: (Lyssaviruses )Rhabdoviridae

: US CDC

()

: University of South Carolina School of Medicine

38

3~712(skunk)8

Control of Communicable Diseases Manual 19th ed

40%Control of Communicable Diseases Manual 19th ed

385-7

2-4

190011 194719591961200220122013213

:2252

YearCasesDeaths1948333319499292 19508383195123823819521021021953525219545858195550501956 (implemented control policies)464619572222195866195900Total 782782 (100%)

7/103PCR1015-110111101123

(furious form) ( paralytic form)

2/3 fluctuating consciousness: hydrophobiaaerophobiaautonomic stimulation signshypersalivation

1/3 (Guillain-Barre syndrome)(percussion myoedema)

>>

Lancet Neurol 2013; 12: 498513

100%1-2Milwaukee protocol

: ()3 1 PCR

24

2451

Rabies virus

3 mL

1 mL

NA

1. 2. 3. 1. 2.

1. 2. 1. 2.

1. 2. 1. 2. 3.

1. 2.

(HRIG)

1570%(2

WHO

+(5)+(5)+ HRIG +(5)+ HRIG+(5)+ HRIG

+(2)+(2) +(5)+(5)

MMWR Recomm Rep. 2010 Mar 19;59(RR-2):1-9

2013/07/31

HRIG-17 ()20 IU/kg7HRIG

HRIG-223 HRIG

50(0)3714 28 ()203

-1HRIG12Guillain-Barr

-230

**!!*2004****14818

**()****......1961....20021..**************** ****