長庚醫院及國立中正大學等共 18 位教授進行演講，會議 session 的主持人則分別

由國立中山大學、長庚大學、國立台灣大學、國立中興大學、輔仁大學、國立師範

大學、國立成功大學、慈濟大學、林口長庚醫院、國立東華大學及高雄醫學大學之

30 位教授擔任。此次會議總共吸引了國內學者、研究生及工業界人士共 300 人與

會。為期 3 天的口頭演講共分 12 個場次進行，其主題分別為質譜分析用於鑑定疾

病生物指標、臨床醫學檢測新式技術、質譜分子影像分析、公共衛生及職業安全、

急診室管理毒物檢測、疾病生物指標-蛋白質、代謝物、及新的質譜技術應用於臨

床醫學。

會議演講休息期間均備有茶飲及點心，第一天為質譜訓練課程，在第二天會後

及研討會第一天，假中山大學校內之西子灣海景餐廳舉辦歡迎晚宴，共有近 130

位與會者參與，晚宴期間所有與會者也藉此一難得的機會，在高雄西子灣進行學術

經驗的交換溝通。綜觀此次會議的召開，報名人數由前年的 267 人，增加到今年的

300 人，顯示本會議主題極具吸引力及重要性。有鑑於此，我們相信這幾屆推廣質

譜分析技術在臨床醫學檢測國際研討會上已逐漸被國內質譜界學者重視。

(1) 會議議程如附件一。

2. 國外講員其他演講行程

本次研討會邀請美國猶他大學病理學系的 Alan Rockwood 教授、日本大阪大

學和田芳直(Yoshinao Wada)教授、澳洲昆士蘭科技大學 Stephen J. Blanksby

教授、德州大學聖安東尼奧醫學中心韓賢林教授、韓國科學技術研究院 Man-Ho

Choi 教授、韓國國家標準與科學研究院 Tae Geol Lee 教授、美國佛羅里達大學

病理學系的 Timothy Garrett 教授、加拿大亞伯達大學化學系的厲良教授、加拿

大英屬哥倫比亞大學的史俊艷博士、美國德州大學奧斯汀分校的張佳玲博士、香

港大學化學系的 Ivan K. Chu 教授、香港理工大學化學系的姚鍾平教授。

一、澳洲昆士蘭科技大學 Stephen J. Blanksby 教授、德州大學聖安東尼奧醫學

中心韓賢林教授亦分別受中央研究院邀請演講，其時間及題目如下：

(1) Stephen J. Blanksby 教授： 10 月 16 日(2:00 pm ~ 3:30 pm)於中央研究院的農業科技大樓 1樓 A134 演

講廳進行演講，題目為＂ Advances in mass spectrometry for the identification of lipid isomers＂

(2) 韓賢林教授: 10 月 16 日(3:30 pm ~ 5:00 pm)於中央研究院的農業科技大樓 1樓 A134 演

講廳進行演講，題目為＂ Lipidomics sheds light on diabetic neuropathy＂

二、美國佛羅里達大學病理學系的 Timothy Garrett 教授受台灣大學邀請演講，

其時間及題目如下：

(1) Timothy Garrett 教授: 10 月 11 日(1:20 pm ~ 2:10 pm)於臺大醫學院基礎醫學大樓 102 講堂進行

演講，題目為＂ Metabolomics: Discovery, Innovation, and Diagnostic Potential＂

三、美國德州大學奧斯汀分校的張佳玲博士受台灣大學邀請演講，其時間及題目

如下：

(1) 張佳玲博士: 10 月 12 日(2:00 pm ~ 3:30 pm)於臺大化學系松柏講堂進行演講，題目為＂ Ambient ionization mass spectrometry for cancer diagnosis and

biomarker discovery＂(但因班機延誤，導致此次演講取消)

四、韓國科學技術研究院 Man-Ho Choi 教授受林口長庚醫院邀請演講，其時間及

題目如下：

(1) Man-Ho Choi 教授: 10 月 12 日(8:30 am ~ 9:30 am)於林口長庚醫院醫學大樓 2 樓檢驗醫學科

大會議室進行演講，題目為＂ Recent Advances in Mass Spectrometry-based Steroid Profiling and Clinical Applications＂

五、日本大阪大學和田芳直(Yoshinao Wada)教授，與德州大學聖安東尼奧醫學

中心韓賢林教授，受高雄醫學大學附設中和紀念醫院邀請於 10/12(四)開了

一個小型座談會，座談會名稱為＂ An Omics Avenue to Precision Medicine＂

其它教授因來台僅 3 日(10 月 12 日至 14 日)，故僅於本會議進行演講，並未安排其它行程。

請見附件二

3. 重要收獲及心得

本次會議以採用 2 個 session 同時並行的方式進行，並很榮幸能邀請到 12 位國外知

名專家學者，與 29 位國內在質譜醫學界極具盛名的學者專家，為本次研討會進行

為期 3 天的演講。並與來自全台各大專院校的研究生及工業界人士共 300 人進行此

4. 建議

本次會議因之補助款項目限制過多，以致一些舉辦會議所需花費無法報支(如場地佈置費、

受邀演講者之交通費)，建議補助款項目可從寬認定，或採實支實付方式，使主辦單位在舉

辦會議時能有更好的發揮空間。

附件一、

2017 Mass Spectrometry for Clinical Diagnosis

October12 Thur. (Training Course) Location: International Research Building, NSYSU

08:30 am ~ 08:55 am Registration & Morning Tea Lobby

08:55 am ~ 09:00 am Opening Remarks

Lecturer：Sy-Chyi Cheng (鄭思齊) 09:00 am ~ 10:20 am “Fundamental of mass analyzers, FT-MS, Q-TOF, QQQ, and

Orbitrap”

WahLee Hall

10:20 am ~ 10:40am Coffee Break Lobby

Lecturer：Jimmy Chan (詹舜安) 10:40 am ~ 12:00 am “Fundamental of ESI, APCI, LC/MS, and LC/MSMS and their

Applications in Clinical Diagnosis” WahLee Hall

12:00 am ~ 14:00 pm Lunch & Discussions & Seminars Discussion Rooms

Lecturer：Chin-Hao Chang (張晉豪)

14:00 pm ~ 15:20 pm “Fundamental of EI, CI, GC/MS, and GC/MSMS and their Applications in Clinical Diagnosis”

WahLee Hall

15:20 pm ~ 15:40 pm Coffee Break Lobby

Lecturer：Shih-Hua Teng (滕士驊) 15:40 pm ~ 17:00 pm “Fundamental of MALDI-TOF/MS and its Applications on Protein

and Microorganism Identification and Molecular Imaging” WahLee Hall

17:30pm ~ 19:00pm Workshop (invited only) “The Future of Clinical Mass Spectrometry”

19:00pm ~ 20:30pm Welcome Dinner (invited only)

2F Palace Banquet Room,

Ambassador Hotel

October13 Fri. (Conference Day 1) Location: International Research Building,

NSYSU 08:20 am ~ 08:50 am Registration & Morning Tea Lobby

08:50 am ~ 09:00 am Opening Remarks

09:00 am ~ 09:30 am

Plenary Lecture I Speaker: Alan Rockwood

(Department of Pathology, The University of Utah, USA) “Personal Perspectives on Mass Spectrometry for Clinical Diagnostics”

Chair: Jentaie Shiea (謝建台) (Department of Chemistry, National Sun Yat-Sen University, Taiwan )

09:30 am ~ 10:00 am

Plenary Lecture II Speaker: Liang Li(厲良)

(Department of Chemistry, The University of Alberta, CA) “Quantitative Metabolomics with Deep Metabolic Coverage for Discovery of

Metabolite Biomarkers of Diseases” Chair: Yi-Ting Chen (陳怡婷)

(Department of Biomedical Sciences, Chang Gung University, Taiwan )

Kwang Chung Hall

10:00 am ~ 10:30 am

Plenary Lecture III Speaker: Timothy Garrett

(Department of Pathology, The University of Florida, USA) “Clinical metabolomics explored from traditional LC-HRMS to direct tissue

analysis using liquid microjunction surface sampling” Chair: Ching-Hua Ku (郭錦樺)

(Department of Pharmacy, National Taiwan University, Taiwan )

10:30 am ~ 11:00 pm

Plenary Lecture IV Speaker: Man-Ho Choi

(Molecular Recognition Research Center, Korea Institute of Science and Technology, Korea)

“Bringing steroid profiling into the clinical chemistry lab” Chair: Chia-Ni Lin (林佳霓)

(Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taiwan )

Kwang Chung Hall

11:00 am ~ 11:10 pm Coffee Break Lobby

Session I: Disease Marker Discovery: Proteins/Peptides

(Location: Discussion RoomA) Chair: Yu-Chang Tyan (田育彰)

(Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical

University)

Session II: Disease Marker Discovery: Proteins/Metabolites/Lipids

(Location: 1F Discussion RoomB) Chair: Chi-Wei Lee (李啟偉)

(Institute of Medical Science and Technology, National Sun Yat-Sen University)

11:10 am ~ 12:10 pm

Speaker: Chuan-Fa Chang (張權發) (Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University)

“Glycoproteomic identification of novel serum biomarkers for oral cancer”

Speaker: Yi-Ting Chen (陳怡婷) (Department of Biomedical Sciences, Chang

Gung University, Taiwan) “An Update on Saliva Protein Biomarkers to

Detect Oral Squamous Cell Carcinoma in a High-Risk Population in Taiwan”

Speaker: Chao-Jung Chen (陳朝榮) (Graduate Institute of Integrated Medicine, China

Medical University) “The discovery of urinary protein markers

for urothelial carcinoma”

Speaker: Hui-Ling Lee (李慧玲) (Department of Chemistry, Fu Jen Catholic

University) “Development of LC-MS/MS analytical

methods for the quantification volatile organic compounds metabolites and oxidative stress

biomarkers in human urine: correlation with tobacco exposure biomarkers NNAL”

Speaker: Hsin-Yi Wu (吳欣怡) (Instrumentation Center, National Taiwan

University) “Quantitative Phosphoproteomic Approaches Delineate System-wide Signaling Networks in

B Cell Activation and Human Chronic Lymphocytic Leukemia B Cells”

Speaker: Chih-Yung Chiu (邱志勇) (Department of Pediatrics, Keelung Chang Gung

Memorial Hospital, Taiwan) “Metabolomic analysis of infectious

parapneumonic effusions in childhood pneumonia”

12:10 pm ~ 02:00 pm Lunch & Poster Exhibition & Seminars

Discussion Room & 2F

Hallway

02:00 pm ~ 02:30 pm

Plenary Lecture V Speaker: Yoshinao Wada

(Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka University, Japan)

“Recent advances in clinical glycoproteomics” Chair: Maw-Rong Lee (李茂榮)

(Department of Chemistry, National Chung-Hsing University, Taiwan )

02:30 pm ~ 03:00pm

Plenary Lecture VI Speaker: Ivan K. Chu

(Department of Chemistry, The University of Hong Kong, Hong Kong) “Protein tyrosine nitration: from bioanalytical to fundamental elucidation”

Chair: Hui-Ling Lee (李慧玲) (Department of Chemistry, Fu Jen Catholic University, Taiwan )

Kwang Chung Hall

03:00 pm ~ 03:30pm

Plenary Lecture VII Speaker: Junyan Shi

(Department of Pathology and Laboratory Medicine, The University of British Columbia, CA)

“Quantitation of C-reactive Protein by Mass Spectrometry for Better Clinical and Research Applications”

Chair: Sung-Fang Chen (陳頌方) (Department of Chemistry, National Taiwan Normal University, Taiwan )

03:30pm ~ 04:00pm

Plenary Lecture VIII Speaker: Zhongping Yao

(Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong)

“Rapid detection and quantitation of drugs-of-abuse in urine and oral fluid by mass spectrometry”

Chair: Pao-Chi Liao (廖寶琦) (Department of Environmental and Occupational Health, National Cheng Kung

University, Taiwan )

Kwang Chung Hall

04:00 pm ~ 04:10 pm Coffee Break Lobby

Session III: Drug Analysis (Location: Discussion RoomA)

Chair: Anren Hu (胡安仁) (Department of Laboratory Medicine and

Biotechnology, Tzu Chi University)

Session IV: Toxicology, Public Health and Protein Markers

(Location:1F Discussion RoomB) Chair: Ming-Tsang Wu (吳明蒼)

(Department of Public Health, Kaohsiung Medical University)

Speaker: Chia-Ni Lin (林佳霓) (Department of Laboratory Medicine, Linkou

Chang Gung Memorial Hospital) “Application of chromatography combined

with mass spectrometry in routine therapeutic drug monitoring of newer antiepileptic drugs”

Speaker: Pao-Chi Liao (廖寶琦) (Department of Environmental and

Occupational Health, National Cheng Kung University)

“HRMS-based metabolomics analysis reveals dissimilar metabolic fates in

urine/hairs and its implication in toxicant exposure assessment”

Speaker: I-Lin Tsai (蔡伊琳) (Department of Biochemistry and Molecular Cell

Biology, Taipei Medical University) “Application of mass spectrometry based

analytical methods for therapeutic drug monitoring and immunoglobulin biomarkers

investigation”

Speaker: Hauh-Jyun Candy Chen (陳皓君) (Department of Chemistry and Biochemistry,

National Chung Cheng University) “Mass spectrometric analysis of

Glyoxal-Induced DNA and protein modifications in blood of poorly controlled

Type 2 diabetes mellitus patients”

04:10 pm ~ 05:10 pm

Speaker: Ching-Hua Kuo (郭錦樺) (Department of Pharmacy, National Taiwan

University) “Developing LC-MS strategies for overcoming

blood volume and hematocrit challenges of dried Blood Spots in clinical analysis”

Speaker: Shu-Hui Chen (陳淑慧) (Department of Chemistry, National Cheng

Kung University) “LC-MS based proteomics for structural

characterization and biomarker discovery of proteins”

05:10 pm ~ 05:20 pm Heading to Sunset Beach Resort

05:20 pm ~ 08:00 pm

Conference Banquet (05:34 pm sunset) (Location: Seaview Restaurant)

October14 Sat. (Conference Day 2) Location: International Research Building, NSYSU

08:00 am ~ 08:30 am Registration & Morning Tea Lobby

08:30 am ~ 09:00 am

Plenary Lecture IX Speaker: Jialing Zhang

(Department of Chemistry and Biochemistry, The University of Texas at Austin, U.S.A.)

“Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system”

Chair: Cheng-Chih Hsu(徐丞志) (Department of Chemistry, National Taiwan University, Taiwan )

09:00 am ~ 09:30 am

Plenary Lecture X Speaker: Tae Geol Lee

(Center for Nano-Bio Measurement, World Class Laboratory, Korea Research Institute of Standards and Science, Korea)

“Surface mass spectrometry analysis for clinical applications” Chair: Yeou-Lih Huang (黃友利)

(Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Taiwan )

Kwang Chung Hall

09:30 am ~ 10:00 am

Plenary Lecture XI Speaker: Stephen J. Blanksby

(Central Analytical Research Facility, Institute for Future Environments, Queensland University of Technology, AU)

“Tracing the ups and downs of lipid isomers by mass spectrometry: sensitive, self-calibrated markers of biochemical change”

Chair: Hay-Yan Jack Wang (汪海晏) (Department of Biological Sciences, Sun Yat-Sen University)

10:00 am ~ 10:30 am

Plenary Lecture XII Speaker: Xianlin Han

(Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, U.S.A.)

“Lipidomics, shotgun lipidomics, and the applications in biological/ biomedical research”

Chair: Chu-Huang Chen (陳珠璜) (Department of Medicine, Kaohsiung Medical University, Taiwan )

10:30 am ~ 10:50 am Coffee Break Lobby

Session V: Emergency Management, Molecular Imaging and Drug Analysis

(Location: Discussion RoomA) Chair: Yen-Peng Ho (何彥鵬)

(Department of Chemistry, National Dong Hwa University)

Session VI: New Techniques and Methods for Clinical Diagnosis

(Location:1F Discussion RoomB) Chair: Bai-Hsiun Chen (陳百薰)

(Graduate Institute of Clinical Medicine, Kaohsiung Medical University )

Speaker: Chi-Wei Lee (李啟偉) (Institute of Medical Science and Technology, Sun

Yat-Sen University) “Point-of-care identification of toxic herbal

ingredients by ambient mass spectrometry in the emergency department”

Speaker: Pawel L. Urban (帕偉鄂本) (Department of Chemistry, National Tsing

Hua University) “Skin metabolite analysis enabled by

micropatch sampling and mass spectrometry”

10:50 am ~ 11:50 am

Speaker: Anren Hu (胡安仁) (Department of Laboratory Medicine and

Biotechnology, Tzu Chi University) “Development of sensitive and advanced clinical mass spectrometry for evaluation on vitamin D3

deficiency”

Speaker: Vinoth Kumar (庫碼) (Department of Medicinal and Applied

Chemistry, Kaohsiung Medical University)“Novel microextraction technique for

clinical analysis”

Speaker: Fu-Der Mai (麥富德) (Department of Biochemistry and Molecular Cell

Biology, Taipei Medical University) “Comprehensive Application of Time-of-flight

Secondary Ion Mass Spectrometry (TOF-SIMS) for Ionic Imaging and Bio-energetic Analysis of Club

Drug-induced Cognitive Deficiency”

Speaker: Cheng-Chih Hsu (徐丞志) (Department of Chemistry, National Taiwan

University) “Paper-based Blood Test and Cancer Diagnosis Using Ambient Ionization

Mass Spectrometry”

11:50 am ~ 12:00 pm Closing Remarks

附件二、

(2017 mass spectrometry for clinical diagnosis symposium) · 病理學系的timothy...

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