lars salmi johansson md, phd gendoktorn medicinsk service · genvägen till ett friskare liv lars...

Genvägen till ett friskare liv

Lars Salmi JohanssonMD, PhD

Gendoktorn Medicinsk Service

main(){// initiera några parametrarGIE = 0;CM1CON0 = 0;CM2CON0 = 0;T0IE = 0;PEIE = 1;TRISB = 0;ANS10 = 0;RB4 = 0;ANS11 = 0;RB5 = 0;RB6 = 0;// Initiera LCD och skriv startmeddelandepause(2000);lcd_init();lcd_clear();lcd_lighton();lcd_goto(0x02);lcd_puts("Spinwest FoU");lcd_goto(0x44);lcd_puts("Proj 010");pause(2000);

// initiera switch, sensor, minuttimer (via TMR2), watchdog-timer, mminit_switch();sensor_setupdigital();if (read_from_eprom(adress_sampletime) == 0xFF)

sensor_storedefault();counter = 0;lightcounter = 0;minute = 0;lighttime = 0;tmr2_start();initiera_wdtimer();GIE = 1;uart_init_comms();sensor_on();sensor_failure_alarm();dataaverage = datavalues_initaverage();antalpunkter = 0;ALARM_SET = 0;

// huvudrutin för läsning av sensordata och larmwhile (1)

{CLRWDT();pause(5000);pause(500);sampleintervall = sensor_getsampleintervall();if (minute >= sampleintervall)

{GIE = 0;lcd_clear();lcd_goto(0);lcd_lighton();lcd_puts("Reading sensor");GIE = 1;sensor_on();sensor_failure_alarm();antalpunkter++;sensor_setprescaler();frekvens = sensor_getfreq();datavalue = datavalues_sample();ALARM_SET = sensor_alarm(datavalue, dataaverage);dataaverage = datavalues_average(datavalue, ALARM_SET);GIE = 0;lcd_clear();lcd_goto(0x40);lcd_puts("Digital: ");lcd_putdec(frekvens);lcd_puts(" kHz");lcd_goto(0);lcd_puts("V:");lcd_putdec(datavalue);lcd_puts(" Va:");lcd_putdec(dataaverage);GIE = 1;minute = 0;sensor_off();uart_putdec(antalpunkter);uart_putspace();uart_putdec(datavalue);uart_putspace();uart_putdec(dataaverage);uart_putnyrad();lighttime = 0;}

if (lighttime >= 1){lcd_lightoff();lighttime = 0;}

}}

CRISPR CAS 9

‘I want to help humans genetically modify themselves’Former Nasa biochemist Josiah Zayner became an online sensation by conducting DIY gene therapy on himself.

Josiah Zayner with his Crispr gene-editing kit.Josiah Zayner, 36, recently made headlines by becoming the first person to use the revolutionary gene-editing tool Crispr to try to change their own genes. Part way through a talk on genetic engineering, Zayner pulled out a syringe apparently containing DNA and other chemicals designed to trigger a genetic change in his cells associated with dramatically increased muscle mass. He injected the DIY gene therapy into his left arm, live-streaming the procedure on the internet.

1. Diagnos (NIPT, CF, SMA)

2. Optimering (Farmakogenetik)

3. Riskhantering(BRCA1,2, Anlagsbärare, Alzheimer)

4. Livsstil

NIPT (Non Invasive Prenatal Test)

Hur säkert?

Vill vi veta?

1. Diagnos

Farmakogenetik

Levermetabolism

Terapisvikt, biverkningar

2. Optimering

BRCA 1,2

Varierande riskprofil

Genetisk rådgivning, handlingsalternativ

3. Riskhantering

Anlagsbärartest

Recessivt (t ex CF, SMA)

Handlingsalternativ (IVF/PGD)

3. Riskhantering

Alzheimer

Multifaktoriell

Riskgener (ApoE, BDNF, m fl)

Förebyggande

3. Riskhantering

Mikrobiom

Sport och träning

Välbefinnande

Släktforskning

4. Livsstil

Vetenskaplighet

Acceptans

Individuellt beslut, egenvård

Kostnader, konsekvenser

Etik

Diagnostik• ökat behov• multifaktoriell analys (AI)• privata alternativ, förebyggande behandling, nätbaserat

Läkemedel• design• produktion• andra behandlingsformer

Organisatoriska förändringar• alternativa leverantörer• nätbaserat

Framtid