口腔診斷學 陳玉昆副教授 : 高雄醫學大學 口腔病理科 07-3121101~2755...

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口腔診斷學

陳玉昆副教授 : 高雄醫學大學 口腔病理科 07-3121101~2755 yukkwa@kmu.edu.tw

Intraoral brown, bluish and black conditions

口腔棕色、藍色、黑色疾病

Understanding:1. Intraoral brown, bluish and black conditions

學 習 目 標學 習 目 標

1. Kaohsiung Medical University, Oral Pathology Department2. Cawson RA: Oral Diseases. 3rd Ed., pp. 11.2-11.103. Cawson RA: Oral Diseases. 3rd Ed., pp. 11.124. Cawson RA: Oral Diseases. 3rd Ed., pp. 11.135. AFIP (American air-force institute of pathology)

References:References:

參考資料

Melanin

Blood

Ref. 1

Hairytongue

Localized

pigmented

Endocrine

disorder

Brownish, BlackishPigmented Lesions

Exogenous Endogenous

Melanocyte Stimulating Hormone

Tyrosinase

Ref. 2

Intraoral brown and black conditions

Normal Lentigo simplex Junctional activity

Compound nevus Intramucosal nevus Blue nevus

Ref. 2

Intraoral brown and black conditions

Junctional activity

Intramucosal nevus

Compound nevusIntraoral Cutaneous

Liminapropria

Refs. 1, 2

Intraoral brown and black conditions

Epithelium

Pigmentedbasalcell

Melanophage

Pigmentedbasal

keratinocyte

Refs. 1, 2

Intraoral brown and black conditions

Oral Melanotic Macule

Amalgam Tatto

Amalgam restoration

Amalgam retrograde filling

Refs. 1, 3

Intraoral brown and black conditions

Graphite Tatto

Ref. 1

Intraoral brown and black conditions

Hairy Tongue

Ref. 1

Intraoral brown and black conditions

Early Changes of Melanoma1. Appear recently2. Change in degree of pigmentation 3. Bleeding or ulceration4. Rapid growth (in size or elevated)

Refs. 1, 2

Melanoma

Ref. 1

Melanoma

Ref. 1

Melanoma

Ref. 1

Melanoma

Ref. 1

Melanoma

Ref. 1

Immunohistochemical staining of HMB-45 (A) and S-100 (B) revealed diffuse positivity in the tumor cells.

Von Reclinghausen’s disease of skinmultiple neurofibroma

Cafa-Au-Lait-spot

Ref. 5

Cafa-Au-Lait-spot

Ref. 1

Addison’s Disease

Pituitary Gland

ACTH

Gluco-cortisoid (Hydrocortisone)

Blood circulation

product

Cause adrenal produce

Into

Ref. 4

Peutz-Jeghers Syndrome

Bluish black macules

Skin pigment but not oral tends fade with age

Intestinal polyp

Refs. 1

Hemangioma Mucocele

Eruption cystHematoma

Bluish Lesions

Ref. 1

Varicoses

Ref. 1

Mucoepidermoid Carcinoma

Ref. 1

Knowing how to differentiatebrown, bluish & black oral conditions

SUMMARY

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