immunology6e ch01
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Kuby IMMUNOLOGYSixth Edition
Chapter 1
Overview of the Immune System
Copyright © 2007 by W. H. Freeman and Company
Kindt • Goldsby • Osborne
Metchinikoff,
Phagocytosis, macrophages surrounding a foreign particel
1990,Ehrlich
Side chain theory
Cells in blood expressed
a variety receptor
Like key and lock
1950, Clonal selection
Rota virus, 1million death/yr
Pseudomonas ingested by macrophage
Candida albicans
Larva of Filaria attacked by macropahges,
120 million infection
Tyrosine
Serine
Threonine
105 MBA per cell
Secreted Ab
EM of APC (right) associating with T lym
CTLs (cytotoxic T lymphocytes)
Lag phase 5-7d
B cell, Th, Plasma cellLag phase 1-2d
Memory B cells
100-1000 folds
Allergic reaction to a bee stingImmune Dysfunction:
Allergies and asthma—anaphylaxis (anaphlactic reaction),
dog against toxin from jellyfish, physalia. IgE and Mast cells
Graft rejection and graft vs host disease, bone marrow transplantation, antigraft drug,
1930,Landsteiner ABO grouping, 1980 Thomas and Murry, MHC
Autoimmune disease—multiple sclerosis, Crohn’s disease, Rheumatic,
Immunodeficiency, IgA lacking, SCID (T, B cells ), AIDS
Asthma
Food allergy
Tree nut, peanuts
3 million American
Ban peanuts from school and airplane
Epinephrine injection or suction
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