pb09207223 张馨元 pb10206066 张希良 pb10207016 高绪远 nano-dendrimers used in drug delivery

Pb09207223 张馨元Pb10206066 张希良Pb10207016 高绪远

Nano-Dendrimers Used in Drug Delivery

OutlineWhy dendrimers?What is dendrimers?How it works?CytotoxicityConjecture

Structures for Drug Delivery Liner polymersLarger nanoparticlesLiposomes

http://www.sciencedirect.com/science/article/pii/S1740674905000107http://trialx.com/curetalk/2012/10/nanotechnology-drug-delivery-systems-an-insight/https://sitn.hms.harvard.edu/sitnflash_wp/2011/06/materials-for-drug-delivery/

What is dendrimers?

Dendrimers are used as well-defined scaffolding or nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties.

What is dendrimers?

http://www.nanotechnologies.qc.ca/projects/nanopatterning/nanopatterning

What is dendrimers?

http://www.pharmainfo.net/reviews/dendrimer-overview

What is dendrimers?

Anupa R. Menjoge et. al, Drug Discovery Today, 2010

How it works?

CytotoxicityConcentrationGenerationSurface charge dependent

Conjecture

?

Hybrid treeIf we combine two of the branches of the

core with some other small molecules which can be easily hydrolyzed to release the active site of the core…

Parrott, M. C.; Benhabbour, S. R.; Saab, C.; Lemon, J. A.; Parker, S.; Valliant, J. F.; Adronov, A. J. Am. Chem. Soc. 2009, 131, 2906-2916.

Sub-Hybrid TreeIf we add some other surface molecules

which can combine the pre- surface, When the generation is over 4…

New cocktail?We know that the release of physically

entrapped guest-type drugs in dendrimeric hosts might be controlled by both surface modification and the density of modifying groups.

Well , what can we do?

Thanks!