Advanced Genomic Technologies for Integrative DNA/RNA Cancer Analysis

Current research progress in metabolism switch: a new hallmark of cancer

About the talkWhole-genome DNA analysis of cancer samples has shown that copy number alterations affect more of the genome than any other DNA abnormality. Many of these alterations are “drivers” of cancer, while others are just “passenger” events. Deciphering which of the DNA alterations are “driver” or “passenger” events has been a challenge. Having the ability to concurrently correlate genome-wide gene expression changes with copy number alterations can help to rapidly identify and prioritize the number of potential driver events, which in turn can lead to the identification of functional biomarkers. Affymetrix microarray technologies offer the complete solution- from sample processing to integrative data analysis- enabling cancer researches to easily and quickly analyze and visualize the functional impact of copy number changes on gene expression in cancer samples, including FFPE tissue.

About the talkWhole-genome DNA analysis of cancer samples has shown that copy number alterations affect more of the genome than any other DNA abnormality. Many of these alterations are “drivers” of cancer, while others are just “passenger” events. Deciphering which of the DNA alterations are “driver” or “passenger” events has been a challenge. Having the ability to concurrently correlate genome-wide gene expression changes with copy number alterations can help to rapidly identify and prioritize the number of potential driver events, which in turn can lead to the identification of functional biomarkers. Affymetrix microarray technologies offer the complete solution- from sample processing to integrative data analysis- enabling cancer researches to easily and quickly analyze and visualize the functional impact of copy number changes on gene expression in cancer samples, including FFPE tissue.

About the SpeakerDr. Chee Wai Fong, Dr Chee graduated from the NUS Pharmacy Department with 2nd Upper Honours and started his scientific career at the Center for Natural Product Research (CNPR), a drug discovery center jointly set up by EDB Singapore & Glaxo Wellcome running high-throughput screens. He was subsequently awarded an overseas postgraduate scholarship to do his PhD studies at the University of Glasgow (UK) focusing on molecular pharmacology of G-protein coupled receptors. When he returned to Singapore, he was posted to the Institute of Molecular & Cell Biology (IMCB) in A*Star to work on cancer cell signaling, primarily on receptor tyrosine kinases & their role in cancer. He then worked as a Field Applications Scientist & trainer with Millipore supporting the regional & Asia Pacific markets on flow cytometry & protein multiplexing systems. Before moving to Research Instruments (RI), he was Head of R&D at Davos Lifescience Pte Ltd which focuses on nutrition & skincare research and human nutrition clinical studies. As the Director for Lifescience Technology, Applications & Lab Services at RI, Dr. Chee heads the field applications support team, oversees the Affymetrix Gene Array service laboratory and evaluates emerging technologies & business opportunities in life science.

About the SpeakerMr. Alex Luan, Alex got his doctoral degree in 2007 from Fudan University, China with work about mammalian developmental disorder and other human complex traits. Since graduation he has been working in life science industries including BD, Illumina and now Seahorse Bioscience as APAC Marketing and Application Manag-er, supporting all Seahorse XF users in the area from science and application aspects.

LUNCHTALK

Date : 11th May 2015Time : 1230 –1400pmVenue : TJ Danaraj & The Cube, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur

FREE ADMISSION. LUNCH IS PROVIDED FOR A MAXIMUM OF 150 PAX ONLY. (Please RSVP via email)

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For more information, please visit :https://ummedicalresearchweek2015.wordpress.com/