a facile access to spiro furanone skeleton based on pd(ii)-mediated cyclization—carbonylation of...

2006 Furan derivatives R 0060 A Facile Access to Spiro Furanone Skeleton Based on Pd(II)-Mediated Cycliza- tion—Carbonylation of Propargylic Esters. — A useful method for transformation of an acetylene unit into a γ-acetoxy-β-ketoester moiety is applied to the preparation of spiro furanones which are of potential pharmacological interest. The steroidal spiro furanone (X) shows vasorelaxant and bradycardiac activities. — (KATO*, K.; et al.; Tetrahedron 62 (2006) 11, 2545-2554; Sch. Pharm. Sci., Toho Univ., Funabashi, Chiba 274, Japan; Eng.) — Nuesgen 26- 105

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Page 1: A Facile Access to Spiro Furanone Skeleton Based on Pd(II)-Mediated Cyclization—Carbonylation of Propargylic Esters

2006

Furan derivativesR 0060 A Facile Access to Spiro Furanone Skeleton Based on Pd(II)-Mediated Cycliza-

tion—Carbonylation of Propargylic Esters. — A useful method for transformation of an acetylene unit into a γ-acetoxy-β-ketoester moiety is applied to the preparation of spiro furanones which are of potential pharmacological interest. The steroidal spiro furanone (X) shows vasorelaxant and bradycardiac activities. — (KATO*, K.; et al.; Tetrahedron 62 (2006) 11, 2545-2554; Sch. Pharm. Sci., Toho Univ., Funabashi, Chiba 274, Japan; Eng.) — Nuesgen

26- 105

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