cheminform abstract: palladium-catalyzed intramolecular alkyne-α,β-unsaturated carbonyl coupling....
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1997 furan derivatives
furan derivativesR 0060
43 - 118Palladium-Catalyzed Intramolecular Alkyne-α,β-Unsaturated Car-bonyl Coupling. A Formal Synthesis of (+)-Pilocarpine. —Pd-catalyzed enyne coupling of (E) or (Z) alkynoates (I) or (III) provides thealkenyl substituted lactones (II) highly stereoselectively. After esterificationwith (+)-dimethyltartrate and following chromatographic separation, thepure diastereomer (IV) is converted to aldehyde (VI), a known precursor of(+)-pilocarpine. — (WANG, Z.; LU, X.; Tetrahedron Lett. 38 (1997) 29,5213-5216; Shanghai Inst. Org. Chem., Acad. Sin., Shanghai 200032, Peop.Rep. China; EN)
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