2019年暑期国际课程项目 -...

1

2019 年暑期国际课程项目International Summer Course Program

中国药科大学教务处

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国际课程汇总表序

号开课单位任课教师任课教师所属院校职称课程名（英文）课程名（中文）授课对象

1

生命科学

与技术学

院

Stefano Moro 意大利帕多瓦大学 Professor

Introduction to

Molecular Modeling and

Drug Design

分子模建与

药物设计导论15 级临药，16-18 级所有专业学生

2

基础医学

与临床药

学学院

Ikumi Tamai 日本金泽大学 ProfessorMembrane Transport and

Pharmacokinetics

跨膜运输与

药代动力学15 级临药，16-18 级所有专业学生

3 理学院 Pui Kai Li美国

俄亥俄州立大学Professor

How are drugs

discovered?

药物研发与

前沿进展15 级临药，16-18 级所有专业学生

4 理学院 Jie Jack Li 美国旧金山大学Associate

Professor

History of Drug

Discovery and Case

Studies

药物发现史及药物

合成实例探究15 级临药，16-18 级所有专业学生

5国际医药

商学院Chiaoyun Kuo 美国南加州大学

Assistant

Professor

Medical Product

Regulations in the U.S.美国药事法规 15 级临药，16-17 级所有专业学生

6国际医药

商学院

JACK WARREN

SALMON

美国伊利诺伊大学

芝加哥分校Professor Global Health Systems 全球卫生体系 15 级临药，16-17 级所有专业学生

7国际医药

商学院王存同


厄巴纳-香槟分校Professor

Quantitative Analysis

of Pharmaceutical

Management

医药管理数量分析 15 级临药，16-18 级所有专业学生

8国际教育

学院汪昕

澳大利亚

麦考瑞大学

SENIOR

LECTURERPsychology of Language 心理语言学 15 级临药，16-18 级所有专业学生

9 外语系Sheri

Sunderland

美国

曼斯菲尔德大学

Assistant

Professor

International Relations

and Global Issues

国际关系和

全球问题15 级临药，16-18 级所有专业学生

3

10 外语系 Baotong Gu美国

佐治亚州立大学

Associate

ProfessorBusiness Writing 商务英语写作 15 级临药，16-18 级所有专业学生

11 外语系George

Pullman

美国

佐治亚州立大学Professor

Rhetoric and Persuasive

Writing

修辞学和议论文写

作15 级临药，16-18 级所有专业学生

12 中药学院陳新澳门大学 Professor Wonder in Life Sciences 生命科學的奇蹟 15 级临药，16-18 级所有专业学生

13 中药学院 Rong L. He美国

芝加哥州立大学

Associate

ProfessorEssential Immunology 免疫学基础 15 级临药，16-18 级所有专业学生

14 中药学院Michael X.

Zhu德克萨斯大学 Professor Neuropharmacology 神经药理学 15 级临药，16-18 级所有专业学生

15 中药学院Kuniyoshi

Shimizu日本九州大学

Associate

Professor

Utilization of natural

resourcesas bioactive

ingredient for

medicine, cosmetics,

functional foods and

aroma

天然功能性成分在

药物、化妆品、功能

食品的应用及植物

芳香成分研究

15 级临药，16-18 级所有专业学生

16 药学院顾晓晨加拿大

曼尼托巴大学Professor

Transdermal Delivery

and Cosmetic

Applications

经皮给药和化妆品

应用15 级临药，16-18 级所有专业学生

17 药学院Richard A.

Gemeinhart


芝加哥分校Professor

Advanced Drug Delivery

System高端药物递送系统

15 级临药，16-17 级药学（包括生科

基地、理科基地）、药物化学、药物

分析、药物制剂、制药工程、食品质

量与安全、临床药学、生物制药、生

物工程、生物技术、海洋药学、中药

学、中药资源与开发、中药制药

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目录

分子模建与药物设计导论 INTRODUCTION TO MOLECULAR MODELING

AND DRUG DESIGN ..............................................................................................6

跨膜运输与药代动力学 MEMBRANE TRANSPORT AND

PHARMACOKINETICS ..........................................................................................9

药物研发与前沿进展 HOW ARE DRUGS DISCOVERED? .............................11

药物发现史及药物合成实例探究 HISTORY OF DRUG DISCOVERY AND

CASE STUDIES ......................................................................................................16

美国药事法规 MEDICAL PRODUCT REGULATIONS IN THE U.S..............18

全球卫生体系 GLOBAL HEALTH SYSTEMS ....................................................22

医药管理数量分析 QUANTITATIVE ANALYSIS OF PHARMACEUTICAL

MANAGEMENT ....................................................................................................26

心理语言学 PSYCHOLOGY OF LANGUAGE ...................................................29

国际关系和全球问题 INTERNATIONAL RELATIONS AND GLOBAL ISSUES

.....................................................................................................................................31

商务英语写作 BUSINESS WRITING ..................................................................34

修辞学和议论文写作 RHETORIC AND PERSUASIVE WRITING ................46

生命科學的奇蹟 WONDER IN LIFE SCIENCES ...............................................53

免疫学基础 ESSENTIAL IMMUNOLOGY .........................................................55

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神经药理学 NEUROPHRAMACOLOGY ...........................................................57

天然功能性成分在药物、化妆品、功能食品的应用及植物芳香成分研究

UTILIZATION OF NATURAL RESOURCESAS BIOACTIVE INGREDIENT

FOR MEDICINE, COSMETICS, FUNCTIONAL FOODS AND AROMA ..59

经皮给药和化妆品应用 TRANSDERMAL DELIVERY AND COSMETIC

APPLICATIONS .....................................................................................................61

高端药物递送系统 Advanced Drug Delivery System................................... 63

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INTRODUCTION TO MOLECULAR MODELING AND DRUG

DESIGN

分子模建与药物设计导论

开课学院：生命科学与技术学院

Resume of Instructor

Stefano Moro received his M.S. degree in Medicinal Chemistry (1991) and thePh.D. degrees in Physical Organic Chemistry (1995) at University of Padova.Following his doctoral studies, from 1996 until 1998, he was FogartyPostdoctoral Associate with Dr. Kenneth Jacobson in the MolecularRecognition Section, National Institute of Diabetes, Digestive, and KidneyDiseases, of the National Institutes of Health in Bethesda (MD, USA), beforejoining again the University of Padova in 1999 as Assistant Professor. In 2003,Dr. Moro was invited as Visiting Professor at the School of Pharmacy of theETH of Zurich, Switzerland. In 2010 he was appointed as Full Professor inMedicinal Chemistry of the University of Padova, Italy.

任课教师Instructor

’sInformatio

n

姓名Name Prof. Stefano Moro

性别Gender 男 Male

国籍Nationalit

y意大利 Italian

职称/职务Title

教授Full Professor

邮箱地址Email

[email protected]

最终学位Degree 博士 Ph.D. 任职单位

Work Place

意大利帕多瓦大学药学与药理学系

Dept. Pharmaceuticaland Pharmacological

SciencesUniversity of Padova

ITALY

课程信息Course

Information

课程名称(中英文对照)Course Name

分子模建与药物设计导论Introduction to Molecular Modeling and Drug

Design授课对象Open to

本科生Undergraduate

学时Class Hour 24

授课时间LectureSchedule

7.7-7.13考核方式Assessment

Method

综合考评Multiple choice

test

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Stefano Moro is the principal investigator of the Molecular Modeling Section(MMS, mms.dsfarm.unipd.it) at the Department of Pharmaceutical andPharmacological Sciences.He has authored or co-authored more than 250 original research papers and 2EU patent. Until today, its H-index is equal to 52 extracted from more than8500 citations (Scopus, 30/01/2019).Stefano Moro is also the recipient of several national and international awards:March 1991: Federchimica National Award for Young Research Excellence inChemistry;October 1993: IBM Foundation National Award for ResearchExcellence in Chemistry; January 1998: N.I.H. Fellow Award for ResearchExcellence; May 2000: Federchimica National Award for Research Excellencein Chemistry; September 2002: Farmindustria National Award for ResearchExcellence in Medicinal Chemistry.His name was included in the VIA-Academy Top Italian Scientists.

Course Description

本课程旨在介绍新药设计优化领域中的先进计算方法学和处理方式的基

本知识，展现药物的理化性质和药理特征之间的关联，并从分子水平上推

测它们可能的作用机制。

课程为理论教学，但须经一系列实验进行巩固，在此过程中学生将学习到

多种计算工具和信息学分析方法，这些工具和方法已被广泛应用于药学和

生物技术领域学术研究和工业实践。This course aims to provide the student with basic knowledge on moderncomputational methodologies and computing in the field of design andoptimization of new drugs, characterization a priori of their chemical-physicaland pharmacological properties, and study at the molecular level of theirpossible mechanisms of action.The course is theoretical but it is corroborated of a series of exercises, where astudent will know some of the computational tools and informatics most usedin both academic and in the various industrial reality to characterpharmaceutical and biotechnology.

Syllabus

Time-independent methodologies in the identification and optimization of drugcandidates:structures and properties similarity,pharmacophore hypothesis,molecular docking,virtual screening.

Time-dependent methodologies in the identification and optimization of drugcandidates:molecular dynamics (MD),supervised molecular dynamics (SuMD)

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free energy perturbation (FEP).

Evaluation. The examination at the end of the course aims to test the student'sability to understand important aspects related to the molecular modeling anddrug design.

Final exam: multiple choice test

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MEMBRANE TRANSPORT AND PHARMACOKINETICS

跨膜运输与药代动力学

开课学院：基础医学与临床药学学院


Ikumi Tamai教授于1988年毕业于日本东京大学，获得药学博士学位，1989

至1991年在美国芝加哥大学和密西根大学从事博士后研究。1992年起工作

于金泽大学、东京理工大学药学院，目前任金泽大学药物跨膜转运及药物

代谢研究室主任，主要研究方向为药物代谢动力学及药物转运体。曾任日

本药动学会《Drug Metabolism&Pharmacokinetics》杂志主编，现任

《Biopharmaceutics & Drug Disposition》副主编，同时为《Drug Metabolism

& Disposition》、《Molecular Pharmaceutics》等四个国际知名杂志的编委。

Course Description

本课程主要将介绍药物代谢动力学以及膜转运体在生理上、药物代谢、药

物治疗以及新药开发中的重要作用。课程将围绕药物代谢动力学和膜转运

体的基本概念，利用各种案例阐明OATP, URAT等转运体的在药物相互作

用、食物与药物相互作用、以及内源性物质转运中重要性。通过课程的学

习，学生可掌握药物代谢动力学的基础知识，同时对药物转运体的作用有

基本的了解。This class mainly deals with the bases of pharmacokinetics, membranetransport and importance of membrane transporters in drug absorption and


’sInformati

on

姓名Name Ikumi Tamai

性别Gender 男

国籍Nationalit

y日本

职称/职务Title 教授邮箱地址

[email protected]

.ac.jp最终学位Degree 博士任职单位

Work Place 日本金泽大学

课程信息Course

Information


跨膜运输与药代动力学Membrane Transport and Pharmacokinetics

授课对象Open to

大一至大三学生

学时Class Hour 24



Method

书面作业 50%，演讲50%

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disposition to understand pharmacokinetic properties of drugs, which should beimportant in drug development and pharmacotherapy. In addition, importanceof membrane transporters for nutrients and physiological compounds aredescribed, including urate and carnitine. More practically, classification ofmembrane transport process and transporter molecules are explained.Pharmacokinetic relevance of transporters are described. Transporter-basedregulations of physiological compounds such as uric acid mainly and carnitineoptionally are described. In addition, the mechanisms for altered serum uricacid levels by clinically used drugs are explained that are important to maintainnormal serum uric acid level. Through this course, students learn currentunderstanding of pharmacokinetics, membrane transport and transporters thatare especially important for students who learn pharmaceutical sciences.

Syllabus

1: Introduction to ADME PK2: Basis of membrane transport and transporters3: Characteristics of drug transporters; MDR1, BCRP, MRPs, OATPs, OATs,OCTs4: Effect of food and PGx on transporters, OATP2B15: Mechanisms regulating SUA mainly by transporters including food effectand uric acid related diseases.

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HOW ARE DRUGS DISCOVERED?

药物研发与前沿进展

开课学院：理学院


Dr. Pui Kai Li is currently the faculty at the Division of Medicinal Chemistry,Colleg of Pharmacy, The Ohio State University. He received his bachelordegree in Pharmacy from the University of Wyoming (1983) and Ph.D degreein Medicinal Chemistry at The Ohio State University (1988). Dr. Li has beeninvolved in teaching Medicinal Chemistry focusing on drug design anddiscovery for more than 25 yrs. He also established research programs indiscovery new drugs for the last 25 yrs and has published more than 100research papers on new drugs development.

Resume: Pui Kai Li, Ph.D.Birthday – August 30, 1957Occupation – ProfessorUniversity name – The Ohio State UniversityAddress – College of Pharmacy, The Ohio State University, Columbus OH43210 USAPhone # 614-688-0253 Fax 614-688-5886email : [email protected] taught the last 3 yrs at The Ohio State University


’sInformatio

n

姓名Name Pui Kai Li （任课教师证

件照）性别Gender Male

国籍Nationalit

yUSA

职称/职务Title Professor 邮箱地址

Email [email protected]

最终学位Degree Ph.D. 任职单位

Work PlaceOhio StateUniversity

课程信息Course

Information


How are drugs discovered?药物研发与前沿进展

授课对象Open to

Undergraduateand graduate

students

学时Class Hour 24


3 hrs a day考核方式Assessment

Method

Short report,group and

individual oralpresentations(in English)

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1. Medicinal chemistry I (for pharmacy students) – focus on drugs for thetreatment

of hypertension and diabetes.2. Medicinal chemistry II (for Pharmacy student) – focus on drugs for thetreatment

of infectious diseases (antibiotics), pain (anti-inflammatory) and cancerimmunotherapeutic agents.

3. Advanced Medicinal Chemistry – Signal Transduction pathway and cancer –overview the major signaling pathways (receptor tyrosine kinase, PI3

kinase Akt,Ras/Raf MAPkinase signaling, STAT, cell cycle signaling, signaling of

immunecells and cancer immunotherapy).

4. Principle of drug action (for pharmacy student) – focus on principle ofdrug

design and action.5. Introduction to Medicinal Chemistry (for undergraduate students) – focuson the

principle of drug design and discovery

Education and Academic position1983 Bachelor degree in Pharmacy, University of Wyoming,1988 Ph.D. degree in Medicinal Chemistry, Division of Medicinal Chemistryand

Pharmacognosy, College of Pharmacy, The Ohio State UniversityAcademic Appointments1984 – 1986 Graduate Teaching Assistant, The Ohio State University,Columbus, OH1986 – 1988 Graduate Research Assistant, The Ohio State University,Columbus, OH 1988 – 1989 Postdoctoral Researcher, Department of MedicinalChemistry, College

of Pharmacy, The Ohio State University, Columbus, OH1989 – 1990 Postdoctoral Researcher, Department of Veterinary Physiologyand

Pharmacology, The Ohio State University, Columbus, OH1990 -1996 Assistant Professor, School of Pharmacy, Department of

Pharmaceutical Chemistry and Pharmaceutics, Duquesne University,Pittsburgh, PA

1995 – 1999 Associate Professor, School of Pharmacy, Department ofPharmaceutical Chemistry and Pharmaceutics, Duquesne University,

Pittsburgh, PA1999 – 2003 Associate Professor, College of Pharmacy, Division of

Medicinal Chemistry and Pharmacy, The Ohio State University,Columbus, OH

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2003 – 2013 Associate Professor, College of Pharmacy, Chair, Division ofMedicinal Chemistry and Pharmacy, The Ohio State University,

Columbus, OH2013 – present Associate Professor, College of Pharmacy, Division of

Medicinal Chemistry and Pharmacy, The Ohio State University,Columbus, OH

Research projects the last 3 yrs1. Design and synthesis of niclosamoide analogs as androgen receptordegradator for prostate cancer.

2. Design, synthesis and studies of Mps1/TTK kinase inhibitors forcancers.

3. Design and synthesis of mixed lineage kinase 4 (MLK4) inhibitors forGlioblastoma.

4. Design, synthesis and studies of STAT3 inhibitors as potential agents forthe

treatment of cancers.5. Design, synthesis and studies of Vitamin E analogs as antitumor

agents forprostate cancer.

Selected Publications (out of a total of 105 publications)

Li, Y.; Li, P. K.; Roberts, M. J.; Arend, R. C.; Samant, R. S.; Buchsbaum, D. J.Multi-targeted therapy of cancer by niclosamide: A new application for an olddrug. Cancer Lett. Jul 10;349(1): 8-14 (2014)

Kim, T.D.; Fuchs, J.R; Schwartz, E.; Abdelhamid D.; Berry, W.L.; Li, C.; Ihnat,M.A;Li, P.K.; Janknecht, R. Pro-growth role of the JMJD2C histone demethylase inHCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.American Journal of Translational Research 15(6), 236 – 47, (2014)

Kesnger, J.W.; Mehta, M.; Lerner, M.R.; Brackett, D.J.; Brueggemeier, R.W.;Li, P.K.'; Panto, J.T. Anticancer Research 35(1) 47-52, (2015)

Arend RC, Londoño-Joshi AI, Gangrade A, Katre AI, Kurpad C, Li Y, SamantRS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, ForeroA, Buchsbaum DJ.

Niclosamide and its derivatives are potent inhibitors of Wnt/-catenin, mTOR

and STAT3 signaling in ovarian cancer. Oncotarget: 7(52): 86803-86815(2016).

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Zhao J, Yu H, Liu Y, Gibson SA, Yan Z, Xu X, Gaggar A, Li PK, Li, C,Benveniste EN, Dong L, Qin H. Protective Effects and Mechanisms ofSuppressing STAT3 Pathway on LPS-induced Acute Lung Injury. Am J PhysiolLung Cell Mol Physiol: 311(5) L868-880 (2016).

Sugimoto Y, Sawant DB, Fisk HA, Mao L, Li C, Chettiar S, Li PK, DarbyMV, Brueggemeier RW. Novel Pyrrolopyrimidines as Mps1/TTK KinaseInhibitors for Breast Cancer. Bioorg Med Chem: 25(7), 2156-2166 (2017).

Course Description

Course description: In the near future, China will be the world leader in drugdiscovery. For students interested in life sciences, it is important to understandthe drug discovery process. This course will present in a simple and clearmanner the process of drug discovery. Students will learn the cutting edgeprocesses of drug discovery with examples of the latest new drugs (for cancers,diabetes and HIV) currently used to treat patients. This course is suitable forundergraduate students majoring in life sciences and also students interested inmedical research.课程描述：在不久的将来，在药物发现领域中国将成为世界领先。对生命

科学感兴趣的学生来说，了解药物发现过程是很重要的。本课程将以简单

明了的方式介绍药物发现的过程。并用最新的治疗癌症、糖尿病和HIV的

药物来向学生们介绍最前沿的药物发现过程。本课程适用于药学、生命科

学专业的本科生以及对医药学研究感兴趣的学生。Course format: course will be delivered (in English) in a more interactivemanner. It will involve lectures will powerpoint presentation. Students will berequired to be involved in research paper review, team based learning andgroup discussions (in English). Students will have a lot of opportunity tocommunicate with the teacher and the other students in English.课程形式：课程全英文授课，将以更具互动性的方式进行。它将包括讲课，

幻灯片演示。学生将被要求参加研究论文的复习，小组学习和小组讨论（英

文）。学生将有很多机会与老师和其他学生用英语交流。

Syllabus

‐ Overview of Drug Discovery- Program selection (what type of diseases do we want to treat, Cancer,

Diabetes, HIV?)‐ Identification of drug targets and drug hit: small molecules or naturalproducts

‐ What are high throughput drug screening and virtual screenings.‐ What are the approaches after identify drug hits (Lead optimization –pharmacophore and structure activity relationships)

‐ Drug optimization methods

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‐ What are ADME (administration, distribution, metabolism, excretion)and drug properties.

‐ Examples of New Drug discoveryFor cancer – latest epigenetic drugsFor Diabetes – glucose transporter inhibitorsFor HIV – Integrase inhibitors

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HISTORY OF DRUG DISCOVERY AND CASE STUDIES

药物发现史及药物合成实例探究

开课学院：理学院


李杰，化学副教授。分别于1983年及1988年于南京大学获得学士学位与硕

士学位，1995于印第安那大学获得博士学位，后于麻省理工学院进行博士

后培训。具有15年药剂师从业经验，先后出版英文书刊25本。

Dr. Jie Jack Li received his BS and MS from Nanjing University in 1983 and

1988, respectively. He earned his PhD at Indiana University in 1995 and

carried out his postdoctoral training at MIT. After 15 years working as a

medicinal chemist, his is now an associate professor of chemistry. He has

published 25 books in English.

Course Description

课程涵盖主要治疗领域的药物史，重点是人文的一面。八种重要药物的合

成将作为案例研究讨论。

This course covers history of medicines in major therapeutic fields, with

emphasis on humanistic side. The synthesis of ten important drugs will be

任课教师Instructor’sInformation

姓名Name Jie Jack Li

性别Gender Male

国籍Nationalit

yUSA

职称/职务Title

AssociateProfessor

邮箱地址Email

[email protected]

最终学位Degree PhD 任职单位

Work Place USF

课程信息Course

Information

课程名称（中英文对照）Course Name

药物发现史及药物合成实例探究History of Drug Discovery and Case Studies

授课对象Open to

WholeStudents

学时Class Hour 24


July 713考核方式Assessment

MethodAn Essay

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discussed as case studies.

Syllabus

Case Study 1: Discovery of linezolid (Zyvox), Inhibitor of the initial phase ofbacterial protein synthesisCase Study 2: Discovery of Imatinib Mesylate (Gleevec), a Protein KinaseInhibitorCase Study 3: Discovery of Amlodipine (Norvasc), A Calcium Channel BlockerCase Study 4: Discovery of Duloxetine (Cymbalta) A Serotonin andNorepinephrine Reuptake Inhibitor (SNRI)Case Study 5: Celecoxib (Celebrex)Case Study 6: Discovery of Sofosbuvir (Sovaldi), an HCV NS5B PolymeraseInhibitorCase Study 7: Entecavir (Baraclude), A Carbocyclic Nucleoside for theTreatment for Chronic Hepatitis BCase Study 8: Syntheses of Atorvastatin (Lipitor)Alternative if Time allowed:Case Study 9: Syntheses of Rivaroxaban (Xarelto): A Factor Xa Inhibitor forthe Treatment of Thrombotic EventsCase Study 10: Discovery of Esomeprazole (Nexium), A Proton Pump Inhibitorfor Treating GERD

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MEDICAL PRODUCT REGULATIONS IN THE U.S.

美国药事法规

开课学院：国际医药商学院

Dr. Kuo is a faculty member in the Department of Regulatory and QualitySciences, School of Pharmacy where he coordinates the courses like “AsianRegulatory Environments”, “Current Thinking in Regulatory Affairs”,“Pharmaceutical Product Reimbursement” and is the principal instructor fortopics of “orphan drug regulations”, “clinical trial application drafting”, and“medical product intellectual property”. He also directs the Consulting Servicein the International Center for Regulatory Science providing consultation onregulatory compliance, submission requirements, and strategic planning forinnovative products to USC investigators and community members. Dr. Kuohas been working in regulatory affairs for the past 15 years and engaged in fullspectrum of medical products and regulatory activities – from drugs andbiologics, to medical devices, dietary supplements, cosmetics, as well as quality,auditing and clinical trials. His prior experiences including basic research,bioinformatics, and patent persecution. Dr. Kuo completed his Ph.D. in thefield of biomedical sciences, received degrees and postdoctoral training at USC


’sInformatio

n

姓名Name Chiaoyun Kuo

性别Gender Male

国籍Nationalit

yUSA

职称/职务Title

AssistantProfessor

邮箱地址Email [email protected]

最终学位Degree PhD 任职单位

Work Place

University ofSouthernCalifornia

课程信息Course

Information

课程名称(中英文对照)Course Name Medical Product Regulations in the U.S.

授课对象Open to

3rd and 4thyear college

students

学时Class Hour 24


6 hours perday, July 8 to

July 12 (5days) in

two-hour & 15minuteperiods

考核方式Assessment

Method

OneMultiple-Choice

Exam (July 12); anda group projectand presentation

(July 12)

19

and Stanford University and is certified by the USPTO and the RegulatoryAffairs Professional Society (RAPS).

Course Description

This introductory course is designed as a first course for students enrolled inthe formal Regulatory Science Master’s program. It also can be an optionalcourse that serves as an overview for international students and students fromother disciplines, such as graduate programs in biomedical, pharmaceutical andengineering fields. The course is designed to introduce the laws, regulationsand institutions governing medical products in North America. Students will beintroduced to the purposes of regulations and their relationships with the law.Particular attention will be paid to regulations that shape the developmentalpath of medical products. The students should be able to map the history ofregulatory policies in the US. They should be able to differentiate the spheresof organization, authority and products regulated of FDA centers and localauthorities. Students will also become familiar with the regulations shaping thestructure and conduct of preclinical and clinical trials.

Syllabus

Medical Product Regulations in the U.S.CPU, NanjingJuly 8-12, 2019

Instructor: Dr. Chiaoyun Benson KuoE-mail address: [email protected]

Required Text:Douglas J. Pisano and David Mantus (2014) FDA Regulatory Affairs (ThirdEdition)(Preview version in PDF format is available)

Course Description :This introductory course is designed as a first course for students enrolled inthe formal Regulatory Science Master’s program. It also can be an optionalcourse that serves as an overview for international students and students fromother disciplines, such as graduate programs in biomedical, pharmaceutical andengineering fields. The course is designed to introduce the laws, regulationsand institutions governing medical products in North America. Students will beintroduced to the purposes of regulations and their relationships with the law.Particular attention will be paid to regulations that shape the developmentalpath of medical products.

General Course Objectives:The textbook, in-class discussions, lecture materials and student presentations

20

are designed to help students:1. To be able to map the history of regulatory policies in the US;2. To be able to differentiate the spheres of organization, authority andproducts regulated of FDA centers; and

3. To become familiar with the regulations shaping the structure and conductof preclinical, clinical trials and post-market surveillance.

Tentative Course Schedule/OutlineJuly 81. Introduction to FDA and Medical Product Regulations1.1. Policy, Law and Regulation1.2. FDAHistory, Structure and Roles1.3. Pharmaceutical Development1.4. Intellectual Property Rights1.5. Preclinical Investigation and Good Laboratory Practice (GCP)1.6. Clinical Studies and Reimbursement

July 92. Drug and Biologics Regulations2.1. Innovative Drug Development2.2. Biologics Product Regulations2.3.Orphan Drug Regulations2.4.Generic Drug Regulations2.5.Over-the-Counter Drugs2.6. TCM and Dietary Supplements

July 103. Medical Device Regulations and Quality System Requirements3.1. Regulations of Medical Devices3.2.Medical Device Classification3.3. Registration, Listing and 510(k) process3.4.De Novo Process3.5.Medical Product Quality3.6. Combination Products

July 114. Clinical Trial Designs and FDA Expedited Programs4.1. Clinical Trials of Drugs: History and Requirements4.2. Clinical Trial Designs4.3. Expediated Review Programs4.4. Post-market Surveillance Programs4.5.Medical Product Reimbursement4.6. Careers in Regulatory Affairs

21

July 125. Review and Group Presentations

Final Exam 10 pre-designed topics will be presented in English by student groups

The course schedule is flexible. If we need more time for a chapter, we willtake the time. Conversely, we may get ahead of schedule at times.Expectations

1. To attend class.2. To participate in class discussions.3. To be prepared for each exam or assignment.4. To work in team and make group presentation.

Course GradesFinal grades will be assigned on the basis of the average of the final exam,written group paper, group presentation and class participation; according tothe following weights:

Final Examination 80%Project 20%

100%GRADING SCALE100 - 93 = A92 - 90 = A-89 - 87 = B+86 - 83 = B82 - 80 = B-79 - 77 = C+76 - 73 = C72 – 70 = C-69 - 67 = D+66 - 63 = D62 - 60 = D-< 60 = F

22

GLOBAL HEALTH SYSTEMS

全球卫生体系


Salmon教授是伊利诺伊大学芝加哥分校药学院教授、公共卫生学院教授、

城市规划与公共事务学院教授、医学院教授，曾任药学院药物政策与经济

学系主任。Salmon教授目前已退休，但仍笔耕不辍，与各国学者合作发表

大量论文、出版著作、撰写医改专栏，还担任费城两所医学院应用健康领

域的客座教授与社区医学与环境卫生领域的副教授。Salmon教授在国际卫

生领域也十分活跃，不仅发起并组织美国诸多合作研究网络，还在德国、

泰国、沙迦、阿联酋、台湾等国家和地区进行讲座和学术交流活动。Salmon


’sInformatio

n

姓名Name JACK WARREN SALMON, Ph.D.

性别Gender 男/Male

国籍Nationalit

y美/USA

职称/职务Title

公共卫生教授、药学教授/Professor ofPublic Health &Pharmacy

邮箱地址Email

[email protected]

最终学位Degree

博士/BS, MS,Ph.D.

任职单位Work Place

伊利诺伊大学芝加哥分校/University ofIllinoisat Chicago(Retired)

课程信息Course

Information

课程名称(中英文对照)

Course Name全球卫生体系/Global Health Systems

授课对象Open to

大二以上/Senior

Undergraduateand

postgraduate

学时ClassHour

24


2019.07.07-12am

每天上午

考核方式Assessme

ntMethod

讨论、报告、论文/class performance,presentation and

thesis

23

教授曾访问中国若干次，和国内学者也联合出版卫生服务和医药产业领域

的著作。任课教师简历和自述请见附件。Professor University of Illinois at Chicago Colleges of Pharmacy, School ofPublic Health College of Urban Planning and Public Affairs, College ofMedicine (retried). Currently active researcher and writer, publishingextensively with colleagues. Previously Adjunct Professor of Allied Health andAssociate Professor of Community Medicine and Environmental Health at twoPhiladelphia Medical Schools. Leadership positions in national professionalorganizations providing extensive friendship network across the USA. Taughtcourses in Germany, Thailand, Sharjah, UAE, Taiwan. Visited China twice andpublished with Chinese colleagues on health care and pharmaceutical industry.See attached curriculum vitae and bibliography of Professor Salmon.

Course Description

全球卫生体系以高年资本科生为主要授课对象。目前中国已经进入全民医

保覆盖的新阶段，领域中的学者和学生都急需了解其他国家卫生服务体系

的设计，在基础上才能更好理解公众的健康需求以及所需要的健康服务、

政策、项目、规范是什么样的。在次背景下，医药产业和跨国药企也产生

了相应的变革。了解上述领域中药师职责和职业环境的变化对我校学生来

说有深刻的影响。课程中还将重点阐述各国药物流行病学的应用。学生将

分组就相关指定命题进行讨论和汇报。教材全部采用英文材料，同时辅助

提供相关联的中文文献便于增强理解。同时，还将设计课堂小测验以了解

学生对所授内容的掌握程度。Global Health Systems for undergrads. While undergoing health care reformtoward universal coverage in China, students need other national health systemperspectives to plan their practice options to address broader public healthneeds. Much is changing worldwide in the profession of pharmacy and withdevelopments the multi-national pharmaceutical industry. Knowledge ofchanging roles and environments for pharmacists can greatly benefit students.The key place of pharmacoepidemiology (drug use in populations) in assessingany system will be highlighted. Small groups of students will be organized forpresentations on assigned topics after lecture discussions encouraging activelearning. Course articles in English, complemented by Chinese literature whereavailable, will provide background for various subjects and nations’ inquiries.Periodic quizzes will be also used to identify students’ grasp of the coveredmaterial.

Syllabus

时间安排/Global Health Systems course topics will include:

07/07 09:00-12:00- Types of Nation’s Health Care Systems (NHS, NHI, Private, and

24

Mixed)/国家卫生服务体系的类型（国家卫生服务体系、国家医保、

商业医疗、混合型）

- Disease structures and varying approaches to health system design/疾

病构成及卫生体系的设计方式

07/08 09:00-12:00- The rise and threat of social epidemics, social and ecological

conditions/社会流行病、社会生态环境的产生及威胁

- Examples: England, Germany, Canada, USA, China, India, Japan,

Developing nations/案例：英国、德国、加拿大、美国、中国、印度、

日本、发展中国家

07/09 09:00-12:00

- The global drug market/全球药物市场

- Multinational Pharmaceutical industry developments/跨国药企的发展

- Importance of advances in medical technology and information

technology/医学技术及信息技术进步的重要性

07/10 09:00-12:00

- Pharmacoeconomic and pharmacoepidemiology analyses/药物经济学

和药物流行病学分析

07/11 09:00-12:00

- Pharmacists relations with other professionals in coordinated care/整合

型服务中药师的作用及与其他执业人员的关系

- Community assessments for drug needs and practical interventions/用

药需要及干预的社区分析

07/12 09:00-12:00

- What way forward for China and the Pharmacy profession?/中国未来

卫生服务体系的道路及药学专业的发展方向？

25

授课形式

Lectures, discussions, small group assignments and presentations, and studentself-study/library research/Internet searches will be utilized to promote learningand understanding of the subject material. Students will be assessed for their

learning and performances/讲座、讨论、小组作业及汇报、自学；图书资料

及网络检索；结课评价将基于学习过程及表现综合评定。

26

QUANTITATIVE ANALYSIS OF PHARMACEUTICALMANAGEMENT

医药管理数量分析


人口学博士、教授。博士毕业于北京大学（与 University of Michigan

合作培养)，就职于美国伊利诺伊大学。从事社会统计及计量经济分析、人

口健康学、人口社会学、人口经济学等领域的研究与教学。

2013 年入选教育部新世纪优秀人才计划，兼任国家人口计生委综合改

革专家组专家、美国人口学会(PAA) 会员、国际人口联盟(IUSSP)会员、IUSSP

社会科学定量方法培训专家组成员、北京大学社会科学方法培训特聘教

授、美国伊利诺伊大学及芝加哥大学合作研究员。

SSCI/SCI 索引期刊发表研究论文 30 余篇、中文核心期刊发表定量研究


’sInformatio

n

姓名Name 王存同

性别Gender 男

国籍Nationalit

y中华人民共和国


[email protected]

最终学位Degree 博士任职单位

Work Place

University ofIllinois at

Urbana-Champaign，UIUC

课程信息Course

Information


Course Name

医药管理数量分析Quantitative Analysis of Pharmaceutical

Management

授课对象Open to 本科生

学时ClassHour

24


2019.7.7-2019.7.12


ntMethod

课堂作业

27

论文 40 余篇，出版著作 4 部；主持国家社科基金项目 2 项、横向课题 12

项；以子课题负责人身份参与国家重大自然科学基金 2 项、国家部委横向

课题 10 余项。

Course Description

随着社会科学研究逐渐向科学化、精细化、实证化发展，在科研过程对于

定量研究所需的能力要求也逐步提高。但在医药卫生经管类专业本科生的

课程设置中，对于此项能力的培养还远未达到实际科研要求，导致本科生

在科研过程中，尤其是研究逐步深入到定量研究阶段，需要设计实验，建

立模型，搜集数据展开分析评价时，需花费大量时间精力自学相关研究方

法，造成了大量的时间、精力的浪费，而且最终学习效果差强人意，影响

研究质量。

本次医药管理数量分析训练营将循序渐进，力图使学员在较短时间内了解

常用健康研究领域计量模型的基本思想、原理、条件及适用范围，并以真

实数据为演示案例，培训学员模型构建、软件应用及结果解读的能力，提

高学员定量论文写作的水平。

With the gradual development of social science research towardsscientificalization, refinement and positivism, the ability requirement forquantitative research in the process of scientific research is gradually improved.However, in the course design of undergraduates majoring in medical andhealth economics and management, the cultivation of this ability is far frommeeting the actual requirements of scientific research. As a result,undergraduates need to design experiments, build models and collect data foranalysis and evaluation, and spend a lot of time and energy on self-study ofrelevant research methods in the process of scientific research, especially in thestage of quantitative research. A lot of time and energy are wasted, and theultimate learning effect is unsatisfactory, which affects the quality of research.

This training camp will step by step, trying to make students understand thebasic ideas, principles, conditions and scope of application of measurement

28

models in the field of health research in a short period of time, and take realdata as demonstration cases to train students ‘ability of model building,software application and result interpretation, so as to improve the students'writing level of quantitative papers.

Syllabus

第一天理论：统计学及计量经济学基本概念

实验：STATA 入门操作

第二天理论：一元与多元线性回归

理论：违背经典回归假定的应对

第三天理论：多元线性回归模型与实验设计

实验与讨论：案例分析与论文写作

第四天理论：二分因变量模型与实验设计


第五天理论：多分类因变量模型与实验设计


第六天理论：定序回归模型、计数变量回归模型与实验设计


29

PSYCHOLOGY OF LANGUAGE

心理语言学

开课学院：国际教育学院

汪昕博士就职于麦考瑞大学语言系。曾在新加坡国立大学，牛津大学

任教。她的研究兴趣主要是心理语言学，双语，二语习得。

Course Description

This course will introduce students to the foundations of Psychology ofLanguage (Psycholinguistics), which examines how the human mind and brainprocess linguistic information. Experimental techniques in studying humanlanguage processing and mechanisms will also be introduced and discussed.Most topics will center on the issue of Bilingualism and Second LanguageAcquisition.

Syllabus

Day 1: How does the human mind/brain process language?


’sInformatio

n

姓名Name 汪昕

性别Gender 女

国籍Nationalit

y中国

职称/职务Title SENIOR LECTURER 邮箱地址

[email protected]

u.au最终学位Degree 博士任职单位

Work PlaceMacquarieUniversity

课程信息Course

Information


Course NamePsychology of Language (心理语言学)

授课对象Open to 本科生

学时ClassHour

24 课时


7 月 9 日至 13日


ntMethod

多项选择和个人课堂 presentation

30

Day 2: Experimental Techniques to do language researchDay 3: Lexical Processing and MechanismsDay 4: Sentence Processing and MechanismsDay 5: Bilingualism and Second Language Acquisition

31

INTERNATIONAL RELATIONS AND GLOBAL ISSUES

国际关系和全球问题

开课学院：外语系


I have a Ph.D. in Political Science from Temple University with aspecialization in international relations. My research interests are broadlyfocused on security studies and more narrowly, on peacekeeping. In particular,I have researched the effectiveness of different types of peacekeeping operationsin Africa.

I have considerable teaching experience. Most recently, I have taught at LockHaven University from 2017-18, Susquehanna University in 2017 and atMansfield University from 2015-16. I have taught a variety of classesincluding International Relations, World Politics, United Nations andInternational Organizations, and World Affairs.


’sInformati

on

姓名Name Dr. Sheri Sunderland

性别Gender Female

国籍Nationalit

yUSA

职称/职务Title

AssistantProfessor

邮箱地址Email

[email protected]

最终学位Degree

PhD (PoliticalScience)


MansfieldUniversity ofPennsylvania,

USA

课程信息Course

Information


Course Name

国际关系和全球问题International Relations and Global Issues

授课对象Open to All Students 学时

Class Hour 16


7/8 – 3 hrs7/9 – 3 hrs7/10 – 4 hrs7/11 – 3 hrs7/12 – 3 hrs

Mornings


Method

In-classactivities

Readings/Homework QuizzesGlobal IssuesProject Final

Quiz

32

My teaching philosophy is based on the importance of student engagement.I believe that engagement is crucial to student success and my students oftencomment that they not only enjoy group discussions, but that they feel thatthey contribute significantly to their learning. Discussions that inspire questions,debates and reflections will help students to think critically and to drawconnections between abstract theoretical concepts and current events. I alsobelieve that prompt responses to student questions and assignments by theprofessor play a key role in keeping students fully engaged in the learningprocess.

Course Description

The course begins with a brief survey of the major theoreotical approaches tointernational relations, including realism, liberalism, and constructivism.Students will also be introduced to fundamental concepts of internationalrelations, including anarchy, sovereignty, balance of power, comparativeadvantage, and globalization, as well as the main actors of internationalrelations, including states, intergovernmental organizations (IGOs),multinational corporations (MNCs), and non-governmental organizations(NGOs).

Next students will be introduced to basic concepts of warand security in international relations, international law, and internationalorganization. Particular attention will be paid to the organization andfunctions of the United Nations.The United Nations was created in theaftermath of World War II as an organization to promote economicdevelopment and conflict resolution. Students will examine the evolutionof the United Nations since 1945, including its increasingattention to human rights issues, the important role of the Security Counciland its permament members in maintaining international stability,and the impact of economic globalization. Students willanalyze the UN General Assembly as a forum for discussinginternational problems and as a forum for collective action.

Throughout the course students will also have the opportunity to analyze anumber of global issues and challenges facing the international community andto recognize the ways in which events abroad affect their lives and the welfareof their society. In addition, students will analyze China’s growing role as aworld leader in the international community.

Syllabus

Text: Bova, Russell. How the World Works: A Brief Survey of International

Relations (3/e), Pearson Press, 2017. Supplemental academic article on Challenges/Issues Confronting the

33

United Nations (TBD) Supplemental academic article on China ’ s Increasing Role in the UN

(TBD) Supplemental academic articles on IR topics (TBD)

Course Requirements and Breakdown of Grade: Tests – 100 points (50%) Homework/In-class Assignments – 80 points (40%) Global Issue Presentation – 20 points (10%)

Tentative Course Outline (5 days): Day 1 – Overview of Fundamental Concepts of IR and IR Theories,

Levels of Analysis, Realism, War and International Security – Bova,Chapters 1-4

Day 2 – Liberalism and Constructivism, International Law andOrganization, Overview of the United Nations – Bova, Chapter 5

Day 3 – Universal Declaration of Human Rights, Peacekeeping,Economic Globalization – Bova, Chapters 6-7

Day 4 – Global Issues Presentations – Bova, Chapter 8 Day 5 – China’s Role in the World and Global Futures – Bova, Chapter 9

34

BUSINESS WRITING

商务英语写作



Dr. Baotong Gu is the Director and associate professor of rhetoric andcomposition at Georgia State University. His research covers such areas aswriting technology theories, content management, and cross-culturalcommunication. In addition to journal articles, Gu has published five editedcollections and one scholarly monograph entitled From Oracle Bones toComputers: The Emergence of Writing Technologies in China. Gu has alsoserved as a referee reader for such journals as Technical CommunicationQuarterly, Technical Communication, Journal of Business and TechnicalCommunication, and Second Language Writing. He was the director of LowerDivision Studies from 2008 to 2010 and the director of the Confucius Instituteat Georgia State University from 2010-2014. He also served on the ExecutiveCommittee of the ATTW and was the conference chair for the 2012 nationalATTW conference.

顾宝桐博士，佐治亚州立大学终身教授，博士生导师。1983年毕业于


’sInformatio

n

姓名Name Baotong Gu 顾宝桐

性别Gender Male 男

国籍Nationalit

yUSA 美国

职称/职务Title

AssociateProfessor副教授


最终学位Degree PhD 博士任职单位

Work Place

Georgia StateUniversity


课程信息Course

Information

课程名称(中英文对照)Course Name Business Writing 商务英语写作

授课对象Open to All students

学时ClassHour

16


Mornings


ntMethod

3 quizzes3 次测验1 designproject1 个设计1 presentation1 次课堂演

讲

35

苏州大学，毕业后留校任教。1992年赴美深造，1994年获得美国衣阿华

州立大学商务与科技英语写作硕士，2000年获得普渡大学修辞与写作博

士。1999－2002年在东华盛顿大学任教，2002年至今在佐治亚州立大学

任教。2008-2010年任佐治亚州立大学英语写作部主任，2010－2014年担

任佐治亚州立大学孔子学院美方院长，现任英语系修辞与写作教研室主

任。

顾宝桐主要从事修辞与写作、特别是 Technical Communication方面的

教学及研究。在美国大学教授修辞与写作各种课程二十余年。任教的本科、

硕士及博士课程包括 English Composition, Business Writing, Technical

Writing, Electronic Writing and Publishing, Digital Rhetoric, Digital Media

Production, Grant and Proposal Writing, Composition Pedagogy等。

顾宝桐的研究领域主要包括科技写作、写作技术理论、跨文化交际等。

主要学术成果除学术期刊论文外，还出版了六本专著与编著，其中包括

From Oracle Bones to Computers: The Emergence of Writing Technologies inChina; Content Management: Bridging the Gap between Theory and Practice;

Designing Web Applications for the 21st Century Writing Classrooms, 以及《当

代西方修辞批评与研究》（上和下，1998年社科院出版社出版）。同时，

他还在各大学术会议上宣读论文 60多篇。

顾宝桐曾担任全美科技英语写作教师协会 ATTW

（AssociationofTeachersofTechnicalWriting）常务理事，ATTW 2012年全美

学术大会主席。他还担任多个学术杂志的评审，包括 Technical

Communication Quarterly, Technical Communication, Journal of Business and

Technical Communication, Second Language Writing等。

Course Description

36

This course will introduce students to different genres of business writing,including but not limited to business memos, business letters, resumes, coverletters, reports, proposals, etc. At the same time, it will also teach studentseffective writing styles, persuasive writing, writing for the audience, writingwithin meaningful business contexts, writing for international audiences, etc. Inteaching students how to write different types of business documents, thiscourse will take into consideration Chinese students’ English proficiency levelsand writing capacity and focus on improving students’ English writing whileteaching them effective rhetorical skills. At the end of the course, students willbe expected to write rather effective business documents in English andbecome cultural competent business writers.

Business Writing deals with various issues involved in the business writingpractice, such as audience, purpose, form, genres, conventions, and strategies.Our focus will be on how to design business communication products so thatthey are effective solutions to real communication problems.

Business Writing has the following objectives: To foster a view of writing as situated action (people acting throughwriting within organizations)

To foster educational practices that demand a consideration ofethics

To create contexts for writing that are real and sophisticated(through the use of cases, real clients, and service learning withcommunity organizations)

To recognize that the use of computers is integral to how peoplewrite in the workplace and the types of documents they produce

To advocate reader/user needs To create contexts for effective collaboration To teach visual and verbal argumentation To teach research practices To teach students to follow and adjust conventions of businesswriting

商务英语写作课程将教授三个方面的主要内容：

第一是指导学生学习写作各式英语商务文书，包括商务备忘录、商

务信函、简历、求职信、商务报告、商务提案等。学生将通过分析

实例及样文学习各种文书的写作格式、规范、正确有效的写作方式

等。

第二是教授学生修辞知识及规则，即如何分析读者/客户的特点、客

37

户的需求、商务文书的具体目的、商务交流中的各种具体情况，从

而设计出最有效的商务文书。

第三，根据中国学生大部分英语水平相对有限或水平参差不齐的实

际情况，着重练习英语写作句法、文风、遣词等等，以有效帮助他

们英语商务文书的写作。

有一定英语基础的学生在修完本课程后，其商务英语写作应该有明显

的进步，应能较自如的应对各种商务英语文书的写作设计。

Syllabus

Course Goals Business Writing is an advanced course that deals with variousissues involved in the business writing practice, such asaudience, purpose, form, genres, conventions, and strategies.Our focus will be on how to design business communicationproducts so that they are effective solutions to realcommunication problems.

Because of such a focus on the real-world practice, this coursewill use a case-based approach—that is, we will read about realor semi-real communication situations/needs and then developsolutions, often in the form of a “text,” an oral report, or someother appropriate product of communication. In some cases, ofcourse, you may find that there is no perfect solution but avariety of possible approaches to the situation, which in itselfwill be a source of learning for you. Such a case approachsimulates the real-life practice of the professional writer andgives you a chance to experience, almost first hand, what it islike to be a business writer. Although every business writer’spractice differs from everybody else’s and it’s impossible tosimulate all the different practices, the rhetorical strategies youlearn in this course should prove to be useful in variousbusiness writing situations.

This course prepares two groups of students: those of you whointend to be professional writers—people who write as aprofession—and those of you who intend to be writingprofessionals—professionals who will write as part of their job.Therefore, Business Writing has the following objectives:

38

To foster a view of writing as situated action (people acting

through writing within organizations)

To foster educational practices that demand a consideration

of ethics

To create contexts for writing that are real and

sophisticated (through the use of cases, real clients, andservice learning with community organizations)

To recognize the fact that computers significantly alter

where and how people work and that the use of computersis integral to how people write in the workplace and thetypes of documents they produce

To advocate reader/user needs

To create contexts for effective collaboration

To teach visual and verbal argumentation

To teach research practices

To teach students to follow and adjust conventions of

business writing

Attendance &Blunt Version

Participation Class participation is mandatory. You are allowed THREE

EXCUSED absences. Anything beyond three excused absences

may affect your grade (at instructor’s discretion). For any

absence, you must inform me in writing before your absence or

as soon after it as possible. This writing can be in either hard

copy (a formal memo) or email. You must convince me why

your absence should be excused. You’re responsible for finding

out about and completing any assignment you may have

missed due to your absence.

39

Reasoned Version

The environment of this class is intended to emulate that of aprofessional workplace. Just as tardiness is not acceptable atworkplace settings, it is not tolerated in this class either. In awriting class, much of the work is done in class, whether it’sgroup work or class discussions. If you’re not there, you’re notcontributing. In most cases, if you have a legitimate reason foryour absence, you’ll be excused. To be fair, anytime you miss aclass, you get an exciting writing opportunity to showcase yoursuperior persuasive writing skills to explain and justify yourabsence.

Tardiness

Just as punctuality is valued and expected at a workplace, so is itin our class. DON’T come to class late! If you have a validreason being late for class, contact me well in advance. Everythird tardiness counts as an absence.\

Other Late Assignments

Policies No late assignments are accepted!Justification? At a workplace,

try how many times you can miss a deadline without being talked

to by your supervisor or getting fired. My 30+ years of teaching

experience tells me most late work is of subpar or poor quality

because they are often completed in haste due to a late start. Start

early and give yourself enough time so that the work you turn in

can represent your true capabilities. The only exception to this

policy is if you have a debilitating injury or illness or very

extenuating circumstances that render you incapable of doing

school work. I reserve the right to make the final assessment

whether your excuse for late turn-in is valid.

Assignment Turn-ins

Turn in all your assignments as email attachments [email protected], unless you’re told otherwise.

40

Cellphones

No cellphone use is allowed in class unless I tell you otherwise.Please put it on silent and keep it out of sight.

Computer UseSince our class is held in a computer classroom, it is tempting tosurf the web or check your email during class time. Please refrainfrom using the computer when you’re not supposed to. I do NOTexpect you to be using a computer when, for example, I’mlecturing or your classmate is doing a presentation. On the otherhand, since we’re in a computer classroom, we should takeadvantage of the technologies available to enhance our learning.

AssignmentsThe course work consists of reading and writing assignments.The reading assignments are indicated in the course schedule.The writing assignments consist of the following:

3 Quizzes (30 points)Three quizzes on commonly used words in business writing.

Brochure Design (50 points)For this project, you will work in groups to design a brochure forthe Business Writing course. You’ll imagine that this course willbe offered again next year. Your brochure will be used topromote this course and recruit students next year.

Oral Presentation of the Brochure Project (20 points)After you have designed the brochure, you’ll present it to yourclient (me or the English Department) in order to persuade youraudience to accept your project. Therefore, you oral presentationneeds to be very persuasive.

Important* A passing grade for all the assignments is a prerequisite to, butnot a guarantee for, passing the course. Observe the followingrules closely: You must complete all the major assignments. If you missany of the projects, you will automatically fail the class.

Your reports and assignments should be presentable. Ifyou hand in poorly proofread documents, they will bereturned to you for correction before they are graded.

If you miss a class, it is your responsibility to find out theassignments you missed. An excused absence will not getyou off the hook for a tardy assignment.

41

A Special Note: Submit your work on time. Lateassignments are generally NOT accepted unless forextenuating circumstances.Work is considered late afterclass begins on the due date, unless noted otherwise. Incases where late work is accepted, there is a 10% gradereduction for each day your assignment is late.

All projects must be submitted electronically via emailunless you’re instructed otherwise.

Plagiarism No plagiarism or any other forms of academic dishonesty will betolerated in this class. Any plagiarismwill result in a grade of F atleast for the assignment (and most likely an F for the entirecourse at the instructor’s discretion). In addition, all universitypolicies related to academic honesty apply.

Grading Since your final course grade will be based predominantly onwriting assignments and the grading of writing cannot be reducedto simple quantitative measures, I will grade your writing on aholistic basis. Each assignment will have specific grading criteria,which I will explain in class. Generally, however, the threegeneral criteria below will be applied to all the majorassignments:

Purpose: How effectively does the document accomplish itsintended task? Does it meet its goals and the demands of its context (bothacademic and organizational)? Does it solve a problem oraddress a significant organizational need? help people?

Does it provide a sound argument in support if its claims? Does it meet readers’ needs and expectations? Improverelations between people?

Does it provide relevant, useful, and accurate information?

Product: How well constructed is the document? Is the presentation of material orderly and coherent? Is design and formatting effective? Are the sentences grammatically correct? Does it use visuals effectively? Does it have a professional tone and style?

Production: How effectively was the document produced? Was the project well planned?

42

Were research and invention well conducted? How did drafting, editing, proofreading go? Was collaboration successful?

The following is a general description of expectations forassignments for each grade:

AYour project is of impeccable (or almost impeccable) quality inboth content and format design, with no major weaknesses in anyarea. It provides adequate information that users need andeffectively fulfills the intended purposes. Presentation is ofprofessional quality. There're few to no mechanical errors.

BYour project is of high quality in most of the major areas. Itfulfills the user's needs and your intended purposes quiteeffectively. Presentation is quite professional. There're only a fewmechanical errors.

CYour project is of reasonable quality in most areas. It fulfills theuser's needs and your intended purposes to a large extent,although major deficiencies are observable. Presentation is ofsemi-professional quality. There're some mechanical errors, butnot to the extent of seriously affecting readers' comprehension.

DYour project is of acceptable quality in most areas. It fulfills theuser's needs and your intended purposes to some extent, butmajor deficiencies exist in several areas. Presentation quality isacceptable but low. There're quite some mechanical errors.

FYour project is unacceptable in quality. It does not fulfill theuser's needs or your intended purposes. Major deficiencies areobserved in most areas. Presentation quality is poor, and there'retoo many mechanical errors.

Business Writing Course Schedule

商务英语写作日程安排

Modes of teaching: lecture, discussions, group work, Q&A, presentations, etc.Assignments: 1)business memo (20%) 2) resume and cover letter

43

(30%) 3) promotional brochure (40%) 4) oral presentation(10%)

Day 1/第 1天（3小时）

In-Class Activities授课内容 Homework课外作业

Instructor and studentself introductions

Course introduction

What is business writing

Memo writing

Audience, purpose, medium, and context

Sample memo analysis

Memo writing practice

Basic design principles: alignment,

proximity

Writing tips: style

Study sample memos

Revise memo written

in class



Peer critique of memo design

Sample student memo analysis and

discussion

Resume content design

Resume format design

Sample resume analysis

Individual work on resume design

Resume design

Cover letter design

44

Basic design principles: contrast, repetition

Cover letter content design

Cover letter format design

Sample cover letter analysis



Peer critique of resume and cover letter

design

Sample student resume and cover letter

analysis and discussion

Introduction to the brochure design project

Brochure groups (4 people each group)

Brochure content design

Sample brochure analysis

Group work: brainstorming, card sorting

Brochure prototype



Peer critique of brochure front panel design

Brochure front panel design analysis

Brochure format design: layout and

typography

Brochure and oral

presentation design

45

Writing tips: persuasive writing

Brochure format design: colors and graphics

Peer critique of brochure design

Introduction to oral presentation project

Oral presentation design

Group work on brochure design

Day 5 /第 5天（4小时）


Oral presentations and instructor comments

(10-15 group presentations depending on theactual number of students, 10-15 minuteseach)

Course wrap-up

Brochure due

46

RHETORIC AND PERSUASIVE WRITING

修辞学和议论文写作



Professional Experience

2016 - Professor of Rhetoric

2011 - 2105 Director of the Center for Instructional Innovation2007 - Director of Critical Thinking through Writing (GSU's QEP)2004 - Director of Writing Across the Curriculum1997 - Associate Professor, Georgia State University1990 - 1997 Assistant Professor, Georgia State University, history and theoryof rhetoric; electronic writing1987 - 1990 Graduate Assistant, Rensselaer Polytechnic Institute1985 - 1987 Teaching Assistant, University of British Columbia

Monographs


’sInformatio

n

姓名Name Dr. George Pullman

性别Gender Male

国籍Nationalit

yAmerican

职称/职务Title Professor 邮箱地址

[email protected]

du

最终学位Degree Ph.D 任职单位

Work Place

Georgia StateUniversity


课程信息Course

Information

课程名称(中英文对照)Course Name Rhetoric and Persuasive Writing

授课对象Open to All students

学时ClassHour

16


See syllabus


ntMethod

3 online quizzes2 written

assignments

47

Writing Online: Rhetoric of the Digital Age, Hackett,Indianapolis/Cambridge. 2016

A Rule Book for Decision Making, Hackett, Indianapolis/Cambridge.2014

Persuasion: History, Theory, Practice, Hackett, Indianapolis/Cambridge.2013

Edited Collections

Designing Web-Based Applications for 21st Century WritingClassrooms. George Pullman and Baotong Gu. Eds. Amityville, NY:Baywood Press. 2012.Content Management: Bridging the gap between theory and practice.George Pullman and Baotong Gu. Eds. Amityville, NY: Baywood Press.2008.

Course Description

This is a quick but thorough introduction to rhetoric and persuasive writingemphasizing clear and effective written English. The goal is to familiarizestudents with the best practices of persuasive writing.

Syllabus

Methods of InstructionOne hour lecture followed by one hour group activity involving discussion andwriting assignment and one hour of assessment and reflection.

Methods of Assessment2 In-class writing assignments3 quizzes

Day 1

Introducing the presenter

A very little bit of information about Professor Pullman, education andnoteworthy publications (vita)

Introducing the subject

Aristotle and Greek rhetoric – World scholars are only slowly becoming moreaware of the mutual influence of East/West trade and interactionParadigm of Gk rhetoric is speech presented for approval to fellow malecitizens of equal standing with equal power – one man one vote. The method ofdelivery, speech, and the context, an open air forum with perhaps as many as6000 voting attendees, influenced what was valued. Easy to understand, easy to

48

remember, easily repeated, vivid, unambiguous, repetitive.In a contemporary business setting we are talking about “the pitch,” arelatively brief presentation often accompanied by slides that proves that theproduct or service being offered will solve the potential client’s problems in theright way at the right price. The tendency among scientific and technicalspecialists is to focus on the product and its features. Persuasion requiresfocusing on the benefits of the product or service and the people involved.Overriding principle, let audience draw conclusions by inference from evidencepresented. Show don’t tell, as the creative writers say. People are morecommitted to self-drawn conclusions because they feel as though they ownthem, they feel smart in arriving at them. While people will accept orders ifthey find themselves in a hierarchical settings or if they accept the goals of theleaders, they prefer to draw their own conclusions when making their owndecisions. Leadership often entails creating intellectual and in some casesphysical conditions that will lead people to draw the desired conclusion.In a business setting these ideas lead to a specific method for being persuasive:

Look right – appearance but also examples of previous successFeel right – Know what others are feeling, know how to alter feelingsSound right – know the questions and the answers in advance. When anunexpected question is asked, have an effective response

Assignment

On your own for a moment, think of a recent experience when you werepersuaded to do or think something, moments when you changed your mind ormade up your mind. Explain what happened and why you think it happened.Now present your thoughts to the group you’ve been assignment to.

Day 2Ethos – representation of self, knowledge, goodwill, efficacy

Succeeds FailsKnows what is good for those he’sadvising

means well, works hard, clueless

Wants what is good for those he’s advising knows what’s needed but refuses to do itor pretends to do it, or does it so slowly asto never finish, not because incompetentbut because he resents, fears, or otherwiseharbors ill will

Does what he says he will fails intentionally or unintentionally

Assignment

Write a 200 hundred word introduction to yourself that attempts to create apositive ethos. Share what you wrote with one or two others in the class. Readwhat they wrote. Offer and receive advice about how to create a positive ethos.

49

Day 3Pathos – how emotions alter inferences and decisions

Temporary states leading to decisions found wanting in some waywhen emotions change

Assignment

Write a 200 word explanation of a decision you made that you now realize isone you made on the basis of a strong emotion. What was the circumstance?What were you feeling? What did you do? How do you feel about it now?When you are finished, if you feel like it, share it with someone else in theclass and talk in general terms how feelings lead to decisions.

Logos – evidence and arguments

Topics

In the field of rhetoric, a topic is a pattern of thought that allows you tocompare two or more competing things and find the better option. The practiceis to try out all of the various possibilities to see which ones offer the mostcompelling arguments. In any given instance, some won’t work at all andothers will be unconvincing, but others will work well and a few might workextremely well. The rhetorical art is in quickly identifying those that will workwell and building an argument from them.

General patterns of persuasive thought

Assignment

On your own, using as many of the general topics as possible, create a list ofarguments for why Nanjing Agricultural University is the best place to get auniversity degree. Join the other members of your group and see if you canextend the list. Choose a spokes-person and share with the rest of the classwhat your group came up with.

Logos – evidence and arguments continued

Enthymemes

An enthymeme is basically a debate-worthy assertion followed by some reasonto believe it is true. Often the reason rests on a further reason readily suppliedby the audience and left unsaid by the speaker so that he or she isn't perceivedas tedious or too precise and so that the audience can feel smart because it canfill in the gaps on its own and by doing so it is owning the argument,participating directly in it, and therefore starting to believe it.

E.G.:

50

Assertion: A graduate degree is more valuable (a greater good) than anundergraduate degree

Reason: because undergraduate degrees are more common [a less trickyassertion would be, because graduate degrees are less common, but byinverting it we make the audience think of a second without running much of arisk of them getting confused or losing the train of thought.]

Unspoken reason: and what is rarer is better than what is more common

We could add weight by adding topics. What is harder to achieve is more rare;what takes a great deal of time and money is more rare; what is possessed by asmall group of select people is more rare; etc. The more ways in whichsomething is rare, the more rare people will tend to think it is and thus thecloser to unique. And people think that what is unique is more valuable,especially if it is unique to them. That's why your dog is a family member andother people's dogs are dogs.

AssignmentCreate an enthymeme for each of the following topics or substitute othersfrom chapter 6, book one. For those that are already enthymemes, likenumber 3 below, extend it enthymeme.

1. That is good of which the contrary is bad2. That which is greater than it should be is bad3. That also is good on which much labor or money has been spent; themere fact of this makes it seem good, and such a good is assumed to bean end -- an end reached through a long chain of means; and any end is agood.

4. Any end is good.5. Good, too, are things that are a man's very own, possessed by no oneelse, exceptional; for this increases the credit of having them

6. Good also are the things by which we shall gratify our friends or annoyour enemies;

7. and the things chosen by those whom we admire.8. [We value those things] for which we are fitted by nature or experience,since we think we shall succeed more easily in these.

Day 4Arrangement – Coherent and persuasive structures

Explanation of the Concept

When we draft, we tend to put the sentences down as they occur to us, whichisn't always the best order to read them in.

51

There's an exchange in a famous dialogue by Plato, called Phaedrus, duringwhich this idea is discussed. I've paraphrased it below.

Soc. Lysias appears to have jumbled his sentences, begun at the endinstead of the beginning. Don't you think, Phaedrus?Phaedr. Yes, indeed, Socrates; he begins at the end.Soc. There's no logical order to the sentences. He seems to have writtenthem down as they occurred to him. Every discourse ought to be a livingcreature, having a body of its own and a head and feet; there should be abeginning, a middle, and an end, adapted to one another and to thewhole?Phaedr. Certainly.Soc. Consider the following poem:

I am a maiden of bronze and lie on the tomb of Midas.So long as water flows and tall trees grow.So long here on this spot by his sad tomb abiding.I shall declare to passers-by that Midas sleeps below.

Soc. In this rhyme whether a line comes first or comes last makes nodifference.Phaedr. Indeed.

The point: If the order of a paragraph's sentences can be shuffled with no lossof meaning, the paragraph is unnecessarily hard to read.

Common Patterns1. Given / New2. General to specific – the funnel3. Spatial – contiguity (side by side), perspective (vanishing point)4. Logical – if/then; when/do5. Chronological6. Narrative (drama, suspense)

Resource

arrangement

Assignment

Correct the structure of each of the following paragraphs. Compare youranswers with others in your group.

Day 5Style – Effective English prose composition: Brevity and clarity

52

sentence revision practice revising sentences

Assignment

Revise 20 sentences from the database at random.

53

WONDER IN LIFE SCIENCES

生命科學的奇蹟

开课学院：中药学院


陳新博士于1984年及1987年在湖北中医药大学获得中医学士及硕士

学位，1991 年在廣州中醫藥大學獲得中醫學博士學位，其後他從荷蘭.内

梅亭大學獲得免疫學博士學位。陳新博士從 1991 年到 1998 年在深圳市中

西醫結合研究所/深圳市第二人民醫院從事臨床及科研工作。其後，陳新博

士在英國朴茨茅斯大學藥學及生物醫學學院接受博士後訓練。他於 1999

年加入美國國家癌症研究所(NCI)/美國國立衛生研究院(NIH)的分子免疫調

節實驗室(LMI), 先後擔任科學家 II 及高級科學家。2003 年至 2014 年，陳

新博士還兼職在 NIH FAES 研究生院從事教學工作。自 2014 年 10 月起，

他任職於澳門大學，現為該校中藥質量研究國家重點實驗室及中華醫藥研

究院的生物醫學教授，同時也是美國國家腫瘤研究所客座研究員。自 2000

年以來，陳新博士發表 SCI 論文 80 多篇，現擔任 Journal of Leukocyte


’sInformatio

n

姓名Name 陳新

（任课教师

性别Gender 男

国籍Nationalit

y美國



最终学位Degree

中醫學博士免疫學博士


澳門大學中華醫藥研究院

课程信息Course

Information


生命科學的奇蹟Wonder in Life Sciences

授课对象Open to 本科生学时

Class Hour 24 學時


3考核方式Assessment

Method

Presentation andtest

54

Biology，Cellular and Molecular Immunology，Chinese Medicine 等雜誌

編委以及 Frontiers in Immunology 客座副主編，并作為特約審稿人為 60

多個國際學術刊物審閱稿件，他是 10 多個國際科研基金評審人。陳博士

現爲美國免疫學會會員、白細胞生物學會會員。

Course Description

This course will address some of the most exciting areas in life sciences,including Chinese medicine/acupuncture, basic immunology, cell biology,cytokine/chemokine, cancer immunology and immunotherapy. Successfulcompletion of the course will provide students with broad fundamentalknowledge in life sciences, especially in immunology.

本課程將介紹生命科學中的一些最令人興奮的領域，包括中醫/針灸，基礎

免疫學，細胞生物學，細胞因子/趨化因子，癌症免疫學和免疫療法。成功

完成課程將為學生提供生命科學方面的廣泛基礎知識，特別是免疫學方面

的知識。

Syllabus

1. Chinese Medicine and Acupuncture: a real Science or a Voodoo

Science?

中醫和針灸：真正的科學還是偽科學？

2. Health and Illness: East vs West View

健康與疾病：東西方的觀點

3. Our Immune System: AWonderful World

我們的免疫系統：一個奇妙的世界

4. The Receptor that Control the “Wandering Cells”: Bright-side and

Dark-side

控制“流浪細胞”的受體：光明面和黑暗面

5. Tumor Necrosis Factor is a Tumor Promoting Factor: it is a question

腫瘤壞死因子還是是腫瘤促進因子：這是一個問題

6. How to Educate Your Immune Cells to Be a Tumor Killer

如何教育你的免疫細胞成為腫瘤殺手

55

ESSENTIAL IMMUNOLOGY

免疫学基础



Dr. Rong L. He is an Associated Professor in the Dept. of Biological Sciencesat Chicago State University. Dr. He has about 20 years of research and teachingexperience on immunology with about 40 publications. Her research isfocusing on the understanding the mechanisms of immune cell activation andinactivation. She is also working on classification of virus and bacterial topredict pathogens using bioinformatics tool. She has awarded NIH, NSF andAHA grants.

Course Description

This course summaries the essential knowledge of how organisms define anddefend themselves from various pathogens. It provides a background to thefunctions of innate and adaptive immunity with respect to the organs, cells andpredominant molecules of the immune system. These principles build aplatform for understanding the mechanisms of normal immune function. Thecourse requires students to read, present and discuss the scientific researchpapers. There will be a student debate on the last day which is required foreveryone to participate.


’sInformatio

n

姓名Name Rong L. He

性别Gender Female

国籍Nationalit

yUSA

职称/职务Title

AssociateProfessor


最终学位Degree Ph.D 任职单位

Work PlaceChicago StateUniversity

课程信息Course

Information


Essential Immunology免疫学基础

授课对象Open to

All CPUundergraduate

s

学时Class Hour 24


July 7-12th, 64 h lectures


Method

StudentPresentation

56

Syllabus

7月 7 (3 h)Important concepts for understanding the mammalianimmune response

7月 8 (3 h)Cells, organs, and microenvironments of the immunesystem

7月 9 (3 h)The organization and expression of lymphocytereceptor genes

7月 10 (3 h)Innate immunity related paper presentation anddiscussion

7月 11 (3 h)Immune receptor signaling system related paperpresentation and discussion

7月 12 (3 h)Lymphocyte receptor generation related paperpresentation and discussion; Infectious diseases andvaccines (student debate)

57

NEUROPHRAMACOLOGY

神经药理学



Michael X. Zhu (朱曦)，1984 年毕业于复旦大学生物学专业获学士学

位， 1991 年毕业于美国德克萨斯大学休斯顿分校获生物化学博士学位，

1991年至1994年在美国德克萨斯大学休斯顿分校贝勒医学院从事博士后

研究。1994 年至 1997 年在加州大学洛杉矶分校做助理研究员。1997 年至

2003 年被美国俄亥俄州立大学聘为助理教授，2003 年被聘为副教授。2010

年至今被德克萨斯大学健康科学中心聘为教授。2010 年被聘为中科院上海

药物所特聘研究员。朱曦教授是许多国际知名期刊的审稿人，并且是

Journal of Cellular Physiology 的副主编和 Molecular Pharmacology 的编

委。

朱曦教授长期从事离子通道与受体的调控和生理病理功能的研究，主

要研究对象为 TRP 离子通道，NAADP 溶酶体钙释放受体，电压门控钙离子


’sInformatio

n

姓名Name Michael X.Zhu

性别Gender 男

国籍Nationalit

y美国


[email protected]

最终学位Degree 博士任职单位

Work Place德克萨斯大学健康科学中心

课程信息Course

Information


Neuropharmacology神经药理学

授课对象Open to 本科生学时

Class Hour 24


2019.07.07-2019.07.12


Method

课堂Presentation

（60%），课堂问答（40%）

58

通道和 G 蛋白偶联受体。在全世界首先克隆 TRPC 离子通道并实现其功能

表达。朱曦教授团队在 Cell, Nature, Nat. Neurosci., PNAS，J. Biol. Chem.

等具有重要影响力的期刊发表上百篇研究论文。

Course Description

本课程将涵盖细胞信号传导的基本原理，主要介绍现代药理学中膜蛋

白受体，离子通道，细胞内信使和电信号产生和作用机理，以身体主要感

知系统：如视觉，嗅觉，味觉，以及痛和痒为例调动学生对生物医学研究

和新药研发的兴趣。本门课程同时重点介绍如何从事科研，从课题设计到

执行，口头与书面交流的能力，以及基金申请和论文写作与发表进行完整

系统的阐述。希望学生对科研的概念及实践能有初步认识，建立正确的思

考与解决问题的方法，为将来从事科研打下较好的基础。

Syllabus

2019-7-7 Lecture 1: Basic principle of cell signaling – receptors and

channels （4 小时）

2019-7-8 Lecture 2: Basic principle of cell signaling – Intracellular

messengers （4 小时）

2019-7-9 Lecture 3: Electric signaling – Communications between

neurons, major sensation of the body（4 小时）

2019-7-10 Lecture 4: Research design and execution, Projectdevelopment-Testable hypothesis – The story of capsaicin receptor

(TRPV1), discovery, function and drug development （4 小时）

2019-7-11 Lecture 5: Research strategies, literature, and presentation (2小

时). Student presentations (first two groups, 2 小时): students will be

divided in 6 groups each given specific topics on research design, paperwriting and presentation skills on the first day of the class. Each studentwill be required to give a short oral presentation on the chosen topic andwill be graded based on their presentation.

2019-7-12 Student presentation (remaining four groups, 4 小时）.

59

UTILIZATION OF NATURAL RESOURCESAS BIOACTIVEINGREDIENT FOR MEDICINE, COSMETICS, FUNCTIONAL FOODSAND AROMA

天然功能性成分在药物、化妆品、功能食品的应用及植物芳

香成分研究



Kuniyoshi Shimizu, Ph. D, male, natural product chemist, graduated fromFaculty of Agriculture, Kyushu University in 2000. Then, he worked in VentureBusiness Laboratory, Kyushu University as a postdoctoral fellow (2000-2002).In 2002, he returned to Faculty of Agriculture, Kyushu University as anassistant professor. Then, in 2014, he got prompt to an associated professor. Hehas focused on the development of biologically natural products from plantsand mushrooms. He got The Japan Wood Research Society Progress Award in2006 and The Japan Wood Research Society Award in 2014. Now he haspublished more than 140 papers.


’sInformatio

n

姓名Name Kuniyoshi Shimizu

性别Gender 男 male

国籍Nationalit

y

日本Japanese

职称/职务Title

副教授AssociateProfessor

邮箱地址Email

[email protected]

最终学位Degree

博士PhD

(Agriculture)


九州大学Kyushu

University,Japan

课程信息Course

Information


Utilization of natural resourcesasbioactive ingredient for medicine,

cosmetics, functional foods and aroma天然功能性成分在药物、化妆品、功能

食品的应用及植物芳香成分研究

授课对象Open to

15 级临药，16-18 级所有

专业学生

学时Class Hour 16



Method

综述Review

60

Course Description

对药物植物、化妆品、功能食品等多个方面以及植物芳香成分的研究进展

进行介绍，其中以本部门深入研究的灵芝、植物及其香性成分研究进展为

具体实例进行阐述。Utilization of natural resources is getting expanding for several areas such asnatural medicine, cosmetics, functional foods, aroma et al. In this course, someintroductory research topic (mushroom, natural plants, aroma et al) areillustrated for understanding how to utilize natural resources.

Syllabus

1. 灵芝功能食品的研究进展（6学时，2天）

2. 植物芳香性成分对人体生理及心理的影响（10学时，3天）

1: Utilization of mushroom (Ganoderma) as a functional food.2018.7.7 The progression of chemical components from Ganoderma(3 schoolhours)2018.7.8 Progression of pharmacological study about Ganoderma(3 schoolhours)2: Utilization of aroma based on its physiological and psychologicalfunction to human.2019.7.9 The progression of aroma from natural resource(4 school hours)2019.7.10 Physiological functionsof aroma components (4 school hours)2019.7.11 Psychological function of aroma compounds ( 2 school hours)

61

TRANSDERMAL DELIVERY AND COSMETIC APPLICATIONS

经皮给药和化妆品应用

开课学院：药学院


顾晓晨，加拿大曼尼托巴院长、教授、博士生导师，教育部海外名师。

于 1990 年获得中国药科大学药学院博士学位，1996 年加入加拿大曼尼托

巴大学，已拥有二十年丰富的教学和科研经历。科研方向为新型药物制剂

的研发，在药物透皮吸收、肾上腺素舌下给药、靶向给药新剂型等研究领

域都有独特贡献。其研究得到了加拿大卫生研究所(CIHR)、加拿大创新基

金会(CFI)、曼尼托巴卫生研究委员会(MHRC)和制药业的支持。他还在加拿

大、美国、中国和巴西建立了大量的国际研究合作关系，是 Elsevier 和开

放皮肤学（The Open Dermatology）的编辑委员会成员。顾晓晨教授是药

剂学领域名师、专家，一直致力于药剂学专业的教育、药物制剂产品设计

研发以及药剂学领域的基础研究中，拥有独到研究特长和技术领域，并已


’sInformatio

n

姓名Name 顾晓晨

性别Gender 男

国籍Nationalit

y加拿大

职称/职务Title 教授（终身）邮箱地址

EmailXiaochen.Gu@um

anitoba.ca最终学位Degree 博士任职单位

Work Place加拿大曼尼托巴大学药学院

课程信息Course

Information


经皮给药和化妆品应用Transdermal Delivery and Cosmetic

Applications授课对象Open to 各年级本科生学时

Class Hour 16


2019.7.8-7.11考核方式Assessment

Method

课堂讨论文献综述

62

在该研究领域中建立了自己的地位，是药剂学领域的技术和学术权威。顾

晓晨教授已和中国药科大学建立了广泛的合作交流关系，他已和药剂教研

室多位教授共同发表高质量研究论文 7 篇，并已在研究生院开设国际化公

开课两次。

Course Description

课程目的：通过暑期国际课程（强化课程）的学习，学生将了解各种剂型

的概念，药物输送，药物剂型与递送优化之间的临床相关性和结果。课程

的主题将重点关注皮肤和化妆品的局部应用，经皮和透皮递送方法，药物

制剂中的新方法和成分，并提供皮肤增强和化妆品应用的最新发展。Upon successful completion of this intensive course, the students willunderstand the concepts of various dosage forms, drug delivery, and theclinical relevance and outcome between dosage forms and deliveryoptimization. The summer course will focus on various subjects of topical,percutaneous and transdermal delivery methods for skin and cosmeticapplications, discuss on new approaches and ingredients in pharmacosmeticalpreparations, and provide latest development in skin enhancement and cosmeticapplications.

Syllabus

1) Topical and transdermal drug delivery;2) Skin permeation enhancement approaches;3) Pharmaceutical and pharmacosmetical use of topical delivery;4) Natural and herbal ingredients in cosmetic applications;5) Nanotechnology and cosmetics6) Physical methods for skin enhancement

63

ADVANCED DRUG DELIVERY SYSTEM

高端药物递送系统

开课学院：药学院


Gemeinhart, Richard A.

1.Purdue University（PhD）

2.Departments of Biopharmaceutical Sciences, Bioengineering, ChemicalEngineering, and Ophthalmology and Visual Sciences


’sInformatio

n

姓名Name Richard A Gemeinhart

性别Gender 男

国籍Nationalit

y美国



最终学位Degree Ph.D. 任职单位

Work Place

The Universityof Illinois at

Chicago

课程信息Course

Information


高端药物递送系统Advanced Drug Delivery System

授课对象Open to

15 级临药，16-17 级药学（包括生科基地、理科基

地）、药物化学、药物分析、药物制剂、制药工程、食品质量与安全、临床药学、生物制药、生物工程、生物技术、海洋药学、中药学、中药资源与开发、

中药制药

学时Class Hour 24


4 hrs 6考核方式Assessment

Method

GroupPresentations

+ Exam

64

The University of Illinois at ChicagoProfessor of Pharmaceutics and Bioengineering, Director of Graduate Studies,and UIC Research Integrity Officer

Course Description

This course deals with the science of delivery of drugs to the body and thedosage forms that enable drug delivery. Material to be covered will includeselected properties of drug substances that have a critical impact on thedelivery of drugs to the human body, the dosage forms available for drugadministration, and the therapeutic effect with respect to physical and chemicalproperties of drugs. These topics will provide the knowledge base upon whicha pharmaceutical scientist will depend to make rational decisions about drugproduct development. The objective of this course consists of (1) to understandthe relationship between dosage forms and drug delivery and thephysicochemical properties and structures of drug molecules; (2) tocomprehend the underlying principles of drug product development and be ableto apply them to engage in critical thinking of drug stability, formulation anddelivery; (3) to identify the relevant information from literature regarding adrug or drug product in order to solve specific questions; and (4) to build up theknowledge in drug development and delivery and develop problem-solvingskills. In particular, this short course will achieve the teaching objectivesthrough discussion of drug products. Students will be encouraged to discuss thematerial throughout the sessions.

Syllabus

Day 1 Morning1. IntroductionThe course will be introduced. I will describe the format, lectures,

discussion, and presentations. I will also describe my desire for the students toparticipate by communicating with me in the discussions and between classsessions.2. General Description of Controlled Drug DeliveryFirst, I will define the terms necessary to understand controlled drug

delivery. I will describe the ideas of conventional, immediate release dosageforms and contrast these ideas with controlled drug delivery.3. Mechanisms and Components of Controlled Drug Delivery SystemsI will describe the components of a controlled delivery system, e.g. rate

controller, energy source, and how these are need in a dosage form. Inaddition, I will describe the fact that each is not necessary serving a singlefunction. Then, I will discuss the different mechanisms of controlled release,specifically diffusion and dissolution-based systems.Day 2 Morning4. Review of Anatomy and Physiology and impact in Drug DeliveryI will review, for important points, the anatomy of the human body and

65

describe the specific aspects that relate to controlled drug delivery. Much focuswill be placed gastrointestinal anatomy and how this relates to peroral drugdelivery.5. Review of PolymersI will review polymer science and how the properties of polymers can

influence the drug release from a dosage form. I will review molecular weight,pendant groups, size of polymers, and how polymers can influence diffusion.6. Discussion and Preparation of Group PresentationsI will describe the group presentation in detail and describe the rubric that

I will use to grade the presentations. I will go through examples of what shouldand shouldn’t be included in the presentations and how the students can preparefor giving a presentation.Day 2 Afternoon7. Searching Pharmaceutical LiteratureI will review how I am able to do a literature and pharmaceutical search

for information described in the scientific literature for a given dosage formand/or active ingredient. I will do a search in Pubmed and a patent search basedon information that can be readily found on the US FDAwebsite.8. Group Research and DiscussionStudents will conduct research and we will discuss methods that can be

used and information that can be identified in the scientific literature.Day 3 Morning9. Review of PharmacokineticsI will review the ideas of pharmacokinetics and the factors that impact the

adsorption, distribution, and metabolism of active ingredients. I will alsodiscuss the mathematic treatment of immediate release and modified releasedosage form pharmacokinetics.10.Case 1: Enteric Coated ParticleI will discuss a single case: Protonix®. This drug is acid unstable in

stomach acid, but stable in gastrointestinal fluid. I will describe how a polymercan be used to inhibit the release and water penetration into a dosage form. Thepharmacokinetics of the system will also be discussed.11. Case 2: Bilayer TabletI will discuss a single case: Mucinex®. This over the counter medication

has an immediate release layer and a controlled release layer. I will discuss howa bilayer tablet can be formed as well as the pharmacokinetic treatment of thetwo layered system.Day 4 Morning12.Case 3: OrosI will discuss a single case: Procardia®. This drug is an oral osmotically

controlled dosage form. The theory behind osmotically controlled dosage formswill be discussed and the resultant pharmacokinetics evaluated. The case willbe compared with other dosage forms for the same therapeutic.13.Case 4: Nanocrystal

66

I will discuss a single case: Rapammune®. I will discuss how thesolubility of the active ingredient has made formulation of an immediaterelease dosage form difficult and that the technology to create nanoparticles ofthe active have allowed improved bioavailability for the active.14.Review of Solid StateA basic review will be completed for the solid state system. We will

discuss crystal forms and the amorphous state. The implications of these stateson the release and activity of an active ingredient will be discussed.Day 4 Afternoon15.Group ResearchStudents will be given time to conduct online literature searches. I will

work with groups and discuss how to improve searches.16.Discussion of how to analyze the literatureStudents will be required to submit questions to me about how to conduct.

We will discuss this as a group and in smaller groups to improve the ability ofthe students to evaluate the literature.Day 5 Morning17.Case 5: Solid DepotI will discuss a single case: Zoladex®. This injectable system is

biodegradable and treats different tumor types. The system is injected forsystemic activity and the pharmacokinetics will be discussed.18.Case 6: Biopharmaceutical SystemI will discuss a single case: Adagen®. The challenges of intravenous

protein administration will be discussed along with the novel method foraddressing these challenges. The chemistry of bioconjugation will be discussedalong with the pharmacokinetic implications of the polymer-modification19.Case 7: InjectableI will discuss a single case: Doxil®. This injectable system is liposomal in

nature and used to solubilize the hydrophobic drug. The structure of liposomeswill be discussed along with the challenges of forming and releasing an activefrom liposomes. The pharmacokinetic implications of liposomes will beemphasized.20.Case 8: TransdermalI will discuss a single case: Catapres TTS. The structure and function of

the system will be presented. The anatomy of skin will be emphasized and howthe structure of a transdermal patch has changed will be discussed. Thepharmacokinetic implications of transdermal will be emphasized.Day 6 Morning &Afternoon21.ExamStudents will be asked to complete a one-hour exam over materials

covered in the exam. The exam will include materials from the reviewsections as well as the discussions of specific approved drugs and dosageforms.22. (through 24) Group Presentations

67

Each student will be assigned a group (14 groups: 3-4/group) and aspecific US FDA approved drug to research on the 2nd day of class (see above).Each group will present the basics of the disease, pharmacokinetic properties ofthe active ingredient, the materials used to modify release, and the mechanismof release. Each group will be graded based on the rubric presented to them andare required to cite relavent literature during the presentation to support theirunderstanding of the drug.

2019年暑期国际课程项目 -...

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