l½,&e¬' m78 e¬f

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2

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Glycemic control

Date OHA regimen HbA1c plasma glucose (mg/dL)

2003/10/7 Metformin 10.2 AC: 138PC: 487

2004/2/27 Amaryl + Metformin one touch: >300

2005/11/23 Amaryl + Metformin AC: 137

2006/6/1 Metformin + Acarbose + Repaglinide 14.2

2006/10/31 Metformin + Acarbose + Gliclazide 7.9

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Kaplan-Meier plot of tuberculosis-free survival by diabetes mellitus and glycemic control status, adjusted for age

p-value from log-rank test for overall difference: 0.0019

14

poor glycemic control (FPG>130 mg/dL)

Results from Cox proportional hazards regression model for association between diabetes status, glycemic control, and risk of TB

15

Dose-response curves for fasting plasma glucose and risk of incident tuberculosis in the Cox proportional hazards model

16

p

Subgroup Analysis or Diabetes Status and Risk of TB

BMI and gender: not statistically significant effect modifiers

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Baker et al, BMC Medicine 2011, 9:81

Lee et al, Plos one 2014

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( ):

WHO: Collaborative framework for care and control of TB and DM

2018

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2018

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27

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2018

PDF: http://www.thearc.org.au/Resources/Uploaded/Resources/21812%20-%20ARC%20TB%20Diabetes%20Flipchart%20-%20WEB.pdf

DM-TB co-management: from evidence to action…

34

A1C : every 3 months

1% solution:

1 2 3 4 5 6

Intensive phase Continuation phase

HERZ HR(E)•

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40

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43

Thanks for your attention!

leepinhui@cdc.gov.tw