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科学研究費助成事業 研究成果報告書
様 式 C-19、F-19、Z-19 (共通)
機関番号:
研究種目:
課題番号:
研究課題名(和文)
研究代表者
研究課題名(英文)
交付決定額(研究期間全体):(直接経費)
17401
挑戦的萌芽研究
2015~2013
ヘテロ構造化ゲルマイクロ粒子の創製
Fabrication of hydrogel microspheres based on polymer network-crosslinked with silica nanoparticles
50332086研究者番号:
高藤 誠(Takafuji, Makoto)
熊本大学・自然科学研究科・准教授
研究期間:
25600045
平成 年 月 日現在28 6 20
円 3,100,000
研究成果の概要(和文):本研究では、反応性ポリマーがコロイダルシリカによりマルチ架橋されたポリマーネットワークをwater-in-oilサスペンション中で形成させることで、新規な球状ハイドロゲル微粒子の作製に成功した。本方法では、サスペンション媒体の粘度を変えることでゲル微粒子のサイズを容易に制御できるとともに、ポリマーの重合度や反応性基の導入率、コロイダルシリカのサイズや濃度を変えることで、容易にゲル微粒子の機能を制御することが可能である。特定のサイズ、強度、膨潤度をもつゲル微粒子が自在に得られることから、医薬、化学工業など様々な分野への応用が期待される。
研究成果の概要(英文):We report the preparation and characterization of novel hybrid hydrogel microspheres having polymer network structure multipully-crosslinked with silica nanoparticles. The hydrogel microspheres were prepared in a facile manner involved simple mixing of an aqueous mixture of a water-soluble copolymer having reactive side chains with silica nanoparticles in water-in-oil suspension. The size of hydrogel particles can be facilely controlled by the viscosity of suspension media and composition of hybrid hydrogels. As expected, the properties of the hydrogel particles such as mechanical strength and swelling property are strongly affected by the polymer network structure which is controlled by the polymer chain length and the number of crosslinking points. Such high tunable hydrogel microspheres are expected to be used in various application fields such as medical and industrial applications.
研究分野: 高分子材料化学
キーワード: ハイブリッドハイドロゲル コロイダルシリカ ポリマーネットワーク構造 ゲル微粒子 マルチ架橋 無機ナノ粒子
2版
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šƆŤŴƉðģŦŲŞƅ[3]ŕƗƼ�ÿ`ŷŞśŲƁDºŸ�(-�Š?ċųŚƆŴĈŝƄƇƆŖ Reference 1. M. Czaun, L. Hevesi, M. Takafuji, H. Ihara.
Chemical Communications, pp.2124-2126, 2008.
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Hirotaka Ihara. Thermosensitive hybrid hydrogels through nanoparticle-crosslinked polymer network. Journal of Colloid and Interface Science, Vol. 405, 109-117 2013. doi: 10.1016/j.jcis.2013.04.054,Ŕ ³ĥŚƅ
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Takafuji, Hirotaka Ihara. Fabrication of hybrid mesoporous microspheres from aqueous droplet containing silica nanoparticles-polymer network in W/O suspension. RSC Advances, Vol. 6, pp.42756-42762, 2016. doi: 10.1039/C6RA05173A,Ŕ ³ĥŚƅ
Řc�çēřǃěŔ LJnjŔ �DŽ 1. Md. Ashraful Alam, Makoto Takafuji,
Hirotaka Ihara. Control of thermal, swelling and release properties of nanoparticle-mediated hybrid polymer hydrogel. Kyusyu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polmers (16th) and Fiber(14th), Saga University (Saga, Japan), 2013. 11. 8-10.
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Hirotaka Ihara. Silica nano particle-crosslinked thermosensitive hybrid hydrogels for potential controlled release. International Soft Matter Conference 2013Ŕ(ISMC 2013), Rome (Italy), 2013. 9. 15-19.
3. Yang Liu, Makoto Takafuji, Hirotaka Ihara,
Meifang Zhu, Mingshan Yang, Kai Gu, Wenli Gou. Programmable responsive shaping gels by multi-dimensional gradients of magnetic nanoparticles. ünjLjLœ)`c�u¾]�, �ĺOŇ�ĪWǃ�ĺDŽ, 2013. 5. 29-31.
4. Makoto Takafujiǃ��ĩÌDŽ
Development of nanoparticle-crosslinked hybrid hydrogels. o]-Ô]ÝYÞ×�đîù��Ł�y Material Research Society ,Sichuan University, Sichuan (China), 2014. 5. 12.
5. œďŔ Ĥǃ��ĩÌDŽ
Development of core-shell hybrid microspheres with nanoparticles shell layer ƠƭƦƴơǂîù�, Ô«]cǃÔ«DŽ, 2014. Ŕ6. 20.
100 µm� 10 µm�
Figure 6 Scanning electron microscopic images of hybrid porous microspheres.
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Kuwahara and Hirotaka Ihara. Spherical hydrogel microparticles using silica nanoparticle as multifunctional crosslinking points. Faraday Discussion: Nanoparticle synthesis and assembly, Argonne National Laboratory, Chigo (USA), 2015. 4. 20-22.
8. Md. Ashraful Alam, Sabrina Sultana, Yutaka
Kuwahara, Makoto Takafuji, Hirotaka Ihara. Preparation of microspherical hydrogels based on hydrophilic polymers crosslinked with nano-silica. ü 64Lœ)`c�u¾]�, ¬sƘǀưǀƚƹǀƞǀơǂǃ¬sDŽ, 2015. 5. 27-29.
9. Sabrina Sultana, Md.Ashraful Alam, Yutaka
Kuwahara, Makoto Takafuji, Hirotaka Ihara. Preparation of hybrid microspheres from hydrophilic polymer gels crosslinked with nano-silica. ünjNJLœ)`c�u¾]�, ¬sƘǀưǀƚƹǀƞǀơǂǃ¬sDŽ, 2015. 5. 27-29.
10. Makoto Takafuji, Md. Ashraful Alam, Yutaka
Kuwahara, Hirotaka Ihara. Microspherical hydrogel particles based on nanoparticle-webbed polymer network. Congress of the European Polymer Federation (EPF-2015), (Dresden) Germany, 2015. 6. 21-26.
11. UÂâćŕµ; øŕœď Ĥŕ�;:ņ Į)`ƨƪƭƋƍƬǂƉ²¼�ŴŨƆƳƻƴǂƩƤƦƿǂƔŸ}� ¡«6c�p�ĹĞû 100Iuĝ�OŇƚǀƳƛƎƶü 52L6cŃķ�ĹCDp]�, 7pOŇ�ĪWǃ7pDŽ, 2015. 6. 27-28.
12. Sabrina Sultana, Md. Ashraful Alam, Yutaka
Kuwahara, Makoto Takafuji, Hirotaka Ihara. Development of porous hybrid microspheres composed of simaltaneous nanosilica particles. International Conference & Exhibition on Advanced & Nano Materials (ICANM 2015), Ottawa (Canada), 2015. 8. 10-12.
13. œď Ĥ, Md. Ashraful Alam, µ; ø, �;:ņ
ƨƪÿ`ƉƴƼƣ²¼�ŴŨƆƫƍƮƻƤƧƗƼƴƍƔƾÿ`Ÿ0Ĕ. ü 64Lœ)`ĜĨ�, ¯7]cǃ�@DŽ, 2015. 9. 15-17.
14. Makoto Takafujiǃ��ĩÌDŽ
Development of nanoparticle-webbed hybrid hydrogels. 2015 Pusan-Gyeongnam/Kyushu-Seibu Joint Symposium on High Polymers (17th) and Fibers (15th)(2015 PGKS), Pusan (Korea), 2015. 11. 12-14.
15. Md. Ashraful Alam, Makoto Takafuji,
Hirotaka Ihara Facile Fabrication of Microspherical Hydrogel particles based on Nanoparticle-crosslinked polymer networks. 1st international conference on Applied Chemistry- ICAC 2015, Jeddah (Saudi Arabia), 2015. 11. 18-19.
16. Makoto Takafuji, Md. Ashraful Alam,
Hirotaka Ihara.ǃ��ĩÌDŽ Hybrid hydrogels composed of polymer network webbed with silica nanoparticles 16th Asian Chemical Congress (16ACC), Dhaka (Bangladesh), 2016. 3. 16-19.
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