KOREAN ADNI… WHERE ARE WE NOW

KOREAN ADNI… WHERE ARE WE NOW

Seol-Heui Han, MD, PhD.On behalf of

Preparatory Committee for K-ADNI

Seol-Heui Han, MD, PhD.On behalf of

Preparatory Committee for K-ADNI

9yr Project

700,000 US dollars /yr

Funded by the Ministry of Health, Welfare, and Family Affairs

Clinical Research Center for Dementia of South Korea (CREDOS)

Clinical Research Center for Dementia of South Korea (CREDOS)

2005 2006 20132007 20092008 2010 2011 2012 2014

Primary focus of CREDOS

svMCI

aMCI

AD

SVaD

Time

Co

gn

ition

Healthy, SMI

Items for historyCognition

ADL

Behaviors

Differential diagnoses

Scales or questionnairesKorean Dementia Screening

Questionnaire (K-DSQ)

Barthel- index

Instrumental ADL (Seoul IADL)

NPI

MMSE

CDR

GDS

Hachinski ischemic scale

Geriatric depression scale

CREDOS

CREDOS protocols CREDOS protocols

MRI

LabVitamin B12FolateVDRLTSH/free T4

Axial T2, T1, FLAIR, (GRE)Coronal T1

Neuropsychological tests

CREDOS D-MatrixCREDOS D-Matrix

　

WMH on MRI

minimal moderate severe

COGNITION

No cognitive impairment I-1 I-2 I-3

Mild cognitive impairment II-1 II-2 II-3

Mild to moderate dementia III-1 III-2 III-3

Severe dementia IV-1 IV-2 IV-3

Healthy, SMI

aMCI, AD

svMCI, SIVD

DESIGNING K-ADNIDESIGNING K-ADNI

K-ADNI: Organization TreeK-ADNI: Organization Tree

K-ADNIPI: SH Han

Assistant administrator:SY Kim , DW Yang

Clinical Core

Biologi-cal Core

Imaging Core

Bio-statis-

tics Core

CREDOS PI:DL Na

Advisory board ADNI: M. Weiner

Stroke riskADAS-Cog, CDRADL,NPI, FBINeurologic scale

CSF tau, amyloidApo E, GWASLipid, homocys-teine, TFT

MRI-VBM, DTI, fMRIFDG-PET, PIB-PET

Main aim: Effects of SVD on Progression of AD

Time

Co

gn

ition

Plan: 500 casesPlan: 500 cases

　　

No cognitive impairment 100 0 0

Mild cognitive impairment 100 50 50

Mild to moderate dementia 100 50 50

Severe dementia 0 0 0

WMH on MRI

mild moderate severe

Co

gn

ition

RecruitmentN=500 Follow up

K-ADNI5yr Longitudinal study

201220112010 2013 2014 2015

Neuropsychological Tests

SNSB, ADL,CGA-NPI, FBI

Biomarker

Blood: Apo E polymorphism, Genome-wide study

CSF

Imaging studies

MRI

PET: FDG-PET, PIB-PET

NPTBiomarkerImaging

NPTBiomarkerImaging

NPTBiomarkerImaging

NPTBiomarkerImaging

NPTBiomarkerImaging

NPTBiomarkerImaging

Ready to goReady to go

Funding sources ($1.5 M/yr for 5 years) Government Private donations Industry support