département des biopolymères artificiels de l'ibmm (ibmm ... · rnjp 2015, la grande-motte,...
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Benjamin Nottelet IBMM-DBA UMR 5247
Université Montpellier – ENSCM
Rencontres Nationales des Jeunes Polyméristes 2015
Département des Biopolymères Artificiels de
l'IBMM (IBMM-DBA):
Polymères pour la Santé.
About IBMM-DBA 2
Funded 30 years ago by
Dr. M. Vert
CHEMISTRY
Design & syntheses
BIOMEDICAL APPLICATIONS
Biological evaluations
CHARACTERI-SATION
Physico-chemistry
Rheology...
15 people + students
CHARACTE-RISATION
BIOLOGY
CHEMISTRY
RNJP 2015, La Grande-Motte, 3 juin 2015
Polymers for Health & Biomedical Applications
Multidisciplinarity
People at IBMM-DBA 3
RNJP 2015, La Grande-Motte, 3 juin 2015
Head
Jean Coudane PU
Assistant Professors & Researchers Technical Staff
PhDs &
Post-docs
Executive assistant
Xavier Garric PU Administration
Carine Carlin
Chemistry
Physico-chemistry
Biological Applications
Denis Durand MCU
Abdel El Ghzaoui MCU
Vincent Letouzey* PHU
Benjamin Nottelet MCU
Hélène Van Den Berghe MCU
Michel Vert DRE
Audrey Bethry IE
Mahfoud Boustta IR
Vincent Darcos IE
Stéphane Dejean T
Sylvie Hunger T
Cédric Paniagua AI
Assala Al Samad PhD
Edouard Girard* PhD
Stéphanie Huberlant* PhD
Salome Leprince PhD
Mira Younis PhD
Anita Schulz Post-doc
Sytze Buwalda Post-doc
* Medical students
4
RNJP 2015, La Grande-Motte, 3 juin 2015
Expertise & skills at IBMM-DBA
Modification of polyesters Customized & functional copolyesters
Biomaterials processing & evaluation
Post-polymerization modification
Surface modification
Processing
Scaffolds Degradation
Biological evaluations
Biomaterials & self-assembly
Elastomers Micelles, micro- &
nanoparticles Hydrogels
Functional monomers & copolymers
Controlled Polymerization
Macromolecular architectures
Poster 1 Poster 2
Poster 3 Poster 4
IBMM
DBA
5
RNJP 2015, La Grande-Motte, 3 juin 2015
Topics at IBMM-DBA
Drug delivery (micelles, nano and microparticules, coatings, hydrogels)
Biomaterials for advanced applications (medical imaging, bioactive surfaces, prodrugs)
Implantable medical devices (functional prostheses, scaffolds, tissue engineering)
Polymers for Health & Biomedical Applications
DOX
6
RNJP 2015, La Grande-Motte, 3 juin 2015
Topics at IBMM-DBA
Drug delivery : particles
Van-Tranh et al. Eur J Pharm Sci 2012
Morille M. et al. J Control Rel 2013
Patent WO2013144341
Better proliferation of hMSC Protection and controlled
release of TGF-b3
Copolymer
Mixture
7
RNJP 2015, La Grande-Motte, 3 juin 2015
Topics at IBMM-DBA
Drug delivery : gels
O
O
O
O
O
O
O
O
D-lactide
L-lactide
PDLA
PLLA
H. Nouailhas et al. J Applied Pol Sci 2011
PEG
PEG
PDLA
PLLA
Improved cristallinity
& stability
Stereocomplexes
Gel
0
10
20
30
40
50
60
70
80
0 5 10 15 20 25 30
0
10
20
30
0 1 2
Temps (jours)
BS
A lib
éré
e (
%)
2KL13/2KD12 (35%)
2KL13 (35%)
Decreased « burst effect »
Time (days)
Rele
ase
d B
SA
(%
)
Stereocomplexed
gel
Gel
8
RNJP 2015, La Grande-Motte, 3 juin 2015
Topics at IBMM-DBA
Implantable medical devices : thermosets
* O O
O On m
*
* O O
O O
I
n m
*
* O O
O O
S(CH2)6 SH
n m
*
i)
ii)
PCL
PCL-I
PCL-HDT
n m
*
* O O
O OS
(CH2)6 S
* O O
O O
S(CH2)6 S
n m
*
Redox
EMSS
a) b)
reduction
Reversibility
S
I
S
SH
SH
B. Nottelet et al. Polym. Chem. 2012
Tensile tests
9
RNJP 2015, La Grande-Motte, 3 juin 2015
Topics at IBMM-DBA
A. Leroy et al. Mater Sci Eng 2013
A. Leroy et al. Biomat Sci 2015
Degradable copolymers synthesis, evaluation & selection
Association with human mesenchymal stem cells Association with cross-linked bovine collagen
Excellent proliferation onto the scaffold
Expression of specific proteins (tenascin,
tenomodulin…)
Excellent proliferation of
ligamentocytes onto the scaffold
Development towards a ligament
patch
Implantable medical devices : thermoplastics
10
RNJP 2015, La Grande-Motte, 3 juin 2015
Topics at IBMM-DBA
Advanced biomaterials : active surfaces
C. Sardo et al. Biomacromolecules 2014
Mild photochemical functionalization
No metal Fast
Antibacterial
surface
Clickable PLA
surface
PLA surface
water/EtOH (1:1 , HCL 0.1N)
UV ,15 min
Collaboration Pr. G.Cavallaro (STEBICEF
Palermo, Itlay)
PHEA cationic derivative
Covalent grafting
80% biofilm decrease
11
RNJP 2015, La Grande-Motte, 3 juin 2015
Topics at IBMM-DBA
Optimum between grafting density and overall Gd3+ content
S. El Habnouni et al. Biomacromolecules 2013
WO2011004332
WO 2013084204
No need of high Gd3+ dose
Advanced biomaterials : medical imaging
IBMM-DBA : a summary
IBMM-DBA
Polymers for health &
biomedical applications
Polymer chemistry
Clinicians Industrial Partners
Innovation Feasibility
Benjamin Nottelet IBMM-DBA UMR 5247
Université Montpellier – ENSCM
Rencontres Nationales des Jeunes Polyméristes 2015
Département des Biopolymères Artificiels de
l'IBMM (IBMM-DBA):
Polymères pour la Santé.
Merci de votre attention
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