mata & ocular adnexa ( bahan kuliah kedokteran
Post on 04-Mar-2015
44 Views
Preview:
TRANSCRIPT
BAGIAN PATOLOGI ANATOMIBAGIAN PATOLOGI ANATOMIFAKULTAS KEDOKTERANFAKULTAS KEDOKTERAN
USU – MEDANUSU – MEDAN20072007
NORMAL ANATOMYNORMAL ANATOMY
PalpebraePalpebraeConjunctivaConjunctivaCorneaCorneaLensLensUvea tractUvea tractRetinaRetinaVitreous humorVitreous humorNerveNerveGlandGlandMuscleMuscleBlood vesselsBlood vessels
NORMAL ANATOMYNORMAL ANATOMY
A - A - Vitreous humorVitreous humor
B - B - LensLens
C - C - CorneaCornea
D - D - PupilPupil
E - E - IrisIris
F - F - ScleraSclera
G - G - Optic NerveOptic Nerve
H - H - RetinaRetina
CHOROIDCHOROID
CHOROID = MIDDLE CHOROID = MIDDLE LAYER EYE LAYER EYE
CONTAINS :CONTAINS :• BLOOD VESSELS &BLOOD VESSELS &• CONNECTIVE TISSUE CONNECTIVE TISSUE
• SUPPLIES NUTRIENTS SUPPLIES NUTRIENTS TO INNER PORTION OF TO INNER PORTION OF EYEEYE
CILIARY BODY CILIARY BODY CILIARY BODYCILIARY BODY = ring of = ring of
tissue tissue encircles the lens. encircles the lens.
Contains : Contains : • smooth muscle fibers smooth muscle fibers
(ciliary muscles)(ciliary muscles)
• control the shape of the control the shape of the lens. lens.
Posterior surface lens Posterior surface lens (CILIARY PROCESSES)(CILIARY PROCESSES)
Contain : capillaries Contain : capillaries
• Secrete fluid (vitreous Secrete fluid (vitreous humor) humor) into the anterior into the anterior segment of the eyeball. segment of the eyeball.
LACRIMAL SYSTEMLACRIMAL SYSTEM
LARGELY : SEROUS TYPE
MINOR MUCINOUS
DISORDER OF EYEDISORDER OF EYE
MICRO ORGANISMS *MICRO ORGANISMS * ANTIGEN *ANTIGEN * TOXIC CHEMICAL *TOXIC CHEMICAL * SOLAR RADIATION *SOLAR RADIATION * SYSTEMIC DISEASE *SYSTEMIC DISEASE *
* * BLINDNESS BLINDNESS
CONGENITAL ANOMALICONGENITAL ANOMALI
RARELY : RARELY : - ANOPTHTHALMOS- ANOPTHTHALMOS
- EYE’S (-)- EYE’S (-)- MICROPHTHALMOS- MICROPHTHALMOS
- MEDIAN EYE- MEDIAN EYE- HYPOPLASIA EYE’S- HYPOPLASIA EYE’S- COLOBOMA- COLOBOMA- CONGENITAL CATARACTS- CONGENITAL CATARACTS
- COLOR BLIND- COLOR BLIND
COLOBOMACOLOBOMA ((Defect in iris)Defect in iris)
Appear : black notch Appear : black notch pupil : irregular (shape) pupil : irregular (shape) May be associated with :May be associated with :
• Hereditary conditionsHereditary conditions• Trauma to the eye, or Trauma to the eye, or • Eye surgeryEye surgery
CONGENITAL CATARACTSCONGENITAL CATARACTS The number of people born with cataracts is low. The number of people born with cataracts is low.
Possible causes :Possible causes :• GalactosemiaGalactosemia • Chondrodysplasia syndrome Chondrodysplasia syndrome • Congenital Congenital rubellarubella syndrome syndrome • Down syndromeDown syndrome (trisomy 21) (trisomy 21) • Pierre-Robin syndrome Pierre-Robin syndrome • Familial congenital cataracts Familial congenital cataracts • Hallerman-Streiff syndrome Hallerman-Streiff syndrome • Lowe syndrome Lowe syndrome • TrisomyTrisomy 13 13 • Conradi syndrome Conradi syndrome • EctodermalEctodermal dysplasiadysplasia syndrome syndrome • Marinesco-Sjogren syndrome Marinesco-Sjogren syndrome
CONGENITAL CATARACTS CONGENITAL CATARACTS
PIGMENTATIONPIGMENTATION
EXOGENEXOGEN ENDOGENENDOGEN
ALBUMIN ALBUMIN MELANOSIS MELANOSIS
MELANINMELANIN
HEMOSIDERINE HEMOSIDERINE
I.O.HI.O.H
IRONIRONCOPPER COPPER SILVERSILVER
PIGMENTATIONPIGMENTATION
KAYSER - FLEISCHER RINGKAYSER - FLEISCHER RING WILSON’S DISEASE (HEPATOLENTIWILSON’S DISEASE (HEPATOLENTI CULAR DEGENERATION)CULAR DEGENERATION)
DEPIGMENTATIONDEPIGMENTATION
VITILIGOVITILIGO
PHYSICAL & CHEMICAL INJURIESPHYSICAL & CHEMICAL INJURIES
TRAUMA : ECCHYMOSISTRAUMA : ECCHYMOSIS SUP.FICIAL :SUP.FICIAL :
• CONTACT LENSCONTACT LENS• FOREIGN BODIESFOREIGN BODIES• ULTRA VIOLETULTRA VIOLET
CAUSTIC CHEMICALCAUSTIC CHEMICAL BLUNT TRAUMA BLUNT TRAUMA FRACTURE OF BONE FRACTURE OF BONE
SKIN APPENDAGES OF EYELIDSSKIN APPENDAGES OF EYELIDS
1.1. SEBACEOUS GLANDS SEBACEOUS GLANDS (ZEIS & MEIBOMIAN)(ZEIS & MEIBOMIAN)
2.2. APOCRINE GLANDS APOCRINE GLANDS (MOLL)(MOLL)
3.3. ECCRINE SWEAT GLANDSECCRINE SWEAT GLANDS
MOLUSCUM CONTANGIOSUMMOLUSCUM CONTANGIOSUM
VIRAL INFECT VIRAL INFECT WART LIKE WART LIKE CENTRAL UMBILICAL CENTRAL UMBILICAL KERATIN KERATIN
CYSTIC LESSIONCYSTIC LESSION SUDORIFERASUDORIFERA SEBACEASEBACEA MEIBOMIANMEIBOMIAN DERMOIDDERMOID
HORDEOLUMHORDEOLUM( = STYE )( = STYE )
ZEIS GLAND (SEBACEOUS GLANDS)ZEIS GLAND (SEBACEOUS GLANDS) EXTERNAL HORDEOLUMEXTERNAL HORDEOLUM
MEIBOMIAN GLANDS MEIBOMIAN GLANDS INTERNAL INTERNAL HORDEOLUMHORDEOLUM
FOLICLE FOLICLE INFECTION STAPHYLLOCOCUS INFECTION STAPHYLLOCOCUS
CELLULITISCELLULITIS
HORDEOLUMHORDEOLUM
EXTERNAL
INTERNAL
CHALAZIONCHALAZION(MEIBOMIAN GLAND LIPOGRANULOMA)(MEIBOMIAN GLAND LIPOGRANULOMA)
A PAINLESS GRANULOMA A PAINLESS GRANULOMA OF THE MEIBOMIAN OF THE MEIBOMIAN GLANDS GLANDS
MEIBOMIAN GLAND MEIBOMIAN GLAND OCCLUTIONOCCLUTION
CHRONIC CHRONIC GRANULATIONGRANULATION
MICROSCOPIC MICROSCOPIC
MULTIPLE FOCI OF GRANULOMATOUS INFLAMMATIONMULTIPLE FOCI OF GRANULOMATOUS INFLAMMATION
XANTHELASMA XANTHELASMA SHARPLY DEMARCATED YELLOWISH SHARPLY DEMARCATED YELLOWISH
(COLLECTION CHOLESTEROL) -(COLLECTION CHOLESTEROL) -UNDERNEATH SKINUNDERNEATH SKIN
USUALLY : ON / AROUND EYELIDSUSUALLY : ON / AROUND EYELIDS
ASSOCIATIONS :ASSOCIATIONS :• CHOLESTEROL CHOLESTEROL ↑↑ (FAMILIAL HYPERCHOL) (FAMILIAL HYPERCHOL) • PRIMARY BILIARY CIRRHOSIS PRIMARY BILIARY CIRRHOSIS • MENOPAUSE MENOPAUSE • DIABETES DIABETES
EXOPTHALMUSEXOPTHALMUS( = PROPTOSIS )( = PROPTOSIS )
PROTUSION (EYEBALL)PROTUSION (EYEBALL)
BILATERALBILATERAL
THYROID DISEASETHYROID DISEASE
EARLY ADULT LIFE (WOMEN), 4/1EARLY ADULT LIFE (WOMEN), 4/1
+ EDEMA (EYELID, CHEMOSIS)+ EDEMA (EYELID, CHEMOSIS)
EXOPTHALMUSEXOPTHALMUS( = PROPTOSIS )( = PROPTOSIS )
PATHOLOGY:PATHOLOGY:• ORBITAL WATER >>ORBITAL WATER >>• EXT.OCULAR MUSCLE >>EXT.OCULAR MUSCLE >>
( + LYMPHOCYTES & MN )( + LYMPHOCYTES & MN )
CLINIC : CLINIC : • EXPOSURE CONJ’TIVA EXPOSURE CONJ’TIVA BLIDING, BLIDING,
ULCERATION, OPTIC NERVE ULCERATION, OPTIC NERVE COMPRESSIONCOMPRESSION
CONJUNCTIVA DISORDERCONJUNCTIVA DISORDER
HYPEREMIAHYPEREMIA HEMORRHAGEHEMORRHAGE INFLAMATIONINFLAMATION THRACHOMATHRACHOMA CHLAMYDIAL INFECTIONCHLAMYDIAL INFECTION OPHTHALMIA NEONATORUMOPHTHALMIA NEONATORUM DRY-EYE SYNDROMEDRY-EYE SYNDROME PINGUECULA & PTERYGIUMPINGUECULA & PTERYGIUM
HYPEREMIA - CONJUCTIVAHYPEREMIA - CONJUCTIVA
DILATASI BLOOD VESELDILATASI BLOOD VESEL CONJUNCTIVITISCONJUNCTIVITIS CORNEA DISEASECORNEA DISEASE IRIDOCYCLITISIRIDOCYCLITIS CORNEA DEFECTCORNEA DEFECT GLAUCOMAGLAUCOMA IRITISIRITIS
HEMORRHAGE CONJUNCTIVAHEMORRHAGE CONJUNCTIVA
TRAUMATRAUMA ANOXIAANOXIA SEVERE COUCHING SEVERE COUCHING SPONTANEUS SPONTANEUS
SUBCONJUNCTIVAL HEMORRHAGE SUBCONJUNCTIVAL HEMORRHAGE
Causes :Causes :
• Minor eye trauma Minor eye trauma • Spontaneously (venous Spontaneously (venous
press press ↑)↑) • Streneuous Exercising Streneuous Exercising • Coughing Coughing • Touching/widening eyes Touching/widening eyes • Sneezing Sneezing • Vomiting (bulimia nervosa) Vomiting (bulimia nervosa) • Severe alcohol intoxication, Severe alcohol intoxication,
blood press blood press ↑↑ • Severe hypertension Severe hypertension
CONJUNCTIVITISCONJUNCTIVITIS
MICRO-ORG MICRO-ORG CONJUNCTIVITIS CONJUNCTIVITIS
KERATITISKERATITIS
CORNEAL ULCERCORNEAL ULCER
HEMATOGEN HEMATOGEN
IATROGENIC INFECTIONIATROGENIC INFECTION
SURGICAL : SURGICAL : CATARACTCATARACT CORNEAL GRAFTCORNEAL GRAFT PROSTHETIC LENSPROSTHETIC LENS
CONJUNCTIVITISCONJUNCTIVITIS
EXUDATE/DISCHARGE :EXUDATE/DISCHARGE :
- PURULENT - PURULENT CLOSE CLOSE
- FIBRINOUS- FIBRINOUS
- SEROUS- SEROUS
- HEMORRHAGIC- HEMORRHAGIC
CONJUNCTIVITISCONJUNCTIVITIS
TRACHOMATRACHOMA INF.CHRONIC (CLAMYDIA TRACHOMATIS)INF.CHRONIC (CLAMYDIA TRACHOMATIS) = SWIMMING POOL CONJUNCTIVITIS= SWIMMING POOL CONJUNCTIVITIS
OCULAR, GENITAL, SYST’MICOCULAR, GENITAL, SYST’MIC BLIND BLIND
CHILD CHILD REMISION (SP) REMISION (SP)
ADULT ADULT PROGRESSIVE PROGRESSIVE
BILATERAL, SUP > INF BILATERAL, SUP > INF
NEW BORN :NEW BORN : PURULENT CONJUNC. PURULENT CONJUNC. (BLENORRHOE)(BLENORRHOE)
ADULT :ADULT :• CHRONIC FOLLICLE CONJ. CHRONIC FOLLICLE CONJ. • LYMPHOCYTE (+)LYMPHOCYTE (+)• HYPERPLASIA HYPERPLASIA GERM. CENTRE NECROTIC GERM. CENTRE NECROTIC • TRACHOMATOUS PANNUSTRACHOMATOUS PANNUS
(EPIT – BOWMANN ZONE)(EPIT – BOWMANN ZONE)• FIBROSIS (CONJ. & EYELIDS) FIBROSIS (CONJ. & EYELIDS)
DISTORS EYELIDSDISTORS EYELIDS PATHOLOGY : PATHOLOGY :
• LOWER TARSAL CONJUNTIVALOWER TARSAL CONJUNTIVA• SCAR & NECROTIC (-)SCAR & NECROTIC (-)• KERATITIS (-)KERATITIS (-)
TRACHOMATRACHOMA(CHLAMYDIAL CONJUNCTIVITIS)(CHLAMYDIAL CONJUNCTIVITIS)
OPHTHALMIA NEONATORUMOPHTHALMIA NEONATORUM
ACUTE ACUTE SEVERE CONJUNCTIVITIS SEVERE CONJUNCTIVITIS COPIUS PURULENT DISCHARGECOPIUS PURULENT DISCHARGE GO GO GO-NEONATORUM GO-NEONATORUM ULC.CORNEA, PERFORATION ULC.CORNEA, PERFORATION
SCAR & PANOPH’ITIS SCAR & PANOPH’ITIS BLIND BLIND PREVENT PREVENT SILVER NITRAT (PNC) SILVER NITRAT (PNC)
OPTHALMIA NEONATORIUMOPTHALMIA NEONATORIUM
Microbial Agent : Neisseria gonorrhoeae Mode of Transmission: From mother to
newborn Classic Feature: purulent destructive
eye disease
DRY EYE SYNDROMEDRY EYE SYNDROME Common condition Common condition
Tear production << (ocular & systemic disease)Tear production << (ocular & systemic disease)
Older Older ♀♀ , menopause , menopause
Assc.: Assc.: “SJOGREN DISEASE”“SJOGREN DISEASE” (keratoconjunctivitis (keratoconjunctivitis sicca) sicca)
middle aged middle aged ♀♀ (atrophy of lacrimal glands) (atrophy of lacrimal glands)
Common causes :Common causes :• AgingAging• Dry environment or workplace (wind, air Dry environment or workplace (wind, air
conditioning) conditioning) • Sun exposure Sun exposure • Smoking / smoke exposure Smoking / smoke exposure • Cold / allergy medicines Cold / allergy medicines • Sjogren's syndrome Sjogren's syndrome includes dry eyes, mouth & mucus includes dry eyes, mouth & mucus
membranesmembranes often RA / other joint disorderoften RA / other joint disorder
The result of :The result of :• Sensitivity of the cornea Sensitivity of the cornea ↓↓• Evaporation of tears Evaporation of tears ↑↑• Disorder in the glands Disorder in the glands
PINGUECULAPINGUECULA
LUMP LUMP YELLOWISH YELLOWISH NASAL TO THE CORNEOSCLERALNASAL TO THE CORNEOSCLERAL SUN DAMAGED SUN DAMAGED INJURY INJURY DOES NOT GROW ONTO CORNEA DEPOSIT OF PROTEIN & FAT PARTICULARLY OLDER PEOPLE
PINGUECULAPINGUECULA
PTERYGIUM FOLD OF VASCULARIZED – RECURS AFTER EXISION FOLD OF VASCULARIZED – RECURS AFTER EXISION
(PINGUECULA)(PINGUECULA)
GROWS : TRIANGULAR SHAPE OVER THE CORNEA (THE TRANSPARENT PART OR FRONT WINDOW OF THE EYEBALL).
MAY GROW LARGE ENOUGH TO INTERFERE WITH VISION
COMMONLY : INNER CORNER OF THE EYE (APEX – PUPIL)
PTERYGIUM
CLOUDY CORNEA CLOUDY CORNEA CORNEA : TRANSPARENT CORNEA : TRANSPARENT
STRUCTURE STRUCTURE
LESS TRANSPARENT & LESS TRANSPARENT & CLOUDY :CLOUDY :• METABOLIC DISEASESMETABOLIC DISEASES• TRAUMATRAUMA• INFECTIOUS DISEASESINFECTIOUS DISEASES• NUTRITIONAL NUTRITIONAL
DEFICIENCIES &DEFICIENCIES &• ENVIRONMENTAL ENVIRONMENTAL
IT CAN LEAD TO VARIOUS IT CAN LEAD TO VARIOUS DEGREES OF VISION LOSS. DEGREES OF VISION LOSS.
CORNEACORNEA
HERPES SIMPLEXHERPES SIMPLEX ONCHOCERCIASISONCHOCERCIASIS ARCUS SENILISARCUS SENILIS BAND KERATOPATHYBAND KERATOPATHY CORNEAL DYSTROPHIESCORNEAL DYSTROPHIES
HERPES KERATITISHERPES KERATITIS
HYPEREMIAHYPEREMIA(TRAUMA)(TRAUMA)
EYE LENS ANATOMY EYE LENS ANATOMY
THE LENS OF THE EYE IS NORMALLY CLEAR.
LENSLENS
CATARACTCATARACT PRESBYOPIAPRESBYOPIA PHACO ANAPHYLACTIC PHACO ANAPHYLACTIC
ENDOPHTHALMITISENDOPHTHALMITIS
CATARACTCATARACT
THE LENS OF THE EYE IS NORMALLY CLEAR. IF THE LENS BECOMES CLOUDY OR IS OPACIFIED IT IS CALLED A CATARACT
NORMAL, NEAR & FARSIGHTEDNESS
UVEAUVEA
SYMPATHETIC OPHTHALMITISSYMPATHETIC OPHTHALMITIS SARCOIDOSISSARCOIDOSIS
RETINARETINA
HEMORRHAGEHEMORRHAGE OCCLUSIVE VASC.DISEASEOCCLUSIVE VASC.DISEASE
- CENTRAL R. ART.OCCLUSION- CENTRAL R. ART.OCCLUSION
- CENTRAL R. VEIN OCCLUSION- CENTRAL R. VEIN OCCLUSION HYPERTENSIVE RETINOPATHYHYPERTENSIVE RETINOPATHY DIABETIC RETINOPATHYDIABETIC RETINOPATHY RETINAL DETACHMENT RETINAL DETACHMENT
RETINARETINA
RETINITIS PIGMENTOSARETINITIS PIGMENTOSA MACULAR DEGENERATIONMACULAR DEGENERATION CHERRY-RED SPOT AT THE MACULACHERRY-RED SPOT AT THE MACULA ANGIOID STREAKSANGIOID STREAKS RETINOPATHY OF PREMATURITYRETINOPATHY OF PREMATURITY
OPTIC NERVEOPTIC NERVE
OPTIC NERVE HEAD EDEMAOPTIC NERVE HEAD EDEMA OPTIC ATROPHYOPTIC ATROPHY
EFFECTS OF INCREASE EFFECTS OF INCREASE INTRAOCULAR PRESSUREINTRAOCULAR PRESSURE
GLAUCOMAGLAUCOMA CORNEA/SCLERA CORNEA/SCLERA
BULGESBULGES OPTIC ATROPHYOPTIC ATROPHY
GLAUCOMA GLAUCOMA
Increased pressure Increased pressure causes compression of :causes compression of :
Retina and Retina and Optic nerve Optic nerve Nerve Nerve
damage. damage.
Glaucoma can cause :Glaucoma can cause :• Partial vision loss, Partial vision loss, • Blindness as a possible Blindness as a possible
eventual outcome. eventual outcome.
GLAUCOMA IS A CONDITION OF INCREASED FLUID GLAUCOMA IS A CONDITION OF INCREASED FLUID PRESSURE INSIDE THE EYE.PRESSURE INSIDE THE EYE.
GLAUCOMAGLAUCOMA
CONGENITAL GLAUCOMACONGENITAL GLAUCOMA INFANTILE GLAUCOMA, INFANTILE GLAUCOMA,
BUPHTHALMOSBUPHTHALMOS PRIMARY OPEN-ANGLE GLAUCOMAPRIMARY OPEN-ANGLE GLAUCOMA PRIMARY CLOSED-ANGLE GLAUCOMAPRIMARY CLOSED-ANGLE GLAUCOMA SECONDARY GLAUCOMASECONDARY GLAUCOMA LOW-TENSION GLAUCOMALOW-TENSION GLAUCOMA
GLAUCOMAGLAUCOMA
NEOPLASMANEOPLASMA
XANTHELASMAXANTHELASMA NEUROFIBROMANEUROFIBROMA PAPILLOMAPAPILLOMA LIPOMALIPOMA HEMANGIOMAHEMANGIOMA LIMPHANGIOMALIMPHANGIOMA NEVUSNEVUS
BENIGNBENIGN MALIGNANTMALIGNANT
BOWEN DISEASEBOWEN DISEASE SQ.CELL.CASQ.CELL.CA BASAL CELL CABASAL CELL CA MALIG. MELANOMAMALIG. MELANOMA AD. CARCINOMAAD. CARCINOMA SARCOMASARCOMA LYMPHOMALYMPHOMA
XANTHELASMAXANTHELASMA
HYPERCHOLESTEROLEMIA HYPERCHOLESTEROLEMIA DM DM REPRODUCTION WOMANREPRODUCTION WOMAN LOC : LOC : CANTUS INTERNAL CANTUS INTERNAL PAL PAL
PEBRAE XANTHELASMAPEBRAE XANTHELASMA FOAMY CELLS FOAMY CELLS MICRO INTRA CYTOMICRO INTRA CYTO
PLASMA VACUOLE.PLASMA VACUOLE.
NEUROFIBROMANEUROFIBROMA
SINGLE OR MULTIPLE SINGLE OR MULTIPLE NEUROFIBRONEUROFIBRO
MATOSIS (VON RECKING HAUSEN.D)MATOSIS (VON RECKING HAUSEN.D) LOC. LOC. PALPEBRAEPALPEBRAE OTHER SITE (+)OTHER SITE (+)
PAPILLOMAPAPILLOMA STOLK (+) STOLK (+) SQ.EPITH.CELL SQ.EPITH.CELL PROLIFERATION PROLIFERATION
LYMPHANGIOMALYMPHANGIOMA
LESS COMMONLESS COMMON LYMPH VESSELLYMPH VESSEL PROLIFERATION PROLIFERATION LUMPLUMP
NEVUSNEVUS
EPITHELIAL CELLSEPITHELIAL CELLS NEVI CELLSNEVI CELLS TYPETYPE : - INTRA DERMAL: - INTRA DERMAL
- JUNCTIONAL- JUNCTIONAL
- COMPOUND- COMPOUND
BOWEN DIASEASEBOWEN DIASEASE
INTRA EPITHELIAL NEOPLASMINTRA EPITHELIAL NEOPLASM CA INSITUCA INSITU ATIPICAL CELLSATIPICAL CELLS PLEOMORFISMPLEOMORFISM UNCOMMONUNCOMMON
SQUAMOUS CELL CASQUAMOUS CELL CA
EPITHELIAL CELLSEPITHELIAL CELLS FORM : - NON KERATINIZINGFORM : - NON KERATINIZING
- KERATINIZING- KERATINIZING PLEOMORFISM CELLSPLEOMORFISM CELLS HYPERCHROMATIC NUCLEUSHYPERCHROMATIC NUCLEUS KERATIN (+/-) KERATIN (+/-)
BASAL CELL CABASAL CELL CA
BASAL CELLSBASAL CELLS MONOTONMONOTON NUCLEUS NUCLEUS BASOPHYLIC BASOPHYLIC STRANDSTRAND PALISADE (+)PALISADE (+)
MALIGNANT MELANOMAMALIGNANT MELANOMA
UVEAL MELANOMAUVEAL MELANOMA MELANOCYTE OR NEVI CELLSMELANOCYTE OR NEVI CELLS CHOROID (COMMON SITE)CHOROID (COMMON SITE) TYPE : MELANOCYTE/AMELANOCYTETYPE : MELANOCYTE/AMELANOCYTE MACRMACR : - CIRCUMSCRIBED: - CIRCUMSCRIBED
- INV.BRUCH’S MEMBRANE- INV.BRUCH’S MEMBRANE MICRMICR: - SPINDLE CELLS : - SPINDLE CELLS
- POLYGONAL CELLS- POLYGONAL CELLS
- EPITHELOID CELLS- EPITHELOID CELLS
ADENO CARCINOMAADENO CARCINOMA
GLAND PATERNGLAND PATERN UNCOMMONUNCOMMON DIFFERENTIATED :DIFFERENTIATED :
- WELL- WELL
- MODERATE- MODERATE
- POORLY- POORLY
SARCOMASARCOMA
CONNECTIVE TISSUECONNECTIVE TISSUE RHABDO/LEIOMYO SARHABDO/LEIOMYO SA FIBRO SAFIBRO SA LIPO SALIPO SA
LYMPHOMALYMPHOMA
LYMPHOID TISSUELYMPHOID TISSUE ROUND CELLSROUND CELLS MONOTONEMONOTONE TYPETYPE : - IMMATURE CELLS: - IMMATURE CELLS
- MATURE CELLS - MATURE CELLS
RETINOBLASTOMARETINOBLASTOMA
IMMATURE CELLSIMMATURE CELLS CHILD ( >> )CHILD ( >> ) FIRST 2 YRS OF LIFE FIRST 2 YRS OF LIFE BIRTH ( +/- )BIRTH ( +/- )
RETINOBLASTOMARETINOBLASTOMA
PATHPATH : - INTERNAL : - INTERNAL VITR.BODY VITR.BODY - EXTERNAL- EXTERNAL
CREAM COLOREDCREAM COLORED CALCIFIED CALCIFIED YELLOW YELLOW MICRMICR : - SMALL CELLS: - SMALL CELLS
- ROUND CELLS- ROUND CELLS - ROSET (+)- ROSET (+) - NECROSIS- NECROSIS - HEMORRHAGIC - HEMORRHAGIC
RETINOBLASTOMARETINOBLASTOMA
EARLY DIAG EARLY DIAG OPERATIVE OPERATIVE SURVIVAL ( 90 % )SURVIVAL ( 90 % ) UNTREATED UNTREATED FATAL FATAL INCIDENT 1/20000 (BIRTH)INCIDENT 1/20000 (BIRTH) FAMILIAL ( 5 – 10 % )FAMILIAL ( 5 – 10 % ) CHROMOSOME 13 (-) CHROMOSOME 13 (-) Q 14 BAND Q 14 BAND
RETINOBLASTOMARETINOBLASTOMA
CLINICCLINIC : : WHITE PUPILS ( LEUCORIA)WHITE PUPILS ( LEUCORIA) POOR VISIONPOOR VISION HYPEMIAHYPEMIA STARBISMUSSTARBISMUS REDRED PAINFUL EYEPAINFUL EYE
INTRAOCULAR PHOTOGRAPH OF AN INTRAOCULAR PHOTOGRAPH OF AN ISOLATED ISOLATED
"ENDOPHYTIC" RETINOBLASTOMA"ENDOPHYTIC" RETINOBLASTOMA
GLIOMA NERVE OPTICUSGLIOMA NERVE OPTICUS
UNCOMMONUNCOMMON CHILD AND ADULTCHILD AND ADULT NEUROFIBROMATOSIS NEUROFIBROMATOSIS GLIOMA GLIOMA VISION VISION << (PROGRESIVA) << (PROGRESIVA) PROPTOSISPROPTOSIS PAPIL EDEMA PAPIL EDEMA MICRMICR : - ASTROSITOMA LIKE CELLS: - ASTROSITOMA LIKE CELLS
- WELL DIFFERENTIATED- WELL DIFFERENTIATED SURGICAL AND RADIOTH/ SURGICAL AND RADIOTH/ OK OK 5 YSR 5 YSR 90 % 90 %
METASTATIC NEOPLASMMETASTATIC NEOPLASM
MORE COMMON X PRIMERMORE COMMON X PRIMER PRIMER LESSION :PRIMER LESSION :
- LEUKEMIA- LEUKEMIA
- BREAST CA- BREAST CA
- LUNG CA- LUNG CA DIAG : DIAG : AFTER DEATH AFTER DEATH
top related