American Life Energy Holding Group, Inc.American Life Energy Holding Group, Inc.

dermagold100

美国和德国的科技结晶

The biological effect of shock The biological effect of shock waves can be specifically waves can be specifically

utilizedutilizedto generate new tissue to generate new tissue

formation and successfullyformation and successfullytreat skin lesionstreat skin lesions

冲击波的生物效应可以专门用来生成新的身体细胞组织，治疗皮肤损伤

什么是冲击波 ?

冲击波是高能量的声波，就像一般的声波，只是能量和压力都要强多了。 它可以在阻抗不变的情况下，一直往前进。 当阻抗改变的时候，它就会释放出能量。当阻抗变化越大时，能量就释放的更多。能量的释放在骨头和肌肉组织的界面，比较皮肤和肌肉界面要强得多。

在冲击波能量的释放下，身体的细胞组织收到了挤压和伸缩，进而产生有效的物理效应。这种效应使得细胞产生了治疗的作用。

冲击波的效果是什么 ?

体外冲击波对骨头和软组织有数种效果，通过机械传导，从而产生治疗效益，经过复杂的生物途径，包括新生血管形成和组织再生。它刺激启动了人体本身迟滞的自我治疗的过程。

• 由于新生血管和生长因子的刺激，能增加血液的供应 ;• 对于以下生长因子，产生良好的影响 e-NOS, TGF-ß, BMP, VEGF, PCNA;• 从新启动长期迟滞的自我治疗能力 ;• 降低发炎 ;• 刺激成骨细胞和成纤维细胞，以重建损伤的组织 ;• 促进肌腱和韧带钙化的吸收• 刺激干细胞的移动 .

This is the first technology to provide:

•Promotion of growth Factors

•Promotion of Nitric Oxide

•Improves vascularity

•Promotion and migration and differentiation of stem cells

Advantages of Softwave technology are:

•Treatments do not require anesthesia

•Larger surfaces such as wounds can be treated faster and easier with shockwave

devices

•Units are smaller and much more economical to operate that “hardwave”

technologies and traditional treatments

•Alleviates costly field service organizations to maintain

Benefits of Softwave TechnologyBenefits of Softwave TechnologyBenefits of Softwave TechnologyBenefits of Softwave Technology

创新的科技 :• 刺激生长因子• 促进一氧化氮• 增进血液的通顺• 促进干细胞的繁殖生长

软性波的优点 :• 治疗并不需要麻醉• 使用冲击波设备，大面積的伤口，可以很快治疗• 比起硬性波技术和一般传统设备的治疗方法，本设备的体积更小，更经济• 维修容易，减少现场维修服务，降低成本

Benefits of Softwave TechnologyBenefits of Softwave Technology软性波的优点软性波的优点

Benefits of Softwave TechnologyBenefits of Softwave Technology软性波的优点软性波的优点

Shoulder Tendinopathies

Case example: 2 sessions of shock wave therapy, a total of 1000 impulses were applied in 3 minutes. Recover in 12 weeks.

2 次治疗，每次 3 分钟，共 1000 次波击 , 12 周恢复期

Achillodynia跟腱炎

Case example: 2 sessions of shock wave therapy, a total of 1000 - 1500 impulses were applied in 3 minutes. Recover in 12 weeks.

2 次治疗，每次 3 分钟，共 1000 - 1500 次波击 , 12 周恢复期

Greater trochanteric pain syndrome股骨大转子疼痛综合征

Case example: 2 sessions of shock wave therapy, a total of 1000 - 2000 impulses were applied in 3 minutes. Recover in 12 weeks.

2 次治疗，每次 3 分钟，共 1000 - 2000 次波击 , 12 周恢复期

Myofascial syndrome肌筋膜综合征

Case example: 1 - 6 sessions of shock wave therapy, a total of 500 - 1000 impulses were applied in 3 minutes. Recover in 12 weeks.

1 – 6 次治疗，每次 3 分钟，共 500 - 1000 次波击 , 每周一次， 12 周恢复期

Arthritis风湿性关节炎

Case example: 6 - 12 sessions of shock wave therapy, a total of 100 0- 2000 impulses were applied in 3 minutes. Recover in 24 weeks.

6 – 12 次治疗，每次 3 分钟，共 1000 - 2000 次波击 , 每周一次， 52 周恢复期

Post-operative healing disorders手术后愈合困难

Case example: 2 sessions of shock wave therapy, a total of 1400 impulses were applied in 4 minutes and 40 seconds.

2 次治疗，每次 4 分又 40 秒，共 1400 次波击

17 weeks

Post-traumatic lesions外伤口复合

Case example: dog bite, 4 sessions of shock wave therapy,a total of 3400 impulses were applied in 11 minutes and 20 seconds.

狗咬伤， 4 次治疗，共 11 分又 20 秒，共 3400 次冲击波

11 weeks

Venous ulcers静脉溃疡

Case example: a venous ulcer at the lower limb persisting for many years, after 14 sessions of shock wave therapy with a total of 5500 impulses applied in 18 minutes and 20 seconds.

14 次的治疗，总共 18 分又 20 秒， 5500 次冲击波

1.5 years

Decubitus ulcers褥疮溃疡

Case example: Weekly sessions were performed over a period of 6 months.

6 个月，每星期一次的治疗

2 years

Diabetic foot syndrome糖尿病足综合症

Case example: 6 sessions of shock wave therapyusing a total of 2300 impulses applied in 7 minutes and 40 seconds.

6 次治疗，总共 7 分又 40 秒， 2300 次冲击波

12 weeks

Arterial ulcer动脉溃疡

Case example: after 2 sessions of shock wave therapy using a total of900 impulses applied in 3 minutes.

2 次的治疗，共 3 分钟， 900 次的冲击波

Burns烫伤

Case example: 4 times shock wave therapy with atotal of 3000 impulses applied in 10 minutes of total treatment time.

4 次治疗，总共 10 分钟， 3000 次冲击波

7 weeks

Results after shock wave treatment

Infection after dog bite

Dermagold100 represents the first therapy system which

specifically utilizes the biological effects of shock waves. In

cooperation with TRT Tissue Regeneration Technologies

LLC, USA, MTS opens up a new field of therapy for chronic

wounds and skin lesions.

The effectiveness of ESWT is fully proven for numerous

indications. Recent research has shown that shock waves

have highly beneficial effects on skin lesions.

It is proven that tissue which is exposed to shock waves

initiates the production of VEGF (vessel endothelial growth

factor), which in turn activates the growth of new blood

vessels. In addition, it has also been established that shock

waves produce an antibacterial effect. The combination of

these two effects initiates a healing process in skin lesions

and stimulates the development of new tissue.

52y, male (injury with lawn-mower); 4 weeks after injury8Treatments (3000 pulses/ ~ 10min.) 4 weeks and 3 months after

first ESWT treatment

71y, female, diabetic, polyneuropathy, ulcer for 2 months 6 treatments (4800 impulses in total / ~ 16 minutes)

4 months -> two surgical revisions

71y, female, diabetic, polyneuropathy, after two surgical revisions 5 treatments (2500 impulses in total / ~ 8 minutes)

2 months

86 y, female – infected hematoma (5 weeks after trauma) ,for 3 weeks no improvement, 4 treatments (1,600 pulses/ ~ 5min.)

5 weeks

8 days after burning injury8 days after burning injury

7 months later after 3 ESWT´s 7 months later after 3 ESWT´s

82y, female (insulin dependent diabetes, chronic renal failure) 33 treatments ( 2300 pulses in total/~ 8 min.); 7 weeks after first ESWTtreatments ( 2300 pulses in total/~ 8 min.); 7 weeks after first ESWT;;

22 years follow-upyears follow-up

65 year old, male, fall over steps, HIV-positive, diabetic

I° open tibia fracture same day UTN

65 year old, male, fall over steps, HIV-positive, diabetic

3 months after trauma => ESWT 3 months after ESWT 3 years after ESWT

ProceduresProceduresProceduresProcedures

Infection after trauma injury

Results after shock wave treatment

Procedures approved for dermagold100• Non-healing lesions• Acute and chronic lesions• Post traumatic lesions• Post-operative healing disorders

Procedures under current investigation• Venous ulcers• Arterial ulcers• Decubitus ulcers• Diabetic foot syndrome• Burns

ProceduresProceduresProceduresProcedures

Infection after trauma injury

Results after shock wave treatment

Procedures approved for dermagold100• Non-healing lesions 无法愈合的傷口• Acute and chronic lesions 急性，慢性皮肤病• Post traumatic lesions 外伤口• Post-operative healing disorders 手术后愈合困难

Procedures under current investigation• Venous ulcers 静脉溃疡• Arterial ulcers 动脉溃疡• Decubitus ulcers 褥疮• Diabetic foot syndrome 糖尿病足综合症• Burns 烧伤

治疗程序1. 清理傷口2. 在傷口抹上超声波胶3. 使用消毒过的薄膜，盖住傷口il4. 抹上超声波使用的胶5. 使用冲击头冲击，在傷口，和附近的部位移动冲击，时间和次数，按照傷口的大小和种类来适度调整。6. 冲击完毕后，换药

Treatment ParametersTreatment Parameters

Energy Flux density: ~ 0.1 mJ/mmEnergy Flux density: ~ 0.1 mJ/mm2 2

Frequency: 4-5 HzFrequency: 4-5 HzNumber of pulses: min.: 350 + 10/cmNumber of pulses: min.: 350 + 10/cm22

伤口大小伤口大小 伤口面积伤口面积 脉冲次数脉冲次数

1 x 1 cm1 x 1 cm 1 cm1 cm22 350 + 10 = 360350 + 10 = 360

2 x 2 cm2 x 2 cm 4 cm4 cm22 350 + 40 = 390350 + 40 = 390

2 x 4 cm2 x 4 cm 8 cm8 cm22 350 + 80 = 430350 + 80 = 430

4 x 5 cm4 x 5 cm 20 cm20 cm22 350 + 200 = 550350 + 200 = 550

6 x 8 cm6 x 8 cm 48 cm48 cm22 350 + 480 = 830350 + 480 = 830

10 x 12 cm10 x 12 cm 120 cm120 cm22 350 + 1200 = 350 + 1200 = 15501550

DirectorDirector

Combat Wound Initiative Program Combat Wound Initiative Program

Complex Wound and Limb Salvage CenterComplex Wound and Limb Salvage Center

COL Alexander Stojadinovic, M.D., FACSCOL Alexander Stojadinovic, M.D., FACS

Combat Wound Initiative Program

+

Translation of fundamental research into individualized treatmentsTranslation of fundamental research into individualized treatments

for patients through: for patients through:

Advanced therapies, Bioinformatics, Tissue BankingAdvanced therapies, Bioinformatics, Tissue Banking

Tissue regeneration – unfocused applicatorTissue regeneration – unfocused applicator

身体细胞组织再生 身体细胞组织再生 - - 未聚焦波治疗未聚焦波治疗能发出独特而非聚焦性的冲击波，特别针对皮肤的治疗。为了达到最佳的治疗效果，波能源的大小和能源的安排 是设定于治疗皮肤损伤。

Treatment without anesthesiaTreatment without anesthesia 无需麻醉的治疗无需麻醉的治疗 由于发射面是比较广的，所以治疗是无需麻醉的。针对肌肤 创伤的种类和表面积，所需要的治疗次数也有所不同。

Uses for the equipment include:•Chronic wounds, burns and ulcers 慢性伤口，烧伤和溃疡•Pseudoarthrosis 不愈合骨折•Tendinopathies and non-healing bone fractures 肌腱炎，不愈合骨折•Avascular conditions of the bone 骨缺血•Multiple periodontal applications 牙周病•Ischemic heart disease缺血性心脏疾病•Tibia Non-union fractures胫骨骨折•Pain therapy 痛楚治疗•Increased blood flow for diabetics 增加糖尿病患者的血流量•Erectile Dysfunction勃起功能障碍•Massage therapy按摩疗法•Spasticity痉挛•Osteomyelitis 骨髓炎•Osteoporosis 骨质疏松•Nerve Regeneration神经再生

Benefits of Softwave TechnologyBenefits of Softwave TechnologyBenefits of Softwave TechnologyBenefits of Softwave Technology

Benefits by CategoryBenefits by CategoryCARDIO

•25% increase in ejection fraction

•Improves wound healing after vein harvesting for coronary artery by-pass

•Decreases morbidity and reduces hospital stay, lower costs, higher patient

satisfaction.

•Causes recruitment of stem cell (VEGF) mitigation to myocardia tissue

ASETHETIC DERMOTOLOGY

•Creates softer tissue with higher skin elasticity

•Reduces appearance of stretch marks and cellulite

•Revitalizes connective tissue

•Performs cosmetic lymph drainage

•Regenerates vaxcular system and efficiently downgrades necrosis

Benefits by CategoryBenefits by CategoryCARDIO 心脏科

•射出率 (ejection fraction) 增加 25%

•心导管手术后，改进傷口的复原。

•降低死亡率，减少住院，减低成本，提供病人满意度 .

•导致干细胞的形成，扩散到心细胞

ASETHETIC DERMOTOLOGY 美容皮肤科

•产生较软的组织，表皮更富弹性

•减少妊娠纹和脂肪的外观

•重新恢复连接的组织

•执行淋巴引流

•血管系统再生，有效降低坏死

Benefits by Category (cont) Benefits by Category (cont)

Orthopedic, Arthritis and Joint Pain 骨科，关节炎，关节疼痛

•每一年， 1-2 次治疗以后，减低 80% 的疼痛

•25% 的病人有种疼痛

•消除足底筋膜炎

•治疗骨折

OTHER 其他

•有效治疗创伤和需要皮肤移植的烧伤

•冲击波大大加速上皮的形成

•减少抗体药物的使用 (最高减低 7 倍 )

•有效治疗糖尿病造成的静脉溃疡

Benefits by Category (cont) Benefits by Category (cont)

Orthopedic, Arthritis and Joint Pain

•Reduces up to 80% of pain with 1-2 treatments annually

•25% of people have this affliction

•Eliminates Plantar Fascitius

•Treats non-unions

OTHER

•Effective in treating traumas and burns requiring skin grafts

•Shock wave significantly accelerates donor site epithalization

•Reduces the need for anti-biotics (up to 7 times less)

•Effective treatment for diabetic and vascular ulcers

Reference from American Medical Reference from American Medical Association JournalAssociation Journal

•The “patented unfocused software technology has the potential to become the

new standard in wound care management”

•Leads to more rapid closure and repair of wounds on organs, skin and heart.

•Substantially lower cost and therapy time than current treatment standard

•Proven to increase permability of cell membranes

•Increased blood flow through angiogenesis

•Up regulation of growth factors

•Stem Cell Activation

•Beneficial to non-bacterial prostatitis (chronic pelvic pain syndrome) and cancer

treatment.

美国医疗协会杂志的推荐美国医疗协会杂志的推荐

•“非聚焦型的冲击波技术将成为傷口治疗的新标准”

•器官，皮肤，心脏的傷口复合，将会更快 .

•比起目前的治疗方式，成本降低更多•已经证明能够增进细胞膜的通透性。•通过血管新生，增加血液的流通•刺激生长因子•干细胞活化 •有利于非细菌性前列腺炎（慢性骨盆疼痛综合征）和癌症的治疗。

Providers who can benefit from DermaGoldProviders who can benefit from DermaGoldTMTMProviders who can benefit from DermaGoldProviders who can benefit from DermaGoldTMTM

Hospitals 医院 Cardiology Surgeons心脏外科 Orthopedics Surgeons 骨科医生 Plastic Surgeons整形外科Sports Medicine Clinics 运动医学诊所Pain Management Clinics 疼痛管理诊所Podiatrists 足病Chiropractors 按摩师General Practices of Medicine 全科医生Veterinarians兽医Dentists牙医

Product LinesProduct Lines 产品系列产品系列Product LinesProduct Lines 产品系列产品系列Total product line is comprised of:

•LithoGold TM (lithotripsy) 碎石•DermaGoldTM (wound care) 傷口治疗•OrthoGold 280 (orthopedics) 骨科•CardioGoldTM (cardiovascular)心血管•VetGold (veterinary) 兽医•Swisspuls (sports medicine, cosmetic and Veterinary medicine 运动，美容All Devices hold CE approval for international distribution and FDA approval is pending

Devices are used in 30 countries including China, Japan, Taiwan and Russia

30 个使用国家，包括中国，日本，台湾，俄国Equipment is made with precision in Germany 德国制做Warranty on material and workmanship for one year 一年保证Maintenance after 100,000 pulses

每 10万次，需更换放射头

Technical Data 技术数据Applicator OP155Therapeutic Focus fz (-6dB): 0 – 82 mmEnergy Flux Density (ED): 0.01 – 0.19 mJ/mm2Focus Energy (E total / -6dB): 0.40 – 3.88 mJDimensions: 21.8 x 40 x 45.9 cmPower Supply: AC 100 - 240 V, 50 - 60 Hz Power Input: 200 VARepetition Rate: 0.5 - 8 HzWeight: 16.5 kg

dermagold100

ManagementManagementManagementManagement美国生命能源控股公司是中国唯一的总代理American Life Energy Holding Group, Inc. (“ALE”) is an exclusive distributor of softwave devices. Softwave devices 的团队包挂诺贝尔奖得主 , Dr. Ferid Murad.

Distributorships available by contacting: 联系方式

American Life Energy Holding Group, Inc. 3091 Governors Lake DriveBuilding 100 Suite 500 Norcross, GA 30071 ， USA