Publications of Takeda Research Laboratories

2013

July 2014

武田研究業績集 2 0 1 3

武 田 薬 品 工 業 株 式 会 社 Takeda Pharmaceutical Company Limited

Osaka, Japan

CONTENTS Originals in English

Organic Chemistry ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 1 Medicinal Chemistry ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 2 Biochemistry and Biotechnology ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 7 Pharmacology ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 7 Basic Biology and Physiology ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 10 Pharmaceutics ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 12 Pharmacokinetics and Drug Metabolism ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 12 Drug Safety Evaluation ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 14 Clinical Research ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 15 Information Science ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 15 Veterinary Science ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 16 Technology Development ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 16

Originals in Japanese

Medicinal Chemistry ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 17 Immunology ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 17 Pharmacology ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 17 Pharmaceutics ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 18 Technology Development ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 18

Author Index ⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅⋅ 20

1

Originals in English

Organic Chemistry [T1] Double Reformatsky Reaction: Divergent Synthesis of δ-Hydroxy-β-ketoesters Masahiro Mineno, Yasuhiro Sawai, Kazuaki Kanno, Naotaka Sawada, Hideya Mizufune J. Org. Chem., 78: 5843−5850 (2013) 峯野雅博、澤井泰宏、菅野和明、沢田直隆、水船秀哉 [T02] Development of a Practical Synthesis of a TORC1/2 Inhibitor: A Scalable Application of Memory of Chirality Frederick Hicks 1, Yongquan Hou 1, Marianne Langston 1, Ashley McCarron 1, Erin O’Brien 1, Tatsuya Ito, Chunrong Ma 2, Chris Matthews 2, Colin O’Bryan 2, David Provencal 2, Yuxin Zhao 2, Jie Huang 3, Qiang Yang 3, Li Heyang 4, Matthew Johnson 4, Yan Sitang 4, Liu Yuqiang 4 Org. Process Res. Dev., 17, 829−837 (2013) 伊藤達也 1 Process Chemistry Research and Development, Millennium: The Takeda Oncology Company, 35

Landsdowne Street, Cambridge, Massachusetts, 02139, United States

2 Process Chemistry, Takeda California, 10410, United States Science Center Drive, San Diego, California 92121, United States

3 Chemical Development Department, AMRI, 21 Corporate Circle, Albany, New York 12203, United States

4 Asymchem Life Science, Tianjin 71 seventh Avenue TEDA, Tianjin, 300457, P.R. China [T03] Convenient and Eco-Friendly Method for the Conversion of Benzylic Alcohols into Aldehydes, Ketones, and Carboxylic Acids Using NaOCl without any Additives in 1,2-Dimethoxyethane Naohiro Fukuda, Takeshi Kajiwara, Tomoaki Katou, Keisuke Majima, Tomomi Ikemoto SYNLETT, 24: 1438–1442 (2013) 福田直弘、梶原武志、加藤友祥、真島桂介、池本朋己 [T04] Convergent and streamlined synthesis of 6-etherified imidazo[1,2-b] pyridazine-2-amine derivatives possessing VEGFR-2 kinase inhibitory activity Kazuhisa Ishimoto, Yasuhiro Sawai, Naohiro Fukuda, Toshiaki Nagata, Tomomi Ikemoto Tetrahedron, 69: 8564-8571 (2013) 石本和久、澤井泰宏、福田直弘、長田敏明、池本朋己

2

[T05] A rapid and diverse construction of 6-substituted-5,6-dihydro-4-hydroxy-2- pyrones through double Reformatsky reaction Masahiro Mineno, Yasuhiro Sawai, Kazuaki Kanno, Naotaka Sawada, Hideya Mizufune Tetrahedron, 69: 10921-10926 (2013) 峯野雅博、澤井泰宏、菅野和明、沢田直隆、水船秀哉 [T06] Synthesis of pyrazolo[1,5-a]pyridines by thermal intramolecular cyclization Yasutaka Hoashi, Takafumi Takai, Etsuo Kotani, Tatsuki Koike Tetrahedron Letters, 54: 2199-2202 (2013) 帆足保孝、高井隆文、小谷悦郎、小池竜樹 Medicinal Chemistry [T07] Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine- Based EGFR T790M/L858R Mutant Inhibitors Satoshi Sogabe, Youichi Kawakita, Shigeru Igaki, Hidehisa Iwata, Hiroshi Miki, Douglas R. Cary, Terufumi Takagi, Shinji Takagi, Yoshikazu Ohta, and Tomoyasu Ishikawa ACS Med. Chem. Lett., 4: 201−205 (2013) 曽我部智、川北洋一、井垣 茂、岩田英久、三木啓司、髙木輝文、髙木慎二、大田義一、 石川智康 [T08] Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors Mitsunori Kono, Takahiro Matsumoto, Toru Kawamura, Atsushi Nishimura, Yoshihiro Kiyota, Hideyuki Oki, Junichi Miyazaki, Shigeru Igaki, Craig A. Behnke 1, Masato Shimojo, Masakuni Kori Bioorganic & Medicinal Chemistry, 21: 28-41 (2013) 髙野光功、松本孝浩、河村 透、西村 篤、清田義弘、沖 英幸、宮崎純一、井垣 茂、 下条雅人，郡 正城 1 Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, United States [T09] Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenyl pyrrolidine derivatives as novel androgen receptor antagonists Satoshi Yamamoto, Hiromi Kobayashi, Tomohiro Kaku, Katsuji Aikawa, Takahito Hara, Masuo Yamaoka, Naoyuki Kanzaki, Atsushi Hasuoka, Atsuo Baba, Mitsuhiro Ito Bioorganic & Medicinal Chemistry, 21: 70-83 (2013) 山本哲史、小林ひろ美、加来智弘、合川勝二、原 隆人、山岡万寿夫、神崎直之、蓮岡 淳、

馬場厚生、伊藤光博 [T10] Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors Youichi Kawakita, Masaki Seto, Tomohiro Ohashi, Toshiya Tamura, Tadashi Yusa, Hiroshi Miki, Hidehisa Iwata, Hidenori Kamiguchi, Toshimasa Tanaka, Satoshi Sogabe, Yoshikazu Ohta,

3

Tomoyasu Ishikawa Bioorganic & Medicinal Chemistry, 21: 2250-2261 (2013) 川北洋一、瀬戸雅樹、大橋知洋、田村寿哉、遊佐 正、三木啓司、岩田英久、上口英則、 田中稔祐、曽我部智、大田義一、石川智康 [T11] Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin- 6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama, Kazuhiro Miwa, Yuya Oguro, Hideyuki Oki, Kengo Okada, Terufumi Takagi, Hidehisa Iwata, Yoshiko Awazu, Seiji Yamasaki, Toshiyuki Takeuchi, Hiroshi Miki, Akira Hori, Shinichi Imamura Bioorganic & Medicinal Chemistry, 21: 2333-2345 (2013) 宮本直樹、坂井 望、平山孝治、三輪憲弘、大黒裕哉、沖 英幸、岡田健吾、髙木輝文、 岩田英久、粟津紀香、山崎誠司、竹内敏之、三木啓司、堀 晃、今村真一 [T12] Novel triple reuptake inhibitors with low risk of CAD associated liabilities: Design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2- methoxyethyl] piperidine and related compounds Yuji Ishichi, Eiji Kimura, Eiji Honda, Masato Yoshikawa, Takashi Nakahata, Yasuko Terao, Atsuko Suzuki, Takayuki Kawai, Yuuichi Arakawa, Hiroyuki Ohta, Naoyuki Kanzaki, Hideyuki Nakagawa, Jun Terauchi Bioorganic & Medicinal Chemistry, 21: 4600-4613 (2013) 石地雄二、木村英司、本多栄治、吉川真人、中畑 崇、寺尾寧子、鈴木敦子、河合隆幸、 荒川佑一、太田浩之、神崎直之、中川秀行、寺内 淳 [T13] Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics Yuya Oguro, Douglas R. Cary, Naoki Miyamoto, Michiko Tawada, Hidehisa Iwata, Hiroshi Miki, Akira Hori, Shinichi Imamura Bioorganic & Medicinal Chemistry, 21: 4714-4729 (2013) 大黒裕哉、宮本直樹、多和田倫子、岩田英久、三木啓司、堀 晃、今村真一 [T14] Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1. Exploration of fused bicyclic core scaffolds using electrostatic potential map Takaharu Hirayama, Masanori Okaniwa, Takashi Imada, Akihiro Ohashi, Momoko Ohori, Kenichi Iwai, Kouji Mori, Tomohiro Kawamoto, Akihiro Yokota, Toshimasa Tanaka, Tomoyasu Ishikawa Bioorganic & Medicinal Chemistry, 21: 5488–5502 (2013) 平山孝治、岡庭正格、今田 岐、大橋紹宏、大堀桃子、岩井謙一、森 考司、河本朋広、 横田彰宏、田中稔祐、石川智康

4

[T15] Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists Moriteru Asano, Kentaro Hashimoto, Bunnai Saito, Zenyu Shiokawa, Hiroyuki Sumi, Masato Yabuki, Mie Yoshimatsu, Kazunobu Aoyama, Teruki Hamada, Nao Morishita, Douglas R. Dougan 1, Clifford D. Mol 1, Sei Yoshida, Tomoyasu Ishikawa Bioorganic & Medicinal Chemistry, 21: 5725-5737 (2013) 浅野壮輝、橋本健太郎、齊藤文内、塩川善右、角 紘幸、矢吹仁人、吉松美恵、青山和誠、

濱田輝基、森下奈央、吉田 聖、石川智康 1 Structural Biology, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, USA [T16] Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists Tomoaki Hasui, Taiichi Ohra, Norio Ohyabu, Kouhei Asano, Hideki Matsui, Atsushi Mizukami, Noriyuki Habuka, Satoshi Sogabe, Satoshi Endo, Christopher S. Siedem 1, Tony P. Tang 1, Cassandra Gauthier 1, Lisa A. De Meese 1, Steven A. Boyd 1, Shoji Fukumoto Bioorganic & Medicinal Chemistry, 21: 5983-5994 (2013) 蓮井智章、邑楽泰一、大藪紀雄、麻野耕平、松井英起、水上温司、羽深典之、曽我部智、 遠藤聡史、福本正司 1 Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, United States [T17] Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors Shigemitsu Matsumoto, Naoki Miyamoto, Takaharu Hirayama, Hideyuki Oki, Kengo Okada, Michiko Tawada, Hidehisa Iwata, Kazuhide Nakamura, Seiji Yamasaki, Hiroshi Miki, Akira Hori, Shinichi Imamura Bioorganic & Medicinal Chemistry, 21: 7686–7698 (2013) 松本重充，宮本直樹，平山孝治，沖 英幸，岡田健吾，多和田倫子，岩田英久，中村一英，

山崎誠司，三木啓司，堀 晃，今村真一 [T18] Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a] indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells Zenyu Shiokawa, Kentaro Hashimoto, Bunnai Saito, Yuya Oguro, Hiroyuki Sumi, Masato Yabuki, Mie Yoshimatsu, Yohei Kosugi, Yasuyuki Debori, Nao Morishita, Douglas R. Dougan 1, Gyorgy P. Snell 1, Sei Yoshida, Tomoyasu Ishikawa Bioorganic & Medicinal Chemistry, 21: 7938–7954 (2013) 塩川善右、橋本健太郎、齊藤文内、大黒裕哉、角 紘幸、矢吹仁人、吉松美恵、小杉洋平、

出掘泰之、森下奈央、吉田 聖、石川智康 1 Structural Biology, Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121,

USA

5

[T19] Structure-based discovery of cellular-active allosteric inhibitors of FAK Naoki Tomita, Yoko Hayashi, Shinkichi Suzuki, Yoshimasa Oomori, Yoshio Aramaki, Yoshihiro Matsushita, Misa Iwatani, Hidehisa Iwata, Atsutoshi Okabe, Yoshiko Awazu, Osamu Isono, Robert J. Skene 1, David J. Hosfield 1, Hiroshi Miki, Tomohiro Kawamoto, Akira Hori, Atsuo Baba Bioorganic & Medicinal Chemistry Letters, 23: 1779-1785 (2013) 冨田直輝、林 陽子、鈴木新吉、大森良真、荒牧慶夫、松下義弘、岩谷美沙、岩田英久、 岡部篤俊、粟津紀香、磯野 修、三木啓司、河本朋宏、堀 晃、馬場厚生 1 Takeda California, 10410 Science Center Drive, San Diego, CA 92121, United States [T20] Design, synthesis and SAR of novel glucokinase activators Zacharia S. Cheruvallath 1, Stephen L. Gwaltney II 2, Mark Sabat 1, Mingnam Tang 1, Jun Feng 3, Haixia Wang 1, Joanne Miura 1, Prasuna Guntupalli 4, Andy Jennings 1, David Hosfield 5, Bumsup Lee 6, Yiqin Wu 7 Bioorganic & Medicinal Chemistry Letters, 23: 2166–2171 (2013) 1 Takeda California, 10410 Science Center Drive, San Diego, CA 92121, USA 2 Global Blood Therapeutics, 400 East Jamie Court, Suite 101, South San Francisco, CA 94080, USA 3 Wellspring Biosciences, 3210 Merryfield Row, San Diego, CA 92121, USA 4 RQX Pharmaceuticals, 11099 North Torry Pines Road, Suite 290, La Jolla, CA 92037, USA 5 Ben May Cancer Institute, University of Chicago, USA 6 Kolon Life Science, Inc., 7FL Kolon Tower Annex, 38 Byeoryangsangga 2-Ro, Gwacheon-Si, Gyeonggi-Do 427-709, Republic of Korea

7 Quanticel Pharmaceuticals Inc., 9393 Towne Centre Drive, Suite 110, San Diego, CA 92121, USA [T21] Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1) Zhe Nie 1, Victoria Feher 1, Srinivasa Natala 1, Christopher McBride 1, Andre Kiryanov 1, Benjamin Jones 1, Betty Lam 1, Yan Liu 1, Stephen Kaldor 1, Jeffrey Stafford 1, Kouki Hikami, Noriko Uchiyama, Tomohiro Kawamoto, Yuichi Hikichi, Shin-ichi Matsumoto, Nobuyuki Amano, Lilly Zhang 1, David Hosfield 1, Robert Skene 1, Hua Zou 1, Xiaodong Cao 1, Takashi Ichikawa Bioorganic & Medicinal Chemistry Letters, 23: 3662–3666 (2013) 氷上光輝、内山紀子、河本朋広、引地裕一、松本真一、天野信之、一川隆史 1 Takeda California, 10410 Science Center Drive, San Diego, CA 92121, USA [T22] The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel Sunghi Ryu, Yumi N. Imai, Shigetoshi Oiki 1 Bioorganic & Medicinal Chemistry Letters, 23: 3848–3851 (2013) 柳 承希、今井友美、老木成稔 1 Department of Molecular Physiology and Biophysics, University of Fukui Faculty of Medical

Sciences, Fukui 910-1193, Japan

6

[T23] Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors Anthony R. Gangloff 1, Jason Brown 1, Ron de Jong 1, Douglas R. Dougan 1,Charles E. Grimshaw 1, Mark Hixon 1, Andy Jennings 1, Ruhi Kamran 1, Andre Kiryanov 1, Shawn O’Connell 2, Ewan Taylor 1, Phong Vu 1 Bioorganic & Medicinal Chemistry Letters, 23: 4501–4505 (2013) 1 Takeda California, 10410 Science Center Dr, San Diego, CA 92121, USA 2 Quanticel Pharmaceuticals, 9393 Towne Center Dr #110, San Diego, CA 92121, USA

[T24] Discovery and characterization of novel allosteric FAK inhibitors Misa Iwatani, Hidehisa Iwata, Atsutoshi Okabe, Robert J. Skene 1, Naoki Tomita, Yoko Hayashi, Yoshio Aramaki, David J. Hosfield 1, Akira Hori, Atsuo Baba, Hiroshi Miki European Journal of Medicinal Chemistry, 61: 49-60 (2013) 岩谷美沙、岩田英久、岡部篤俊、冨田直輝、林 陽子、荒牧慶夫、堀 晃、馬場厚生、 三木啓司 1 Takeda California, 10410 Science Center Drive, San Diego, CA 92121, United States

[T25] Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic Kentaro Hashimoto, Bunnai Saito, Naoki Miyamoto, Yuya Oguro, Daisuke Tomita, Zenyu Shiokawa, Moriteru Asano, Hiroyuki Kakei, Naohiro Taya, Masanori Kawasaki, Hiroyuki Sumi, Masato Yabuki, Kenichi Iwai, Sei Yoshida, Mie Yoshimatsu, Kazunobu Aoyama, Yohei Kosugi, Takashi Kojima, Nao Morishita, Douglas R. Dougan,1 Gyorgy P. Snell,1 Shinichi Imamura, and Tomoyasu Ishikawa J. Med. Chem., 56: 1228-1246 (2013) 橋本健太郎、齊藤文内、宮本直樹、大黒裕哉、冨田大介、塩川善右、浅野壮輝、筧 広行、

田家直博、川崎昌紀、角 紘幸、矢吹仁人、岩井謙一、吉田 聖、吉松美恵、青山和誠、 小杉洋平、小嶌隆史、森下奈央、今村真一、石川智康 1 Structural Biology, Takeda California, Inc., 10410 Science Center Drive, San Diego, California 92121, United States

[T26] Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives Masanori Okaniwa, Masaaki Hirose, Takeo Arita, Masato Yabuki, Akito Nakamura, Terufumi Takagi, Tomohiro Kawamoto, Noriko Uchiyama, Akihiko Sumita, Shunichirou Tsutsumi, Tsuneaki Tottori, Yoshitaka Inui, Bi-Ching Sang 1, Jason Yano 1, Kathleen Aertgeerts 1, Sei Yoshida, and Tomoyasu Ishikawa J. Med. Chem., 56: 6478-6494 (2013) 岡庭正格、広瀬雅朗、有田健雄、矢吹仁人、中村鑑斗、髙木輝文、河本朋広、内山紀子、 隅田昭彦、堤俊一郎、鳥取恒彰、乾 嘉孝、吉田 聖、石川智康 1 Structural Biology, Takeda California, Inc., 10410 Science Center Drive, San Diego, California

7

92121, United States

[T27] Design, Synthesis, and Biological Evaluation of Novel Investigational Nonapeptide KISS1R Agonists with Testosterone-Suppressive Activity Taiji Asami, Naoki Nishizawa, Hisanori Matsui, Kimiko Nishibori, Yoshihiro Ishibashi, Yasuko Horikoshi, Masaharu Nakayama, Shin-ichi Matsumoto, Naoki Tarui, Masashi Yamaguchi, Hirokazu Matsumoto, Tetsuya Ohtaki, and Chieko Kitada J. Med. Chem., 56: 8298−8307 (2013) 浅見泰司、西澤直城、松井久典、西堀貴美子、石橋祥弘、堀越康子、中山政治、松本真一、

樽井直樹、山口昌史、松本寛和、大瀧徹也、北田千恵子 [T28] Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins Yuta Tanaka, Katsuji Aikawa, Goushi Nishida, Misaki Homma, Satoshi Sogabe, Shigeru Igaki, Yumi Hayano, Tomoya Sameshima, Ikuo Miyahisa, Tomohiro Kawamoto, Michiko Tawada, Yumi Imai, Masakazu Inazuka, Nobuo Cho, Yasuhiro Imaeda, and Tomoyasu Ishikawa J. Med. Chem., 56: 9635–9645 (2013) 田中雄太，合川勝二，西田剛士，本間実咲，曽我部智，井垣 茂，早野有美，鮫島知哉， 宮久郁夫，河本朋広，多和田倫子，今井友美，稲塚雅一，長 展生，今枝泰宏，石川智康 Biochemistry and Biotechnology [T29] Unique binding behavior of the recently approved angiotensin II receptor blocker azilsartan compared with that of candesartan Shin-ichiro Miura 1,2,3, Atsutoshi Okabe, Yoshino Matsuo 1, Sadashiva S Karnik 3 and Keijiro Saku 1,2

Hypertension Research, 36: 134–139 (2013) 三浦伸一郎、岡部篤俊、松尾佳野、朔啓二郎 1 Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan 2 Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of

Medicine, Fukuoka, Japan 3 Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic

Foundation, Cleveland, OH, USA Pharmacology [T30] Cerebroprotective effects of TAK-937, a novel cannabinoid receptor agonist, in permanent and thrombotic focal cerebral ischemia in rats: Therapeutic time window, combination with t-PA and efficacy in aged rats Koji Murakami, Motohisa Suzuki, Noriko Suzuki, Kazuhiro Hamajo, Tetsuya Tsukamoto, Masato Shimojo Brain Research, 1526: 84-93 (2013) 村上浩司、鈴木基久、鈴木敬子、浜條和弘、塚本徹哉、下条雅人

8

[T31] TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats Ryo Ito, Yoshiyuki Tsujihata, Kae Matsuda-Nagasumi, Ikuo Mori, Nobuyuki Negoro, Koji Takeuchi British Journal of Pharmacology, 170: 568–580 (2013) 伊藤 亮、辻畑善行、松田香絵、森 郁生、根来伸行、武内浩二

[T32] Antitumor Activity of the Selective Pan-RAF Inhibitor TAK-632 in BRAF Inhibitor-Resistant Melanoma Akito Nakamura, Takeo Arita, Shuntarou Tsuchiya, Jill Donelan, Jouhara Chouitar, Elizabeth Carideo, Katherine Galvin, Masanori Okaniwa, Tomoyasu Ishikawa, and Sei Yoshida Cancer Res., 73(23): 7043–7055 (2013) 中村鑑斗、有田健雄、土屋俊太郎、岡庭正格、石川智康、吉田 聖 [T33] Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase Yoshiko Awazu, Akio Mizutani, Yoshinori Nagase, Shuntarou Tsuchiya, Kazuhide Nakamura, Yuichi Kakoi, Osamu Kitahara, Toshiyuki Takeuchi, Seiji Yamasaki, Naoki Miyamoto,Hidehisa Iwata, Hiroshi Miki, Shinichi Imamura and Akira Hori Cancer Sci., 104(4): 486-494 (2013) 粟津紀香、水谷明生、長瀬由典、土屋俊太郎、中村一英、栫 雄一、北原 治、 竹内敏之、山崎誠司、宮本直樹、岩田英久、三木啓司、今村真一、堀 晃 [T34] BTZO-2, an antioxidant response element-activator, provides protection against lethal endotoxic shock in mice Hiroshi Yukitake, Haruhide Kimura, Yasukazu Tajima, Yoshimi Sato, Hirobumi Suzuki, Masahiro Kajino, Seiichi Tanida, Masayuki Takizawa European Journal of Pharmacology, 700: 80–85 (2013) 行武 洋、木村温英、田島泰一、佐藤佳美、鈴木博文、梶野正博、谷田清一、瀧澤正之 [T35] Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice Takukyu Sha, Keiko Igaki, Masashi Yamasaki, Takeshi Watanabe, Noboru Tsuchimori International Immunopharmacology, 15: 23-29, (2013) 謝 卓丘、井垣啓子、山嵜将司、渡辺武志、土森 登 [T36] TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling Naokazu Ibuki 1, Mazyar Ghaffari 1,2, Mitali Pandey 1, Irene Iu 1, Ladan Fazli 1, Masahide Kashiwagi, Hideaki Tojo, Osamu Nakanishi, Martin E. Gleave 1,3 and Michael E. Cox 1,3 Int. J. Cancer, 133: 1955–1966 (2013) 伊夫貴直和、柏木正英、東條英明、中西 理

9

1 The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada 2 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 3 Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia,

Canada [T37] Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model Akiko Nakayama, Shinji Takagi, Tadashi Yusa, Masahiro Yaguchi, Akira Hayashi, Toshiya Tamura, Youichi Kawakita, Tomoyasu Ishikawa, Yoshikazu Ohta Journal of Cancer, 4(7): 557-565 (2013) 中山明子、髙木慎二、遊佐 正、矢口正宏、林 哲、田村寿哉、川北洋一、石川智康、 大田義一 [T38] Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats Takahito Hara, Jin Kouno, Tomohiro Kaku, Toshiyuki Takeuchi, Masami Kusaka, Akihiro Tasaka, Masuo Yamaoka Journal of Steroid Biochemistry & Molecular Biology, 134: 80-91 (2013) 原 隆人、河野 仁、加来智弘、竹内敏之、日下雅美、田坂昭弘、山岡万寿夫 [T39] Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys Masuo Yamaoka, Takahito Hara, Hideo Araki, Tomohiro Kaku, Takenori Hitaka, Akihiro Tasaka, Masami Kusaka Journal of Steroid Biochemistry & Molecular Biology, 138: 298–306 (2013) 山岡万寿夫、原 隆人、荒木秀夫、加来智弘、飛髙武憲、田坂昭弘、日下雅美 [T40] Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins Hiroyuki Sumi, Masato Yabuki, Kenichi Iwai, Megumi Morimoto, Ryosuke Hibino, Masakazu Inazuka, Kentaro Hashimoto, Yohei Kosugi, Kazunobu Aoyama, Shunsuke Yamamoto, Mie Yoshimatsu, Hideki Yamasaki, Ryuichi Tozawa, Tomoyasu Ishikawa, and Sei Yoshida Mol. Cancer Ther., 12(2): 230-240 (2013) 角 紘幸、矢吹仁人、岩井謙一、森本 恵、日比野良祐、稲塚雅一、橋本健太郎、 小杉洋平、青山和誠、山本俊輔、吉松美恵、山﨑秀樹、兎沢隆一、石川智康、吉田 聖 [T41] Biological Characterization of TAK-901, an Investigational, Novel, Multitargeted Aurora B Kinase Inhibitor Pamela Farrell 1, Lihong Shi 1, Jennifer Matuszkiewicz 1, Deepika Balakrishna 1, Takashi Hoshino, Lilly Zhang 2, Sarah Elliott 1, Robyn Fabrey 1, Bumsup Lee 1, Petro Halkowycz 1, BiChing Sang 3, Seigo Ishino, Toshiyuki Nomura 1, Mika Teratani, Yoshikazu Ohta, Charles Grimshaw 1,

10

Bheema Paraselli 4, Takashi Satou, and Ron de Jong 1 Mol. Cancer Ther., 12(4): 460–470 (2013) 星野 崇、石野誠悟、野村俊之、寺谷実佳、大田義一、佐藤貴史 1 Discovery Biology; 2 Analytical Sciences and DMPK; 3 Structural Biology; 4 Chemistry, Takeda

California, Inc., California [T42] A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1 Chiori Yabuki, Hidetoshi Komatsu, Yoshiyuki Tsujihata, Risa Maeda, Ryo Ito, Kae Matsuda-Nagasumi, Kensuke Sakuma, Kazumasa Miyawaki, Naoya Kikuchi, Koji Takeuchi, Yugo Habata, Masaaki Mori PLOS ONE, 8(10): e76280 (2013) 矢吹千織、小松秀俊、辻畑善行、前田理紗、伊藤 亮、松田香絵、佐久間健介、宮脇一真、

菊池直也、武内浩二、羽畑祐吾、森 正明

Basic Biology and Physiology [T43] Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition K. Matsuda-Nagasumi, R. Takami-Esaki, K. Iwachidow, Y. Yasuhara, H. Tanaka, K. Ogi, M. Nakata, T. Yano, S. Hinuma, S. Taketomi, H. Odaka & Y. Kaisho Diabetes, Obesity and Metabolism, 15: 538–545 (2013) 松田香絵、高見律子、岩知道公彦、安原吉高、田中秀幸、大儀和宏、中田 貢、矢野 隆、 日沼州司、武冨滋久、小高裕之、改正善彦 [T44] Does kisspeptin signaling have a role in the testes? Hua Mei 1, Joanne Doran 2,Victoria Kyle 3, Shel-HwaYeo 3 and William H. Colledge 3 Front. Endocrinol., 4: 198 (2013) 1 Jules Stein Eye Institute, University of California, Los Angeles, CA, USA 2 Takeda Cambridge Ltd., Cambridge, UK 3 Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge,

UK [T45] Comparison of Contrast Agents for Atherosclerosis Imaging Using Cultured Macrophages: FDG Versus Ultrasmall Superparamagnetic Iron Oxide Tomoko Satomi, Mikako Ogawa 1, Ikuo Mori, Seigo Ishino, Kazuki Kubo, Yasuhiro Magata 1, Tomoyuki Nishimoto The Journal of Nuclear Medicine, 54(6): 999-1004 (2013) 里見朋子，小川美香子，森 郁生，石野誠悟，久保一樹，間賀田泰寛，西本誠之 1 Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu,

Japan

11

[T46] Differential Effects of Continuous Exposure to the Investigational Metastin/Kisspeptin Analog TAK-683 on Pulsatile and Surge Mode Secretion of Luteinizing Hormone in Ovariectomized Goats. Tomomi Tanaka 1, Satoshi Ohkura 2, Yoshihiro Wakabayashi 3, Takenobu Kuroiwa 1,Kiyosuke Nagai 1, Natsumi Endo 1, Akira Tanaka, Hisanori Matsui, Masami Kusaka,and Hiroaki Okamura 3 J. Reprod. Dev., 59: 563-568 (2013) 田中知己, 大蔵 聡, 若林嘉浩, 黒岩武信, 永井淸亮, 遠藤なつ美, 田中 晃、松井久典、 日下雅美, 岡村裕昭 1 Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo

183-8509, Japan

2 Laboratory of Animal Production Science, Nagoya University, Nagoya 464-8601, Japan

3 Laboratory of Neurobiology, National Institute of Agrobiological Science, Ibaraki 305-8602, Japan [T47] Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers Tsutomu Oshima, Shuji Sato, Junichi Kato, Yuki Ito, Takahiro Watanabe, Isamu Tsuji, Akira Hori, Tomofumi Kurokawa and Toshio Kokubo 1 Molecular Cancer, 12: 60 (2013) 大島 勉、佐藤秀司、加藤潤一、井藤勇輝、渡辺高広、辻 勇、堀 晃、黒川智文、 小久保利雄 1 Present address: Center for Behavioral Molecular Genetics, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba, Ibaragi, 305-8575, Japan.

[T48] Neuronal Expression of F-Box and Leucine-Rich-Repeat Protein 2 Decreases over Braak Stages in the Brains of Alzheimer’s Disease Patients Tomomichi Watanabe, Heinz von der Kammer 1, Xiaolu Wang 1, Yasushi Shintani, Takashi Horiguchi Neurodegener. Dis., 11: 1-12 (2013) 渡邉知倫、新谷 靖、堀口隆司 1 Evotec AG, Hamburg , Germany [T49] Orphan nuclear receptor HNF4G promotes bladder cancer growth and invasion through the regulation of the hyaluronan synthase 2 gene Takatsugu Okegawa 1, Kazutaka Ushio, Mayumi Imai, Megumi Morimoto, Takahito Hara Oncogenesis, 2: e58 (2013) 桶川隆嗣、潮 和敬、今井真由美、森本 恵、原 隆人 1 Department of Urology, Kyorin University School of Medicine, Mitaka, Japan [T50] Identification of the Cancer Cell Proliferation and Survival Functions of proHB-EGF by Using an Anti-HB-EGF Antibody Shuji Sato 1, Hiroko Kamada, Takahiro Watanabe, Isamu Tsuji, Jinhong Fan 1 PLOS ONE, 8(1): e54509 (2013) 佐藤秀司、鎌田寛子、渡辺高広、辻 勇 1 Takeda San Francisco, Inc., South San Francisco, California, United States of America

12

Pharmaceutics

[T51] Preparation and evaluation of unpleasant taste-masked pioglitazone orally disintegrating tablets Yoshinori Nakano, Arisa Maeda, Shinya Uchida 1, Noriyuki Namiki 1 International Journal of Pharmaceutics, 446: 160-165 (2013) 仲野慶則、前田ありさ、内田信也、並木徳之 1 Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of

Shizuoka; 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

[T52] Quantitative analysis of the layer separation risk in bilayer tablets using terahertz pulsed imaging Masahiro Niwa, Yasuhiro Hiraishi, Norio Iwasaki, Katsuhide Terada 1 International Journal of Pharmaceutics, 452: 249–256 (2013) 丹羽雅裕、平石恭大、岩崎紀夫、寺田勝英 1 Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan

[T53] Coupling biorelevant dissolution methods with physiologically based pharmacokinetic modelling to forecast in-vivo performance of solid oral dosage forms Keiichi Otsuka, Yasushi Shono and Jennifer Dressman 1 Journal of Pharmacy and Pharmacology, 65: 937–952 (2013) 大塚圭一、正野泰士 1 Goethe University, Frankfurt am Main

[T54] A Novel Inhibitor of c-Met and VEGF Receptor Tyrosine Kinases with a Broad Spectrum of In Vivo Antitumor Activities Yoshiko Awazu, Kazuhide Nakamura, Akio Mizutani, Yuichi Kakoi, Hidehisa Iwata, Seiji Yamasaki, Naoki Miyamoto, Shinichi Imamura, Hiroshi Miki, and Akira Hori Mol. Cancer Ther., 12: 913-924 (2013) 粟津紀香、中村一英、水谷明生、栫 雄一、岩田英久、山崎誠司、宮本直樹、今村真一、 三木啓司、堀 晃

Pharmacokinetics and Drug Metabolism [T55] Species differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs Toshiyuki Takeuchi, Fumihiro Jinno, Takuya Ebihara, Yuu Moriya, Rie Kadotani, Yoshihiko Tagawa, Takahiro Kondo, Tomoo Itoh 1, and Satoru Asahi Biopharm. Drug Dispos., 34: 236–246 (2013) 竹内敏之、神野文宏、蛯原卓哉、守屋 優、角谷理恵、田川吉彦、近藤孝浩、伊藤智夫、 朝日 知

13

1 School of Pharmacy, Kitasato University, Shirokane 5-9-1, Minato-ku, Tokyo, Japan [T56] Impact of Physicochemical Profiling for Rational Approach on Drug Discovery Shoko Nakashima, Katsuhiko Yamamoto, Yuta Arai, and Yukihiro Ikeda Chem. Pharm. Bull., 61(12): 1228–1238 (2013) 中嶋祥子、山本克彦、新井勇太、池田幸弘 [T57] Retrospective Analysis of P-Glycoprotein–Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans Hiroshi Sugimoto, Hideki Hirabayashi, Nobuyuki Amano, Toshiya Moriwaki Drug Metab. Dispos., 41(4): 683-688 (2013) 杉本宏史、平林英樹、天野信之、森脇俊哉 [T58] Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto,Kimio Tohyama, Takahiro Kondo, Shimoga Prakash 1, Wen Chyi Shyu 1, and Satoru Asahi Drug Metab. Dispos., 41(4): 727–734 (2013) 小亀暁史、田川吉彦、柴田早智雄、東條英明、宮本真紀、遠山季美夫、近藤孝浩、 朝日 知 1 Millennium Pharmaceuticals Inc., Cambridge, Massachusetts [T59] Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration Kathryn W. Woodburn 1, Kei-Lai Fong 1, Susan D. Wilson 1, Steven Sloneker 1, Paul Strzemienski 1, Eric Solon 1, Yuu Moriya, and Yoshihiko Tagawa Drug Metab. Dispos., 41(4): 774–784 (2013) 守屋 優、田川吉彦 1 Affymax, Inc., Palo Alto, California (K.W.W.); Accellient Partners LLC, Berkeley, California

(K.-L.F.); Aclairo Pharmaceutical Development Group, Inc., Vienna, Virginia (S.D.W.); Calvert Laboratories Inc., Scott Township, Pennyslvania (S.S.); QPS LLC, Newark, Delaware (P.S., E.S.)

[T60] UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B15*2 Mutation Mitsuhiro Nishihara, Yuto Hiura, Naohiro Kawaguchi, Junzo Takahashi, Satoru Asahi Drug Metab. Pharmacokinet., 28 (6): 475–484 (2013) 西原光洋、日浦悠斗、川口直広、高橋順三、朝日 知

14

[T61] The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent Frances Stringer, Graham Scott 1, Marian Valbuena 1, Judith Kinley 1, Mitsuhiro Nishihara, Richard Urquhart Eur. J. Clin. Pharmacol., 69: 423-430 (2013) 西原光洋 1 Takeda Global Research & Development, London, UK [T62] Highly sensitive liquid chromatography-tandem mass spectrometry method for quantification of TAK-448 in human plasma Yoji Kuze, Fumihiro Jinno, Takahiro Kondo, Satoru Asahi Journal of Pharmaceutical and Biomedical Analysis, 83: 75–81 (2013) 久世洋司、神野文宏、近藤孝浩、朝日 知 [T63] Absorption of TAK-491, a new angiotensin II receptor antagonist, in animals Naohiro Kawaguchi, Takuya Ebihara, Toshiyuki Takeuchi, Akio Morohashi, Hitomi Yamasaki, Yoshihiko Tagawa, Junzo Takahashi, Takahiro Kondo, and Satoru Asahi Xenobiotica, 43(2): 182-192 (2013) 川口直広、蛯原卓哉、竹内敏之、諸橋昭雄、山崎仁美、田川吉彦、高橋順三、近藤孝浩、 朝日 知 [T64] Evaluation of low background liquid scintillation counter for non-clinical ADME studies Akemi Onishi, Akifumi Kogame, Yoshihiko Tagawa, Takahiro Kondo, and Satoru Asahi Xenobiotica, 43(6): 520-526 (2013) 大西明美、小亀暁史、田川吉彦、近藤孝浩、朝日 知 Drug Safety Evaluation [T65] A Case of Metastatic Adrenocortical Carcinoma Diagnosed with Steroidogenic Factor-1 in a Sprague-Dawley Rat Yuichi Takai, Tomoya Sano, Takeshi Watanabe, and Ryo Fukuda J. Toxicol. Pathol., 26: 319–323 (2013) 高井有一、佐野智弥、渡辺武志、福田 良 [T66] Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid Kiyohiro Hashimoto, Takeshi Todo 1 Mutagenesis, 28(4): 457-464 (2013) 橋本清弘、藤堂 剛 1 Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka

University B4, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan

15

[T67] Identification of Novel Liver-Specific mRNAs in Plasma for Biomarkers of Drug-Induced Liver Injury and Quantitative Evaluation in Rats Treated With Various Hepatotoxic Compounds Shingo Okubo 1,2, Makoto Miyamoto 1,2, Kenji Takami 1,2, Masayuki Kanki 2,3, Atsushi Ono 2,4, Noriyuki Nakatsu 2, Hiroshi Yamada 2, Yasuo Ohno 4, and Tetsuro Urushidani 2,5 Toxicological Sciences, 132(1): 21–31 (2013) 大久保慎吾、宮本 実、髙見健治、神吉将之、小野 敦、中津則之、山田 弘、大野泰雄、

漆谷哲朗 1 Drug Safety Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251–8555, Japan

2 Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, Ibaraki, Osaka 567-0085, Japan

3 Molecular Toxicology, Drug Safety Research Laboratories, Astellas Pharmaceutical Incorporated, Yodogawa-ku, Osaka 532–8514, Japan

4 National Institute of Health Sciences, Setagaya-ku, Tokyo 158–8501, Japan 5 Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Doshisha Women’s

College of Liberal Arts, Kyotanabe, Kyoto 610-0395, Japan Clinical Research [T68] Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer Masaaki Iwatsuki 1, Kousei Toyoshima, Masayuki Watanabe 1, Naoko Hayashi 1, Takatsugu Ishimoto 1, Kojiro Eto 1, Shiro Iwagami 1, Yoshifumi Baba 1, Naoya Yoshida 1, Akira Hayashi, Yoshikazu Ohta, Hideo Baba 1 British Journal of Cancer, 109: 2829–2832 (2013) 岩槻政晃、豊島功正、渡邊雅之、林 尚子、石本崇胤、江藤弘二郎、岩上志朗、馬場祥史、

吉田直矢、林 哲、大田義一、馬場秀夫 1 Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto

University, 1-1-1 Honjo, Kumamoto 860-8556, Japan Information Science [T69] Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory Mimi A. Trinh, Eric Klann 1 Neurobiology of Learning and Memory, 105: 93–99 (2013) 1 Center for Neural Science, New York University, New York, NY 10003, USA

16

Veterinaly Science

[T70] Expression of Steroidogenic Factor 1 and Pituitary Specific Transcription Factor 1 in Rat Pituitary Adenomas Hironobu Yasuno, Takeshi Watanabe, Yumiko Miyamoto, Hitoshi Kandori, Hideki Yamasaki, Ryo Fukuda J. Toxicol. Pathol., 26: 209–213 (2013) 安野弘修、渡辺武志、宮本由美子、神鳥仁志、山﨑秀樹、福田 良

Technology Development [T71] Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer’s disease Satoshi Yamamoto, Yuki Ooshima, Mitsugu Nakata, Takashi Yano, Kunio Matsuoka, Sayuri Watanabe, Ryouta Maeda, Hideki Takahashi, Michiyasu Takeyama, Yoshio Matsumoto, Tadatoshi Hashimoto Transgenic Res., 22: 537–547 (2013) 山本 智、大島裕貴、中田 貢、矢野 隆、松岡邦夫、渡辺小百合、前田良太、高橋秀樹、

竹山道康、松本芳男、橋本忠俊

17

Originals in Japanese

Medicinal Chemistry [T72] 新規アンジオテンシンⅡ受容体拮抗薬アジルサルタンの創製

久保惠司、楠本啓司 MEDCHEM NEWS, 23(1): 26-32, (2013) Discovery of a Novel Angiotensin Receptor Antagonist, Azilsartan Keiji Kubo, Keiji Kusumoto MEDCHEM NEWS, 23(1): 26-32, (2013) Immunology [T73] 制御性 T細胞を標的とした創薬開発

杉村杏子、戎野幸彦 医学のあゆみ, 246(10): 927-936 (2013) Therapeutic opportunities for regulatory T cells in autoimmune disease Kyoko Sugimura, Yukihiko Ebisuno Journal of Clinical and Experimental Medicine, 246(10): 927-936 (2013) [T74] 抗体依存性疾患治療薬としてのプロテアソーム阻害薬

糸見安生，相良将樹，藤谷靖志，河村 透，瀧澤正之 日本薬理学雑誌, 142(2): 68-72, (2013) Proteasome inhibitor for antibody-mediated disease therapy Yasuo Itomi, Masaki Sagara, Yasushi Fujitani, Toru Kawamura, Masayuki Takizawa Folia Pharmacologica Japonica, 142(2): 68-72, (2013) Pharmacology [T75] ホルモンを基盤とした前立腺がん治療薬研究開発～ Kisspeptin と生殖機能との関

係を中心に～

松井久典 日本薬理学雑誌, 142: 150-155 (2013) Research activities on hormonal agents ̶ focusing on kisspeptin and reproductive functions Hisanori Matsui Folia Pharmacol. Jpn., 142: 150-155 (2013) [T76] 新規カリウムイオン競合型アシッドブロッカーTAK-438の作用および特徴

松川 純、稲富信博 消化器内科, 56 (2): 194-200 (2013) Antisecretory efficacy and characteristics of a novel synthesized potassium-competitive acid blocker, TAK-438 Jun Matsukawa, Nobuhiro Inatomi

18

Gastroenterology, 56 (2): 194-200 (2013) Pharmaceutics [T77] 混合粉砕による医薬品原薬の cocrystal 結晶化

効率的な cocrystal 探索法としての cocktail cocrystal grinding の確立

山本克彦、池田幸弘 製剤機械技術学会誌, 22(1): 15-21 (2013) Crystallization of Pharmaceutical Cocrystals by Grinding: "Cocktail Cocrystal Grinding Method" for Efficient Screening Katsuhiko Yamamoto, Yukihiro Ikeda Journal of Pharmaceutical Machinery and Engineering, 22(1): 15-21 (2013) [T78] Miconazole の塩および共結晶調製による物性改善研究および単結晶構造解析による

結晶状態の分類

Part 1: Miconazole の塩および共結晶の結晶化スクリーニング

堤俊一郎、池田幸弘 製剤機械技術学会誌, 22 (4): 11-15 (2013) Preparation of Miconazole Salts and Cocrystals with Improved Physicochemical Properties, and Classification of Their Crystalline States by Single Crystal Structure Analysis Part 1: Crystallization Screening of Miconazole Salts and Cocrystals Shunichiro Tsutsumi, Yukihiro Ikeda Journal of Pharmaceutical Machinery and Engineering, 22 (4): 11-15 (2013) Technology Development [T79] 水和物原薬の真空乾燥での取得法の理論的考察と生産への適用

向井浩二 分離技術, 43: 372-375 (2013) Theoretical study of the preparation method for hydrate drugs using vacuum drying and its application to production. Koji Mukai Bunri Gijutsu, 43: 372-375 (2013) [T80] ﾘｭｰﾌﾟﾘﾝ（マイクロカプセル型長期徐放性注射製剤）

村田直之 DDS 学会誌, 28(1): 56-62 (2013) Leuplin (Microsphere powder type sustained release formulation) Noayuki Murata Drug Delivery System, 28(1): 56-62 (2013) [T81] においセンサー識別システムおよび官能試験によるにおいの評価 －貼付剤から放散

するにおいについて－

高野 岳 1、小管浩樹 1、福﨑有起、村川祐介、御前雅文

19

フレグランスジャーナル, 41(4): 86-89 (2013) Evaluation of odor with an electronic nose system and by a sensory test - Concerning the odor discharged from patches - Takeshi Takano 1, Hiroki Kosuga 1, Yuki Fukusaki, Yusuke Murakawa, Masafumi Misaki Fragrance Journal, 41(4): 86-89 (2013)

1 Shimadzu Techno-Research INC. [T82] iPS 細胞を用いた膵β細胞への分化誘導

細谷昌樹 内分泌・糖尿病・代謝内科, 36(3): 220-225 (2013) Differentiation of pancreatic b cells from human iPS cells Masaki Hosoya Endocrinology, Diabetology & Metabolism, 36(3): 220-225 (2013)

20

Author Index

[A]

Aikawa, Katsuji (合川勝二) T09, T28

Amano, Nobuyuki (天野信之) T21, T57

Andre Kiryanov T21, T23

Andy Jennings T20, T23

Anthony R. Gangloff T23

Aoyama, Kazunobu (青山和誠) T15, T25, T40

Arai, Yuta (新井勇太) T56

Arakawa, Yuuichi (荒川佑一) T12

Araki, Hideo (荒木秀夫) T39

Aramaki, Yoshio (荒牧慶夫) T19, T24

Arita, Takeo (有田健雄) T26, T32

Asahi, Satoru (朝日 知)

T55, T58, T60, T62, T63, T64

Asami, Taiji (浅見泰司) T27

Asano, Kouhei (麻野耕平) T16

Asano, Moriteru (浅野壮輝) T15, T25

Ashley McCarron T02

Awazu, Yoshiko (粟津紀香) T11, T19, T33, T54

[B]

Baba, Atsuo (馬場厚生) T09, T19, T24

Baba, Hideo (馬場秀夫) T68

Baba, Yoshifumi (馬場祥史) T68

Benjamin Jones T21

Betty Lam T21

Bheema Paraselli T41

BiChing Sang T41

Bi-Ching Sang T26

Bumsup Lee T20, T41

[C]

Cassandra Gauthier T16

Charles E. Grimshaw T23

Charles Grimshaw T41

Cho, Nobuo (長 展生) T28

Chris Matthews T02

Christopher McBride T21

Christopher S. Siedem T16

Chunrong Ma T02

Clifford D. Mol T15

Colin O’Bryan T02

Craig A. Behnke T08

[D]

David Hosfield T20, T21

David J. Hosfield T19, T24

David Provencal T02

Debori, Yasuyuki (出掘泰之) T18

Deepika Balakrishna T41

Douglas R. Cary T07, T13

Douglas R. Dougan T15, T18, T23, T25

21

[E]

Ebihara, Takuya (蛯原卓哉) T55, T63

Ebisuno, Yukihiko (戎野幸彦) T73

Elizabeth Carideo T32

Endo, Natsumi (遠藤なつ美) T46

Endo, Satoshi (遠藤聡史) T16

Eric Klann T69

Eric Solon T59

Erin O’Brien T02

Eto, Kojiro (江藤弘二郎) T68

Ewan Taylor T23

[F]

Frances Stringer T61

Frederick Hicks T02

Fujitani, Yasushi (藤谷靖志) T74

Fukuda, Naohiro (福田直弘) T03, T04

Fukuda, Ryo (福田 良) T65, T70

Fukumoto, Shoji (福本正司) T16

Fukusaki, Yuki (福﨑有起) T81

[G]

Graham Scott T61

Gyorgy P. Snell T18, T25

[H]

Habata, Yugo (羽畑祐吾) T42

Habuka, Noriyuki (羽深典之) T16

Haixia Wang T20

Hamada, Teruki (濱田輝基) T15

Hamajo, Kazuhiro (浜條和弘) T30

Hara, Takahito (原 隆人) T09, T38, T39, T49

Hashimoto, Kentaro (橋本健太郎)

T15, T18, T25, T40

Hashimoto, Kiyohiro (橋本清弘) T66

Hashimoto, Tadatoshi (橋本忠俊) T71

Hasui, Tomoaki (蓮井智章) T16

Hasuoka, Atsushi (蓮岡 淳) T09

Hayano, Yumi (早野有美) T28

Hayashi, Akira (林 哲) T37, T68

Hayashi, Naoko (林 尚子) T68

Hayashi, Yoko (林 陽子) T19, T24

Heinz von der Kammer T48

Hibino, Ryosuke (日比野良祐) T40

Hikami, Kouki (氷上光輝) T21

Hikichi, Yuichi (引地裕一) T21

Hinuma, Shuji (日沼州司) T43

Hirabayashi, Hideki (平林英樹) T57

Hiraishi, Yasuhiro (平石恭大) T52

Hirayama, Takaharu (平山孝治) T11, T14, T17

Hirose, Masaaki (広瀬雅朗) T26

Hitaka, Takenori (飛髙武憲) T39

Hiura, Yuto (日浦悠斗) T60

Hoashi, Yasutaka (帆足保孝) T06

22

Homma, Misaki (本間実咲) T28

Honda, Eiji (本多栄治) T12

Hori, Akira (堀 晃)

T11, T13, T17, T19, T24, T33, T47, T54

Horiguchi, Takashi (堀口隆司) T48

Horikoshi, Yasuko (堀越康子) T27

Hoshino, Takashi (星野 崇) T41

Hosoya, Masaki (細谷昌樹) T82

Hua Mei T44

Hua Zou T21

[I]

Ibuki, Naokazu (伊夫貴直和) T36

Ichikawa, Takashi (一川隆史) T21

Igaki, Keiko (井垣啓子) T35

Igaki, Shigeru (井垣 茂) T07, T08, T28

Ikeda, Yukihiro (池田幸弘) T56, T77, T78

Ikemoto, Tomomi (池本朋己) T03, T04

Imaeda, Yasuhiro (今枝泰宏) T28

Imada, Takashi (今田 岐) T14

Imai, Mayumi (今井真由美) T49

Imai, N. Yumi (今井友美) T22, T28

Imamura, Shinichi (今村真一)

T11, T13, T17, T25, T33, T54

Inatomi, Nobuhiro (稲富信博) T76

Inazuka, Masakazu (稲塚雅一) T28, T40

Inui, Yoshitaka (乾 嘉孝) T26

Irene Iu T36

Ishibashi, Yoshihiro (石橋祥弘) T27

Ishichi, Yuji (石地雄二) T12

Ishikawa, Tomoyasu (石川智康)

T07, T10, T14, T15, T18, T25, T26, T28, T32,

T37, T40

Ishimoto, Kazuhisa (石本和久) T04

Ishimoto, Takatsugu (石本崇胤) T68

Ishino, Seigo (石野誠悟) T41, T45

Isono, Osamu (磯野 修) T19

Ito, Mitsuhiro (伊藤光博) T09

Ito, Ryo (伊藤 亮) T31, T42

Ito, Tatsuya (伊藤達也) T02

Ito, Yuki (井藤勇輝) T47

Itoh, Tomoo (伊藤智夫) T55

Itomi, Yasuo (糸見安生) T74

Iwachidow, Kimihiko (岩知道公彦) T43

Iwagami, Shiro (岩上志朗) T68

Iwai, Kenichi (岩井謙一) T14, T25, T40

Iwasaki, Norio (岩崎紀夫) T52

Iwata, Hidehisa (岩田英久)

T07, T10, T11, T13, T17, T19, T24, T33, T54

Iwatani, Misa (岩谷美沙) T19, T24

Iwatsuki, Masaaki (岩槻政晃) T68

[J]

Jason Brown T23

Jason Yano T26

Jeffrey Stafford T21

Jennifer Dressman T53

23

Jennifer Matuszkiewicz T41

Jie Huang T02

Jill Donelan T32

Jinhong Fan T50

Jinno, Fumihiro (神野文宏) T55, T62

Joanne Doran T44

Joanne Miura T20

Jouhara Chouitar T32

Judith Kinley T61

Jun Feng T20

[K]

Kadotani, Rie (角谷理恵) T55

Kaisho, Yoshihiko (改正善彦) T43

Kajino, Masahiro (梶野正博) T34

Kajiwara, Takeshi (梶原武志) T03

Kakei, Hiroyuki (筧 広行) T25

Kakoi, Yuichi (栫 雄一) T33, T54

Kaku, Tomohiro (加来智弘) T09, T38, T39

Kamada, Hiroko (鎌田寛子) T50

Kamiguchi, Hidenori (上口英則) T10

Kandori, Hitoshi (神鳥仁志) T70

Kanki, Masayuki (神吉将之) T67

Kanno, Kazuaki (菅野和明) T01, T05

Kanzaki, Naoyuki (神崎直之) T09, T12

Kashiwagi, Masahide (柏木正英) T36

Katherine Galvin T32

Kathleen Aertgeerts T26

Kathryn W. Woodburn T59

Kato, Junichi (加藤潤一) T47

Katou, Tomoaki (加藤友祥) T03

Kawaguchi, Naohiro (川口直広) T60, T63

Kawai, Takayuki (河合隆幸) T12

Kawakita, Youichi (川北洋一) T07, T10, T37

Kawamoto, Tomohiro (河本朋宏)

T14, T19, T21, T26, T28

Kawamura, Toru (河村 透) T08, T74

Kawasaki, Masanori (川崎昌紀) T25

Kei-Lai Fong T59

Kikuchi, Naoya (菊池直也) T42

Kimura, Eiji (木村英司) T12

Kimura, Haruhide (木村温英) T34

Kitada, Chieko (北田千恵子) T27

Kitahara, Osamu (北原 治) T33

Kiyota, Yoshihiro (清田義弘) T08

Kobayashi, Hiromi (小林ひろ美) T09

Kogame, Akifumi (小亀暁史) T58, T64

Koike, Tatsuki (小池竜樹) T06

Kojima, Takashi (小嶌隆史) T25

Kokubo, Toshio (小久保利雄) T47

Komatsu, Hidetoshi (小松秀俊) T42

Kondo, Takahiro (近藤孝浩)

T55, T58, T62, T63, T64

Kono, Mitsunori (髙野光功) T08

Kori, Masakuni (郡 正城) T08

Kosuga, Hiroki (小管浩樹) T81

Kosugi, Yohei (小杉洋平) T18, T25, T40

Kotani, Etsuo (小谷悦郎) T06

Kouno, Jin (河野 仁) T38

24

Kubo, Kazuki (久保一樹) T45

Kubo, Keiji (久保惠司) T72

Kuroiwa, Takenobu (黒岩武信) T46

Kurokawa, Tomofumi (黒川智文) T47

Kusaka, Masami (日下雅美) T38, T39, T46

Kusumoto, Keiji (楠本啓司) T72

Kuze, Yoji (久世洋司) T62

[L]

Ladan Fazli T36

Li Heyang T02

Lihong Shi T41

Lilly Zhang T21, T41

Lisa A. De Meese T16

Liu Yuqiang T02

[M]

Maeda, Arisa (前田ありさ) T51

Maeda, Risa (前田理紗) T42

Maeda, Ryouta (前田良太) T71

Magata, Yasuhiro (間賀田泰寛) T45

Majima, Keisuke (真島桂介) T03

Marian Valbuena T61

Marianne Langston T02

Mark Hixon T23

Mark Sabat T20

Martin E. Gleave T36

Matsuda-Nagasumi, Kae (松田香絵)

T31, T42, T43

Matsui, Hideki (松井英起) T16

Matsui, Hisanori (松井久典) T27, T46, T75

Matsukawa, Jun (松川 純) T76

Matsumoto, Hirokazu (松本寛和) T27

Matsumoto, Shigemitsu (松本重充) T17

Matsumoto, Shin-ichi (松本真一) T21, T27

Matsumoto, Takahiro (松本孝浩) T08

Matsumoto, Yoshio (松本芳男) T71

Matsuo, Yoshino (松尾佳野) T29

Matsuoka, Kunio (松岡邦夫) T71

Matsushita, Yoshihiro (松下義弘) T19

Matthew Johnson T02

Mazyar Ghaffari T36

Michael E. Cox T36

Miki, Hiroshi (三木啓司)

T07, T10, T11, T13, T17, T19, T24, T33, T54

Mimi A. Trinh T69

Mineno, Masahiro (峯野雅博) T01, T05

Mingnam Tang T20

Misaki, Masafumi (御前雅文) T81

Mitali Pandey T36

Miura, Shin-ichiro (三浦伸一郎) T29

Miwa, Kazuhiro (三輪憲弘) T11

Miyahisa, Ikuo (宮久郁夫) T28

Miyamoto, Maki (宮本真紀) T58

Miyamoto, Makoto (宮本 実) T67

Miyamoto, Naoki (宮本直樹)

T11, T13, T17, T25, T33, T54

25

Miyamoto, Yumiko (宮本由美子) T70

Miyawaki, Kazumasa (宮脇一真) T42

Miyazaki, Junichi (宮崎純一) T08

Mizufune, Hideya (水船秀哉) T01, T05

Mizukami, Atsushi (水上温司) T16

Mizutani, Akio (水谷明生) T33, T54

Mori, Ikuo (森 郁生) T31, T45

Mori, Kouji (森 考司) T14

Mori, Masaaki (森 正明) T42

Morimoto, Megumi (森本 恵) T40, T49

Morishita, Nao (森下奈央) T15, T18, T25

Moriwaki, Toshiya (森脇俊哉) T57

Moriya, Yuu (守屋 優) T55, T59

Morohashi, Akio (諸橋昭雄) T63

Mukai, Koji (向井浩二) T79

Murakami, Koji (村上浩司) T30

Murakawa, Yusuke (村川祐介) T81

Murata, Naoyuki (村田直之) T80

[N]

Nagai, Kiyosuke (永井淸亮) T46

Nagase, Yoshinori (長瀬由典) T33

Nagata, Toshiaki (長田敏明) T04

Nakagawa, Hideyuki (中川秀行) T12

Nakahata, Takashi (中畑 崇) T12

Nakamura, Akito (中村鑑斗) T26, T32

Nakamura, Kazuhide (中村一英) T17, T33, T54

Nakanishi, Osamu (中西 理) T36

Nakano, Yoshinori (仲野慶則) T51

Nakashima, Shoko (中嶋祥子) T56

Nakata, Mitsugu (中田 貢) T43, T71

Nakatsu, Noriyuki (中津則之) T67

Nakayama, Akiko (中山明子) T37

Nakayama, Masaharu (中山政治) T27

Namiki, Noriyuki (並木徳之) T51

Negoro, Nobuyuki (根来 伸行) T31

Nishibori, Kimiko (西堀貴美子) T27

Nishida, Goushi (西田剛士) T28

Nishihara, Mitsuhiro (西原光洋) T60, T61

Nishimoto, Tomoyuki (西本誠之) T45

Nishimura, Atsushi (西村 篤) T08

Nishizawa, Naoki (西澤直城) T27

Niwa, Masahiro (丹羽雅裕) T52

Nomura, Toshiyuki (野村俊之) T41

[O]

Odaka, Hiroyuki (小高裕之) T43

Ogawa, Mikako (小川美香子) T45

Ogi, Kazuhiro (大儀和宏) T43

Oguro, Yuya (大黒裕哉) T11, T13, T18, T25

Ohashi, Akihiro (大橋紹宏) T14

Ohashi, Tomohiro (大橋知洋) T10

Ohkura, Satoshi (大蔵 聡) T46

Ohno, Yasuo (大野泰雄) T67

Ohori, Momoko (大堀桃子) T14

Ohra, Taiichi (邑楽泰一) T16

Ohta, Hiroyuki (太田浩之) T12

26

Ohta, Yoshikazu (大田義一)

T07, T10, T37, T41, T68

Ohtaki, Tetsuya (大瀧徹也) T27

Ohyabu, Norio (大藪紀雄) T16

Oiki, Shigetoshi (老木成稔) T22

Okabe, Atsutoshi (岡部篤俊) T19, T24, T29

Okada, Kengo (岡田健吾) T11, T17

Okamura, Hiroaki (岡村裕昭) T46

Okaniwa, Masanori (岡庭正格) T14, T26, T32

Okegawa, Takatsugu (桶川隆嗣) T49

Oki, Hideyuki (沖 英幸) T08, T11, T17

Okubo, Shingo (大久保慎吾) T67

Onishi, Akemi (大西明美) T64

Ono, Atsushi (小野 敦) T67

Oomori, Yoshimasa (大森良真) T19

Ooshima, Yuki (大島裕貴) T71

Oshima, Tsutomu (大島 勉) T47

Otsuka, Keiichi (大塚圭一) T53

[P]

Pamela Farrell T41

Paul Strzemienski T59

Petro Halkowycz T41

Phong Vu T23

Prasuna Guntupalli T20

[Q]

Qiang Yang T02

[R]

Richard Urquhart T61

Robert J. Skene T19, T24

Robert Skene T21

Robyn Fabrey T41

Ron de Jong T23, T41

Ruhi Kamran T23

Ryu, Sunghi (柳 承希) T22

[S]

Sadashiva S. Karnik T29

Sagara, Masaki (相良将樹) T74

Saito, Bunnai (齊藤文内) T15, T18, T25

Sakai, Nozomu (坂井 望) T11

Saku, Keijiro (朔啓二郎) T29

Sakuma, Kensuke (佐久間健介) T42

Sameshima, Tomoya (鮫島知哉) T28

Sano, Tomoya (佐野智弥) T65

Sarah Elliott T41

Sato, Shuji (佐藤秀司) T47, T50

Sato, Yoshimi (佐藤佳美) T34

Satomi, Tomoko (里見朋子) T45

Satou, Takashi (佐藤貴史) T41

Sawada, Naotaka (沢田直隆) T01, T05

Sawai, Yasuhiro (澤井泰宏) T01, T04, T05

Seto, Masaki (瀬戸雅樹) T10

Sha, Takukyu (謝 卓丘) T35

Shawn O’Connell T23

27

Shel-Hwa Yeo T44

Shibata, Sachio (柴田早智雄) T58

Shimoga Prakash T58

Shimojo, Masato (下条雅人) T08, T30

Shintani, Yasushi (新谷 靖) T48

Shiokawa, Zenyu (塩川善右) T15, T18, T25

Shono, Yasushi (正野泰士) T53

Sogabe, Satoshi (曽我部智) T07, T10, T16, T28

Srinivasa Natala T21

Stephen Kaldor T21

Stephen L. Gwaltney II T20

Steven A. Boyd T16

Steven Sloneker T59

Sugimoto, Hiroshi (杉本宏史) T57

Sugimura, Kyoko (杉村杏子) T73

Sumi, Hiroyuki (角 紘幸) T15, T18, T25, T40

Sumita, Akihiko (隅田昭彦) T26

Susan D. Wilson T59

Suzuki, Atsuko (鈴木敦子) T12

Suzuki, Hirobumi (鈴木博文) T34

Suzuki, Motohisa (鈴木基久) T30

Suzuki, Noriko (鈴木敬子) T30

Suzuki, Shinkichi (鈴木新吉) T19

[T]

Tagawa, Yoshihiko (田川吉彦)

T55, T58, T59, T63, T64

Tajima, Yasukazu (田島泰一) T34

Takagi, Shinji (髙木慎二) T07, T37

Takagi, Terufumi (髙木輝文) T07, T11, T26

Takahashi, Hideki (高橋秀樹) T71

Takahashi, Junzo (高橋順三) T60, T63

Takai, Takafumi (高井隆文) T06

Takai, Yuichi (高井有一) T65

Takami, Kenji (髙見健治) T67

Takami, Ritsuko (高見律子) T43

Takano, Takeshi (高野 岳) T81

Taketomi, Shigehisa (武冨滋久) T43

Takeuchi, Koji (武内浩二) T31, T42

Takeuchi, Toshiyuki (竹内敏之)

T11, T33, T38, T55, T63

Takeyama, Michiyasu (竹山道康) T71

Takizawa, Masayuki (瀧澤正之) T34, T74

Tamura, Toshiya (田村寿哉) T10, T37

Tanaka, Akira (田中 晃) T46

Tanaka, Hideyuki (田中秀幸) T43

Tanaka, Tomomi (田中知己) T46

Tanaka, Toshimasa (田中稔祐) T10, T14

Tanaka, Yuta (田中雄太) T28

Tanida, Seiichi (谷田清一) T34

Tarui, Naoki (樽井直樹) T27

Tasaka, Akihiro (田坂昭弘) T38, T39

Tawada, Michiko (多和田倫子) T13, T17, T28

Taya, Naohiro (田家直博) T25

Terada, Katsuhide (寺田勝英) T52

Terao, Yasuko (寺尾寧子) T12

Teratani, Mika (寺谷実佳) T41

Terauchi, Jun (寺内 淳) T12

Todo, Takeshi (藤堂 剛) T66

28

Tohyama, Kimio (遠山季美夫) T58

Tojo, Hideaki (東條英明) T36, T58

Tomita, Daisuke (冨田大介) T25

Tomita, Naoki (冨田直輝) T19, T24

Tony P. Tang T16

Tottori, Tsuneaki (鳥取恒彰) T26

Toyoshima, Kousei (豊島功正) T68

Tozawa, Ryuichi (兎沢隆一) T40

Tsuchimori, Noboru (土森 登) T35

Tsuchiya, Shuntarou (土屋俊太郎) T32, T33

Tsuji, Isamu (辻 勇) T47, T50

Tsujihata, Yoshiyuki (辻畑善行) T31, T42

Tsukamoto, Tetsuya (塚本徹哉) T30

Tsutsumi, Shunichiro (堤俊一郎) T26, T78

[U]

Uchida, Shinya (内田信也) T51

Uchiyama, Noriko (内山紀子) T21, T26

Urushidani, Tetsuro (漆谷哲朗) T67

Ushio, Kazutaka (潮 和敬) T49

[V]

Victoria Feher T21

Victoria Kyle T44

[W]

Wakabayashi, Yoshihiro (若林嘉浩) T46

Watanabe, Masayuki (渡邊雅之) T68

Watanabe, Sayuri (渡辺小百合) T71

Watanabe, Takahiro (渡辺高広) T47, T50

Watanabe, Takeshi (渡辺武志) T35, T65, T70

Watanabe, Tomomichi (渡邉知倫) T48

Wen Chyi Shyu T58

William H. Colledge T44

[X]

Xiaodong Cao T21

Xiaolu Wang T48

[Y]

Yabuki, Chiori (矢吹千織) T42

Yabuki, Masato (矢吹仁人)

T15, T18, T25, T26, T40

Yaguchi, Masahiro (矢口正宏) T37

Yamada, Hiroshi (山田 弘) T67

Yamaguchi, Masashi (山口昌史) T27

Yamamoto, Katsuhiko (山本克彦) T56, T77

Yamamoto, Satoshi (山本 智) T71

Yamamoto, Satoshi (山本哲史) T09

Yamamoto, Shunsuke (山本俊輔) T40

Yamaoka, Masuo (山岡万寿夫) T09, T38, T39

Yamasaki, Hideki (山﨑秀樹) T40, T70

Yamasaki, Hitomi (山崎仁美) T63

Yamasaki, Masashi (山嵜将司) T35

Yamasaki, Seiji (山崎誠司) T11, T17, T33, T54

29

Yan Liu T21

Yan Sitang T02

Yano, Takashi (矢野 隆) T43, T71

Yasuhara, Yoshitaka (安原吉高) T43

Yasuno, Hironobu (安野弘修) T70

Yiqin Wu T20

Yokota, Akihiro (横田彰宏) T14

Yongquan Hou T02

Yoshida, Naoya (吉田直矢) T68

Yoshida, Sei (吉田 聖)

T15, T18, T25, T26, T32, T40

Yoshikawa, Masato (吉川真人) T12

Yoshimatsu, Mie (吉松美恵)T15, T18, T25, T40

Yukitake, Hiroshi (行武 洋) T34

Yusa, Tadashi (遊佐 正) T10, T37

Yuxin Zhao T02

[Z]

Zacharia S. Cheruvallath T20

Zhe Nie T21