磷酸二酯酶 (pde) 及其 抑制剂概述
Post on 13-Jan-2016
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(PDE)
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PDE,(cAMP),cAMP/cGMP PDE,cAMP
PDE,?
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PDE PDE3PDE4PDE5PDE
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PDEphosphodies-terasePDE 20 %25 %,PDE PDE
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AC[cAMP][cGMP]PDE1-4,8,10GC5pAMP5pGMPATPGTP PDE5,7
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PDE3PDE3cAMPcAMPCa2+
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NO
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20-301.5-2h
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PDE4PDE 4 ,(M) ( EOS)
PDE 2 ,HPDE LPDE ,HPDE ,LPDE PDE
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PDE 4 PDE 4 rolipram-cilomilast,Byk-Gulden roflumilast
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(rolipram)AdeoSchering AGRolipram PDE4COPDRolipramPDEHPDE4
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cilomilastPDE4COPDPDELCOPD/
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( roflumilast)COPD
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PDE5PDE 5 ,cGMP (zaprinast)
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PDE5
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SildenafilsildenafilNO ,NO/cGMP
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PDE5
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PDE5PDE5CYP450 3A4-
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(dipyriamole) A
BACPDEcAMPACcAMPPDE
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DNARNA
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ZaprinastcAMPcAMP10mg,20mg10-20mg,tid
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PDE PDE PDE3PDE3PDE4 COPD ,PDE ,,
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PDE
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PDE15038.53dX0.25g,bid0.4g,qd30mg,tid32h
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245500mg,bid0.2g,tid1.5-2h
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PDEs ,PDEs PDEs PDE PDEs ,,,,
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Thank you!
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