ab penisiln 2. powerpoint presentation
TRANSCRIPT
8/18/2019 AB Penisiln 2. PowerPoint Presentation
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ANTI BIOTIKAPENISILIN
DRS JUZRAL JIVAI MS APT
FAKULTAS KEDOKTERANUNIVERSITAS BAITURRAHMAH
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FARMAKOLOGI : FARMAKODINAMI ANTASID
ANTIHISTAMIN ANTIPIRETIKA ANTITUSIV ANTIBIOTIKA
SPEKTRUM : SEMPIT ; Penisilin
LUAS ; Ampisilin
GOLONGAN : PENISILIN – SEFALOSPORIN
TETRASIKLIN – KLORAMFENIKOL
AMINOGLIKOSIDMAKROLID
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FARMAKOKINETIK LIBERASI ABSORBSI DISTRIBUSI METABOLISME EKSKRESI
Efe O!"# A"n Te$%"&i Ap"!il" O!"# Men'"p"i T"$(e#
Den("n D)sis *"n( Tep"#
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AM AM
M H
H KEADAAN FISIK
M SIFAT SIFAT
AM MEKANISME KER+ADOSIS
,AKTU PEMBERIAN
-ARA PEMBERIAN
LAMA PEMBERIAN
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S -H.
H – NH – -H -H - – -H.
O / - N -H – -OOH
-0H12N2O.S
As"m 34"min) Penisilin"# 534APA6
S -H.
C6H5.CH2.CO7NH – -H -H - – -H.
O / - N -H – -OOH
-13H10N2O8S
Benil Penisilin / Penisilin G
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S -H.
C6H5.CH(NH2).CO7NH – -H -H - – -H.
O / - N -H – -OOH
-13H1N.O8S
Ampisilin
S -H.
HO7C6H4.CH(NH2).CO7NH – -H -H - – -H.
O / - N -H – -OOH
-13H1N.O<S
Am)silin
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PENEMU I PENISILIN FLEMING 51206 LONDON
FLORE* UNIV7 O=FORD O!"# #e$"pi Sis#emi
Bi""n Peni'illi>m n)#"#>m
PD7 II Ke!>#>?"n Penisilin menin("#Peni'illi>m '?$@s)(en>m 5Penisilin #e$!"i6
Be$&"s"$"n Pem!>"#"nn@" :
Al"mi : Penisilin G Ben"#in PenisilinSemisin#e#i : Ampisilin Kl)s"silin
Be$&"s"$"n Spe#$>m :
Sempi# : Benil Pen7 Ben"#in Pen75G$"m 6
L>"s : Am)sisilin Ampisilin
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Pen(()l)n("n Penisilin :
Kel7 1 : Penisilin G Penisilin V &"n Penisilin B7
Spe#$>m Sempi#
Ti&" T"?"n Penisilin"se
T"?"n As"m Ke'>"li Penisilin G
Kel7 2 : Penisilin An#i S#"Cl))>s
Me#isilin N"fsilin
Spe#$>m Sempi#
T"?"n Penisilin"se
Ti&" T"?"n As"m
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Kel7 . :Penisilin Is)s")l
Os"silin Kl)s"silin Dil)s"silinFl>l)s"silin
Spe#$>m Sempi# T"?"n Penisilin"se
T"?"n As"m
Kel7 8 :Amin) Penisilin
Ampisilin Am)silin Es#e$ Ampisilin 5Pi"mpisilin B""mpisilin T"l"mpisilin6
Spe#$>m L>"s
Ti&" T"?"n Penisilin"se
T"?"n As"m
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Kel7 < : Penisilin An#i Pse>&)m)n"s
K"$!enisilin Ti"$silin Al)silin
Spe#$>m L>"s
Ti&" T"?"n Penisilin"se Ti&" T"?"n As"m
Kel7 3 : Penislin &en("n Spe#$>m &ipe$l>"s
Mel)silin Pipe$silinSpe#$>m L>"s
Ti&" T"?"n Penisilin"se
Ti&" T"?"n As"m
Le!i? >"# ># Pse>&)m)n"s "e$>(in)s"&"$i K"$!enisilin &"n !"i ># ($"m 4
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Me!"#$%e Ke&'!
Penisilin men(?"m!"# sin#esis &in&in( sel Mi$)!"5P"&" pem!en#>"n M>)pep#i&"6
Pe"#$##" (A!%#)B"#e$i)s#"#i &"n B"#e$i)si&
Efe#if #e$?"&"p !"#e$i G$"m P)s &"n Spi$)'?"e#" %>(" G)n))>s 5K)>s G$"m Ne( @( #& men(?sl
Penisilin"se6Penisilin G 5("$"m N"K6 S"n("# l"$># &"l"m "i$
L"$>#"n 1 5pH << – <6 I"#"n P$)#ein 8< – 3<
Es$esi 'ep"# mel"l>i #>!>l>s (in%"l 5)$"l 2 IM
346
Ben#> se&i""n O!"# In%esi )$"l >li# m"#"
Di"n#"$" G$"m P)s7 efe p"lin( $en&"? "&"l"?En#e$))>s
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Pe"#$##" V (!!%#)
AM >m>mn@" s"m" &en("n Pen7G se&ii# le!i?"#if #e$?"&"p S#"Cl))>s se&ii# >$"n( "#if
#e$?"&"p S#$ep#) )>s &"n le!i? >$"n( "#if#e$?"&"p G$"m Ne(7
S>"$ l"$># &"l"m "i$ l"$>#"n < 5pH 28 – 86
A!s)$!si >m>mn@" 'ep"# &"n le!i? )mpli# 5O$"l6
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G"$"m -" &"n ("$"m K "!s)$!si le!i? 'ep"#
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Pne>m))>s '>>p sensi#if &en("n Penisilin G#i&" &i (>n""n Penisilin V 5Menin(i#isEn&)"$&i#is Pnem)ni6
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Fe"e*#$##" (Pe"#$##" B.)
AM >m>mn@" s"m" &en("n Pen7G &"n VM>&"? l"$># &"l"m "i$ l"$>#"n 1 5pH <<–<6
A!s)$!si le!i? )mpli# &"$i Pen7G >m>mn@"'ep"#
I"#"n Pl"sm" <
Es$esi mel"l>i (in%"l 5s"mp"i 3 6
Ben#> se&i""n )$"l
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Me*#$##" N!+ ($e%#$#"*e*#)
AM !"#e$i)si& #e$?&p s#"Cl)) "#if #e$?"&"pS#$ep#)
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A!s)$!si 'ep"# 5IM6 I"#"n Pl"sm" 8
Es$esi mel"l>i (in%"l 53 6 Empe&> 52 6
Ben#> se&i""n O!"# In%esi m"#"N!,$##" N! ($e%#$#"*e*#)
AM>m>mn@" s"m" &en("n Kl)s"silin
M>&"? l"$># &"l"m "i$ l"$>#"n . 5pH <–6
A!s)$!si !"i mel"l>i IM &"n #i&" )mpli# mel"l>i O$"l
I"#"n Pl"sm" s"mp"i
Es$esi mel"l>i empe&> (in%"l 1 7
Ben#> se&i""n O!"# In%esi O$"l
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K-$!$##" N! ($e%#$#"*e*#)
AM B"#e$i)si& "#if #e$?"&"p !"#e$i G$"m P)s Neisse$i"
5>$"n( "#if &"$i Pen7G6 #e#"pi #e$?&p S#"Cl)) @"n($esis#en pe" Penisilin "#ifn@" 8 – 0 "li Me#isilin
M>&"? l"$># &"l"m "i$ l"$>#"n 1 5pH <4 67
A!s)$!si !"i !e$>$"n( "&"n@" m""n"n 5IM le!i? !"i6
I"#"n Pl"sm" 8
Es$esi mel"l>i (in%"l 5. IM 2 )$"l6 1 empe&>
Ben#> se&i""n In%esi O$"l #elin("
O$!$##" N! ($e%#$#"*e*#)
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M>&"? l"$># &"l"m "i$ l"$>#"n 1 5pH 8<4<6
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I"#"n Pl"sm" 8
Es$esi mel"l>i (in%"l empe&>
Ben#> se&i""n In%esi &"n O$"l
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D#-$!$##" N! ($e%#$#"*e*#)
AM s"m" &en("n Kl)s"silin7 M>&"? l"$># "i$7
A!s)$!si le!i? !"i &$ Kl)s"si !e$>$"n( "&"n@"
mn"nI"#"n Pl"sm" 3 7 Es$esi mel"l>i (in%"l 567
Ben#> se&i"n O$"l
F-$!$##" N! ($e%#$#"*e*#)
AM s"m" &en("n Kl)s"silin7
M>&"? l"$># &"l"m "i$ l"$>#"n 1 5pH 36
A!s)$!si le!i? !"i &"$i Kl)s" !e$>$"n( "&"n@"mn"n
I"#"n Pl"sm" < 7 Es$esi mel"l>i (in%"l 5< 6
Ben#> se&i""n In%esi &"n O$"l
# ## ( # # #)
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A%/#$##" ($e%#$#"*e*#)
AM !"#e$i)si& !"i #e$?"&"p !"#e$i G$"m P)s G$"mNe( Lis#e$i" #e#"pi #i&" "#if #e$?"&"p Pse>&)m)n"s7
S>"$ l"$># &"l"m "i$ l"$>#"n 2< 5pH .< 4 <<67A!s)$!si !"i !e$>$"n( "&"n@" m""n"n
I"#"n Pl"sm" 2< Es$esi mel"l>i (in%"l empe&> C'es
Ben#> se&i""n O!"# in%esi )$"lA%-$##" ($e%#$#"*e*#)
AM !"#e$i)si& >m>mn@" / Ampisilin se&ii# le!i?"#if
#e$?"&"p S#$ep#) P$)#e>s Se$$"#i" &"n S"lm)nell"7S>"$ l"$># &"l"m "i$ l"$>#"n 2 5pH .< – <<6
A!s)$!si !"i #i&" &ipen("$>?i m""n"n
Es$esi mel"l>i (in%"l 53 6
Ben#> se&i""n O!"# In%esi )$"l
P# # ## HC ( # # #) E A # ##
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P#0!%/#$##" HC ($e%#$#"*e*#) E$*e& A%/#$##"
AM s"m" &en("n Ampisilin M>&"? l"$># &"l"m "i$
A!s)$!si !"i #i&" &ipen("$>?i m""n"n &"l"m
&"$"? &"n %"$in("n m>&"? &i?i&$)lis" men%"&i AmpisilinEs$esi mel"l>i Gin%"l 5 6
Ben#> se&i""n O$"l
T!!%/#$##" HC ($e%#$#"*e*#) E$*e& A%/#$##"
AM s"m" &en("n Ampisilin M>&"? l"$># &"l"m "i$A!s)$!si !"i #i&" &ipen("$>?i m""n"n &"l"m&"$"?
&"n %"$in("n m>&"? &i?i&$)lis" men%"&i Ampisilin
Es$esi mel"l>i Gin%"l 5 6Ben#> se&i""n O$"l
1 # ## ( # # #)
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K!&1e"#$##" ($e%#$#"*e*#)
Ti&" T"?"n As"m #e#"pi K"$in&"silin5K"$!enisilin4in&"nil6
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@"n( Resis#en Ampisilin 5P$)#e>s Mi$"!ilis6M>&"? l"$># &"l"m "i$ l"$>#"n 1 5pH 3406
I"#"n P$)#ein <
Es$esi mel"l>i >$in 50 6
T#!&$##" N! ($e%#$#"*e*#)
AM s"m" &en("n K"$!enisilin #e#"pi "#iC#"s
#e$?"&"p Pse>&)m)n"s mele!i?i K"$!enisilin
S 1 # ## N ( # # #)
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S1e"#$##" N! ($e%#$#"*e*#)
AM "#iC#"sn@" #e$?"&"p E7 ')li &"n P$)#e>s /K"$!enisilin #e$?"&"p Pse>&)m7 "e$>(in)s"
se&ii# mele!i?i K"$!enisilinA-$##" ($e%#$#"*e*#)
AM #e$?"&"p Pse>&)m)n"s 1 le!i? >"# &$K"$!enisilin
Me-$##" ($e%#$#"*e*#)
AM #e$?"&"p Pse>&)m)n"s se!"n&in( &en("nK"$!enisilin
#e#"pi #e$?"&"p Kle!siel" le!i? >"# &"$iK"$!enisilin
P#/e&$##" ($e%#$#"*e*#)
AM #e$?"&"p Pse>&)m)n"s / Al)silin
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ANTI BIOTIKA
SEFALOSPORIN
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S
H – NH –-H 0-H 2-H2 J
O / 3- <N .- – -H27O7-O7-H.
8- – -OOH
-1H12N2O<S
4 "min) Sef"l)sp)$in"# 5 – A-A6
/ -in'in Di?i&$)#i"in
J / -in'in J l"#"m
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Sef"l)sp)$i n #e$&i$i &"$i
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Sef"l)sp)$i n #e$&i$i &"$i :
e"e&!$# 3 Sef"l)#in Sef"pi$in Sef")linSef"lesin Sef$"&in Sef"&$)sil
A#if #e$?"&"p B"#e$i G$"m P)s &"n !"#e$i pen(?"silPenisi lin"se 5Be$!e&" &en("n Penisilin6
Efe#if ># S#"Cl))>s S#$ep#) p@)(enes S#$epi$i&"ns S#$ep pne>m)nie %>(" ># >m"n ($"m p)s S#"n"e$)! -l)s#$i&i>m pe$f$in(ens Lis#e$i"m)n)'@#)(enes ')$@n) !"'#e$ &ip?#e$i"e
Se,!-*#" T"?"n Penisilin"se (IV+ IM)
AM se&ii# le!i? "#if #e$?"&"p S#"Cl))>s ">$e>s #e#"p#i&" !e$m"nf""# >n#> #e$"pi Menin(i#is "$en" #i&"men'"p"i '"i$"n )#" E -)li P$ Mi$"!ilis &"n #i&" "#if#e$?"&"p B f$"(ilis s"l>$"n 'e$n"7
I"#"n P$)#ein Es$esi mel7 Gin%"l !# >#>?
S , # # (IV IM)
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Se,!/#&#" (IV+ IM)
AM s"m" &en("n Sef"l)#in
Se,!-#" (IV+ IM)
AM s"m" &en("n Sef"l)#in "&"$ )!"# &lm &"$"?< le!i? #in((i &"$i Sef"l)#in &"n #e$?"&"p E ')liLe!i? "#if &"$i Sef"l)#in
A!s)$!si >$"n( !"i 5IMIV6 I"#"n Pl"sm" 0<
Es$esi mel"l>i >$in 50 6
Se,!e$#" (O&!)
K>$"n( "#if #e$?&p S7">$e>s pen(?"sil Penisilin"se
Se,&!#" (O&!+ IV+ IM)AM mi$ip Sef"lesin 5in i#$)6
Se,!&-$# (O&!)
AM mi$ip Sef"lesin "&"$ pl"sm" le!i? #in((i
e"e&!$# 2 Sef"m"n&)l Sef)si#in Sef"l)$
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e"e&!$# 2 Sef"m"n&)l Sef)si#in Sef"l)$Sef>$)sim Sef)nisi& Sef)$"ni& Sef)le#"n
K>$"n( "#if ># >m"n G$"m p)s &i!"n&in("n
Gene$"si 1 #e#"pi le!i? "#if ># >m"n G$"m ne( 5Hin>en" P$ mi$" !ilis E ')li Klensiell"6 &"n #i&""#if ># Ps ">$e(in)s" En#e$))>s
Se,!%e"- (IV+ IM)
AM le!i? "#if &"$i Gene$"si 1 #e$?"&"p G$"m ne(5H in> en" sp en#e$)!"'#e$ P$)#e>s in&)l E')li sp Kle!siel"6 sensi#if ># se!"(i"n !es"$)>s ($"m p)s7
Se,-$#*#" (IV+ IM)K>$"n( "#if ># sp en#e$)!"'#e$ H in>en"&i!"n&in("n Sef"men&)l &"n >$"n( "#if >#>m"n G$"m p)s &i!"n&in("n &(n Sef"men&)l &"n
Gene$"si 1
#e#"pi ># >m"n "n"e$)! 5B f$"(ilis6 le!i? "#if &"$i
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#e#"pi ># >m"n "n"e$)! 5B f$"(ilis6 le!i? "#if &"$iGen71 &"n Gen72 l"inn@" %>(" efe#if ># N()n)$$?)e"e pen(?"sil Penisilin"se7
Se,!-& (O&!)AM le!i? "#if ># H in>en" &"$i p"&" Gen7 1
Men(?"sil"n "&"$ &"l"m &"$"? < &i!"n&in("n Sef"lesin 5Gen7 16 &en("n &)sis
s"m"Se,&-$#% (IV+ IM)
AM mi$ip Sef"men&)l efe#if ># #e$"pi menin(i#is)le?
H inf>len" N menin(i#i"e S#$ep#) pne>m)ni"e "$en" "&"$ )!"# &"l"m '"i$"n se$e!$)spin"l 1 &$ &lm pl"sm"
e"e&!$# 2 !#""! mi$ip Sef"men&)l >m>mn@">$"n( "#if ># H in>en"
e"e&!$# 7 Sef)#"sim M)s"l"#"m
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e"e&!$# 7 Sef)#"sim M)s"l"#"mSef#i)sin
Sef#$i")n Sef"pe$")n Sef#"i&in
SeCsinAM #e?"&"p >m"n G$"m p)s >m>mn@" >$"n("#if &"$i p"&" Gen7 1 #e#"pi %">? le!i? "#if >#En#e$)!"'#e$ #e$ms s#$"in pen(?"sil penisilin"s
&"n p"&" ()l)n("n ini "&" @( "#if >#Pse>&)m)n" "e$>(in)s"
Se,-*!$#% IV+ IM
AM "#if ># G$"m p)s &"n G$"m ne( "n"e$)!A#ii#"s ># B f$"(ilis s"n("# lem"?5&i!"n&in("n &(n Klin&"misin Me#$)ni&")l6
Efe#if ># menin(i#is )le? >m"n G$"m ne(
M-$!!*!% IV IM
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M-$!!*!% IV+ IM
AM Te$?"&"p >m"n G$"m ne( 5H in>en" &"n En#e$)!"'#e$6 >$"n( "#if &i!"n&in("n &(n Sef)#"sim #e#"pile!i? "#if ># Ps "e$>(in)s" &"n B f$"(ilis
D"p"# men@e!"!"n Hip)p$)#$)m!inemi" &"n &isf>n(si#$)m!)si# 5Pe$&"$"?"n6 pe$l> &i#"m!"? Vi#"min K
Se,*&#!$-" IV+ IM
AM >m>mn@" "#if ># >m"n G$"m p)s #e#"pi >$"n("#if &i!"n&in("n &(n Gen7 17 I"#"n p$)#ein 0. – 3
Se,-/e&!-" IV+ IM
AM P"&" Ps "e$>(in)s" le!i? "#if &i!"n&in("n &(nSef) #"sim &"n M)s"l"#"m &"n &"p"# ># #e$"pi
menin(i#is
Es$esi mel"l>i empe&> 5#e$#in((i6
I"#"n p$)#ein 02 – .
Se,*!##% IV IM
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