presentation on cancer

CANCER

Shantanu Sen Product Specialist The Himalaya Drug Company

WHAT IS CANCER ?

TYPES OF TUMORS

TYPES OF CANCER

• lung cancer• Breast cancer• Colon and rectal cancer• Endometrial cancer• Pancreatic cancer• Kidney cancer• Prostrate cancer• Thyroid cancer• leukemia

KINDS OF CANCERS

NAMING OF CANCER

ETIOLOGY

Environmental factors• Tobacco• Alcohol• Dietary Factors• Occupational exposures• Viruses• Parasites• Customs ,habits, Lifestyles• Others – sunlight, pollution,

drugs

GeneticEg• Retinoblastoma in Children• Leukemia in Mongols

CAUSES OF CANCER

Factors Believed to Contribute to Global Causes of Cancer

EPIDEMOLOGY OF CANCER

2013 ESTIMATES

CANCER CAUSES IN DEVELOPED AND DEVELOPING ECONOMIES

Cancer scenario in India

Year wise total cancer prevalence in India [ICMR, 2006; ICMR, 2009]

ETIOLOGICAL FACTORS FOR DIFFERENT CANCERS IN INDIA

SMOKING & HOOKAH

BIDI & HOOKAH SMOKING

SMOKED MEAT,TOBACCO, HOOKAH

BETEL NUT,PANMASALA, ALCOHOL

BETEL CHEWING

PAN MASALA AND ALCOHOL

NUCLEAR POLLUTION

AIR POLLUTION

PAN MASALA & GUTKA

Etiological factors for the prevalence of different cancers in India [Koul et al, 2010; ICMR, 2001;Somdatta et al, 2008; Sharma et al, 2009; Gaur et al, 2006; Prasad et al, 2005; Malothu et al, 2010; Sumathi et al, 2009; (b): http//

TOBACCO USE IN DIFFERENT FORM

TUIBUR

GALL STONES

COMPARISON OF CANCERINDIA WITH GLOBAL SCENARIO

• 2020- 10 million deaths,70% in developing countries ( Murray et al,1996)

• Incidence in India less than developed countries (Fenley et al ,2001)

• Lung cancer worldwide 14%,all of india 6.8%(Nandakumar,2001)

• South east asian countries including India, lower rates of stomach cancer (Parkin et al,1999,WHO,2001),mizoram shows increased no cases ( Hadjiiski et al, 2006)

Pathogenesis Of Cancer

Management Of Cancer

• Surgery• Radiotherapy• Chemotherapy• Immunotherapy• Hormone therapy• Gene therapy• Cancer-specific immune system cells to treat

cancer

Preventive measures of cancer

o physical activities

o avoiding obesities

o healthy dietary practices

o reducing occupational and environmental exposures

o reducing alcohol uses

o immunization against hepatitis B virus

o safe sexual practices for avoiding cancer genesis

RECENT STUDIES

• Lifestyle changes reduce the risk of prostate cancer( published in the journal Nutrition and Cancer, was carried out by researchers at UCLA's Jonsson Comprehensive Cancer Center (JCCC).)

• Researchers Aiming To Suppress Therapy Resistance In Brain Cancer (http://www.medicalnewstoday.com/releases/262571.php)

• Fish Oils Reduce Risk Of Breast Cancer (http://www.medicalnewstoday.com/articles/262612.php)

Life style changes reduce the risk of prostate cancer (Nutrition and Cancer" Lenore Arab, PhD, et al. Nutrition and Cancer Jun-2013)

• Focuses on 8 new lifestyle recommendation by WCRF

• Encouraged physical activity and consumption of food low in caloric density(under 125kcal/100 grams of food)

• who followed less than 4 recommendation at higher risk(38%)

Research aiming to suppress therapy resistance in brain cancer (Helmholtz Association of German Research Centres.  Medical News Today.

MediLexicon, Intl., 29 Jun. 2013. Web)

• Gliomas are malignant brain tumors, treatment combines radiotherapy with anticancer drug temozolomide

• Some cases shows resistance , DNA repair mechanism aided by NAD+ molecule

• QRTP enzyme break down quinolinic acid to NAD+ molecule

• Agent directed against enzyme help suppress therapy resistance in brain

Fish oil reduces the risk of breast cancer (Nordqvist, Joseph.

"Fish Oils Reduce Risk Of Breast Cancer." Medical News Today. MediLexicon, Intl., 28 Jun. 2013. Web.)

• Links fish,n-3PUFA intake and risk of breast cancer

• Marine n-3PUFA intake associated with 14% reduced risk of breast cancer

• For every 0.1g/day increase in consumption ,risk reduced by 5%

Anticancer Drugs With Their MOA

Schematic Representation Of MOA

Limitations Of Presently Available Drugs• Myelotoxicity

• Alopecia • loss of appetite & weight

• nausea & vomitus

• taste change

• stomatitis, esophagitis, constipation, diarrhea

•Cardiotoxicity

•Neurotoxicity

•lung damage

•sterility & teratogenicity

•hepatotoxicity & nefrotoxicity

•↓ wound healing •↓ growth (children)

•carcinogenicity

Anticancer Drugs In The Market

Market share of Anticancer Drug Makers

Growth In Cancer Market

REFERENCE

• All about cancer http://www.medicalnewstoday.com/info/cancer-oncology/

• Imran Ali,Waseem A. Wani and Kishwar Saleem,( 2011)Cancer Scenario in India with Future Perspectives, Cancer Therapy Vol 8, 56-70

• National cancer institute, http://www.cancer.gov/

• Gobal cancer facts and figures, http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-027766.pdf

THANK YOU