화학생물학 topic - 임영재
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Chemical biology
Biomedical Technology
2009111565 Yiem Young Jae
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TOPICS
1. DNA Recombination
- Recombinant carbon anhydrase for making carbonic
acid compound ()
2. Stem cell treatments
3. Nano DNA Robot- Target Cancer With DNA Robots
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1. DNA Recombination : Recombinant carbon
anhydrase
for
making carbonic acid compound
production of Recombinant carbon anhydrase
1. Host plasmid is spilt by restrict enzyme
2. Gene that express carbon anhydrase insert
to Host plasmid.
3. Recombinant DNA can make carbon anhydrase
Gene that express carbon anhydrase
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1. DNA Recombination : Recombinant carbon
anhydrase
for
making carbonic acid compound
Recombinant carbon anhydrase function :
Recombinant carbon anhydrase can convert COwith H2Oto carbonic acidcompound HCO( Carbonic acid ) CO+ H2O
Cabonic acid compounds use for artificial bone synthesis
Advantage of using Recombinant carbon anhydrase is mass production of
Cabonic acid compounds
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2. Stem cell treatments
-
Treatment for myocardial infarction
Stem cell treatments : medical strategy that inject(or insert) new cells
from embryo, bone marrow into damaged tissue treats disease or injury.
The ability of stem cells is self-renew and stimulation of variable
differentiation .
Possible Application : adult and embryonic stem cells will soon be able
to treat cancer, Type 1 diabetes mellitus, Parkinson's disease,
Huntington's disease, Celiac Disease, cardiac failure, muscle damage
and neurological disorders.
Adult stem cell treatment for myocardial infarction is developed by korean
research team.
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2
. Stem cell treatments
-
Treatment for myocardial infarction
Step ofAMI function
1. Take myocardial infarction patients
Adult cell from Bone marrow
2. Take culure of patients adult cell
( This process need high culture
skill and purification)
3. Take coronary arteries stent (
) treatment for extension
vessel
3. Inject the cultured adult cell to
coronary arteries
The effect of medicine (-AMI)-AMI improves the blood stream through coronary arteries inleft ventricle of heart() .
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3. Nano DNA Robot - Target Cancer With DNA Robots
concept of nano robot : An autonomous DNA nanorobot
can transport molecular payloads to cancer cells
step of nano robot function
1 step nano robot sense the cancer cell surface inputs(= cancer cell
protein at cancer cell) .
2 step nanorobot complex (nanorobot + cancer cell ) is triggeredactivation and reconfiguring its structure for payload delivery.
3 step nanoroot release payload to cancer cell
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3. Nano DNA Robot
- Target Cancer With DNA Robots
composition of DNA nanorobot :
structural DNA
+
Antibodies
+
aptamers metal atomic clusters (= specific
targeting of human cancers and T-cells.)
: http://wyss.harvard.edu/viewpressrelease/75/
http://wyss.harvard.edu/viewpressrelease/75/http://wyss.harvard.edu/viewpressrelease/75/
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