concentrations of anti-ron adcs ( μ g/ml)
Post on 30-Dec-2015
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Caption: Effect of Zt/g4-DM1 on reduction of cell viability in CRC cell lines expressing different numbers of RON receptor. LoVo: RON per cell 100 - PowerPoint PPT Presentation
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Concentrations of Anti-RON ADCs (μg/ml)
Ce
ll v
iab
ilit
y (
% o
f c
on
tro
l)
IC50 (μg/ml) Zt/g4-DM1: 1.65 Zt/c1-DM1: 6.24
LoVo: RON per cell <10
DLD1: RON per cell ~4,480
HT29: RON per cell ~18,797
IC50 (μg/ml) Zt/g4-DM1: 4.03 Zt/c1-DM1: 4.36
IC50 (μg/ml) Zt/g4-DM1: 20.36 Zt/c1-DM1: 21.14
IC50 (μg/ml) Zt/g4-DM1: >100 Zt/c1-DM1: >100
SW620: RON per cell ~11,256
0
20
40
60
80
100
0 3 6 9 12 15
Feng et al. Supplementary Fig. 3
Caption: Effect of Zt/g4-DM1 on reduction of cell viability in CRC cell lines expressing different numbers of RON receptor
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