hema diseases
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HEMATOLOGIC DISORDERS
BY: JOHN ARBIE T. TATTAO, RN
ANEMIAA reduction in RBC that in turn ↓ the oxygen carrying capacity of the blood
MAJOR CAUSES OF ANEMIA
Loss of RBC’sDeficiencies and abnormalities of erythrocyte production
Destruction of RBC
MAJOR CLASSIFICATION OF ANEMIA
A. Hypoproliferative Anemia
Bone marrow cannot produce adequate number of RBC
MAJOR CLASSIFICATION OF ANEMIA
B. Hemolytic AnemiaResults in premature destruction of RBC
MAJOR CLASSIFICATION OF ANEMIA
C. Anemia resulting from loss of RBC
> ex: bleeding from GIT, trauma, menorrhagia, chronic epistaxis
IRON- DEFICIENCY ANEMIA
PROBLEM: chronic, microcytic, hypochromic anemia resulting from inadequate absorption or excessive loss of iron leading to hypoxemic tissue injury
IRON- DEFICIENCY ANEMIA
CAUSES:Predisposing FactorsA.Chronic blood loss 1. Trauma2. Menorrhagia3. GIT bleeding
IRON- DEFICIENCY ANEMIAB. Inadequate intake of food rich in iron
1. Chronic diarrhea2. Malabsorption syndrome3. High cereal intake with low
animal protein ingestion4. Subtotal gastrectomy
IRON- DEFICIENCY ANEMIAS/SX OR CLINICAL MANIFESTATIONS:
Plummer Vinsons SyndromeEarly Sx are nonspecific, includes fatigue, weakness, SOB, pale conjunctiva
KoilonychiaCheilosisPICA
IRON- DEFICIENCY ANEMIA Peripheral blood smear reveals microcytic and hypochromic RBC
CBC reveals:↓ Hgb to as low as 6-9 g/dl↓ total RBC count↓ Hct levels in relation to ↓ HgbRBC indices reveals ↓ MCV, MCH, MCHC
IRON- DEFICIENCY ANEMIA Serum iron reveals ↓ levels
IDA - ↓ 10mg/dl N: 50 – 150 mg/dl
Decreased serum ferritin levels
Complete absence of hemosiderin
IRON- DEFICIENCY ANEMIAMANAGEMENT:Drugs/Pharmacology:Iron Supplementa. Oral (Ferrous sulfate, Ferrous
gluconate, Ferrous Fumarate)NURSING RESPONSIBILITY:1. Advice pt. to take supplement 1
hr. Before meal
IRON- DEFICIENCY ANEMIA2. Administer iron supplement with meals if taking it on empty stomach causes gastric distress
3. Administer w/ straw if diluting in iron liquid prep.
4. Do not take antacids or dairy products w/ Fe
IRON- DEFICIENCY ANEMIA5. ↑ intake of Fe: Take iron w/ orange juice
6. Monitor and inform patient for S/E
a. Melenab. Anorexiac. Diarrhea/Constipationd. N/Ve. Abdominal pain
IRON- DEFICIENCY ANEMIAParenteral Iron TherapyAdministered to pt. Who:a. Have an intolerance to oral
preparationsb.Continue to suffer blood lossc. Habitually forgetting to take
their medication
IRON- DEFICIENCY ANEMIANURSING RESPONSIBILITY1. Administer with the use of Z tract
method2. Don’t massage injection site3. Ambulate4. Monitor pt for S/E
a. Fever/chillsb. Lymphadenopathyc. Urticartia
IRON- DEFICIENCY ANEMIAd. Pain at injury sitee. Localized abscessf. Hypotension sec. to anaphylactic shock
DIET: Iron rich foods (ex: egg yolk, legumes, raisins, beans, organ meat, GLV)
IRON- DEFICIENCY ANEMIA
Monitor signs of bleeding
Advice pt. to have CBRProvide good oral care Instruct pt. to avoid taking tea/coffee
IRON- DEFICIENCY ANEMIAEncourage intake of Fe rich foods
Encourage pts. to continue Fe therapy as long as it is prescribed even though patient may no longer feel fatigued
Inform pt. that iron causes the stool to become dark green or black in color
IRON- DEFICIENCY ANEMIA
Administer meds as ordered
Blood transfusion as necessary
MEGALOBLASTIC/MACROCYTIC ANEMIA Anemias caused by deficiencies of Vit. B12 and folic acid
Characterized by the appearance of megaloblasts (large, primitive RBC’s) in blood and bone marrow
PERNICIOUS ANEMIA
PROBLEM: Chronic, macrocytic, hyperchromic anemia caused by failure of absorption of Vit. B12 due to deficiency of intrinsic factor leading to hypochlorhydria
PERNICIOUS ANEMIACAUSES: Total gastrectomy/Ileal resection
Atrophy of gastric mucosa Imflammatory disease of ileum
Strict vegetarian diet Absence of intrinsic factor Heredity
PERNICIOUS ANEMIAS/SX: Red beefy tongue Headache, dizziness, dyspnea, palpitations, generalized body malaise, pallor
PERNICIOUS ANEMIAGIT changes – mild diarrheaDyspepsia Neurologic Manifestations:a. Peripheral Neuropathy and
loss of balanceb. Confusionc. Paresthesia in extremities
PERNICIOUS ANEMIA Lack of balance, uncoordinated movement
Loss of proprioception Depression, psychosis Achlorhydria
PERNICIOUS ANEMIALABS/DX EVALS: Schillings Test – measure the absorption of orally administered radioactive Vit B12 before and after parenteral administration of intrinsic factor
Purpose: Used to detect Vit B12 absorption
PERNICIOUS ANEMIA Procedure:1.Administration of oral
radioactive vit B122.Administration of large,
nonradioactive parenteral dose of vit b12 followed in a few hrs.
Interpretation: Cause of deficiency
PERNICIOUS ANEMIAProcedure:3. The same procedure is repeated, but this time intrinsic factor is added to the oral radioactive Vit b12
Interpretation: Absorption of Vit B12
PERNICIOUS ANEMIANursing Responsibility:1. Collect 24 hour urine
specimen2. Keep pt NPO, except for H2O
8-12 hours before the test3. Promote pt understanding
on proc. And emphasize ability to comply with urine collection
PERNICIOUS ANEMIAMANAGEMENT:Drug/Pharmacology:a. Vit B12 injectionsNx. Resp:1. Administer Vit B12 injections at
monthly intervals for lifetime as ordered.
2. Oral administration is used only in cases of nutritional deficiency
PERNICIOUS ANEMIADiet:↑ calorie or CHO, ↑ CHON, iron and Vit. C
Nursing Intervention:1. Enforce CBR2. Administer medication as
ordered3. Avoid irritating mouthwash.
Use of soft bristled tb is encouraged
PERNICIOUS ANEMIANursing Intervention:4. Avoid applying electric heating pads
5. Administer blood transfusion as needed
6. Physical examination q 6 months
FOLIC ACID DEFICIENCY ANEMIAPROBLEM: malabsorption of dietary folic acid due to lack of intake or absorption
CAUSE:a. Poor dietary intakeb.Poor GI absorptionc. Folate antagonistsd. Increased req.
FOLIC ACID DEFICIENCY ANEMIA
d. Increase requirementS/SX:Same to PA but w/o neurologic involvement
Signs of poor oxygenationa. Dizzinessb. Irritabilityc. dyspnea
FOLIC ACID DEFICIENCY ANEMIA
d. Pallore. Headachef. Oral ulcersg. Tachycardia
FOLIC ACID DEFICIENCY ANEMIALabs/Dx Evals:1. RBC indices reveals ↑ MCV and ↓MCHC2. Serum folate levels reveals less than 4
mg/ml (N: 7 to 20 mg/ml)3. Schilling test reveals normal finding4. Blood smear reveals large RBC5. Therapeutic trial reveals client
responding to 50 to 100mg folic acid administered IM for 10 days.
FOLIC ACID DEFICIENCY ANEMIAMANAGEMENT:Drug/Pharma Therapy1.Administer oral doses of
folic acid 0.1 to 5.0 mg/day until the blood profile improves or until the cause of intestinal malabsorption is corrected
FOLIC ACID DEFICIENCY ANEMIA2. Clients with malabsorption syndromes may need parenteral folic acid initially, followed by maintenance therapy with oral doses
Diet/Nutritional Therapy↑ foods high in FA (mostly plant sources)
Daily req: 100 to 200 mg/day
FOLIC ACID DEFICIENCY ANEMIA
Nursing Intervention:1.Administer meds as
ordered2.Referral to AA for
alcoholic patients3.Proper food preparation
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