amlodipine -calcium channel blocker- 15.06.05 목희연

Amlodipine

-Calcium Channel Blocker-

15.06.05

목희연

화학명 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester

분류 고혈압 치료제 (dihydropyridine 계열 )

약리 Calcium Channel Blocker

적응증 고혈압

상품명 Norvasc

개발회사 Pfizer

Amlodipine

∙Three Classes of CCBDs

Chemical Type Chemical Names Brand Names

Phenylalkylamines Verapamil Calan,Isoptin

Benzothiazepines Diltiazem Cardizem

1,4-Dihydropyridines Nifedipine

NicardipineIsradipineFelodipineAmlodipine

Adalat,Procardia

CardeneDynaCircPlendilNorvasac

Calcium Channel Blocking Drugs

Verapamil

∙Three Classes of CCBDs

Chemical Type Chemical Names Brand Names

Phenylalkylamines Verapamil Calan,Isoptin

Benzothiazepines Diltiazem Cardizem

1,4-Dihydropyridines Nifedipine

NicardipineIsradipineFelodipineAmlodipine

Adalat,Procardia

CardeneDynaCircPlendilNorvasac

Calcium Channel Blocking Drugs

Diltiazem

∙Three Classes of CCBDs

Chemical Type Chemical Names Brand Names

Phenylalkylamines Verapamil Calan,Isoptin

Benzothiazepines Diltiazem Cardizem

1,4-Dihydropyridines Nifedipine

NicardipineIsradipineFelodipineAmlodipine

Adalat,Procardia

CardeneDynaCircPlendilNorvasac

Calcium Channel Blocking Drugs

Amlodipine

Calcium channel

Type Most often found in

L-type calcium channel ("Long-Lasting" AKA "DHP Receptor") 골격근 , 평활근 , 심장근육

P-type calcium channel ("Purkinje") /Q-type calcium channel 푸르키니에 섬유

N-type calcium channel ("Neural"/"Non-L") 뇌 신경

R-type calcium channel ("Residual") 소뇌 과립세포

T-type calcium channel ("Transient") 신경세포 , 심장근육

Voltage-gated Calcium channel

Calcium binding mechanism

혈관확장 , 동방결절 전기 신호 억제

Calcium channel Blocking

혈관확장 심장수축저해 동방결절억제 방실결절억제

Effects of CCBDs

Benzothiazepines

1,4-Dihydropyridines

Phenylalkylamines

혈관 선택성 Ca2+ 길항작용 : 1,4-Dihydropyridines심장 선택성 Ca2+ 길항작용 : Phenylalkylamines, Benzothiazepines

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