Analytic Chemistry

Spring, 2008 by

駱碧秀老師

• 醫學一 A ： 13:10-14:00 (Mon. at E307) & 8:10-10:10 (Tue. at C108)

• 醫學一 B ： 10:10-12:00 (Tue. at C107) & 13:10-14:00 (Wed. at E307)• Office ： 醫學大樓 6F，自然科共同實驗室，分機： 5018

• 教學網站： http://memo.cgu.edu.tw/bih-show/

• E-mail: blou@mail.cgu.edu.tw

• Office Hours: Mon. Wed.17:10-18:30

Lecture & Assignment Schedule:Week Date Topics

1 2/25-27 Introduction & Naming Compounds 2 3/03-05 Chapter 3 Math Toolkit3 3/10-12 Chapter 4 Statistics4 3/17-19 Chapter 9~10 Buffers & Titrations 5 3/24-26 Chapter 11 Polyprotic Acids & Bases6 4/01 期中考 I (18:00)7 4/07-09 Chapter 18 Let There Be Light 8 4/14-16 Chapter 19 Spectrometry 9 4/21-23 Chapter 19 Spectrometry10 4/28-4/30 Chapter 14 Electrochemistry11 5/05-07 Chapter 15 Electrode Measurements12 5/13 期中考 II (18:00)13 5/19-21 Chapter 13 Coordination Chemistry & EDTA Titrations 14 5/26-28 Chapter 21 Principles of Chromatography15 6/02-04 Chapter 21 Principles of Chromatography16 6/09-11 Chapter 22 GC & LC17 6/16-18 Chapter 23 Capillary Electrophoresis18 06/23 期末考 (18:00)

Text Book

Daniel C. Harris,

“Exploring Chemical Analysis”,

3rd Edition, 2005 by W.H. Freeman & Company.

Grade:

•課程參與度（含小考） : 10%

•期中考 : 30%

•期末考 : 30%

「成績，不只是在於你知道什麼，而在於你表現什麼。」

成功法則第一招：一定要來上課！

For most its users, analytical chemistry is a tool – not an end in itself.

If you are interested in biology, medicine, environmental science, geology, oceanography, or archeology, you will rely on chemical analyses to answer important questions.

It is possible that you will make measurements yourself, but it is more likely that you will simply be a consumer of analytical results.

What Am I Doing in This Course?

Goals of this course

(1) To understand how analysts derive the results that you will use.

(2) To understand the limitations (the uncertainties) of the results.

(3) To develop laboratory skills and careful work habits that you can apply in your field.

This course will help you, as an informed citizen

To appreciate how quantitative information is obtained and interpreted.

And it should help give you a basis for positive actions in your own field of interest.

How do you measure the caffeine content of a chocolate bar ?

Extracting fat from chocolate

Centrifugation & Filtration

Chemical Analysis

Calibration

Results:

FYI:

General Steps in a Chemical Analysis

1) Formulation the question

2) Selecting analytical procedures

3) Sampling

4) Sample preparation

5) Analysis

6) Reporting & interpretation

7) Drawing conclusions

Atomic elements

WebElements™ periodic table

• http://www.webelements.com/

Naming Simple Compounds IUPAC - I

1. Binary compounds (Type I ; ionic)1) cation + anion (ide)

Left right

2) See p.35 rules & examples : NaCl

3) Table 2.3 sodium chlorine ide

2. Binary compounds (Type II ; ionic)– for metals with more than one type of ion– Table 2.4 -ic / -ous– exception : IA , IIA , Al3+ , Zn2+ , Ag+

Naming Simple Compounds IUPAC - II

3. Polyatomic ions1) NH4NO3 NH4

+ + NO3-

2) Table 2.5 (memorized !!)

3) O : hypo- / -ite / -ate / per-

4. Binary compounds (Type III ; covalent : nonmetals)– see p.39-40 for rules & examples

– H2O (water) , NH3 (ammonia) , CH4 (methane)

– Table 2.6

Naming chemical compounds

Naming acids

Chapter 1 Chemical Measurements

• Microelectrode by Optical Micrograph

SI units

Ex: Exocytosis of Neurotransmitters

• ppm = 106(mass of substance/mass of sample)• ppb = 109(mass of substance/mass of sample)

• 1ppm ～ 1ug/mL

• 1ppb ～ 1 ng/mL