کلیرانس
DESCRIPTION
PharmacyTRANSCRIPT
Clearance study
Clearance study . ( Clear ) PAH . . .
( ) . Flame Photometer .
( ) ( ) .
(Excretion rate) ( ) () .
(V) (Ux) :UxV1: =
(Px) ( Cx) :
PxCx2: =
:
UxV = PxCx 3: 1= 2: 3 :
UxV = PxCx ( Cx = UxV/Px
1- (Ccrt):
(Ccrt) .
(Ucrt) (V) (Pcrt) :
Pcrt = 1mg/mlV = 1ml/min = 1440 ml/day
Ucrt =125mg/ml
:
Ccrt = Ucrt V/ Pcrt = 125 x 1/1 = 125ml/min
125 .
( ) (Glomerular Filtration Rate = GFR) .
Ccrt = GFR = 125ml/min
GFR ( Filtered Loadx) :
Filtered Loadx = GFR x Px
:
Ucrt V = GFR x Pcrt ( 125 x1 = 125 x1 = 125mg/min
125 () . 2- (CGlc): (CGlc) .
(UGlc) (V) (PGlc) :
PGlc = 100mg/dl = 1mg/ml = 1gr/L
V = 1ml/min = 1440 ml/day
UGlc = 0
:
CGlc = UGlc V/PGlc = 0
.
:
Filtered LoadGlc = GFR x PGlc (GFR = 125ml/min= 180L/day, PGlc = 1mg/ml= 1gr/L ( Filtered LoadGlc = 125 x 1 = 125 mg/min or = 180 x 1 = 180gr/day
125 180 . .
3- PAH (CPAH): (para-aminohippuric acid or PAH) (CPAH) PAH .
PAH (UPAH) (V) PAH (PPAH) :
PPAH= 0.01mg/ml
V= 1ml/min
UPAH= 5.85mg/ml
PAH :
CPAH= UPAH x V/PPAH= 5.85 x 1/0.01= 585ml/min
585 PAH .
PAH PAH PAH (RPF) .
PAH 90% 9/. (Extraction Ratio) PAH (ERPF) .
CPAH= ERPF= 585ml/min
(TRPF or RPF) :
TRPF or RPF= ERPF/0.9= 585/0.9= 650ml/min
55% 45% (RBF) :
RBF= RPF/1-Hct= 650/1-0.45= 1182ml/min
4- (COsm):
(COsm) . (COsm) (V) (
UOsm) . .
(UOsm) (V) (POsm) :
300mOsm/L :
- : 2 5/1 . 600 () . :
V= 1.5 L/day
UOsm= 400 mOsm/LPOsm= 300 mOsm/L :
COsm= UOsm x V/POsm= 400 x 1.5/300= 2L/day
2 600 (300 x 2) . . 5/1 400 .
- : . .
:
V= 12 L/day
UOsm= 50 mOsm/L
POsm= 300mOsm/L :
COsm= UOsm x V/POsm= 50 x 12/300= 2L/day
2 600 (300 x 2) . . .
- : . .
:
V= 0.5 L/day
UOsm= 1200 mOsm/L
POsm= 300mOsm/L :
COsm= UOsm x V/POsm= 1200 x 0.5/300= 2L/day
2 600 (300 x 2) . . . () .
() .
5- (CH2O):
. .
(V) :CH2O= V COsm
:
-
V = COsm ( CH2O = 0
2 300 600
2 300 .-
V ( COsm ( CH2O ( 0 or CH2O is Positive 2 300 600 2 12 50 (600/12=50mOsm/L) .
-
V ( COsm ( CH2O( 0 or CH2O is Negative 2 300 600 2 1200 (600/0.5=1200mOsm/L) .
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