劑量反應評估 - 慢性毒性為主
Post on 19-Mar-2016
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劑量反應評估 - 慢性毒性為主. 風險評估架構. 危害 確認 (Hazard Identification) 確認危害物質. 曝露量評估 (Exposure Assessment). 劑量效應評估 (Dose Response Assessment). ￬. 毒性資料整合. 受體與曝露途徑. ￬. 致癌斜率與非致癌參考劑量. ￬. 曝露劑量. 風險特徵描述 (Risk Characterization) 致癌風險 非致癌風險 不確定性分析. 劑量反應評估. - PowerPoint PPT Presentation
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Risk
Assessment
0
25
50
75
100
0
1
2
3
4
5
6
7
8
Risk
Assessment
-LC50
The concentration of a chemical in an environment (generally air or water) which produces death in 50% of an exposed population of test animals in a specified time frame
Normally expressed as milligrams of substance per liter of air or water mg/L (or as ppm)
Risk
Assessment
-LD50
The amount (dose) of a chemical which produces death in 50% of a population of test animals to which it is administered by any of a variety of methods
Normally expressed as milligrams of substance per kilogram of animal body weight (mg/kg)
Risk
Assessment
Risk
Assessment
1.(oral)(inhalation)
Risk
Assessment
2.(oral)(dermal)
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