adrenergic agonist drugs objectives discuss the pharmacology of catecholamines classify &...
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Adrenergic agonist drugs
Objectives
•Discuss the pharmacology of catecholamines•Classify & describe adrenergic α-agonists including actions, therapeutic uses & adversereactions.
•Classify & describe adrenergic β-agonists including actions, therapeutic uses & adversereactions
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Adrenergic transmission
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Catacholamines - Epinephrine (α1α2β1β2),Norepinephrine(α1α2β1), Isoproterenol (β1β2)
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Adrenaline- α1 α2 β1 β2
ADR-
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Other catecholaminesNoradrenaline (α1 α2 β1 ) is used in severe shock
• NA adverse effects are similat to adrenaline. In addition NA causes severe sloughing of skin due vasoconstriction
• Dobutamine(β1) is preferred in Acute congestive
heart failure
• Dopamine- (α, β1, D ) -used in cardiogenic & septic shock-
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Therapeutic classification of adrenergic drugs
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Ephedrine
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Phenylepherine
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Nasal decongestants
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Amphetamine
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Anorectics
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Clonidine
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β2 adrenergic agonist
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Uterine relaxants
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Summary of Sympathomimmetics – α- agonist
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Summary of β- Agonists
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References-
• Lippincotts Illustrated pharmacology• Katzung Basic & Clinical Pharmacology